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Protein

Alpha-2B adrenergic receptor

Gene

ADRA2B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei79Implicated in ligand bindingBy similarity1
Sitei163Implicated in catechol agonist bindingBy similarity1
Sitei167Implicated in catechol agonist bindingBy similarity1

GO - Molecular functioni

  • adrenergic receptor activity Source: GO_Central
  • alpha2-adrenergic receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2B adrenergic receptor
Alternative name(s):
Alpha-2B adrenoreceptor
Short name:
Alpha-2B adrenoceptor
Short name:
Alpha-2BAR
Gene namesi
Name:ADRA2B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei‹1 – 25Helical; Name=1By similarityAdd BLAST›25
Topological domaini26 – 36CytoplasmicBy similarityAdd BLAST11
Transmembranei37 – 62Helical; Name=2By similarityAdd BLAST26
Topological domaini63 – 72ExtracellularBy similarity10
Transmembranei73 – 95Helical; Name=3By similarityAdd BLAST23
Topological domaini96 – 117CytoplasmicBy similarityAdd BLAST22
Transmembranei118 – 140Helical; Name=4By similarityAdd BLAST23
Topological domaini141 – 156ExtracellularBy similarityAdd BLAST16
Transmembranei157 – 180Helical; Name=5By similarityAdd BLAST24
Topological domaini181 – 356CytoplasmicBy similarityAdd BLAST176
Transmembranei357 – 380Helical; Name=6By similarityAdd BLAST24
Topological domaini381 – ›392ExtracellularBy similarityAdd BLAST›12

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000069086‹1 – ›392Alpha-2B adrenergic receptorAdd BLAST›392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 151PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO77700
PRIDEiO77700

Interactioni

Subunit structurei

Interacts with RAB26. Interacts with PPP1R9B.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012514

Chemistry databases

BindingDBiO77700

Structurei

3D structure databases

ProteinModelPortaliO77700
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi283 – 292Poly-Glu10

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiO77700

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000207 ADRA2B_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00559 ADRENRGCA2BR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Fragment.

O77700-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AIAAVITFLI LFTIFGNALV ILAVLTSRSL RAPQNLFLVS LAAADILVAT
60 70 80 90 100
LIIPFSLANE LLGYWYFWRT WCEVYLALDV LFCTSSIVHL CAISLDRYWA
110 120 130 140 150
VSRALEYNSK RTPRRIKFII LIVWLIAAVI SLPPLIYKGD QGPQPLARPQ
160 170 180 190 200
CKLNQEAWYI LASSIGSFFA PCLIMILVYL RIYLIAKRSH CRGPRAKGGP
210 220 230 240 250
GERESKQPHP VPGEVSDSAK LPTLASQLAT PGEANGCSQP RPGEKGDGET
260 270 280 290 300
PEAPGTPALP PSWPAIPKSG QGQKEGVCGS SPEEEAEEEE EEGCEPQALP
310 320 330 340 350
ASPASACSPP LQQPQGSRVL ATLRGQVLLG RGTGTAGAQW WRRRTQLSRE
360 370 380 390
KRFTFVLAVV IGVFVLCWFP FFFSYSLGAI CPQHCKVPHG LF
Length:392
Mass (Da):42,840
Last modified:August 14, 2001 - v2
Checksum:i471596A7446475E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei3921

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15944 Genomic DNA Translation: CAA75897.2
UniGeneiBt.112377

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15944 Genomic DNA Translation: CAA75897.2
UniGeneiBt.112377

3D structure databases

ProteinModelPortaliO77700
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012514

Chemistry databases

BindingDBiO77700

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO77700
PRIDEiO77700

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiO77700

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000207 ADRA2B_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00559 ADRENRGCA2BR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADA2B_BOVIN
AccessioniPrimary (citable) accession number: O77700
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 14, 2001
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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