Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein PFC0760c

Gene

PFC0760c

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PFC0760c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PFC0760c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_0317300

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • membrane Source: UniProtKB

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Possible candidate for an effective malaria vaccine as determined by epitope response in sera.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003887541 – 3394Protein PFC0760cAdd BLAST3394

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O77384

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Developmental stagei

Merozoite

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
1209731, 16 interactors

Protein interaction database and analysis system

More...
IntActi
O77384, 13 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O77384

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O77384

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi32 – 56Asn-richSequence analysisAdd BLAST25
Compositional biasi466 – 3391Asn-richSequence analysisAdd BLAST2926
Compositional biasi1044 – 1103Asp-richSequence analysisAdd BLAST60
Compositional biasi2647 – 2670Asp-richSequence analysisAdd BLAST24
Compositional biasi3005 – 3380Asp-richSequence analysisAdd BLAST376

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O77384

Identification of Orthologs from Complete Genome Data

More...
OMAi
NQHINQG

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O77384-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNDFMKNEK DDYDKVNEEE YSLENFRGID MNNNVDISNM NNNLNDVGEL
60 70 80 90 100
INIDNNDKYD EDQLSLIKES LEYGELLLSN VKEEDENNRR EHFKKNDYMK
110 120 130 140 150
DTEDVHYKES KIGQDKRFMH SLCVKELKST EEGELFDDEK YKDKDTLINM
160 170 180 190 200
LRKKLEIKIK DYNLIMDTLI LTKEECSKKE EQLKDYKMKY NKMEKECYSL
210 220 230 240 250
KNEIERKNNE KHLNIGSFSF YKNEYDDMKY KLLKCEEKNK ILLNKNQELH
260 270 280 290 300
QTIIQMKNDS YNQNIKFKKD IDVLTEDKKN ILIQNKNFTK QNKILIDKYL
310 320 330 340 350
RQEKIIYKLK KHNEEQEIII KECHKKIEFV NKNSVNHLNK VRDVLNKSLI
360 370 380 390 400
KSEEHVKLYT NLKKENDSLK IEYNKSKTNI QQLNEQLVNY KNFIKEMEKK
410 420 430 440 450
YKQLVVKNNS LFSITHDFIN LKNSNIIIIR RTSDMKQIFK MYNLDIEHFN
460 470 480 490 500
EQDHLSVIYI YEILYNTNDN NNNDNDNNND NNNNNNNNND NNNNNNNDNN
510 520 530 540 550
NNNNNYNNIM MMIENMNSGN HPNSNNLHNY RHNTNDENNL SSLKTSFRYK
560 570 580 590 600
INNKSGKSRS IKSRSHFSGD NEYIQDQLSN REMKDHYNYI ERYNHSSNRN
610 620 630 640 650
DIHNLYYMEE NVSHNNNKSD YDEDGDAENN NYYIKIKKNK YKKLNDLLNK
660 670 680 690 700
AQMKIITLTR ANEMFEKYCS NIKNTLIRDD MKKFRKPDIS DVHILHNEKI
710 720 730 740 750
YLEKLLNEKL NYIKDIEKKL DELHGVINKN KEDIYILQVE KQTLIKVISS
760 770 780 790 800
