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Protein

Probable ethanolamine kinase

Gene

EMB1187

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis (By similarity).By similarity

Catalytic activityi

ATP + ethanolamine = ADP + O-phosphoethanolamine.

Pathwayi: phosphatidylethanolamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable ethanolamine kinase (EMB1187)
  2. Ethanolamine-phosphate cytidylyltransferase (PECT1)
  3. Choline/ethanolaminephosphotransferase 2 (AAPT2), Choline/ethanolaminephosphotransferase 1 (AAPT1)
This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93ATPBy similarity1
Binding sitei252ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

  • phosphatidylethanolamine biosynthetic process Source: UniProtKB-UniPathway
  • phospholipid biosynthetic process Source: TAIR

Keywordsi

Molecular functionKinase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G26830-MONOMER
ReactomeiR-ATH-1483213 Synthesis of PE
UniPathwayi
UPA00558;UER00741

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ethanolamine kinase (EC:2.7.1.82)
Alternative name(s):
Protein EMBRYO DEFECTIVE 1187
Gene namesi
Name:EMB1187
Ordered Locus Names:At2g26830
ORF Names:F12C20.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G26830
TAIRilocus:2039518 AT2G26830

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004233491 – 374Probable ethanolamine kinaseAdd BLAST374

Proteomic databases

PaxDbiO81024
PRIDEiO81024

Expressioni

Gene expression databases

ExpressionAtlasiO81024 baseline and differential
GenevisibleiO81024 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G26830.1

Structurei

3D structure databases

ProteinModelPortaliO81024
SMRiO81024
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

eggNOGiKOG4720 Eukaryota
COG0510 LUCA
HOGENOMiHOG000004856
InParanoidiO81024
KOiK00894
OMAiWGVWALI
OrthoDBiEOG09360D8L
PhylomeDBiO81024

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
SUPFAMiSSF56112 SSF56112, 1 hit

Sequencei

Sequence statusi: Complete.

O81024-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAAKNIWAL ANAEDAANDA EQIPYSSFVV DTSLPLPLMI PRIIELCKDL
60 70 80 90 100
FKNWGELDDS LFSVERVSGG ITNLLLKVSV KEDTNKEVSV TVRLYGPNTE
110 120 130 140 150
YVINREREIL AIKYLSAAGF GAKLLGGFGN GMVQSFINAR TLEPSDMREP
160 170 180 190 200
KIAAQIAREL GKFHKVDIPG SKEPQLWVDI LKFYEKASTL TFEEPDKQKL
210 220 230 240 250
FETISFEELH KEIIELREFT GLLNAPVVFA HNDLLSGNFM LNDEEEKLYL
260 270 280 290 300
IDFEYGSYNY RGFDIGNHFN EYAGYDCDYS LYPSKEEQYH FIKHYLQPDK
310 320 330 340 350
PDEVSIAEVE SVFVETDAYK LASHLYWAIW AIIQARMSPI EFEYLGYFFL
360 370
RYNEYKKQKP LTFSLVTSHL SASL
Length:374
Mass (Da):42,860
Last modified:November 1, 1998 - v1
Checksum:i7E02759EA384DEDD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150P → Q in AAM65218 (Ref. 4) Curated1
Sequence conflicti211K → T in AAM65218 (Ref. 4) Curated1
Sequence conflicti374L → M in AAM65218 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005168 Genomic DNA Translation: AAC32242.1
CP002685 Genomic DNA Translation: AEC07895.1
AK229423 mRNA Translation: BAF01284.1
AY087681 mRNA Translation: AAM65218.1
PIRiT02652
RefSeqiNP_180251.1, NM_128240.4
UniGeneiAt.38841

Genome annotation databases

EnsemblPlantsiAT2G26830.1; AT2G26830.1; AT2G26830
GeneIDi817224
GrameneiAT2G26830.1; AT2G26830.1; AT2G26830
KEGGiath:AT2G26830

Similar proteinsi

Entry informationi

Entry nameiEKI_ARATH
AccessioniPrimary (citable) accession number: O81024
Secondary accession number(s): Q8LAQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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