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Entry version 145 (02 Jun 2021)
Sequence version 2 (19 Sep 2006)
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Protein

Decapping and exoribonuclease protein

Gene

DXO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (PubMed:28283058).

The NAD-cap is present at the 5'-end of some RNAs and snoRNAs (PubMed:28283058).

In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:28283058).

Preferentially acts on NAD-capped transcripts in response to environmental stress (PubMed:31101919).

Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation (By similarity).

Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control (By similarity).

Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (PubMed:29601584).

In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA (By similarity).

Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs (PubMed:29601584).

Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei58SubstrateBy similarity1
Binding sitei101SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi192Magnesium 1By similarity1
Metal bindingi192Magnesium 2By similarity1
Binding sitei217SubstrateBy similarity1
Metal bindingi234Magnesium 2By similarity1
Binding sitei234Substrate; via amide nitrogenBy similarity1
Metal bindingi236Magnesium 11 Publication1
Metal bindingi236Magnesium 2By similarity1
Metal bindingi253Magnesium 11 Publication1
Metal bindingi254Magnesium 1; via carbonyl oxygenBy similarity1
Binding sitei255SubstrateBy similarity1
Binding sitei280SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding
LigandMagnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O77932

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Decapping and exoribonuclease protein1 Publication (EC:3.6.1.-1 Publication)
Short name:
DXO1 Publication
Alternative name(s):
5'-3' exoribonuclease DXOCurated (EC:3.1.13.-1 Publication)
Dom-3 homolog Z1 Publication
NAD-capped RNA hydrolase DXOCurated (EC:3.6.1.-By similarity)
Short name:
DeNADding enzyme DXOCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DXO1 PublicationImported
Synonyms:DOM3L, DOM3Z1 Publication, NG6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:2992, DXO

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605996, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O77932

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000204348.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi7 – 8KR → AA: Impaired subcellular location, leading to localization both in cytoplasm and nucleus. 1 Publication2
Mutagenesisi236D → A: Abolishes the decapping activity on incomplete m7G cap mRNAs; when associated with A-253. 1 Publication1
Mutagenesisi253E → A: Abolishes the decapping activity on incomplete m7G cap mRNAs; when associated with A-236. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1797

Open Targets

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OpenTargetsi
ENSG00000204348

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27458

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
O77932, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
DXO

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002498221 – 396Decapping and exoribonuclease proteinAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei392PhosphothreonineBy similarity1
Modified residuei394PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O77932

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O77932

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O77932

MaxQB - The MaxQuant DataBase

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MaxQBi
O77932

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O77932

PeptideAtlas

More...
PeptideAtlasi
O77932

PRoteomics IDEntifications database

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PRIDEi
O77932

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
50418

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O77932

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O77932

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204348, Expressed in right adrenal gland and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O77932, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O77932, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000204348, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
108132, 18 interactors

Protein interaction database and analysis system

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IntActi
O77932, 14 interactors

Molecular INTeraction database

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MINTi
O77932

STRING: functional protein association networks

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STRINGi
9606.ENSP00000364498

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
O77932, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O77932

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 37DisorderedSequence analysisAdd BLAST37
Regioni131 – 133Substrate bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 19Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DXO/Dom3Z family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1982, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000006425

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_024877_1_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O77932

Identification of Orthologs from Complete Genome Data

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OMAi
YETREGW

Database of Orthologous Groups

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OrthoDBi
1034620at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O77932

TreeFam database of animal gene trees

More...
TreeFami
TF322812

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013961, RAI1
IPR039039, RAI1-like_fam

