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Entry version 137 (16 Oct 2019)
Sequence version 2 (25 Jan 2012)
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Protein

Putative transcription elongation factor SPT5 homolog 2

Gene

At2g34210

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate transcription elongation by RNA polymerase II. May enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative transcription elongation factor SPT5 homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At2g34210
ORF Names:F13P17.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G34210

The Arabidopsis Information Resource

More...
TAIRi
locus:2040954 AT2G34210

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002084761 – 989Putative transcription elongation factor SPT5 homolog 2Add BLAST989

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O80770

PRoteomics IDEntifications database

More...
PRIDEi
O80770

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O80770 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O80770 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT2G34210.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O80770

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini260 – 287KOW 1Add BLAST28
Domaini412 – 439KOW 2Add BLAST28
Domaini464 – 491KOW 3Add BLAST28
Domaini588 – 615KOW 4Add BLAST28
Domaini683 – 710KOW 5Add BLAST28
Domaini936 – 963KOW 6Add BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 84Asp-richAdd BLAST79

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SPT5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1999 Eukaryota
COG5164 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000038564

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O80770

KEGG Orthology (KO)

More...
KOi
K15172

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPRTEYD

Database of Orthologous Groups

More...
OrthoDBi
828863at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06081 KOW_Spt5_1, 1 hit
cd06082 KOW_Spt5_2, 1 hit
cd06083 KOW_Spt5_3, 1 hit
cd06084 KOW_Spt5_4, 1 hit
cd06086 KOW_Spt5_6, 1 hit
cd09888 NGN_Euk, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.30, 4 hits
3.30.70.940, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005824 KOW
IPR041973 KOW_Spt5_1
IPR041975 KOW_Spt5_2
IPR041976 KOW_Spt5_3
IPR041977 KOW_Spt5_4
IPR041980 KOW_Spt5_6
IPR005100 NGN-domain
IPR006645 NGN_dom
IPR036735 NGN_dom_sf
IPR039385 NGN_Euk
IPR014722 Rib_L2_dom2
IPR005825 Ribosomal_L24/26_CS
IPR039659 SPT5
IPR022581 Spt5_N
IPR017071 TF_Spt5_eukaryote
IPR008991 Translation_prot_SH3-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11125 PTHR11125, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00467 KOW, 2 hits
PF03439 Spt5-NGN, 1 hit
PF11942 Spt5_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036945 Spt5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00739 KOW, 6 hits
SM00738 NGN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50104 SSF50104, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01108 RIBOSOMAL_L24, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O80770-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQYSDDDYS HEDDSEMEDE DEEDEYEPRS SRKGRSGKKR GRSNSDSDGR
60 70 80 90 100
RGSKKKSSGS AFIDWEVEVD DDVEDDDDDV DVEDGKQQLK FGDFSLCFIV
110 120 130 140 150
SGEADLPNED SDHRRQYYQR GFHPHEEDVD ELEKRTLERL STKYAKDDYE
160 170 180 190 200
LDDVNDVDQQ ALLPSVRDPK LWLVKCAIGR EREVAVCLMQ KIVDRGSEFK
210 220 230 240 250
IRSAIALDHL QNYVYIEADM EAHVKEAIKG MRNIYANQKI LLVPIKEMTA
260 270 280 290 300
VLSVESKAID LSRDSWVRMK LGIYKGDLAQ VVDVDNVRKR VTVKLIPRID
310 320 330 340 350
LQALANKLEG TENVKKKAFA PPPRFMNIDE ARELHIRVEH RRDPMTGDYF
360 370 380 390 400
ENIGGMLFKD GFLYKKVSTK SIAAQNVTPT FDELERFKRP NENGEIDFVD
410 420 430 440 450
ESTLFANRKK GHFMKGDAVI VIKGDLKNLK GWIEKVDEEN VLIRSEMKDL
460 470 480 490 500
PNPIAVNGRE LCKYFEPGNF VKVVSGIHEG GTGMIVKVDQ HMLIILSDTT
510 520 530 540 550
KEHICVFADH VAKSAEVTKG VTKIGDYELH DLVILSDFSF GVILKLDSEA
560 570 580 590 600
IQILKGVPDS SEVSIVKASE IKYKIWKKIN VQDRYKNVVA VKDVVRVIEG
610 620 630 640 650
PSKGKQGPVV QIYKGVLFIH DRHNLEHTGF ICTRCSSCVL AGGNFKTPAL
660 670 680 690 700
VPPSPRRFQR ADMGYNPGAG GRHQGGRGRR GDDHLVGTYV KIRLGPFKGY
710 720 730 740 750
SGRLVEVKDK LVRVELEAKI VTVERKAISD MTDNVVATPQ YNMGSQTPMH
760 770 780 790 800
PSRTPLHPCM TPMRHSGATP IHDGMRTPMR GRAWNPYMPM SPPRDNWEDG
810 820 830 840 850
NPGSWGTSPY EAATPGSDWG SSTPGRSSYR DAGTPINNAN APSPMTPSST
860 870 880 890 900
SYLPTTPGGQ AMTPGTDLDV MSLDIGGDAE TRFIPGILVN VHKAGEDRNP
910 920 930 940 950
GVIRDVLPDG SCVVALGHRG EGETIRATQN KVSLVCPKKN ERVKILGGKY
960 970 980
CGSTAKVIGE DGQDGIVKLD ESLDIKILKL TILAKLVHE
Length:989
Mass (Da):110,277
Last modified:January 25, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA940B90557C3A11C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8AZ96A0A1P8AZ96_ARATH
Transcription elongation factor SPT...
SPT5-1 At2g34210, F13P17.5, F13P17_5
977Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC27397 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004481 Genomic DNA Translation: AAC27397.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC08936.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T02309

