VLN1

Functionⁱ

Binds actin and actin filament bundles in a Ca²⁺/calmodulin-insensitive manner, but is unable to sever, cap, and nucleate actin filament formation in vitro. Does not protect individual filaments from severing by VLN3 (AC O81645).3 Publications

GO - Molecular functionⁱ

actin filament binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament bundle assembly Source: InterPro
actin filament capping Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin capping, Actin-binding
Ligand	Calcium

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Villin-11 Publication
Gene namesⁱ	Name:VLN11 Publication Ordered Locus Names:At2g29890Imported ORF Names:F6K5.2Imported, T27A16.1
Organismⁱ	Arabidopsis thaliana (Mouse-ear cress)
Taxonomic identifierⁱ	3702 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
Proteomesⁱ	UP000006548 Componentⁱ: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal More...Araportⁱ	AT2G29890

Araportⁱ

AT2G29890

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000218732	1 – 909	Villin-1Add BLAST		909

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	780	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	O81643
PRIDEⁱ	O81643

PTM databases

iPTMnetⁱ	O81643

iPTMnetⁱ

O81643

Expressionⁱ

Tissue specificityⁱ

Expressed in all tissues examined. Mainly detected in the vascular tissue and the pericycle of roots and in the vasculature of leaves. Not expressed in the root cap.2 Publications

Gene expression databases

ExpressionAtlasⁱ	O81643 baseline and differential
Genevisibleⁱ	O81643 AT

Interactionⁱ

GO - Molecular functionⁱ

actin filament binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	2889, 1 interactor
STRINGⁱ	3702.AT2G29890.3

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O81643
SMRⁱ	O81643
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	29 – 79	Gelsolin-like 1Sequence analysisAdd BLAST	51
Repeatⁱ	149 – 189	Gelsolin-like 2Sequence analysisAdd BLAST	41
Repeatⁱ	262 – 305	Gelsolin-like 3Sequence analysisAdd BLAST	44
Repeatⁱ	391 – 448	Gelsolin-like 4Sequence analysisAdd BLAST	58
Repeatⁱ	529 – 569	Gelsolin-like 5Sequence analysisAdd BLAST	41
Repeatⁱ	631 – 672	Gelsolin-like 6Sequence analysisAdd BLAST	42
Domainⁱ	844 – 909	HPPROSITE-ProRule annotationAdd BLAST	66

Sequence similaritiesⁱ

Belongs to the villin/gelsolin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0443 Eukaryota ENOG410XR0A LUCA
HOGENOMⁱ	HOG000233631
InParanoidⁱ	O81643
PhylomeDBⁱ	O81643

Family and domain databases

Gene3Dⁱ	1.10.950.10, 1 hit 3.40.20.10, 6 hits
InterProⁱ	View protein in InterPro IPR029006 ADF-H/Gelsolin-like_dom_sf IPR007123 Gelsolin-like_dom IPR030010 Villin-1-like_plant IPR007122 Villin/Gelsolin IPR003128 Villin_headpiece IPR036886 Villin_headpiece_dom_sf
PANTHERⁱ	PTHR11977 PTHR11977, 1 hit PTHR11977:SF25 PTHR11977:SF25, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00626 Gelsolin, 4 hits PF02209 VHP, 1 hit
PRINTSⁱ	PR00597 GELSOLIN
SMARTⁱ	View protein in SMART SM00262 GEL, 6 hits SM00153 VHP, 1 hit
SUPFAMⁱ	SSF47050 SSF47050, 1 hit
PROSITEⁱ	View protein in PROSITE PS51089 HP, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 1 isoform ⁱ produced by alternative splicing. Align Add to basket

Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: O81643-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRLSKDIDS AFQGVGTKSG LEIWCVYNKQ LISIPKSSFG KFHSGNAYLV 
        60         70         80         90        100
LRTFLRKIES PQYDIHYWLG IDANEVDSIL ASDKALDLDA ALGCCTVQYR 
       110        120        130        140        150
EVQGQETEKF LSYFKPCIIP VEGKYSPKTG IAGETYQVTL LRCKGDHVVR 
       160        170        180        190        200
VKEVPFLRSS LNHDDVFILD TASKVFLFAG CNSSTQEKAK AMEVVEYIKD 
       210        220        230        240        250
NKHDGRCEVA TIEDGKFSGD SDAGEFWSFF GGYAPIPKLS SSTTQEQTQT 
       260        270        280        290        300
PCAELFWIDT KGNLHPTGTS SLDKDMLEKN KCYMLDCHSE VFVWMGRNTS 
       310        320        330        340        350
LTERKTSISS SEEFLRKEGR STTTSLVLLT EGLENARFRS FFNKWPQTVE 
       360        370        380        390        400
SSLYNEGREK VAALFKQKGY DVEELPDEED DPLYTNCRDN LKVWRVDGDD 
       410        420        430        440        450
VSLLSIPDQT KLFTGDCYLV QYKYTYKERT EHLLYVWIGC ESIQQDRADA 
       460        470        480        490        500
ITNASAIVGT TKGESVLCHI YQGNEPSRFF PMFQSLVVFK GGLSRRYKVL 
       510        520        530        540        550
LAEKEKIGEE YNENKASLFR VVGTSPRNMQ AIQVNLVATS LNSSYSYILQ 
       560        570        580        590        600
YGASAFTWIG KLSSDSDHEV LDRMLYFLDT SCQPIYIREG NETDTFWNLL 
       610        620        630        640        650
GGKSEYPKEK EMRKQIEEPH LFTCSCSSDV LKVKEIYNFV QDDLTTEDVF 
       660        670        680        690        700
LLDCQSEVYV WIGSNSNIKS KEEALTLGLK FLEMDILEEG LTMRTPVYVV 
       710        720        730        740        750
TEGHEPPFFT RFFEWVPEKA NMHGNSFERK LASLKGKKTS TKRSSGSQYR 
       760        770        780        790        800
SQSKDNASRD LQSRSVSSNG SERGVSPCSS EKLLSLSSAE DMTNSSNSTP 
       810        820        830        840        850
VVKKLFSESL LVDPNDGVAR QESSSKSDIS KQKPRVGINS DLSSLESLAY 
       860        870        880        890        900
SYEQLRVDSQ KPVTDIDATR REAYLTEKEF EERFGMAKSE FYALPKWKQN 

KLKISLHLF

Length:909

Mass (Da):102,950

Last modified:May 15, 2007 - v2

Checksum:ⁱ4F04501BC4523FCC

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
F4ILN8	F4ILN8_ARATH	Villin-like 1 Villin-like 1	VLN1 ATVLN1, villin 1, villin-like 1, At2g29890, F6K5.2	933	Annotation score:
O82373	FK128_ARATH	F-box/kelch-repeat protein At2g2983... F-box/kelch-repeat protein At2g29830	At2g29830, T27A16.1	383	Annotation score:
Q2V445	Q2V445_ARATH	Villin-like 1 Villin-like 1	VLN1 ATVLN1, villin 1, villin-like 1, At2g29890, F6K5.2	911	Annotation score:
A0A1P8AZB7	A0A1P8AZB7_ARATH	Villin-like 1 Villin-like 1	VLN1 ATVLN1, villin 1, villin-like 1, At2g29890, F6K5.2	892	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	8	I → F in AAC31605 (PubMed:10631247).Curated	1
Sequence conflictⁱ	347 – 353	QTVESSL → SDRWSLAF in AAC31605 (PubMed:10631247).Curated	7
Sequence conflictⁱ	585	I → T in AAC31605 (PubMed:10631247).Curated	1
Sequence conflictⁱ	811	L → V in AAC31605 (PubMed:10631247).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF081201 mRNA Translation: AAC31605.1 AC007113 Genomic DNA Translation: AAD23629.2 CP002685 Genomic DNA Translation: AEC08315.1 CP002685 Genomic DNA Translation: ANM61989.1
PIRⁱ	H84701 T50671
NCBI Reference Sequences More...RefSeqⁱ	NP_001324173.1, NM_001336228.1 [O81643-1] NP_029567.1, NM_128543.4 [O81643-1]
UniGeneⁱ	At.11948

Genome annotation databases

EnsemblPlantsⁱ	AT2G29890.1; AT2G29890.1; AT2G29890 [O81643-1] AT2G29890.5; AT2G29890.5; AT2G29890 [O81643-1]
GeneIDⁱ	817539
Grameneⁱ	AT2G29890.1; AT2G29890.1; AT2G29890 [O81643-1] AT2G29890.5; AT2G29890.5; AT2G29890 [O81643-1]
KEGGⁱ	ath:AT2G29890

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O81643	Putative villin 1 VLN1		ARATH		718	UniRef90_O81643
Villin-like 1		ARATH		933
Villin-like 1		ARATH		911
Uncharacterized protein		ARATH		226
Villin-like 1		ARATH		892

Protein	Similar proteins		Species	Score	Length	Source
O81643	Putative villin 1 VLN1		ARATH		718	UniRef50_O81643
Villin headpiece		Macleaya cordata		933
Uncharacterized protein		EUTSA		929
Villin-1 (Fragment)		NOCCA		901
Predicted protein		ARALL		911
+19

Entry informationⁱ

Entry nameⁱ	VILI1_ARATH
Accessionⁱ	O81643Primary (citable) accession number: O81643 Secondary accession number(s): O82367, Q9SIK8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
	Last sequence update:	May 15, 2007
	Last modified:	May 23, 2018
	This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O81643 (VILI1_ARATH)

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Villin-1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