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Entry version 176 (29 Sep 2021)
Sequence version 3 (13 Sep 2005)
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Protein

Fibulin-1

Gene

fbl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes.

6 Publications

Involved in regulating the shape and adhesion of cells in the developing pharynx, intestine, body-wall muscle and gonadal tissue (PubMed:16120639).

During gonadogenesis, regulates the width of gonads and the migration of distal tip cells (DTC) (PubMed:15556862, PubMed:17043142, PubMed:22298704).

Together with type IV collagen let-2 and downstream of metalloprotease mig-17, recruits nidogen nid-1 to the gonad basement membrane thereby inducing basement membrane remodeling required for the directional migration of DTCs (PubMed:15556863, PubMed:19104038).

Acts antagonistically with metalloprotease gon-1 to maintain optimal levels of type IV collagen emb-9 in the gonad basement membrane during gonadogenesis (PubMed:15556862, PubMed:17043142, PubMed:22298704).

Required for larval development (PubMed:17043142).

5 Publications

Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall-muscle basement membranes.

1 Publication

Miscellaneous

Although involved in the same pathway as gon-1 and mig-17, it is probably not cleaved by these metalloproteases.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • extracellular matrix structural constituent Source: WormBase
  • peptidase activator activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibulin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fbl-1
Synonyms:fbln1
ORF Names:F56H11.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
F56H11.1a ; CE26701 ; WBGene00001403 ; fbl-1
F56H11.1b ; CE26702 ; WBGene00001403 ; fbl-1
F56H11.1c ; CE38374 ; WBGene00001403 ; fbl-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Gonads have short and swollen arms. Pharyngeal defects. Movement is lethargic.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi288G → E in k201/tk51; slight defect in posterior DTC migration. In a let-2 (k196) mutant background, partially prevents anterior DTC migration. Restores normal DTC migration and nid-1 basement membrane localization in a mig-17 (k174) mutant background but not in a mig-17 (k174) and nid-1 (cg119) mutant background. Restores nid-1 basement membrane localization in a mig-17 (k174) mutant background. 2 Publications1
Mutagenesisi290H → Y in k206; No defect in DTC migration. In a let-2 (k196) mutant background, partially prevents anterior DTC migration. Restores normal DTC migration and nid-1 basement membrane localization in a mig-17 (k174) mutant background but not in a mig-17 (k174) and nid-1 (cg119) mutant background. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000756718 – 728Fibulin-1Add BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi23 ↔ 49PROSITE-ProRule annotation
Disulfide bondi24 ↔ 56PROSITE-ProRule annotation
Disulfide bondi37 ↔ 57PROSITE-ProRule annotation
Disulfide bondi66 ↔ 94PROSITE-ProRule annotation
Disulfide bondi79 ↔ 95PROSITE-ProRule annotation
Disulfide bondi97 ↔ 121PROSITE-ProRule annotation
Disulfide bondi98 ↔ 128PROSITE-ProRule annotation
Disulfide bondi111 ↔ 129PROSITE-ProRule annotation
Disulfide bondi159 ↔ 168PROSITE-ProRule annotation
Disulfide bondi164 ↔ 178PROSITE-ProRule annotation
Disulfide bondi180 ↔ 279PROSITE-ProRule annotation
Disulfide bondi285 ↔ 298PROSITE-ProRule annotation
Disulfide bondi292 ↔ 307PROSITE-ProRule annotation
Disulfide bondi347 ↔ 359PROSITE-ProRule annotation
Disulfide bondi353 ↔ 368PROSITE-ProRule annotation
Disulfide bondi375 ↔ 388PROSITE-ProRule annotation
Disulfide bondi394 ↔ 404PROSITE-ProRule annotation
Disulfide bondi399 ↔ 413PROSITE-ProRule annotation
Disulfide bondi415 ↔ 428PROSITE-ProRule annotation
Disulfide bondi434 ↔ 448PROSITE-ProRule annotation
Disulfide bondi442 ↔ 457PROSITE-ProRule annotation
Disulfide bondi459 ↔ 472PROSITE-ProRule annotation
Disulfide bondi478 ↔ 489PROSITE-ProRule annotation
Disulfide bondi485 ↔ 498PROSITE-ProRule annotation
Disulfide bondi500 ↔ 513PROSITE-ProRule annotation
Disulfide bondi519 ↔ 534PROSITE-ProRule annotation
Disulfide bondi530 ↔ 543PROSITE-ProRule annotation
Disulfide bondi545 ↔ 558PROSITE-ProRule annotation
Disulfide bondi564 ↔ 576PROSITE-ProRule annotation
Disulfide bondi569 ↔ 585PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi624N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O77469

PeptideAtlas

More...
PeptideAtlasi
O77469

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O77469

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in head muscle cells, anterior and posterior intestinal cells (PubMed:15556862). Isoform a: Expressed in male and hermaphrodite gonad, anterior and posterior intestine and pharyngeal basement membranes, body-wall muscle, GLR cells, uterine attachment and mechanosensory neurons (PubMed:15556863, PubMed:16120639, PubMed:17043142). Isoform c: Expressed on ALM/PLM mechanosensory neuron attachments, in flexible tracks connecting the pharyngeal, body-wall-muscle basement membranes and in uterine attachments (PubMed:16120639).4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from late embryonic stage onwards.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001403, Expressed in material anatomical entity and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O77469, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomultimerizes and interacts with various extracellular matrix components.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
42893, 7 interactors