The PANTHER Classification System

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PANTHERi
PTHR12395, PTHR12395, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08652, RAI1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O77932-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPRGTKRGA EKTEVAEPRN KLPRPAPSLP TDPALYSGPF PFYRRPSELG
60 70 80 90 100
CFSLDAQRQY HGDARALRYY SPPPTNGPGP NFDLRDGYPD RYQPRDEEVQ
110 120 130 140 150
ERLDHLLCWL LEHRGRLEGG PGWLAEAIVT WRGHLTKLLT TPYERQEGWQ
160 170 180 190 200
LAASRFQGTL YLSEVETPNA RAQRLARPPL LRELMYMGYK FEQYMCADKP
210 220 230 240 250
GSSPDPSGEV NTNVAFCSVL RSRLGSHPLL FSGEVDCTDP QAPSTQPPTC
260 270 280 290 300
YVELKTSKEM HSPGQWRSFY RHKLLKWWAQ SFLPGVPNVV AGFRNPDGFV
310 320 330 340 350
SSLKTFPTMK MFEYVRNDRD GWNPSVCMNF CAAFLSFAQS TVVQDDPRLV
360 370 380 390
HLFSWEPGGP VTVSVHQDAP YAFLPIWYVE AMTQDLPSPP KTPSPK
Length:396
Mass (Da):44,929
Last modified:September 19, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17C8119037EB6892
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WC68F8WC68_HUMAN
Decapping nuclease
DXO
210Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5D2H7C5D2_HUMAN
Decapping nuclease
DXO
174Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB67983 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB89306 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02749228S → T2 PublicationsCorresponds to variant dbSNP:rs1056694Ensembl.1
Natural variantiVAR_02749363D → E. Corresponds to variant dbSNP:rs2746396Ensembl.1
Natural variantiVAR_027494261H → Q1 PublicationCorresponds to variant dbSNP:rs17207867EnsemblClinVar.1
Natural variantiVAR_027495332A → V. Corresponds to variant dbSNP:rs12205138Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF059252 mRNA Translation: AAC78603.1
AF019413 Genomic DNA Translation: AAB67983.1 Sequence problems.
AL049547 Genomic DNA Translation: CAB89305.1
AL049547 Genomic DNA Translation: CAB89306.1 Sequence problems.
AL662849 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
CR753822 Genomic DNA No translation available.
CR759782 Genomic DNA No translation available.
AL645922 Genomic DNA No translation available.
CR753845 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03558.1
BC009344 mRNA Translation: AAH09344.1
BC019083 mRNA Translation: AAH19083.1
AF059253 mRNA Translation: AAC78604.1
AF059254 mRNA Translation: AAC78605.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4732.1

NCBI Reference Sequences

More...
RefSeqi
NP_005501.2, NM_005510.3
XP_006715068.1, XM_006715005.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337523; ENSP00000337759; ENSG00000204348
ENST00000375349; ENSP00000364498; ENSG00000204348
ENST00000375356; ENSP00000364505; ENSG00000204348
ENST00000383330; ENSP00000372820; ENSG00000206346
ENST00000399936; ENSP00000382818; ENSG00000206346
ENST00000399937; ENSP00000382819; ENSG00000206346
ENST00000414092; ENSP00000391123; ENSG00000236765
ENST00000419797; ENSP00000391532; ENSG00000234798
ENST00000426498; ENSP00000394167; ENSG00000225682
ENST00000427627; ENSP00000413860; ENSG00000234798
ENST00000427690; ENSP00000406143; ENSG00000225682
ENST00000432110; ENSP00000401315; ENSG00000236765
ENST00000439989; ENSP00000395262; ENSG00000224313
ENST00000443250; ENSP00000415675; ENSG00000224313
ENST00000446967; ENSP00000391349; ENSG00000234798
ENST00000453742; ENSP00000410404; ENSG00000225682
ENST00000454430; ENSP00000411380; ENSG00000224313
ENST00000458308; ENSP00000400173; ENSG00000236765