VYDYTKMESE NHIFKMNTTW NKMLNNVHMS SNKDYNNQNN QNIENNQNIE
810 820 830 840 850
NNQNNQNIEN NQNIENNQNN QNNQNNQNNQ NNQNNQNNQN NAGIHISPDD
860 870 880 890 900
FLKYRMSLEK FIQFTIKEHI VYIMKDEKKK TSNIIKESIS LKKKHTKKSI
910 920 930 940 950
INNNNDNNNE DDDDNDMLSV MYSNDDVIKN KRKENNKEIL EEHVSFSSFS
960 970 980 990 1000
NNEYIAHSFN SILLQLSNYI FNIECKQMEY FKNSNLLSYV DDYTITIELF
1010 1020 1030 1040 1050
YRLKKYNNIF SIEQILGTQY PSILQKLHDG IYCLKDNNKK KNNDGDNKSQ
1060 1070 1080 1090 1100
EDDDGNKKKN NDGDNKSQED DDGNKKKNND GDNKSQEDDY GNKKKNNDDD
1110 1120 1130 1140 1150
DDDSYKIELI VDELNKCKKN YTDEELYELM KGSDFDIFKK YKNFYLNHFI
1160 1170 1180 1190 1200
NINNIFSTII SFHIHNIEDK YKKVYERYFN LFNFNFSNVE LSFDLLIRRF
1210 1220 1230 1240 1250
DKILRLTKKY EQLLEENYEK IKNKNEKEEY LHACIKELEM NLERYNNEKI
1260 1270 1280 1290 1300
ILDEQINEKE KKINIINEKY LILEKEYEEY QNKNIFINAQ IENLEKEKKQ
1310 1320 1330 1340 1350
LQEEIIQKDM INVKLNEKNC DIIKIYEKEK QYLHTLLQEN KDSHNYLKDK
1360 1370 1380 1390 1400
FENLLNLNEK LKYDHDISLN KINTLWLEEK ENNKKNTFHM NNLRVENNNL
1410 1420 1430 1440 1450
LLKMKELQNK YNIIKKELNE RIKQINVFRN NVSTLSLRDN RSTRGSIHQI
1460 1470 1480 1490 1500
NNMYMNNTHL GFMGASKINN NISNLYYSNM IHMSHRGSII KNKEDAEGNS
1510 1520 1530 1540 1550
TQARMNNKDS TDNIINNIHN TDNINNMNNI NNNTLNSINS NHLYYPFPFH
1560 1570 1580 1590 1600
NNVNSPKMVG MCDVTLASGV NKKDDFLLNL EENEENSFLE YEIRIKSLQE
1610 1620 1630 1640 1650
ELCDKESEIL KIKGEKNILI TCIETWKCFC KNSKEEISRL KEICKEQLEK
1660 1670 1680 1690 1700
HKEFLLINKS NEDKLKYINS LLCDEKDKYD IVVKDIKNNM RNEIDKLNND
1710 1720 1730 1740 1750
INEKSYEIKL LKHENNNLIN EMNILKNKET ENMNIKQKEE DYIKLIKKDK
1760 1770 1780 1790 1800
TNIQNEYNDL LEKYNEVVVK NNMLYNDMNV LLKEHKEEIF LLKENIKILQ
1810 1820 1830 1840 1850
KDNTYLNDMF KNQINYVDNN LLKNRLDQLF NINQDLQKHL DTNQKHLEQL
1860 1870 1880 1890 1900
KYDYIEIKER LKIEKTKINK QEKYIIQLQK DNNLILNDFN STTTTTNNNN
1910 1920 1930 1940 1950
NNDNNNDNNN DNNDNNNDTY QQFIHSLKAN LENSRLELKE LSNLNEKIQL
1960 1970 1980 1990 2000
SDEKNRMKIT ILEDKLFKNE KDKMKLQQII DDNNKNYMIQ YNKLKTNLDM
2010 2020 2030 2040 2050
LSEENRMLLL NKEEYEKQIE QLNHDHKLFI STKNNDIQII ENEKLQEQVD
2060 2070 2080 2090 2100
QYITTINEKD KIIVHLNLQI KKLANQNEHM RSRCDIFNVA HSQDNIKNDH
2110 2120 2130 2140 2150
MVVGEDIMGD TNHDVNKNID QGTNQHINQG TNQHINQGTN QHDTCDGPNY
2160 2170 2180 2190 2200
NYVKVQNATN REDNKNKERN LSQEIYKYIN ENIDLTSELE KKNDMLENYK
2210 2220 2230 2240 2250
NELKEKNEEI YKLNNDIDML SNNCKKLKES IMMMEKYKII MNNNIQEKDE
2260 2270 2280 2290 2300
IIENLKNKYN NKLDDLINNY SVVDKSIVSC FEDSNIMSPS CNDILNVFNN
2310 2320 2330 2340 2350
LSKSNKKVCT NMDICNENMD SISSINNVNN INNVNNINNV NNINNVNNIN
2360 2370 2380 2390 2400
NVKNIVDINN YLVNNLQLNK DNDNIIIIKF NILKLFKLGS CYLYIINRNL
2410 2420 2430 2440 2450
KEIQMLKNQI LSLEESIKSL NEFINNLKNE NEKNELIKIN NFEEILKLKN
2460 2470 2480 2490 2500
NLQDNESCIQ NLNNYLKKNE ELNKINVKNI FKYKGYIIHL IQQSNVFCKI
2510 2520 2530 2540 2550
