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Protein

Short-chain dehydrogenase/reductase 3

Gene

DHRS3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.By similarity

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei175SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1

GO - Molecular functioni

  • NADP-retinol dehydrogenase activity Source: UniProtKB-EC
  • retinol dehydrogenase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain dehydrogenase/reductase 3 (EC:1.1.1.300)
Alternative name(s):
Retinal short-chain dehydrogenase/reductase 1
Short name:
retSDR1
Gene namesi
Name:DHRS3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546431 – 302Short-chain dehydrogenase/reductase 3Add BLAST302

Proteomic databases

PaxDbiO77769
PRIDEiO77769

Expressioni

Tissue specificityi

In the retina, expressed in cone but not rod outer segments.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033930

Structurei

3D structure databases

ProteinModelPortaliO77769
SMRiO77769
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1201 Eukaryota
COG1028 LUCA
HOVERGENiHBG051352
InParanoidiO77769
KOiK11146

Family and domain databases

InterProiView protein in InterPro
IPR032969 DHRS3
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PANTHERiPTHR24322:SF483 PTHR24322:SF483, 1 hit
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

O77769-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVWKRLGALV VFPLQMIYLV VKAAVGLVLP AKLRDLSREN VLITGGGRGI
60 70 80 90 100
GRQLAREFAE RGARKIVLWG RTEKCLKETT EEIRQMGTEC HYFICDVGNR
110 120 130 140 150
EEVYQTAKAV REKVGDITIL VNNAAVVHGK SLMDSDDDAL PKSQHINTLG
160 170 180 190 200
QFWTTKAFLP RMLELQNGHI VCLNSVLALS AIPGAIDYCT SKASAFAFME
210 220 230 240 250
SLTLGLLDCP GVSATTVLPF HTSTEMFQGM RVRFPNLFPP LKPETVARRT
260 270 280 290 300
VEAVQLNQAL LLLPWTMHAL IILKSILPQA ALEEIHKFSG TYTCINTFKG

RT
Length:302
Mass (Da):33,496
Last modified:November 1, 1998 - v1
Checksum:i855FD2488ACB243E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56R → L in AAI04576 (Ref. 2) Curated1
Sequence conflicti141P → L in AAI04576 (Ref. 2) Curated1
Sequence conflicti295I → M in AAI04576 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061742 mRNA Translation: AAC63264.1
BC104575 mRNA Translation: AAI04576.1
RefSeqiNP_776605.2, NM_174180.3
UniGeneiBt.5530

Genome annotation databases

GeneIDi281482
KEGGibta:281482

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061742 mRNA Translation: AAC63264.1
BC104575 mRNA Translation: AAI04576.1
RefSeqiNP_776605.2, NM_174180.3
UniGeneiBt.5530

3D structure databases

ProteinModelPortaliO77769
SMRiO77769
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033930

Proteomic databases

PaxDbiO77769
PRIDEiO77769

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281482
KEGGibta:281482

Organism-specific databases

CTDi9249

Phylogenomic databases

eggNOGiKOG1201 Eukaryota
COG1028 LUCA
HOVERGENiHBG051352
InParanoidiO77769
KOiK11146

Family and domain databases

InterProiView protein in InterPro
IPR032969 DHRS3
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PANTHERiPTHR24322:SF483 PTHR24322:SF483, 1 hit
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHRS3_BOVIN
AccessioniPrimary (citable) accession number: O77769
Secondary accession number(s): Q3MHX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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