Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Decapping and exoribonuclease protein

Gene

DXO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).By similarity

Caution

In contrast to canonical decapping enzymes DCP2 and NUDT16, which release m7pppG (m7GDP), the decapping activity releases the entire cap structure GpppN and a 5' end monophosphate RNA.Curated

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei58SubstrateBy similarity1
Binding sitei101SubstrateBy similarity1
Binding sitei132SubstrateBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi192Magnesium 1By similarity1
Metal bindingi192Magnesium 2By similarity1
Binding sitei217SubstrateBy similarity1
Metal bindingi234Magnesium 2By similarity1
Binding sitei234SubstrateBy similarity1
Metal bindingi236Magnesium 1By similarity1
Metal bindingi236Magnesium 2By similarity1
Metal bindingi253Magnesium 1By similarity1
Metal bindingi254Magnesium 1; via carbonyl oxygenBy similarity1
Binding sitei280SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding
LigandMagnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Decapping and exoribonuclease protein (EC:3.1.13.-, EC:3.6.1.-)
Short name:
DXO
Alternative name(s):
Dom-3 homolog Z
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DXO
Synonyms:DOM3L, DOM3Z, NG6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204348.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2992 DXO

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605996 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O77932

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1797

Open Targets

More...
OpenTargetsi
ENSG00000204348

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27458

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DXO

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002498221 – 396Decapping and exoribonuclease proteinAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei392PhosphothreonineBy similarity1
Modified residuei394PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O77932

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O77932

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O77932

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O77932

PeptideAtlas

More...
PeptideAtlasi
O77932

PRoteomics IDEntifications database

More...
PRIDEi
O77932

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50418

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O77932

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O77932

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204348 Expressed in 221 organ(s), highest expression level in right adrenal gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_DOM3Z

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O77932 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O77932 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046708

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108132, 15 interactors

Protein interaction database and analysis system

More...
IntActi
O77932, 8 interactors

Molecular INTeraction database

More...
MINTi
O77932

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337759

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O77932

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O77932

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DXO/Dom3Z family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1982 Eukaryota
ENOG410ZAFR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006425

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080627

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O77932

KEGG Orthology (KO)

More...
KOi
K14845

Identification of Orthologs from Complete Genome Data

More...
OMAi
MAYWGYK

Database of Orthologous Groups

More...
OrthoDBi
1034620at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O77932

TreeFam database of animal gene trees

More...
TreeFami
TF322812

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013961 RAI1
IPR039039 RAI1-like_fam

The PANTHER Classification System

More...
PANTHERi
PTHR12395 PTHR12395, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08652 RAI1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O77932-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPRGTKRGA EKTEVAEPRN KLPRPAPSLP TDPALYSGPF PFYRRPSELG
60 70 80 90 100
CFSLDAQRQY HGDARALRYY SPPPTNGPGP NFDLRDGYPD RYQPRDEEVQ
110 120 130 140 150
ERLDHLLCWL LEHRGRLEGG PGWLAEAIVT WRGHLTKLLT TPYERQEGWQ
160 170 180 190 200
LAASRFQGTL YLSEVETPNA RAQRLARPPL LRELMYMGYK FEQYMCADKP
210 220 230 240 250
GSSPDPSGEV NTNVAFCSVL RSRLGSHPLL FSGEVDCTDP QAPSTQPPTC
260 270 280 290 300
YVELKTSKEM HSPGQWRSFY RHKLLKWWAQ SFLPGVPNVV AGFRNPDGFV
310 320 330 340 350
SSLKTFPTMK MFEYVRNDRD GWNPSVCMNF CAAFLSFAQS TVVQDDPRLV
360 370 380 390
HLFSWEPGGP VTVSVHQDAP YAFLPIWYVE AMTQDLPSPP KTPSPK
Length:396
Mass (Da):44,929
Last modified:September 19, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17C8119037EB6892
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WC68F8WC68_HUMAN
Decapping and exoribonuclease prote...
DXO
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5D2H7C5D2_HUMAN
Decapping and exoribonuclease prote...
DXO
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB67983 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB89306 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02749228S → T2 PublicationsCorresponds to variant dbSNP:rs1056694Ensembl.1
Natural variantiVAR_02749363D → E. Corresponds to variant dbSNP:rs2746396Ensembl.1
Natural variantiVAR_027494261H → Q1 PublicationCorresponds to variant dbSNP:rs17207867Ensembl.1
Natural variantiVAR_027495332A → V. Corresponds to variant dbSNP:rs12205138Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF059252 mRNA Translation: AAC78603.1
AF019413 Genomic DNA Translation: AAB67983.1 Sequence problems.
AL049547 Genomic DNA Translation: CAB89305.1
AL049547 Genomic DNA Translation: CAB89306.1 Sequence problems.
AL662849 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
CR753822 Genomic DNA No translation available.
CR759782 Genomic DNA No translation available.
AL645922 Genomic DNA No translation available.
CR753845 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03558.1
BC009344 mRNA Translation: AAH09344.1
BC019083 mRNA Translation: AAH19083.1
AF059253 mRNA Translation: AAC78604.1
AF059254 mRNA Translation: AAC78605.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4732.1

NCBI Reference Sequences

More...
RefSeqi
NP_005501.2, NM_005510.3
XP_006715068.1, XM_006715005.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.153299

