UniProtKB - O77621 (ADA1A_CANLF)
Protein
Alpha-1A adrenergic receptor
Gene
ADRA1A
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity
GO - Molecular functioni
- alpha1-adrenergic receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: GO_Central
- protein heterodimerization activity Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
- cell-cell signaling Source: GO_Central
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- positive regulation of heart rate by epinephrine-norepinephrine Source: GO_Central
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of vasoconstriction Source: GO_Central
- regulation of cardiac muscle contraction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-1A adrenergic receptorAlternative name(s): Alpha-1A adrenoreceptor Short name: Alpha-1A adrenoceptor Alpha-1C adrenergic receptor |
Gene namesi | Name:ADRA1A Synonyms:ADRA1C |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Other locations
- caveola By similarity
Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity).By similarity
Nucleus
- nuclear membrane Source: UniProtKB
- nucleus Source: UniProtKB
Plasma Membrane
- caveola Source: UniProtKB-SubCell
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularBy similarityAdd BLAST | 27 | |
Transmembranei | 28 – 51 | Helical; Name=1By similarityAdd BLAST | 24 | |
Topological domaini | 52 – 64 | CytoplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 65 – 88 | Helical; Name=2By similarityAdd BLAST | 24 | |
Topological domaini | 89 – 99 | ExtracellularBy similarityAdd BLAST | 11 | |
Transmembranei | 100 – 122 | Helical; Name=3By similarityAdd BLAST | 23 | |
Topological domaini | 123 – 143 | CytoplasmicBy similarityAdd BLAST | 21 | |
Transmembranei | 144 – 167 | Helical; Name=4By similarityAdd BLAST | 24 | |
Topological domaini | 168 – 181 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 182 – 205 | Helical; Name=5By similarityAdd BLAST | 24 | |
Topological domaini | 206 – 273 | CytoplasmicBy similarityAdd BLAST | 68 | |
Transmembranei | 274 – ›295 | Helical; Name=6By similarityAdd BLAST | ›22 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069061 | 1 – ›295 | Alpha-1A adrenergic receptorAdd BLAST | ›295 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 7 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 13 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 22 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 99 ↔ 176 | PROSITE-ProRule annotation | ||
Modified residuei | 215 | Phosphoserine; by PKASequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | O77621 |
Interactioni
Subunit structurei
Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.
Interacts with CAVIN4.
By similarityGO - Molecular functioni
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000012820 |
Chemistry databases
BindingDBi | O77621 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | O77621 |
OMAi | HLQSVTH |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR001004, ADRA1A_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00557, ADRENRGCA1AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
O77621-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVFLSGNASD SSNCTHPPAP VNISKAILLG VILGGLIIFG VLGNILVILS
60 70 80 90 100
VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN
110 120 130 140 150
IWAAVDVLCC TASIMGLCII SIDRYIGVSY PLRYPTIVTQ KRGLMALLCV
160 170 180 190 200
WALSLVISIG PLFGWRQPAP EDETICQITE EPGYVLFSAL GSFYVPLTII
210 220 230 240 250
LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN APVGGTGVSS
260 270 280 290
AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 295 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF068283 mRNA Translation: AAC23861.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF068283 mRNA Translation: AAC23861.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000012820 |
Chemistry databases
BindingDBi | O77621 |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PaxDbi | O77621 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | O77621 |
OMAi | HLQSVTH |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR001004, ADRA1A_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00557, ADRENRGCA1AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADA1A_CANLF | |
Accessioni | O77621Primary (citable) accession number: O77621 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families