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Protein

Peroxidase 46

Gene

PER46

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei65Transition state stabilizerPROSITE-ProRule annotation1
Active sitei69Proton acceptorPROSITE-ProRule annotation1
Metal bindingi70Calcium 1PROSITE-ProRule annotation1
Metal bindingi73Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi75Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi77Calcium 1PROSITE-ProRule annotation1
Metal bindingi79Calcium 1PROSITE-ProRule annotation1
Metal bindingi192Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi193Calcium 2PROSITE-ProRule annotation1
Metal bindingi246Calcium 2PROSITE-ProRule annotation1
Metal bindingi249Calcium 2PROSITE-ProRule annotation1
Metal bindingi254Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G31760-MONOMER

Protein family/group databases

PeroxiBasei212 AtPrx46

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 46 (EC:1.11.1.7)
Short name:
Atperox P46
Alternative name(s):
ATP48
Gene namesi
Name:PER46
Synonyms:P46
Ordered Locus Names:At4g31760
ORF Names:F28M20.50
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G31760

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000002371228 – 326Peroxidase 46Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi38 ↔ 114PROSITE-ProRule annotation
Disulfide bondi71 ↔ 76PROSITE-ProRule annotation
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi120 ↔ 322PROSITE-ProRule annotation
Disulfide bondi199 ↔ 233PROSITE-ProRule annotation
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO81772

Expressioni

Gene expression databases

ExpressionAtlasiO81772 baseline and differential
GenevisibleiO81772 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G31760.1

Structurei

3D structure databases

ProteinModelPortaliO81772
SMRiO81772
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE9G Eukaryota
ENOG410Y94T LUCA
HOGENOMiHOG000237556
InParanoidiO81772
KOiK00430
OrthoDBiEOG09360JGY
PhylomeDBiO81772

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O81772-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSYRINCS TLLHLLMFLS SLLTSSANLS FNFYASSCSV AEFLVRNTVR
60 70 80 90 100
SATSSDPTIP GKLLRLFFHD CFVQGCDASV LIQGNSTEKS DPGNASLGGF
110 120 130 140 150
SVIDTAKNAI ENLCPATVSC ADIVALAARD AVEAAGGPVV EIPTGRRDGK
160 170 180 190 200
ESMAANVRPN IIDTDFTLDQ MIDAFSSKGL SIQDLVVLSG AHTIGASHCN
210 220 230 240 250
AFNGRFQRDS KGNFEVIDAS LDNSYAETLM NKCSSSESSS LTVSNDPETS
260 270 280 290 300
AVFDNQYYRN LETHKGLFQT DSALMEDNRT RTMVEELASD EESFFQRWSE
310 320
SFVKLSMVGV RVGEDGEIRR SCSSVN
Length:326
Mass (Da):35,244
Last modified:November 1, 1998 - v1
Checksum:i1FC9CA566895967B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031004 Genomic DNA Translation: CAA19747.1
AL161579 Genomic DNA Translation: CAB79894.1
CP002687 Genomic DNA Translation: AEE85954.2
PIRiT05094
RefSeqiNP_194904.3, NM_119325.3

Genome annotation databases

EnsemblPlantsiAT4G31760.1; AT4G31760.1; AT4G31760
GeneIDi829304
GrameneiAT4G31760.1; AT4G31760.1; AT4G31760
KEGGiath:AT4G31760

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031004 Genomic DNA Translation: CAA19747.1
AL161579 Genomic DNA Translation: CAB79894.1
CP002687 Genomic DNA Translation: AEE85954.2
PIRiT05094
RefSeqiNP_194904.3, NM_119325.3

3D structure databases

ProteinModelPortaliO81772
SMRiO81772
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G31760.1

Protein family/group databases

PeroxiBasei212 AtPrx46

Proteomic databases

PaxDbiO81772

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G31760.1; AT4G31760.1; AT4G31760
GeneIDi829304
GrameneiAT4G31760.1; AT4G31760.1; AT4G31760
KEGGiath:AT4G31760

Organism-specific databases

AraportiAT4G31760

Phylogenomic databases

eggNOGiENOG410IE9G Eukaryota
ENOG410Y94T LUCA
HOGENOMiHOG000237556
InParanoidiO81772
KOiK00430
OrthoDBiEOG09360JGY
PhylomeDBiO81772

Enzyme and pathway databases

BioCyciARA:AT4G31760-MONOMER

Miscellaneous databases

PROiPR:O81772

Gene expression databases

ExpressionAtlasiO81772 baseline and differential
GenevisibleiO81772 AT

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER46_ARATH
AccessioniPrimary (citable) accession number: O81772
Secondary accession number(s): F4JSS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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