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Protein

Proliferating cell nuclear antigen

Gene

PCNA

Organism
Pisum sativum (Garden pea)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi61 – 80Sequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cell nuclear antigen
Gene namesi
Name:PCNA
OrganismiPisum sativum (Garden pea)
Taxonomic identifieri3888 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaePisum

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491851 – 266Proliferating cell nuclear antigenAdd BLAST266

Proteomic databases

PRIDEiO82134

Structurei

3D structure databases

ProteinModelPortaliO82134
SMRiO82134
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.Curated

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
PS00293 PCNA_2, 1 hit

Sequencei

Sequence statusi: Complete.

O82134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELRLVQGS LLKKVLESIK ELVNDANFDC SSTGFSLQAM DSSHVALVAL
60 70 80 90 100
LLRSEGFEHY RCDRNLSMGM NLNNMAKMLK CAGNDDIITI KADDGSDTVT
110 120 130 140 150
FMFESPTQDK ISDFEMKLMD IDSEHLGIPE AEYHAIVRMP SAEFARICKD
160 170 180 190 200
LSSIGDTVVI AVSKEGVKFS TKGDIGSANI VCRQNTTVDK PEEATVIEMN
210 220 230 240 250
EPVALQFALR YMNSFTKATP LSSSVTISLS NELPVVVEYK IAEMGYVRFY
260
LAPKIEEDEE ETKPQA
Length:266
Mass (Da):29,474
Last modified:November 1, 1998 - v1
Checksum:iE61D2130D1B112B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008186 mRNA Translation: BAA33151.1
Y16796 mRNA Translation: CAA76392.1

Similar proteinsi

Entry informationi

Entry nameiPCNA_PEA
AccessioniPrimary (citable) accession number: O82134
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1998
Last modified: October 25, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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