UniProtKB - O80856 (ARC1A_ARATH)
Protein
Actin-related protein 2/3 complex subunit 1A
Gene
ARPC1A
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.By similarity
GO - Molecular functioni
- actin filament binding Source: GO_Central
GO - Biological processi
- actin filament organization Source: TAIR
- Arp2/3 complex-mediated actin nucleation Source: GO_Central
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Actin-related protein 2/3 complex subunit 1AAlternative name(s): Actin-related protein C1 Actin-related protein C1A Arp2/3 complex 41 kDa subunit p41-ARC |
Gene namesi | Name:ARPC1A Ordered Locus Names:At2g30910 ORF Names:F7F1.12 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G30910 |
TAIRi | locus:2052871, AT2G30910 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- Arp2/3 protein complex Source: GO_Central
Nucleus
- nucleus Source: TAIR
Other locations
- cytoplasm Source: TAIR
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000422526 | 1 – 378 | Actin-related protein 2/3 complex subunit 1AAdd BLAST | 378 |
Proteomic databases
PaxDbi | O80856 |
ProteomicsDBi | 245182 [O80856-1] |
PTM databases
iPTMneti | O80856 |
Expressioni
Tissue specificityi
Expressed at low levels in all tissues with a relatively highest expression in inflorescences.1 Publication
Gene expression databases
ExpressionAtlasi | O80856, baseline and differential |
Genevisiblei | O80856, AT |
Interactioni
Subunit structurei
Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
GO - Molecular functioni
- actin filament binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 2990, 1 interactor |
STRINGi | 3702.AT2G30910.3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 8 – 47 | WD 1Add BLAST | 40 | |
Repeati | 53 – 92 | WD 2Add BLAST | 40 | |
Repeati | 97 – 138 | WD 3Add BLAST | 42 | |
Repeati | 143 – 182 | WD 4Add BLAST | 40 | |
Repeati | 203 – 242 | WD 5Add BLAST | 40 | |
Repeati | 257 – 295 | WD 6Add BLAST | 39 | |
Repeati | 331 – 375 | WD 7Add BLAST | 45 |
Sequence similaritiesi
Belongs to the WD repeat ARPC1 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1523, Eukaryota |
HOGENOMi | CLU_034396_0_0_1 |
InParanoidi | O80856 |
OMAi | FNTFRNA |
PhylomeDBi | O80856 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR024977, Apc4_WD40_dom IPR017383, ARPC1 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10709, PTHR10709, 1 hit |
Pfami | View protein in Pfam PF12894, ANAPC4_WD40, 1 hit |
PIRSFi | PIRSF038093, ARP2/3_su1, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketNote: A number of isoforms are produced. According to EST sequences.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O80856-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVVDVHRFA ESITCHAWSP DLSMVALCPN NTEVHIYKSL SQDHWERLHV
60 70 80 90 100
LQKHDQIVSG IDWSSKSNKI VTVSHDRNSY VWSLEGAEWV PTLVILRLNR
110 120 130 140 150
AALCVQWSPK ENKFAVGSGA KTVCICYYEQ ENNWWVSKLI RKRHESSVTS
160 170 180 190 200
VAWHPNNVLL ATTSTDGKCR VFSTFIKGVD TKDSKAGSPA ETKFGEQILQ
210 220 230 240 250
LDLSYSWAFG VKWSPSGNTL AYVGHSSMIY FVDDVGPSPL AQSVAFRDLP
260 270 280 290 300
LRDVLFISEK MVIGVGYDSN PMVFASDDTG IWSFIRYIGE KKAASSNSSY
310 320 330 340 350
SSQFSEAFGK FYGSQSKSTT ANDASESRGG VHDNCINSIV SLSKAGSPKV
360 370
MRFSTSGLDG KVAIWDLENM EQELGNQF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF4IPT5 | F4IPT5_ARATH | Actin-related protein 2/3 complex s... | ARPC1A ACTIN-RELATED PROTEIN C1, actin-related protein C1A, ARPC1, At2g30910, F7F1.12 | 378 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004669 Genomic DNA Translation: AAC20725.1 CP002685 Genomic DNA Translation: AEC08455.1 CP002685 Genomic DNA Translation: AEC08457.1 BT004616 mRNA Translation: AAO42862.1 AK227543 mRNA Translation: BAE99541.1 |
PIRi | B84714 |
RefSeqi | NP_001189645.1, NM_001202716.1 [O80856-1] NP_180648.1, NM_128643.4 [O80856-1] |
Genome annotation databases
EnsemblPlantsi | AT2G30910.1; AT2G30910.1; AT2G30910 [O80856-1] AT2G30910.3; AT2G30910.3; AT2G30910 [O80856-1] |
GeneIDi | 817641 |
Gramenei | AT2G30910.1; AT2G30910.1; AT2G30910 [O80856-1] AT2G30910.3; AT2G30910.3; AT2G30910 [O80856-1] |
KEGGi | ath:AT2G30910 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004669 Genomic DNA Translation: AAC20725.1 CP002685 Genomic DNA Translation: AEC08455.1 CP002685 Genomic DNA Translation: AEC08457.1 BT004616 mRNA Translation: AAO42862.1 AK227543 mRNA Translation: BAE99541.1 |
PIRi | B84714 |
RefSeqi | NP_001189645.1, NM_001202716.1 [O80856-1] NP_180648.1, NM_128643.4 [O80856-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 2990, 1 interactor |
STRINGi | 3702.AT2G30910.3 |
PTM databases
iPTMneti | O80856 |
Proteomic databases
PaxDbi | O80856 |
ProteomicsDBi | 245182 [O80856-1] |
Genome annotation databases
EnsemblPlantsi | AT2G30910.1; AT2G30910.1; AT2G30910 [O80856-1] AT2G30910.3; AT2G30910.3; AT2G30910 [O80856-1] |
GeneIDi | 817641 |
Gramenei | AT2G30910.1; AT2G30910.1; AT2G30910 [O80856-1] AT2G30910.3; AT2G30910.3; AT2G30910 [O80856-1] |
KEGGi | ath:AT2G30910 |
Organism-specific databases
Araporti | AT2G30910 |
TAIRi | locus:2052871, AT2G30910 |
Phylogenomic databases
eggNOGi | KOG1523, Eukaryota |
HOGENOMi | CLU_034396_0_0_1 |
InParanoidi | O80856 |
OMAi | FNTFRNA |
PhylomeDBi | O80856 |
Miscellaneous databases
PROi | PR:O80856 |
Gene expression databases
ExpressionAtlasi | O80856, baseline and differential |
Genevisiblei | O80856, AT |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR024977, Apc4_WD40_dom IPR017383, ARPC1 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10709, PTHR10709, 1 hit |
Pfami | View protein in Pfam PF12894, ANAPC4_WD40, 1 hit |
PIRSFi | PIRSF038093, ARP2/3_su1, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARC1A_ARATH | |
Accessioni | O80856Primary (citable) accession number: O80856 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2013 |
Last sequence update: | November 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families