UniProtKB - O80983 (FTSH4_ARATH)
Protein
ATP-dependent zinc metalloprotease FTSH 4, mitochondrial
Gene
FTSH4
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complex V of the mitochondrial oxidative phosphorylation system.1 Publication
Miscellaneous
In contrast to fungi and metazoa, plant mitochondria have more than one i-AAA-like complexes.
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 486 | Zinc; catalyticBy similarity | 1 | |
Active sitei | 487 | By similarity | 1 | |
Metal bindingi | 490 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 564 | Zinc; catalyticBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 267 – 274 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP-dependent peptidase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- metalloendopeptidase activity Source: InterPro
GO - Biological processi
- meristem maintenance Source: TAIR
- proteolysis Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 3.4.24.B20, 399 |
Protein family/group databases
MEROPSi | M41.018 |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-dependent zinc metalloprotease FTSH 4, mitochondrial (EC:3.4.24.-)Short name: AtFTSH4 |
Gene namesi | Name:FTSH4 Ordered Locus Names:At2g26140 ORF Names:T19L18.5 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G26140 |
TAIRi | locus:2057386, AT2G26140 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication3 Publications; Single-pass membrane protein 3 Publications; Intermembrane side 3 Publications
Chloroplast
- chloroplast thylakoid Source: GO_Central
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: TAIR
Other locations
- integral component of membrane Source: UniProtKB-KW
- plastid Source: TAIR
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 181 – 201 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 53 | Mitochondrion1 PublicationAdd BLAST | 53 | |
ChainiPRO_0000341330 | 54 – 717 | ATP-dependent zinc metalloprotease FTSH 4, mitochondrialAdd BLAST | 664 |
Proteomic databases
PaxDbi | O80983 |
PRIDEi | O80983 |
ProteomicsDBi | 228957 |
PTM databases
SwissPalmi | O80983 |
Expressioni
Inductioni
By high light.1 Publication
Gene expression databases
ExpressionAtlasi | O80983, baseline and differential |
Genevisiblei | O80983, AT |
Interactioni
Subunit structurei
Homooligomer. The complex formed by FTSH4 does not contain FTSH11.
1 PublicationProtein-protein interaction databases
BioGRIDi | 2506, 2 interactors |
STRINGi | 3702.AT2G26140.1 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 41 – 44 | Poly-Gly | 4 | |
Compositional biasi | 685 – 707 | Ala-richAdd BLAST | 23 |
Sequence similaritiesi
In the N-terminal section; belongs to the AAA ATPase family.Curated
In the C-terminal section; belongs to the peptidase M41 family.Curated
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0734, Eukaryota |
HOGENOMi | CLU_000688_9_3_1 |
InParanoidi | O80983 |
OMAi | SFPRWIR |
OrthoDBi | 217929at2759 |
PhylomeDBi | O80983 |
Family and domain databases
Gene3Di | 1.20.58.760, 1 hit |
HAMAPi | MF_01458, FtsH, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR005936, FtsH IPR027417, P-loop_NTPase IPR000642, Peptidase_M41 IPR037219, Peptidase_M41-like |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF01434, Peptidase_M41, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF140990, SSF140990, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01241, FtsH_fam, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O80983-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAWRRIITKV SSHERELSSL RSLLVRAYSS FPRVGVTGAV GGGGASLPRT
