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Entry version 128 (07 Apr 2021)
Sequence version 1 (01 Nov 1998)
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Protein

Neutrophil cytosol factor 2

Gene

NCF2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neutrophil cytosol factor 2
Short name:
NCF-2
Alternative name(s):
67 kDa neutrophil oxidase factor
Neutrophil NADPH oxidase factor 2
p67-phox
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001063601 – 527Neutrophil cytosol factor 2Add BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei233PhosphothreonineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei400PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O77775

PeptideAtlas

More...
PeptideAtlasi
O77775

PRoteomics IDEntifications database

More...
PRIDEi
O77775

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4.

Interacts with NCF4.

Interacts (via the C-terminal SH3 domain) with NCF1 (via C-terminus).

Interacts with SYTL1 and RAC1. May interact with NOXO1.

Interacts with S100A8 and calprotectin (S100A8/9) (By similarity).

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O77775, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000010525

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O77775

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati37 – 70TPR 1Add BLAST34
Repeati71 – 104TPR 2Add BLAST34
Repeati121 – 154TPR 3Add BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini240 – 299SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini352 – 430PB1PROSITE-ProRule annotationAdd BLAST79
Domaini458 – 517SH3 2PROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The OPR/PB1 domain mediates the association with NCF4/p40-PHOX.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NCF2/NOXA1 family.Curated

Keywords - Domaini

Repeat, SH3 domain, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4225, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O77775

Database of Orthologous Groups

More...
OrthoDBi
431898at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06406, PB1_P67, 1 hit
cd11871, SH3_p67phox_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034889, P67-PHOX
IPR035546, p67phox_SH3_1
IPR000270, PB1_dom
IPR034885, PB1_P67
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR001440, TPR_1
IPR019734, TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR15175:SF3, PTHR15175:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00564, PB1, 1 hit
PF00018, SH3_1, 2 hits
PF00515, TPR_1, 1 hit
PF13181, TPR_8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00666, PB1, 1 hit
SM00326, SH3, 2 hits
SM00028, TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit
SSF50044, SSF50044, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51745, PB1, 1 hit
PS50002, SH3, 2 hits
PS50005, TPR, 3 hits
PS50293, TPR_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O77775-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLAEAISLW NEGVLAADKK DWKGALDAFT GVQDPHSRIC FNVGCIYTIL
60 70 80 90 100
GNLPEAEKAF TKSINRDKHL AVSYFQRGML YYQMEKYDSA IKDLKEALTQ
110 120 130 140 150
LRGNQLIDYK ILGLQFKLFA CEVLYNIAFM YAKREEWKKA EEHLALAVSM
160 170 180 190 200
KSEPRHSKID RAMESVWKQK LYEPVVIPVG RLFRPNEKQV AQLVKKDYLG
210 220 230 240 250
KATVVASVVD QDSFSGFAPL QPQAAEPPPR PKTPEIFRAL EGEAHRVLFG
260 270 280 290 300
FVPETPEELQ VMPGNIVFVL KKGNDNWATV MFNGQKGLVP CNYLEPVELR
310 320 330 340 350
IHPQQQPQEE TSLESDIPAP PSSSAPGRPQ LSPGQKGKEE PKQEIKLSVP
360 370 380 390 400
KSYTLKVHYK YTVVMETQFR LPYSQVRDMV AKKLDLLPEH TKLSYRRQDS
410 420 430 440 450
NELVPLSEFS MKDAWAQVKN YCLTLWCENT VGDQGFPDEP EESKKSDANN
460 470 480 490 500
QTTEPELKEG SKVVALFSYE ATQPEDLEFL EGDVILVIST VNEQWLEGEC
510 520
KGKVGIFPKA FVEQHPTTDL ESTPGRV
Length:527
Mass (Da):59,663
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i430D33FE1DF68BD1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF079303 mRNA Translation: AAC82463.1

NCBI Reference Sequences

More...
RefSeqi
NP_776545.1, NM_174120.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
281346

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:281346

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079303 mRNA Translation: AAC82463.1
RefSeqiNP_776545.1, NM_174120.2

3D structure databases

SMRiO77775
ModBaseiSearch...

Protein-protein interaction databases

IntActiO77775, 2 interactors
STRINGi9913.ENSBTAP00000010525

Proteomic databases

PaxDbiO77775
PeptideAtlasiO77775
PRIDEiO77775

Genome annotation databases

GeneIDi281346
KEGGibta:281346

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4688

Phylogenomic databases

eggNOGiKOG4225, Eukaryota
InParanoidiO77775
OrthoDBi431898at2759

Family and domain databases

CDDicd06406, PB1_P67, 1 hit
cd11871, SH3_p67phox_N, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR034889, P67-PHOX
IPR035546, p67phox_SH3_1
IPR000270, PB1_dom
IPR034885, PB1_P67
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR001440, TPR_1
IPR019734, TPR_repeat
PANTHERiPTHR15175:SF3, PTHR15175:SF3, 1 hit
PfamiView protein in Pfam
PF00564, PB1, 1 hit
PF00018, SH3_1, 2 hits
PF00515, TPR_1, 1 hit
PF13181, TPR_8, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00666, PB1, 1 hit
SM00326, SH3, 2 hits
SM00028, TPR, 3 hits
SUPFAMiSSF48452, SSF48452, 1 hit
SSF50044, SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51745, PB1, 1 hit
PS50002, SH3, 2 hits
PS50005, TPR, 3 hits
PS50293, TPR_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCF2_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O77775
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: April 7, 2021
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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