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Entry version 108 (12 Aug 2020)
Sequence version 1 (01 Nov 1998)
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Protein

Solute carrier family 40 member 1

Gene

IREG1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in iron transport and iron homeostasis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.100.1.3, the ferroportin (fpn) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 40 member 1
Alternative name(s):
Ferroportin-1
Iron-regulated transporter 1
Short name:
AtIREG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IREG1
Synonyms:FPN1
Ordered Locus Names:At2g38460
ORF Names:T19C21.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G38460

The Arabidopsis Information Resource

More...
TAIRi
locus:2057222, AT2G38460

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei70 – 92HelicalSequence analysisAdd BLAST23
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004158981 – 524Solute carrier family 40 member 1Add BLAST524

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O80905

PRoteomics IDEntifications database

More...
PRIDEi
O80905

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
232833

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O80905, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O80905, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
3769, 4 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT2G38460.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2601, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020370_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O80905

KEGG Orthology (KO)

More...
KOi
K14685

Identification of Orthologs from Complete Genome Data

More...
OMAi
ACVEKLC

Database of Orthologous Groups

More...
OrthoDBi
334057at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O80905

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009716, Ferroportin-1
IPR036259, MFS_trans_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11660, PTHR11660, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06963, FPN1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O80905-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENETELRVV HQEEQQREEG EDESQPQNPP PALRRRFVIY LYVGYFLARW
60 70 80 90 100
SARTWEFSVA LYMIHLWPNS LLLAAIYGAI ESGSTAIFGP IVGQWVEGMD
110 120 130 140 150
YVKVLRLWLL FQNLSYTIAG GAVIKLLLVS DLKSRNLPVF AILIVLTNLA
160 170 180 190 200
GAIGVLSTLA GTILIERDWA VVMSEGHPPA VLTKMNSVIR GIDLSSKLLS
210 220 230 240 250
PVITGLIISF VSLKASAITF AAWATITAWV EYWLFISVYS GVPAITRSNE
260 270 280 290 300
RRILRSRTKQ VEGRDAPVSV SIVPGTEEGY TGNPPSRTGI LVILDRMSKS
310 320 330 340 350
SFVGAWRIYF NQEVVLPGVS LALLFFTVLS FGTLMTATLQ WEGIPTYIIG
360 370 380 390 400
IGRGISATVG LAATLVYPLM QSRLSTLRTG LWSFWSQWSC LLVCVGSIWV
410 420 430 440 450
KKDKIASYML MAGVAASRLG LWMFDLAVIQ QMQDLVSESD RCVVGGVQNS
460 470 480 490 500
LQSALDLMAY LLGIIVSNPK DFWILTLISF STVSLAGMLY TIHLYRIRNH
510 520
IFHLEKIPLL NKCIFKLLPS RGNV
Length:524
Mass (Da):58,204
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i781C6C0A697FADB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8AXC7A0A1P8AXC7_ARATH
Solute carrier family 40 protein
IREG1 ATIREG1, FERROPORTIN 1, FPN1, iron regulated 1, At2g38460
379Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004683 Genomic DNA Translation: AAC28758.1
CP002685 Genomic DNA Translation: AEC09539.1
CP002685 Genomic DNA Translation: ANM61309.1
CP002685 Genomic DNA Translation: ANM61311.1
CP002685 Genomic DNA Translation: ANM61312.1
CP002685 Genomic DNA Translation: ANM61313.1
CP002685 Genomic DNA Translation: ANM61315.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T02499

NCBI Reference Sequences

More...
RefSeqi
NP_001323535.1, NM_001336703.1
NP_001323537.1, NM_001336700.1
NP_001323538.1, NM_001336704.1
NP_001323539.1, NM_001336701.1
NP_001323541.1, NM_001336705.1
NP_181380.1, NM_129402.6

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G38460.1; AT2G38460.1; AT2G38460
AT2G38460.3; AT2G38460.3; AT2G38460
AT2G38460.4; AT2G38460.4; AT2G38460
AT2G38460.6; AT2G38460.6; AT2G38460
AT2G38460.7; AT2G38460.7; AT2G38460
AT2G38460.8; AT2G38460.8; AT2G38460

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
818427

Gramene; a comparative resource for plants

More...
Gramenei
AT2G38460.1; AT2G38460.1; AT2G38460
AT2G38460.3; AT2G38460.3; AT2G38460
AT2G38460.4; AT2G38460.4; AT2G38460
AT2G38460.6; AT2G38460.6; AT2G38460
AT2G38460.7; AT2G38460.7; AT2G38460
AT2G38460.8; AT2G38460.8; AT2G38460

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G38460

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004683 Genomic DNA Translation: AAC28758.1
CP002685 Genomic DNA Translation: AEC09539.1
CP002685 Genomic DNA Translation: ANM61309.1
CP002685 Genomic DNA Translation: ANM61311.1
CP002685 Genomic DNA Translation: ANM61312.1
CP002685 Genomic DNA Translation: ANM61313.1
CP002685 Genomic DNA Translation: ANM61315.1
PIRiT02499
RefSeqiNP_001323535.1, NM_001336703.1
NP_001323537.1, NM_001336700.1
NP_001323538.1, NM_001336704.1
NP_001323539.1, NM_001336701.1
NP_001323541.1, NM_001336705.1
NP_181380.1, NM_129402.6

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi3769, 4 interactors
STRINGi3702.AT2G38460.1

Protein family/group databases

TCDBi2.A.100.1.3, the ferroportin (fpn) family

Proteomic databases

PaxDbiO80905
PRIDEiO80905
ProteomicsDBi232833

Genome annotation databases

EnsemblPlantsiAT2G38460.1; AT2G38460.1; AT2G38460
AT2G38460.3; AT2G38460.3; AT2G38460
AT2G38460.4; AT2G38460.4; AT2G38460
AT2G38460.6; AT2G38460.6; AT2G38460
AT2G38460.7; AT2G38460.7; AT2G38460
AT2G38460.8; AT2G38460.8; AT2G38460
GeneIDi818427
GrameneiAT2G38460.1; AT2G38460.1; AT2G38460
AT2G38460.3; AT2G38460.3; AT2G38460
AT2G38460.4; AT2G38460.4; AT2G38460
AT2G38460.6; AT2G38460.6; AT2G38460
AT2G38460.7; AT2G38460.7; AT2G38460
AT2G38460.8; AT2G38460.8; AT2G38460
KEGGiath:AT2G38460

Organism-specific databases

AraportiAT2G38460
TAIRilocus:2057222, AT2G38460

Phylogenomic databases

eggNOGiKOG2601, Eukaryota
HOGENOMiCLU_020370_1_0_1
InParanoidiO80905
KOiK14685
OMAiACVEKLC
OrthoDBi334057at2759
PhylomeDBiO80905

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O80905

Gene expression databases

ExpressionAtlasiO80905, baseline and differential
GenevisibleiO80905, AT

Family and domain databases

InterProiView protein in InterPro
IPR009716, Ferroportin-1
IPR036259, MFS_trans_sf
PANTHERiPTHR11660, PTHR11660, 1 hit
PfamiView protein in Pfam
PF06963, FPN1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS40A1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O80905
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: November 1, 1998
Last modified: August 12, 2020
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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