Database of genes from NCBI RefSeq genomes

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GeneIDi
1797

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1797

UCSC genome browser

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UCSCi
uc003nyp.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059252 mRNA Translation: AAC78603.1
AF019413 Genomic DNA Translation: AAB67983.1 Sequence problems.
AL049547 Genomic DNA Translation: CAB89305.1
AL049547 Genomic DNA Translation: CAB89306.1 Sequence problems.
AL662849 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
CR753822 Genomic DNA No translation available.
CR759782 Genomic DNA No translation available.
AL645922 Genomic DNA No translation available.
CR753845 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03558.1
BC009344 mRNA Translation: AAH09344.1
BC019083 mRNA Translation: AAH19083.1
AF059253 mRNA Translation: AAC78604.1
AF059254 mRNA Translation: AAC78605.1
CCDSiCCDS4732.1
RefSeqiNP_005501.2, NM_005510.3
XP_006715068.1, XM_006715005.3

3D structure databases

SMRiO77932
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi108132, 18 interactors
IntActiO77932, 14 interactors
MINTiO77932
STRINGi9606.ENSP00000364498

PTM databases

iPTMnetiO77932
PhosphoSitePlusiO77932

Genetic variation databases

BioMutaiDXO

Proteomic databases

EPDiO77932
jPOSTiO77932
MassIVEiO77932
MaxQBiO77932
PaxDbiO77932
PeptideAtlasiO77932
PRIDEiO77932
ProteomicsDBi50418

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
45412, 126 antibodies

The DNASU plasmid repository

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DNASUi
1797

Genome annotation databases

EnsembliENST00000337523; ENSP00000337759; ENSG00000204348
ENST00000375349; ENSP00000364498; ENSG00000204348
ENST00000375356; ENSP00000364505; ENSG00000204348
ENST00000383330; ENSP00000372820; ENSG00000206346
ENST00000399936; ENSP00000382818; ENSG00000206346
ENST00000399937; ENSP00000382819; ENSG00000206346
ENST00000414092; ENSP00000391123; ENSG00000236765
ENST00000419797; ENSP00000391532; ENSG00000234798
ENST00000426498; ENSP00000394167; ENSG00000225682
ENST00000427627; ENSP00000413860; ENSG00000234798
ENST00000427690; ENSP00000406143; ENSG00000225682
ENST00000432110; ENSP00000401315; ENSG00000236765
ENST00000439989; ENSP00000395262; ENSG00000224313
ENST00000443250; ENSP00000415675; ENSG00000224313
ENST00000446967; ENSP00000391349; ENSG00000234798
ENST00000453742; ENSP00000410404; ENSG00000225682
ENST00000454430; ENSP00000411380; ENSG00000224313
ENST00000458308; ENSP00000400173; ENSG00000236765
GeneIDi1797
KEGGihsa:1797
UCSCiuc003nyp.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1797
DisGeNETi1797

GeneCards: human genes, protein and diseases

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GeneCardsi
DXO
HGNCiHGNC:2992, DXO
HPAiENSG00000204348, Tissue enhanced (testis)
MIMi605996, gene
neXtProtiNX_O77932
OpenTargetsiENSG00000204348
PharmGKBiPA27458
VEuPathDBiHostDB:ENSG00000204348.9

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1982, Eukaryota
GeneTreeiENSGT00390000006425
HOGENOMiCLU_024877_1_2_1
InParanoidiO77932
OMAiYETREGW
OrthoDBi1034620at2759
PhylomeDBiO77932
TreeFamiTF322812

Enzyme and pathway databases

PathwayCommonsiO77932

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
1797, 39 hits in 973 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DXO, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DOM3Z

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1797
PharosiO77932, Tbio

Protein Ontology

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PROi
PR:O77932
RNActiO77932, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204348, Expressed in right adrenal gland and 237 other tissues
ExpressionAtlasiO77932, baseline and differential
GenevisibleiO77932, HS

Family and domain databases

InterProiView protein in InterPro
IPR013961, RAI1
IPR039039, RAI1-like_fam
PANTHERiPTHR12395, PTHR12395, 1 hit
PfamiView protein in Pfam
PF08652, RAI1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDXO_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O77932
Secondary accession number(s): A2CER3
, B0UZ80, O15004, O78127, O78128, Q5ST60, Q6IPZ2, Q9NPK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: June 2, 2021
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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