NCBI Reference Sequences

More...
RefSeqi
NP_180968.2, NM_128972.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G34210.1; AT2G34210.1; AT2G34210

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
817982

Gramene; a comparative resource for plants

More...
Gramenei
AT2G34210.1; AT2G34210.1; AT2G34210

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G34210

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004481 Genomic DNA Translation: AAC27397.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC08936.1
PIRiT02309
RefSeqiNP_180968.2, NM_128972.2

3D structure databases

SMRiO80770
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G34210.1

Proteomic databases

PaxDbiO80770
PRIDEiO80770

Genome annotation databases

EnsemblPlantsiAT2G34210.1; AT2G34210.1; AT2G34210
GeneIDi817982
GrameneiAT2G34210.1; AT2G34210.1; AT2G34210
KEGGiath:AT2G34210

Organism-specific databases

AraportiAT2G34210
TAIRilocus:2040954 AT2G34210

Phylogenomic databases

eggNOGiKOG1999 Eukaryota
COG5164 LUCA
HOGENOMiHOG000038564
InParanoidiO80770
KOiK15172
OMAiNPRTEYD
OrthoDBi828863at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O80770

Gene expression databases

ExpressionAtlasiO80770 baseline and differential
GenevisibleiO80770 AT

Family and domain databases

CDDicd06081 KOW_Spt5_1, 1 hit
cd06082 KOW_Spt5_2, 1 hit
cd06083 KOW_Spt5_3, 1 hit
cd06084 KOW_Spt5_4, 1 hit
cd06086 KOW_Spt5_6, 1 hit
cd09888 NGN_Euk, 1 hit
Gene3Di2.30.30.30, 4 hits
3.30.70.940, 1 hit
InterProiView protein in InterPro
IPR005824 KOW
IPR041973 KOW_Spt5_1
IPR041975 KOW_Spt5_2
IPR041976 KOW_Spt5_3
IPR041977 KOW_Spt5_4
IPR041980 KOW_Spt5_6
IPR005100 NGN-domain
IPR006645 NGN_dom
IPR036735 NGN_dom_sf
IPR039385 NGN_Euk
IPR014722 Rib_L2_dom2
IPR005825 Ribosomal_L24/26_CS
IPR039659 SPT5
IPR022581 Spt5_N
IPR017071 TF_Spt5_eukaryote
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11125 PTHR11125, 1 hit
PfamiView protein in Pfam
PF00467 KOW, 2 hits
PF03439 Spt5-NGN, 1 hit
PF11942 Spt5_N, 1 hit
PIRSFiPIRSF036945 Spt5, 1 hit
SMARTiView protein in SMART
SM00739 KOW, 6 hits
SM00738 NGN, 1 hit
SUPFAMiSSF50104 SSF50104, 2 hits
PROSITEiView protein in PROSITE
PS01108 RIBOSOMAL_L24, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPT52_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O80770
Secondary accession number(s): F4IGX3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 25, 2012
Last modified: October 16, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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