FKHFNENKII DQSIINKLLY LKKSFDFYMY DSVIQEIREN KNIIINQDFL
2560 2570 2580 2590 2600
TDEYFKHIQT FTKTCNVLIQ RGYLSILKDT NNDFFIQNKQ SNQQGNQNGN
2610 2620 2630 2640 2650
HINMCNIYPD DEINVTADQQ IFDGTENVQQ SLQNEEDYVN NEEMYTDKMD
2660 2670 2680 2690 2700
LDNNMNGDDD DDDDDDDDDD NNNNNNNNNN NNNNNMGDED NHLVNAFNNH
2710 2720 2730 2740 2750
NLLTNGNVKS DQINNETLER YEENIIQNIY TNDNVDNNQV IENINKILIK
2760 2770 2780 2790 2800
DKQDIINNDE LKNEHNNLIR LINESIENAH NLENVYVQND ANNLINDNIK
2810 2820 2830 2840 2850
KEETLTYVDE KDNVSNESNS KCDDDKKENE DIIQAKNENY PVSTHYDNND
2860 2870 2880 2890 2900
DINKDNINND NNNDNINDDN NNDNINNDNN NDNINNDNIN NDNINNDNNN
2910 2920 2930 2940 2950
DNNNDNSNNG FVCELSSNIN DFNNILNVNK DNFQGINKSN NFSTNLSEYN
2960 2970 2980 2990 3000
YDAYVKIVEA GSALENKKQQ DKKRKYFSDS EITKENGYLG ESNSIKIRKV
3010 3020 3030 3040 3050
SVGGDNDNND DDNNDDNDDD DNDDDNNDDD NNNDDDNDDS YDDEEKEQEN
3060 3070 3080 3090 3100
YSNDVNTELN NHVTFEDISV HNNIQENKKN YFSNVHENTF NLHVDENVHE
3110 3120 3130 3140 3150
DLQNYEDYVN NNNNNNDDDN EEESNNSCYI ISSDDEGDKK NVSKQNDDDE
3160 3170 3180 3190 3200
DDDDNGDDDD NEDDDDNEDD DNGDDDDNED DDNGDDDDNE DDNYDDEDND
3210 3220 3230 3240 3250
NYENEDDDNY ANEDDDNYEN DDDDNYENDD DDNYENDDDN YENDDDDNYE
3260 3270 3280 3290 3300
NGDDDNDNDH NDDNNDEEKY SCHDDKNEHT NNDLLNIDHD NNKNNITDEL
3310 3320 3330 3340 3350
YSTYNVSVSH NKDPSNKENE IQNLISIDSS NENDENDEND ENDENDENDE
3360 3370 3380 3390
NDENDENDEN DENDEKDEND ENDENDENFD NNNEGTLNEM NSEE
Length:3,394
Mass (Da):402,952
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81BB86F2056A4B57
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844502 Genomic DNA Translation: CAB11140.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18501

NCBI Reference Sequences

More...
RefSeqi
XP_001351243.1, XM_001351207.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAB11140; CAB11140; PF3D7_0317300

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0317300.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
814487

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0317300

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844502 Genomic DNA Translation: CAB11140.1
PIRiT18501
RefSeqiXP_001351243.1, XM_001351207.1

3D structure databases

ProteinModelPortaliO77384
SMRiO77384
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1209731, 16 interactors
IntActiO77384, 13 interactors

Proteomic databases

PRIDEiO77384

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAB11140; CAB11140; PF3D7_0317300
GeneDBiPF3D7_0317300.1:pep
GeneIDi814487
KEGGipfa:PF3D7_0317300

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0317300

Phylogenomic databases

InParanoidiO77384
OMAiNQHINQG

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRR4_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O77384
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again