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Protein

Dehydration-responsive element-binding protein 2A

Gene

DREB2A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi78 – 135AP2/ERFPROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: TAIR
  • sequence-specific DNA binding Source: TAIR
  • transcription regulatory region DNA binding Source: TAIR

GO - Biological processi

  • heat acclimation Source: TAIR
  • positive regulation of transcription, DNA-templated Source: GO_Central
  • response to heat Source: TAIR
  • response to hydrogen peroxide Source: TAIR
  • response to UV-B Source: TAIR
  • response to water deprivation Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processStress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydration-responsive element-binding protein 2A
Short name:
Protein DREB2A
Gene namesi
Name:DREB2A
Synonyms:ERF045
Ordered Locus Names:At5g05410
ORF Names:K18I23.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G05410
TAIRilocus:2153504 AT5G05410

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi91V → A: Affects the binding to the CRT/DRE cis-element. 1 Publication1
Mutagenesisi96E → D: Affects the binding to the CRT/DRE cis-element. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001125341 – 335Dehydration-responsive element-binding protein 2AAdd BLAST335

Post-translational modificationi

Ubiquitinated by DRIP1 and DRIP2. Ubiquitination probably leads to its subsequent degradation, thus negatively regulating response to drought.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiO82132

Expressioni

Tissue specificityi

Expressed preferentially in roots and stems, and at a lower level in leaves.2 Publications

Inductioni

By high-salt and drought stresses.3 Publications

Gene expression databases

ExpressionAtlasiO82132 baseline and differential
GenevisibleiO82132 AT

Interactioni

Subunit structurei

Interacts with MED25.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi15703, 9 interactors
DIPiDIP-40571N
IntActiO82132, 31 interactors
STRINGi3702.AT5G05410.1

Structurei

3D structure databases

ProteinModelPortaliO82132
SMRiO82132
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi19 – 55Nuclear localization signalSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi230 – 234Poly-Gln5

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IXVH Eukaryota
ENOG410YKCQ LUCA
HOGENOMiHOG000015215
InParanoidiO82132
KOiK09286
OMAiNGAYTHE
OrthoDBiEOG09360JWK
PhylomeDBiO82132

Family and domain databases

CDDicd00018 AP2, 1 hit
Gene3Di3.30.730.10, 1 hit
InterProiView protein in InterPro
IPR001471 AP2/ERF_dom
IPR036955 AP2/ERF_dom_sf
IPR016177 DNA-bd_dom_sf
PfamiView protein in Pfam
PF00847 AP2, 1 hit
PRINTSiPR00367 ETHRSPELEMNT
SMARTiView protein in SMART
SM00380 AP2, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS51032 AP2_ERF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O82132-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVYDQSGDR NRTQIDTSRK RKSRSRGDGT TVAERLKRWK EYNETVEEVS
60 70 80 90 100
TKKRKVPAKG SKKGCMKGKG GPENSRCSFR GVRQRIWGKW VAEIREPNRG
110 120 130 140 150
SRLWLGTFPT AQEAASAYDE AAKAMYGPLA RLNFPRSDAS EVTSTSSQSE
160 170 180 190 200
VCTVETPGCV HVKTEDPDCE SKPFSGGVEP MYCLENGAEE MKRGVKADKH
210 220 230 240 250
WLSEFEHNYW SDILKEKEKQ KEQGIVETCQ QQQQDSLSVA DYGWPNDVDQ
260 270 280 290 300
SHLDSSDMFD VDELLRDLNG DDVFAGLNQD RYPGNSVANG SYRPESQQSG
310 320 330
FDPLQSLNYG IPPFQLEGKD GNGFFDDLSY LDLEN
Length:335
Mass (Da):37,703
Last modified:November 1, 1998 - v1
Checksum:i9742CE579CC7314C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MSB1A8MSB1_ARATH
DRE-binding protein 2A
DREB2A DRE-binding protein 2A, DREB2, At5g05410, K18I23.22, K18I23_22
302Annotation score:

Sequence cautioni

The sequence AAU93685 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162V → M in AAU93685 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007790 mRNA Translation: BAA33794.1
AB016570 Genomic DNA Translation: BAA36705.1
AB010692 Genomic DNA Translation: BAB09984.1
CP002688 Genomic DNA Translation: AED90870.1
AY063972 mRNA Translation: AAL36328.1
AY691903 Genomic DNA Translation: AAU93685.1 Sequence problems.
PIRiT51833
RefSeqiNP_196160.1, NM_120623.3 [O82132-1]
UniGeneiAt.25247

Genome annotation databases

EnsemblPlantsiAT5G05410.1; AT5G05410.1; AT5G05410 [O82132-1]
GeneIDi830424
GrameneiAT5G05410.1; AT5G05410.1; AT5G05410 [O82132-1]
KEGGiath:AT5G05410

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007790 mRNA Translation: BAA33794.1
AB016570 Genomic DNA Translation: BAA36705.1
AB010692 Genomic DNA Translation: BAB09984.1
CP002688 Genomic DNA Translation: AED90870.1
AY063972 mRNA Translation: AAL36328.1
AY691903 Genomic DNA Translation: AAU93685.1 Sequence problems.
PIRiT51833
RefSeqiNP_196160.1, NM_120623.3 [O82132-1]
UniGeneiAt.25247

3D structure databases

ProteinModelPortaliO82132
SMRiO82132
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi15703, 9 interactors
DIPiDIP-40571N
IntActiO82132, 31 interactors
STRINGi3702.AT5G05410.1

Proteomic databases

PaxDbiO82132

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G05410.1; AT5G05410.1; AT5G05410 [O82132-1]
GeneIDi830424
GrameneiAT5G05410.1; AT5G05410.1; AT5G05410 [O82132-1]
KEGGiath:AT5G05410

Organism-specific databases

AraportiAT5G05410
TAIRilocus:2153504 AT5G05410

Phylogenomic databases

eggNOGiENOG410IXVH Eukaryota
ENOG410YKCQ LUCA
HOGENOMiHOG000015215
InParanoidiO82132
KOiK09286
OMAiNGAYTHE
OrthoDBiEOG09360JWK
PhylomeDBiO82132

Miscellaneous databases

PROiPR:O82132

Gene expression databases

ExpressionAtlasiO82132 baseline and differential
GenevisibleiO82132 AT

Family and domain databases

CDDicd00018 AP2, 1 hit
Gene3Di3.30.730.10, 1 hit
InterProiView protein in InterPro
IPR001471 AP2/ERF_dom
IPR036955 AP2/ERF_dom_sf
IPR016177 DNA-bd_dom_sf
PfamiView protein in Pfam
PF00847 AP2, 1 hit
PRINTSiPR00367 ETHRSPELEMNT
SMARTiView protein in SMART
SM00380 AP2, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS51032 AP2_ERF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDRE2A_ARATH
AccessioniPrimary (citable) accession number: O82132
Secondary accession number(s): Q5Y4C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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