Database of interacting proteins

More...
DIPi
DIP-26629N

Protein interaction database and analysis system

More...
IntActi
O77469, 7 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F56H11.1c

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O77469

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 64Anaphylatoxin-like 1Add BLAST42
Domaini65 – 96Anaphylatoxin-like 2Add BLAST32
Domaini97 – 129Anaphylatoxin-like 3Add BLAST33
Domaini155 – 194EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini195 – 280EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST86
Domaini281 – 344EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST64
Domaini343 – 389EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST47
Domaini390 – 429EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini430 – 473EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini474 – 514EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini515 – 559EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST45
Domaini560 – 610EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST51

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fibulin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156642

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O77469

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEECINT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O77469

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000020, Anaphylatoxin/fibulin
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR017048, Fibulin-1
IPR009030, Growth_fac_rcpt_cys_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 6 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036313, Fibulin-1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 8 hits
SM00179, EGF_CA, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01177, ANAPHYLATOXIN_1, 1 hit
PS00010, ASX_HYDROXYL, 4 hits
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform c (identifier: O77469-1) [UniParc]FASTAAdd to basket
Also known as: Fibulin-1D

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRICFLLLAF LVAETFANEL TRCCAGGTRH FKNSNTCSSI KSEGTSMTCQ
60 70 80 90 100
RAASICCLRS LLDNACDSGT DIAKEEESCP SNINILGGGL KKECCDCCLL
110 120 130 140 150
AKDLLNRNEP CVAPVGFSAG CLRSFNKCCN GDIEITHASE IITGRPLNDP
160 170 180 190 200
HVLHLGDRCA SSHCEHLCHD RGGEKVECSC RSGFDLAPDG MACVDRNECL
210 220 230 240 250
TRQSPCTQSE DCVNTIGGYI CQRRISRLVP HRHRANRIGN APRRMRDDPY
260 270 280 290 300
SRAGEYREAS QANTEFGCPM GWLFQHGHCV DVDECNLGSH DCGPLYQCRN
310 320 330 340 350
TQGSYRCDAK KCGDGELQNP MTGECTSITC PNGYYPKNGM CNDIDECVTG
360 370 380 390 400
HNCGAGEECV NTPGSFRCQQ KGNLCAHGYE VNGATGFCED VNECQQGVCG
410 420 430 440 450
SMECINLPGT YKCKCGPGYE FNDAKKRCED VDECIKFAGH VCDLSAECIN
460 470 480 490 500
TIGSFECKCK PGFQLASDGR RCEDVNECTT GIAACEQKCV NIPGSYQCIC
510 520 530 540 550
DRGFALGPDG TKCEDIDECS IWAGSGNDLC MGGCINTKGS YLCQCPPGYK
560 570 580 590 600
IQPDGRTCVD VDECAMGECA GSDKVCVNTL GSFKCHSIDC PTNYIHDSLN
610 620 630 640 650
KNQIADGYSC IKVCSTEDTE CLGNHTREVL YQFRAVPSLK TIISPIEVSR
660 670 680 690 700
IVTHMGVPFS VDYNLDYVGQ RHFRIVQERN IGIVQLVKPI SGPTVETIKV
710 720
NIHTKSRTGV ILAFNEAIIE ISVSKYPF
Length:728
Mass (Da):79,321
Last modified:September 13, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBD2484CC6FD53A9
GO
Isoform a (identifier: O77469-2) [UniParc]FASTAAdd to basket
Also known as: C, Fibulin-1C

The sequence of this isoform differs from the canonical sequence as follows:
     196-280: RNECLTRQSP...GWLFQHGHCV → IDECATLMDD...AMDSETERCR
     603-728: QIADGYSCIK...IEISVSKYPF → RCNRQPSACG...TVHPPLMKIR

Show »
Length:712
Mass (Da):77,009
Checksum:i52CE8CF8BF296BC5
GO
Isoform b (identifier: O77469-3) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     196-280: RNECLTRQSP...GWLFQHGHCV → IDECATLMDD...AMDSETERCR

