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Protein

Telomerase reverse transcriptase

Gene

TERT

Organism
Tetrahymena thermophila
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi618Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi815Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi816Magnesium; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Nucleotidyltransferase, RNA-directed DNA polymerase, Transferase
LigandMagnesium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Telomerase reverse transcriptase (EC:2.7.7.49)
Alternative name(s):
Telomerase catalytic subunit
Telomerase subunit P133
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TERT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetrahymena thermophila
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5911 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000549291 – 1117Telomerase reverse transcriptaseAdd BLAST1117

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O77448

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-60200N

Protein interaction database and analysis system

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IntActi
O77448, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O77448

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O77448

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O77448

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini517 – 881Reverse transcriptasePROSITE-ProRule annotationAdd BLAST365

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000477 RT_dom
IPR021891 Telomerase_RBD
IPR003545 Telomerase_RT

The PANTHER Classification System

More...
PANTHERi
PTHR12066 PTHR12066, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00078 RVT_1, 1 hit
PF12009 Telomerase_RBD, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01365 TELOMERASERT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00975 Telomerase_RBD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50878 RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O77448-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKINNINNN KQMLTRKEDL LTVLKQISAL KYVSNLYEFL LATEKIVQTS
60 70 80 90 100
ELDTQFQEFL TTTIIASEQN LVENYKQKYN QPNFSQLTIK QVIDDSIILL
110 120 130 140 150
GNKQNYVQQI GTTTIGFYVE YENINLSRQT LYSSNFRNLL NIFGEEDFKY
160 170 180 190 200
FLIDFLVFTK VEQNGYLQVA GVCLNQYFSV QVKQKKWYKN NFNMNGKATS
210 220 230 240 250
NNNQNNANLS NEKKQENQYI YPEIQRSQIF YCNHMGREPG VFKSSFFNYS
260 270 280 290 300
EIKKGFQFKV IQEKLQGRQF INSDKIKPDH PQTIIKKTLL KEYQSKNFSC
310 320 330 340 350
QEERDLFLEF TEKIVQNFHN INFNYLLKKF CKLPENYQSL KSQVKQIVQS
360 370 380 390 400
ENKANQQSCE NLFNSLYDTE ISYKQITNFL RQIIQNCVPN QLLGKKNFKV
410 420 430 440 450
FLEKLYEFVQ MKRFENQKVL DYICFMDVFD VEWFVDLKNQ KFTQKRKYIS
460 470 480 490 500
DKRKILGDLI VFIINKIVIP VLRYNFYITE KHKEGSQIFY YRKPIWKLVS
510 520 530 540 550
KLTIVKLEEE NLEKVEEKLI PEDSFQKYPQ GKLRIIPKKG SFRPIMTFLR
560 570 580 590 600
KDKQKNIKLN LNQILMDSQL VFRNLKDMLG QKIGYSVFDN KQISEKFAQF
610 620 630 640 650
IEKWKNKGRP QLYYVTLDIK KCYDSIDQMK LLNFFNQSDL IQDTYFINKY
660 670 680 690 700
LLFQRNKRPL LQIQQTNNLN SAMEIEEEKI NKKPFKMDNI NFPYYFNLKE
710 720 730 740 750
RQIAYSLYDD DDQILQKGFK EIQSDDRPFI VINQDKPRCI TKDIIHNHLK
760 770 780 790 800
HISQYNVISF NKVKFRQKRG IPQGLNISGV LCSFYFGKLE EEYTQFLKNA
810 820 830 840 850
EQVNGSINLL MRLTDDYLFI SDSQQNALNL IVQLQNCANN NGFMFNDQKI
860 870 880 890 900
TTNFQFPQED YNLEHFKISV QNECQWIGKS IDMNTLEIKS IQKQTQQEIN
910 920 930 940 950
QTINVAISIK NLKSQLKNKL RSLFLNQLID YFNPNINSFE GLCRQLYHHS
960 970 980 990 1000
KATVMKFYPF MTKLFQIDLK KSKQYSVQYG KENTNENFLK DILYYTVEDV
1010 1020 1030 1040 1050
CKILCYLQFE DEINSNIKEI FKNLYSWIMW DIIVSYLKKK KQFKGYLNKL
1060 1070 1080 1090 1100
LQKIRKSRFF YLKEGCKSLQ LILSQQKYQL NKKELEAIEF IDLNNLIQDI
1110
KTLIPKISAK SNQQNTN
Length:1,117
Mass (Da):133,318
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5AF15E86B0F0CD8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF062652 Genomic DNA Translation: AAC39135.1
AF061284 mRNA Translation: AAC39140.1

Protein sequence database of the Protein Information Resource

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PIRi
T14891

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062652 Genomic DNA Translation: AAC39135.1
AF061284 mRNA Translation: AAC39140.1
PIRiT14891

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B2AX-ray2.22A/B/C2-191[»]
2R4GX-ray1.71A254-519[»]
5C9HX-ray3.00A/B217-516[»]
6D6Velectron microscopy4.80A1-1117[»]
ProteinModelPortaliO77448
SMRiO77448
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60200N
IntActiO77448, 1 interactor

Proteomic databases

PRIDEiO77448

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO77448

Family and domain databases

InterProiView protein in InterPro
IPR000477 RT_dom
IPR021891 Telomerase_RBD
IPR003545 Telomerase_RT
PANTHERiPTHR12066 PTHR12066, 1 hit
PfamiView protein in Pfam
PF00078 RVT_1, 1 hit
PF12009 Telomerase_RBD, 1 hit
PRINTSiPR01365 TELOMERASERT
SMARTiView protein in SMART
SM00975 Telomerase_RBD, 1 hit
PROSITEiView protein in PROSITE
PS50878 RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTERT_TETTH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O77448
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: December 5, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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