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337523; ENSP00000337759; ENSG00000204348
ENST00000375349; ENSP00000364498; ENSG00000204348
ENST00000375356; ENSP00000364505; ENSG00000204348
ENST00000383330; ENSP00000372820; ENSG00000206346
ENST00000399936; ENSP00000382818; ENSG00000206346
ENST00000399937; ENSP00000382819; ENSG00000206346
ENST00000414092; ENSP00000391123; ENSG00000236765
ENST00000419797; ENSP00000391532; ENSG00000234798
ENST00000426498; ENSP00000394167; ENSG00000225682
ENST00000427627; ENSP00000413860; ENSG00000234798
ENST00000427690; ENSP00000406143; ENSG00000225682
ENST00000432110; ENSP00000401315; ENSG00000236765
ENST00000439989; ENSP00000395262; ENSG00000224313
ENST00000443250; ENSP00000415675; ENSG00000224313
ENST00000446967; ENSP00000391349; ENSG00000234798
ENST00000453742; ENSP00000410404; ENSG00000225682
ENST00000454430; ENSP00000411380; ENSG00000224313
ENST00000458308; ENSP00000400173; ENSG00000236765

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1797

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1797

UCSC genome browser

More...
UCSCi
uc003nyp.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059252 mRNA Translation: AAC78603.1
AF019413 Genomic DNA Translation: AAB67983.1 Sequence problems.
AL049547 Genomic DNA Translation: CAB89305.1
AL049547 Genomic DNA Translation: CAB89306.1 Sequence problems.
AL662849 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
CR753822 Genomic DNA No translation available.
CR759782 Genomic DNA No translation available.
AL645922 Genomic DNA No translation available.
CR753845 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03558.1
BC009344 mRNA Translation: AAH09344.1
BC019083 mRNA Translation: AAH19083.1
AF059253 mRNA Translation: AAC78604.1
AF059254 mRNA Translation: AAC78605.1
CCDSiCCDS4732.1
RefSeqiNP_005501.2, NM_005510.3
XP_006715068.1, XM_006715005.3
UniGeneiHs.153299

3D structure databases

ProteinModelPortaliO77932
SMRiO77932
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108132, 15 interactors
IntActiO77932, 8 interactors
MINTiO77932
STRINGi9606.ENSP00000337759

PTM databases

iPTMnetiO77932
PhosphoSitePlusiO77932

Polymorphism and mutation databases

BioMutaiDXO

Proteomic databases

EPDiO77932
jPOSTiO77932
MaxQBiO77932
PaxDbiO77932
PeptideAtlasiO77932
PRIDEiO77932
ProteomicsDBi50418

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1797
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337523; ENSP00000337759; ENSG00000204348
ENST00000375349; ENSP00000364498; ENSG00000204348
ENST00000375356; ENSP00000364505; ENSG00000204348
ENST00000383330; ENSP00000372820; ENSG00000206346
ENST00000399936; ENSP00000382818; ENSG00000206346
ENST00000399937; ENSP00000382819; ENSG00000206346
ENST00000414092; ENSP00000391123; ENSG00000236765
ENST00000419797; ENSP00000391532; ENSG00000234798
ENST00000426498; ENSP00000394167; ENSG00000225682
ENST00000427627; ENSP00000413860; ENSG00000234798
ENST00000427690; ENSP00000406143; ENSG00000225682
ENST00000432110; ENSP00000401315; ENSG00000236765
ENST00000439989; ENSP00000395262; ENSG00000224313
ENST00000443250; ENSP00000415675; ENSG00000224313
ENST00000446967; ENSP00000391349; ENSG00000234798
ENST00000453742; ENSP00000410404; ENSG00000225682
ENST00000454430; ENSP00000411380; ENSG00000224313
ENST00000458308; ENSP00000400173; ENSG00000236765
GeneIDi1797
KEGGihsa:1797
UCSCiuc003nyp.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1797
DisGeNETi1797
EuPathDBiHostDB:ENSG00000204348.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DXO

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0166417
HGNCiHGNC:2992 DXO
HPAiHPA046708
MIMi605996 gene
neXtProtiNX_O77932
OpenTargetsiENSG00000204348
PharmGKBiPA27458

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1982 Eukaryota
ENOG410ZAFR LUCA
GeneTreeiENSGT00390000006425
HOVERGENiHBG080627
InParanoidiO77932
KOiK14845
OMAiMAYWGYK
OrthoDBi1034620at2759
PhylomeDBiO77932
TreeFamiTF322812

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DXO human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DOM3Z

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1797

Protein Ontology

More...
PROi
PR:O77932

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204348 Expressed in 221 organ(s), highest expression level in right adrenal gland
CleanExiHS_DOM3Z
ExpressionAtlasiO77932 baseline and differential
GenevisibleiO77932 HS

Family and domain databases

InterProiView protein in InterPro
IPR013961 RAI1
IPR039039 RAI1-like_fam
PANTHERiPTHR12395 PTHR12395, 1 hit
PfamiView protein in Pfam
PF08652 RAI1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDXO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O77932
Secondary accession number(s): A2CER3
, B0UZ80, O15004, O78127, O78128, Q5ST60, Q6IPZ2, Q9NPK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: January 16, 2019
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again