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Entry version 147 (02 Dec 2020)
Sequence version 2 (01 Jun 2002)
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Protein

La-related protein 6B

Gene

LARP6B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
La-related protein 6B
Short name:
AtLARP6b
Alternative name(s):
VirF-interacting protein FIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LARP6B
Synonyms:FIP1
Ordered Locus Names:At2g43970
ORF Names:F6E13.10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G43970

The Arabidopsis Information Resource

More...
TAIRi
locus:2051734, AT2G43970

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004286701 – 545La-related protein 6BAdd BLAST545

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O80567

PRoteomics IDEntifications database

More...
PRIDEi
O80567

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
238530 [O80567-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O80567

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O80567, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O80567, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4338, 2 interactors

Protein interaction database and analysis system

More...
IntActi
O80567, 2 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT2G43970.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O80567

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini187 – 278HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST92
Domaini285 – 383RRMAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 47Ser-richAdd BLAST39
Compositional biasi54 – 107Pro-richAdd BLAST54
Compositional biasi79 – 126His-richAdd BLAST48
Compositional biasi476 – 496His-richAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1855, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_033595_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O80567

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEYYPAV

Database of Orthologous Groups

More...
OrthoDBi
1179659at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O80567

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12288, RRM_La_like_plant, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034878, La-rel_plant_RRM
IPR006630, La_HTH
IPR002344, Lupus_La
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05383, La, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00302, LUPUSLA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00715, LA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50961, HTH_LA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O80567-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADQQTLDSS TPPPTQSDDL SHSHSTSSTT SASSSSDPSL LRSLSLSRLN
60 70 80 90 100
AGAPEFVPGR TTPPLPQPPR MIIPPPPPHG MLHMYHHQPP FNTPVLGPVP
110 120 130 140 150
IQPHLVPVQN HHPHHRFHQH HHHNRHQNQQ YVPVRNHGEY QQRGGVGGEQ
160 170 180 190 200
EPDLVSKKND RRDHSKRESK NDQVTETGAS VSIDSKTGLP EDSIQKIVNQ
210 220 230 240 250
VEYYFSDLNL ATTDHLMRFI CKDPEGYVPI HVVASFKKIK AVINNNSQLA
260 270 280 290 300
AVLQNSAKLF VSEDGKKVRR ISPITESAIE ELQSRIIVAE NLPEDHCYQN
310 320 330 340 350
LMKIFSTVGS VKNIRTCQPQ NNGSGAPPAA RSAAKSDGTL FSNKVHAFVE
360 370 380 390 400
YEIVELAERA VTELSEAGNW RSGLKVRLML KHQTKEPKQG QGRGRKGHDA
410 420 430 440 450
DVEHEEDDAT TSEQQPIEKQ SDDCSGEWDT HMQEQPIGED QGNEKAAGQR
460 470 480 490 500
KGRNRGRGKG RGRGQPHQNQ NQNNNHSHNQ NHNHNGRGNH HHHHHHQVGT
510 520 530 540
QPSNNPMNNM EQPGMGKQQP PGPRMPDGTR GFSMGRGKPV MVQAE
Length:545
Mass (Da):60,589
Last modified:June 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1A933261FE1ED80
GO
Isoform 2 (identifier: O80567-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-61: Missing.

Show »
Length:494
Mass (Da):55,381
Checksum:i3686934EB972DF61
GO
Isoform 3 (identifier: O80567-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-360: Missing.

Show »
Length:529
Mass (Da):58,732
Checksum:i1774861298D8A007
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL06505 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti306S → P in BAH57224 (PubMed:19423640).Curated1
Sequence conflicti415Q → E in BAH57224 (PubMed:19423640).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05417611 – 61Missing in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_054177345 – 360Missing in isoform 3. CuratedAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF332565 mRNA Translation: AAK06847.1
AC004005 Genomic DNA Translation: AAC23405.2
CP002685 Genomic DNA Translation: AEC10356.1
CP002685 Genomic DNA Translation: AEC10357.1
AF375410 mRNA Translation: AAK52994.1
AF367277 mRNA Translation: AAK56266.1
AF412052 mRNA Translation: AAL06505.1 Different initiation.
AY056238 mRNA Translation: AAL07087.1
AY129474 mRNA Translation: AAM91060.1
AK319109 mRNA Translation: BAH57224.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T00677

NCBI Reference Sequences

More...
RefSeqi
NP_566004.1, NM_129959.3 [O80567-1]
NP_850406.1, NM_180075.2 [O80567-3]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G43970.1; AT2G43970.1; AT2G43970 [O80567-1]
AT2G43970.2; AT2G43970.2; AT2G43970 [O80567-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
819002

Gramene; a comparative resource for plants

More...
Gramenei
AT2G43970.1; AT2G43970.1; AT2G43970 [O80567-1]
AT2G43970.2; AT2G43970.2; AT2G43970 [O80567-3]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G43970

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332565 mRNA Translation: AAK06847.1
AC004005 Genomic DNA Translation: AAC23405.2
CP002685 Genomic DNA Translation: AEC10356.1
CP002685 Genomic DNA Translation: AEC10357.1
AF375410 mRNA Translation: AAK52994.1
AF367277 mRNA Translation: AAK56266.1
AF412052 mRNA Translation: AAL06505.1 Different initiation.
AY056238 mRNA Translation: AAL07087.1
AY129474 mRNA Translation: AAM91060.1
AK319109 mRNA Translation: BAH57224.1
PIRiT00677
RefSeqiNP_566004.1, NM_129959.3 [O80567-1]
NP_850406.1, NM_180075.2 [O80567-3]

3D structure databases

SMRiO80567
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4338, 2 interactors
IntActiO80567, 2 interactors
STRINGi3702.AT2G43970.1

PTM databases

iPTMnetiO80567

Proteomic databases

PaxDbiO80567
PRIDEiO80567
ProteomicsDBi238530 [O80567-1]

Genome annotation databases

EnsemblPlantsiAT2G43970.1; AT2G43970.1; AT2G43970 [O80567-1]
AT2G43970.2; AT2G43970.2; AT2G43970 [O80567-3]
GeneIDi819002
GrameneiAT2G43970.1; AT2G43970.1; AT2G43970 [O80567-1]
AT2G43970.2; AT2G43970.2; AT2G43970 [O80567-3]
KEGGiath:AT2G43970

Organism-specific databases

AraportiAT2G43970
TAIRilocus:2051734, AT2G43970

Phylogenomic databases

eggNOGiKOG1855, Eukaryota
HOGENOMiCLU_033595_1_0_1
InParanoidiO80567
OMAiFEYYPAV
OrthoDBi1179659at2759
PhylomeDBiO80567

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O80567

Gene expression databases

ExpressionAtlasiO80567, baseline and differential
GenevisibleiO80567, AT

Family and domain databases

CDDicd12288, RRM_La_like_plant, 1 hit
Gene3Di1.10.10.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034878, La-rel_plant_RRM
IPR006630, La_HTH
IPR002344, Lupus_La
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383, La, 1 hit
PRINTSiPR00302, LUPUSLA
SMARTiView protein in SMART
SM00715, LA, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50961, HTH_LA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRP6B_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O80567
Secondary accession number(s): C0Z3E5
, F4IT26, Q945N2, Q9C5X1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: June 1, 2002
Last modified: December 2, 2020
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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