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UniProtKB - O82233 (IF4G2_ARATH)

Entry version 117 (02 Dec 2020)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
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Protein

Eukaryotic translation initiation factor isoform 4G-2

Gene

EIF(ISO)4G2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the accumulation of some potyvirus during viral infection.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis, Translation regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor isoform 4G-2
Short name:
eIF(iso)4G-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF(ISO)4G2
Ordered Locus Names:At2g24050
ORF Names:T29E15.25
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT2G24050

The Arabidopsis Information Resource

More...TAIRi		locus:2061370, AT2G24050

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Displays no resistance to potyvirus. Possesses reduced amounts of chlorophyll a and b. I4g1 and i4g2 double mutants show reduced germination rates, slow growth rates, moderate chlorosis, late flowering, impaired fertility and reduced long term seed viability. They also exhibit altered responses to dehydration, salinity, and heat stress. The i4g1 and i4g2 double mutant has reduced amounts of chlorophyll a and b.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004205431 – 747Eukaryotic translation initiation factor isoform 4G-2Add BLAST747

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O82233

PRoteomics IDEntifications database

More...PRIDEi		O82233

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		232202

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O82233

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O82233, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O82233, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

EIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. In higher plants two isoforms of EIF4F have been identified, named isoform EIF4F and isoform EIF(iso)4F. Isoform EIF4F has subunits p220 and p26, whereas isoform EIF(iso)4F has subunits p82 and p28.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		2291, 3 interactors

Protein interaction database and analysis system

More...IntActi		O82233, 3 interactors

STRING: functional protein association networks

More...STRINGi		3702.AT2G24050.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O82233

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini176 – 400MIF4GPROSITE-ProRule annotationAdd BLAST225
Domaini582 – 704MIPROSITE-ProRule annotationAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 19Poly-Gly5
Compositional biasi29 – 33Poly-Ser5
Compositional biasi436 – 440Poly-Asn5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic initiation factor 4G family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0401, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021872_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O82233

Identification of Orthologs from Complete Genome Data

More...OMAi		ENAILQP

Database of Orthologous Groups

More...OrthoDBi		594395at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O82233

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.180, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51366, MI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O82233-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQQQGEPSVL SLRPGGGGGK SRLFVPRFSS SSSFDLTNGG SEETPFPVKR 
        60         70         80         90        100
ENSGERVRFS REEILQHRES VQVSDEILRR CKEIAVELFG EEQSWGNHAA 
       110        120        130        140        150
ESKITNHTQH RHTETDNRDW HSRSQIPTSG KEWLRDDPRE AKSTWQGSGP 
       160        170        180        190        200
TPVLIKAEVP WSAKRGALSD KDRVVKSVKG ILNKLTPEKY ELLKGQLIDA 
       210        220        230        240        250
GITSADILKE VIQLIFENAI LQPTFCEMYA LLCFDINGQL PSFPSEEPGG 
       260        270        280        290        300
KEITFKRVLL NNCQEAFEGA GKLKEEIRQM TNPDQEMERM DKEKMAKLRT 
       310        320        330        340        350
LGNIRLIGEL LKQKMVPEKI VHHIVQELLG DDTKACPAEG DVEALCQFFI 
       360        370        380        390        400
TIGKQLDDSP RSRGINDTYF GRLKELARHP QLELRLRFMV QNVVDLRANK 
       410        420        430        440        450
WVPRREEVKA KKINEIHSEA ERNLGMRPGA MASMRNNNNN RAAVSGAADG 
       460        470        480        490        500
MGLGNILGRP GTGGMMPGMP GTRVMPMDED GWEMARTRSM PRGNRQTVQQ 
       510        520        530        540        550
PRFQPPPAIN KSLSVNSRLL PQGSGGLLNG GGRPSPLLQG NGSSSAPQAS 
       560        570        580        590        600
KPIPTVEKPQ PRSQPQPQPQ AAPLANSLNA GELERKTKSL LEEYFSIRLV 
       610        620        630        640        650
DEALQCVEEL KSPSYHPELV KETISLGLEK NPPLVEPIAK LLKHLISKNV 
       660        670        680        690        700
LTSKDLGAGC LLYGSMLDDI GIDLPKAPNS FGEFLGELVS AKVLDFELVR 
       710        720        730        740 
DVLKKMEDEW FRKTVLNAVI KSVRECPSGQ SVLDSQAVEV EACQSLL
Length:747
Mass (Da):82,890
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7AFC0731A8341FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti576N → D in AAL32572 (PubMed:14593172).Curated1
Sequence conflicti576N → D in AAN72098 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC005170 Genomic DNA Translation: AAC63673.1
CP002685 Genomic DNA Translation: AEC07523.1
AY062494 mRNA Translation: AAL32572.1
BT002087 mRNA Translation: AAN72098.1

Protein sequence database of the Protein Information Resource

More...PIRi		A84632

NCBI Reference Sequences

More...RefSeqi		NP_179983.1, NM_127967.4

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT2G24050.1; AT2G24050.1; AT2G24050

Database of genes from NCBI RefSeq genomes

More...GeneIDi		816939

Gramene; a comparative resource for plants

More...Gramenei		AT2G24050.1; AT2G24050.1; AT2G24050

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT2G24050

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005170 Genomic DNA Translation: AAC63673.1
CP002685 Genomic DNA Translation: AEC07523.1
AY062494 mRNA Translation: AAL32572.1
BT002087 mRNA Translation: AAN72098.1
PIRiA84632
RefSeqiNP_179983.1, NM_127967.4

3D structure databases

SMRiO82233
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi2291, 3 interactors
IntActiO82233, 3 interactors
STRINGi3702.AT2G24050.1

PTM databases

iPTMnetiO82233

Proteomic databases

PaxDbiO82233
PRIDEiO82233
ProteomicsDBi232202

Genome annotation databases

EnsemblPlantsiAT2G24050.1; AT2G24050.1; AT2G24050
GeneIDi816939
GrameneiAT2G24050.1; AT2G24050.1; AT2G24050
KEGGiath:AT2G24050

Organism-specific databases

AraportiAT2G24050
TAIRilocus:2061370, AT2G24050

Phylogenomic databases

eggNOGiKOG0401, Eukaryota
HOGENOMiCLU_021872_0_0_1
InParanoidiO82233
OMAiENAILQP
OrthoDBi594395at2759
PhylomeDBiO82233

Miscellaneous databases

Protein Ontology

More...PROi		PR:O82233

Gene expression databases

ExpressionAtlasiO82233, baseline and differential
GenevisibleiO82233, AT

Family and domain databases

Gene3Di1.25.40.180, 2 hits
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
PfamiView protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
SMARTiView protein in SMART
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS51366, MI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF4G2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O82233
Secondary accession number(s): Q8W4L4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: November 1, 1998
Last modified: December 2, 2020
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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