UniProtKB - O82144 (CHSY_HYDMC)
Protein
Chalcone synthase
Gene
CHS
Organism
Hydrangea macrophylla (Bigleaf hydrangea) (Viburnum macrophyllum)
Status
Functioni
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
Catalytic activityi
- 4-coumaroyl-CoA + 2 H+ + 3 malonyl-CoA = 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoAPROSITE-ProRule annotationEC:2.3.1.74PROSITE-ProRule annotation
: flavonoid biosynthesis Pathwayi
This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 164 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- naringenin-chalcone synthase activity Source: UniProtKB-EC
GO - Biological processi
- flavonoid biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Flavonoid biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00154 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CHS |
Organismi | Hydrangea macrophylla (Bigleaf hydrangea) (Viburnum macrophyllum) |
Taxonomic identifieri | 23110 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › Cornales › Hydrangeaceae › Hydrangeeae › Hydrangea › Hydrangea sect. Macrophyllae |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215981 | 1 – 389 | Chalcone synthaseAdd BLAST | 389 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR012328, Chalcone/stilbene_synth_C IPR018088, Chalcone/stilbene_synthase_AS IPR001099, Chalcone/stilbene_synthase_N IPR011141, Polyketide_synthase_type-III IPR016039, Thiolase-like |
PANTHERi | PTHR11877, PTHR11877, 1 hit |
Pfami | View protein in Pfam PF02797, Chal_sti_synt_C, 1 hit PF00195, Chal_sti_synt_N, 1 hit |
PIRSFi | PIRSF000451, PKS_III, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
PROSITEi | View protein in PROSITE PS00441, CHALCONE_SYNTH, 1 hit |
i Sequence
Sequence statusi: Complete.
O82144-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVTVEEVRKA QRAEGPATIL AIGTATPPNY VDQSTYPDFY FRVTNSEHKK
60 70 80 90 100
ELKAKFQRMC DNSQIKKRYM HLTEEILKEN PNICAYMAPS LDARQDMVVV
110 120 130 140 150
EIPKLGKEAA TRAIKEWGQP KSKITHLVFC TTSGVDMPGA DYQLTKLLGL
160 170 180 190 200
RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITAVTFRG
210 220 230 240 250
PSDTHLDSLV GQALFGDGAA AVIIGSDPMP EVEKPLFEIV SAAQTILPDS
260 270 280 290 300
DGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLVEAFRPL DISDWNSIFW
310 320 330 340 350
IAHPGGPAIL DQVEKKLALK PEKLRATRNV LSDYGNMSSA CVLFIMDEMR
360 370 380
KNSAEEGLMT TGEGLEWGVL FGFGPGLTVE TVVLHGVST
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011467 mRNA Translation: BAA32732.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011467 mRNA Translation: BAA32732.1 |
3D structure databases
SMRi | O82144 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00154 |
Family and domain databases
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR012328, Chalcone/stilbene_synth_C IPR018088, Chalcone/stilbene_synthase_AS IPR001099, Chalcone/stilbene_synthase_N IPR011141, Polyketide_synthase_type-III IPR016039, Thiolase-like |
PANTHERi | PTHR11877, PTHR11877, 1 hit |
Pfami | View protein in Pfam PF02797, Chal_sti_synt_C, 1 hit PF00195, Chal_sti_synt_N, 1 hit |
PIRSFi | PIRSF000451, PKS_III, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
PROSITEi | View protein in PROSITE PS00441, CHALCONE_SYNTH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CHSY_HYDMC | |
Accessioni | O82144Primary (citable) accession number: O82144 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1998 | |
Last modified: | October 7, 2020 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families