60 70 80 90 100
RFQSSYVGSF ARRVRDREEV NEVAHLRELI RRNDPEAVIR MFESQPSLHA
110 120 130 140 150
NASALSEYIK ALVKVDRLDQ SELVRTLQRG IAGVAREEET FGGLGAFRNV
160 170 180 190 200
GKPTKDGVLG TASAPIHTIS TERTHFKEQL WSTIRTIGVG FLLISGIGAL
210 220 230 240 250
IEDRGIGKGL GLHEEVQPSM DSSTKFSDVK GVDEAKAELE EIVHYLRDPK
260 270 280 290 300
RFTRLGGKLP KGVLLVGPPG TGKTMLARAI AGEAGVPFFS CSGSEFEEMF
310 320 330 340 350
VGVGARRVRD LFSAAKKCSP CIIFIDEIDA IGGSRNPKDQ QYMKMTLNQM
360 370 380 390 400
LVELDGFKQN EGIIVVAATN FPESLDKALV RPGRFDRHIV VPNPDVEGRR
410 420 430 440 450
QILESHMSKV LKAEDVDLMI IARGTPGFSG ADLANLVNVA ALKAAMDGSK
460 470 480 490 500
DVTMSDLEFA KDRIMMGSER KSAVISDESR KLTAFHEGGH ALVAIHTEGA
510 520 530 540 550
LPVHKATIVP RGMALGMVSQ LPDKDETSIS RKQMLARLDV CMGGRVAEEL
560 570 580 590 600
IFGESEVTSG ASSDLEQATK LARAMVTKFG MSKEVGLVAH NYDDNGKSMS
610 620 630 640 650
TETRLLIESE VKQLLEKAYN NAKTILTVYN KELHALANAL LQHETLSGKQ
660 670 680 690 700
IKELLTDLNS PLLQKRQEVV TKQSNPVPPS TPSSASSAAA AAAAAAAAAA
710
AAAATAATKG KDMAPVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004747 Genomic DNA Translation: AAC31223.2 CP002685 Genomic DNA Translation: AEC07799.1 AK220842 mRNA Translation: BAD94171.1 |
PIRi | T02610 |
RefSeqi | NP_565616.1, NM_128172.4 |
Genome annotation databases
EnsemblPlantsi | AT2G26140.1; AT2G26140.1; AT2G26140 |
GeneIDi | 817154 |
Gramenei | AT2G26140.1; AT2G26140.1; AT2G26140 |
KEGGi | ath:AT2G26140 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004747 Genomic DNA Translation: AAC31223.2 CP002685 Genomic DNA Translation: AEC07799.1 AK220842 mRNA Translation: BAD94171.1 |
PIRi | T02610 |
RefSeqi | NP_565616.1, NM_128172.4 |
3D structure databases
SMRi | O80983 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 2506, 2 interactors |
STRINGi | 3702.AT2G26140.1 |
Protein family/group databases
MEROPSi | M41.018 |
PTM databases
SwissPalmi | O80983 |
Proteomic databases
PaxDbi | O80983 |
PRIDEi | O80983 |
ProteomicsDBi | 228957 |
Genome annotation databases
EnsemblPlantsi | AT2G26140.1; AT2G26140.1; AT2G26140 |
GeneIDi | 817154 |
Gramenei | AT2G26140.1; AT2G26140.1; AT2G26140 |
KEGGi | ath:AT2G26140 |
Organism-specific databases
Araporti | AT2G26140 |
TAIRi | locus:2057386, AT2G26140 |
Phylogenomic databases
eggNOGi | KOG0734, Eukaryota |
HOGENOMi | CLU_000688_9_3_1 |
InParanoidi | O80983 |
OMAi | SFPRWIR |
OrthoDBi | 217929at2759 |
PhylomeDBi | O80983 |
Enzyme and pathway databases
BRENDAi | 3.4.24.B20, 399 |
Miscellaneous databases
PROi | PR:O80983 |
Gene expression databases
ExpressionAtlasi | O80983, baseline and differential |
Genevisiblei | O80983, AT |
Family and domain databases
Gene3Di | 1.20.58.760, 1 hit |
HAMAPi | MF_01458, FtsH, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR005936, FtsH IPR027417, P-loop_NTPase IPR000642, Peptidase_M41 IPR037219, Peptidase_M41-like |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF01434, Peptidase_M41, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF140990, SSF140990, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01241, FtsH_fam, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FTSH4_ARATH | |
Accessioni | O80983Primary (citable) accession number: O80983 Secondary accession number(s): Q56ZW8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families