Show »
Length:689
Mass (Da):74,625
Checksum:i0FED2023E11D6AFB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A061AIV4A0A061AIV4_CAEEL
Fibulin-1
fbl-1 CELE_F56H11.1, F56H11.1
751Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061ADQ1A0A061ADQ1_CAEEL
Fibulin-1
fbl-1 CELE_F56H11.1, F56H11.1
644Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061AKL1A0A061AKL1_CAEEL
Fibulin-1
fbl-1 CELE_F56H11.1, F56H11.1
667Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061ACF5A0A061ACF5_CAEEL
Fibulin-1
fbl-1 CELE_F56H11.1, F56H11.1
605Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061ACI3A0A061ACI3_CAEEL
Fibulin-1
fbl-1 CELE_F56H11.1, F56H11.1
628Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti195D → DH in AAC24035 (PubMed:9923656).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001388196 – 280RNECL…HGHCV → IDECATLMDDCLESQRCLNT PGSFKCIRTLSCGTGYAMDS ETERCR in isoform a and isoform b. 3 PublicationsAdd BLAST85
Alternative sequenceiVSP_001390603 – 728QIADG…SKYPF → RCNRQPSACGLPEECSKVPL FLTYQFISLARAVPISSHRP AITLFKVSAPNHADTEVNFE LQLKTTIVGAPNVLPAIRAN FLLQKGEKRNSAVVTLRDSL DGPQTVKLQLLLRMSKKGKN FNTYAANLIVDVAAHKRHNT VHPPLMKIR in isoform a. 3 PublicationsAdd BLAST126

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB212860 mRNA Translation: BAD98165.1
AY851363 mRNA Translation: AAW34127.1
AF051401 mRNA Translation: AAC28321.1
AF051402 mRNA Translation: AAC28322.1
AF051403 Genomic DNA Translation: AAC28323.1
AF051403 Genomic DNA Translation: AAC28324.1
AF070477 Genomic DNA Translation: AAC24035.1
Z68749, Z68219 Genomic DNA Translation: CAA92962.2
Z68749, Z68219 Genomic DNA Translation: CAC35817.1
Z68749, Z68219 Genomic DNA Translation: CAC35818.1

Protein sequence database of the Protein Information Resource

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PIRi
T22793
T42760
T42990
T43210

NCBI Reference Sequences

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RefSeqi
NP_001023236.1, NM_001028065.2 [O77469-2]
NP_001023237.1, NM_001028066.4 [O77469-3]
NP_501694.2, NM_069293.4 [O77469-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
F56H11.1a.1; F56H11.1a.1; WBGene00001403 [O77469-2]
F56H11.1b.1; F56H11.1b.1; WBGene00001403 [O77469-3]
F56H11.1c.1; F56H11.1c.1; WBGene00001403 [O77469-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
177788

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_F56H11.1

UCSC genome browser

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UCSCi
F56H11.1a.1, c. elegans [O77469-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB212860 mRNA Translation: BAD98165.1
AY851363 mRNA Translation: AAW34127.1
AF051401 mRNA Translation: AAC28321.1
AF051402 mRNA Translation: AAC28322.1
AF051403 Genomic DNA Translation: AAC28323.1
AF051403 Genomic DNA Translation: AAC28324.1
AF070477 Genomic DNA Translation: AAC24035.1
Z68749, Z68219 Genomic DNA Translation: CAA92962.2
Z68749, Z68219 Genomic DNA Translation: CAC35817.1
Z68749, Z68219 Genomic DNA Translation: CAC35818.1
PIRiT22793
T42760
T42990
T43210
RefSeqiNP_001023236.1, NM_001028065.2 [O77469-2]
NP_001023237.1, NM_001028066.4 [O77469-3]
NP_501694.2, NM_069293.4 [O77469-1]

3D structure databases

SMRiO77469
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi42893, 7 interactors
DIPiDIP-26629N
IntActiO77469, 7 interactors
STRINGi6239.F56H11.1c

PTM databases

iPTMnetiO77469

Proteomic databases

PaxDbiO77469
PeptideAtlasiO77469

Genome annotation databases

EnsemblMetazoaiF56H11.1a.1; F56H11.1a.1; WBGene00001403 [O77469-2]
F56H11.1b.1; F56H11.1b.1; WBGene00001403 [O77469-3]
F56H11.1c.1; F56H11.1c.1; WBGene00001403 [O77469-1]
GeneIDi177788
KEGGicel:CELE_F56H11.1
UCSCiF56H11.1a.1, c. elegans [O77469-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
177788
WormBaseiF56H11.1a ; CE26701 ; WBGene00001403 ; fbl-1
F56H11.1b ; CE26702 ; WBGene00001403 ; fbl-1
F56H11.1c ; CE38374 ; WBGene00001403 ; fbl-1

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
GeneTreeiENSGT00940000156642
InParanoidiO77469
OMAiFEECINT
PhylomeDBiO77469

Miscellaneous databases

Protein Ontology

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PROi
PR:O77469

Gene expression databases

BgeeiWBGene00001403, Expressed in material anatomical entity and 4 other tissues
ExpressionAtlasiO77469, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000020, Anaphylatoxin/fibulin
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR017048, Fibulin-1
IPR009030, Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 6 hits
PIRSFiPIRSF036313, Fibulin-1, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 8 hits
SM00179, EGF_CA, 8 hits
SUPFAMiSSF57184, SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS01177, ANAPHYLATOXIN_1, 1 hit
PS00010, ASX_HYDROXYL, 4 hits
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 8 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBLN1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O77469
Secondary accession number(s): O18026
, O77474, Q20903, Q50JF9, Q5I5Q9, Q95NZ3, Q9TZS1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 13, 2005
Last modified: September 29, 2021
This is version 176 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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