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Entry version 107 (02 Jun 2021)
Sequence version 1 (01 Nov 1998)
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Protein
Submitted name:

TVN-junction protein 1

Gene

PF3D7_0310400

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TVN-junction protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0310400Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
PlasmoDB:PF3D7_0310400

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB11638, Artenimol

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500415986818 – 1294Sequence analysisAdd BLAST1277

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O77361

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O77361

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O77361, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni168 – 204DisorderedSequence analysisAdd BLAST37
Regioni387 – 420DisorderedSequence analysisAdd BLAST34
Regioni730 – 757DisorderedSequence analysisAdd BLAST28
Regioni954 – 1043DisorderedSequence analysisAdd BLAST90
Regioni1064 – 1099DisorderedSequence analysisAdd BLAST36
Regioni1273 – 1294DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili488 – 508Sequence analysisAdd BLAST21
Coiled coili1145 – 1168Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi387 – 401Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi402 – 420Polar residuesSequence analysisAdd BLAST19
Compositional biasi731 – 749Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi963 – 978Polar residuesSequence analysisAdd BLAST16
Compositional biasi979 – 1036Basic and acidic residuesSequence analysisAdd BLAST58
Compositional biasi1064 – 1089Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1273 – 1287Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006426_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O77361

Identification of Orthologs from Complete Genome Data

More...
OMAi
KLKHMIY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003378, Fringe-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02434, Fringe, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O77361-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVGIIFFCL FFFVVLGACN NVKERIFKNI KKRTKFIILN EPIVDLSFSE
60 70 80 90 100
NLFHTLLFDL DVDKNLYTLD ESLLNLENLN YSSIFRLLVD TYKNIKENED
110 120 130 140 150
DNKNIRYIFL GTSFSRIHPL NFEYFLRKLN KYIYNGNIYE KGNVDIRGIL
160 170 180 190 200
EEYNKEIEEK KLEKQKLNKI KDKNNNNNNN NNSKFSKDGD NEDFNNKNDL
210 220 230 240 250
YNPSDKLYNN NDDIDVHELL EEIITKEKRF FLNDDDDNDS NDKYILKTDE
260 270 280 290 300
VNKYKGFFIG YGFNDDIPSV IHHYNFDKNF LFPSLNSGII LDITLLKNIY
310 320 330 340 350
EVSNILLSNN EKDQSIHIDY IYEVTKYIKE NLRVRLTHSE NVCLNEEQNI
360 370 380 390 400
HLLDNDPNNF EIYKYYQVLN LFKDYNKNTE EKQYEKIGHE NVRHEETSSE
410 420 430 440 450
GNENLNRNTK HNNDNNNDNN NYSEDAIAEL LLSYFNVFYP ISTCMCYSIR
460 470 480 490 500
SKHESLMDYD KYHMINLEND IKLKHYIKET EEIHFNSIEE YKMKLNRINY
510 520 530 540 550
KYDTLLEEHE NLVTHKNILI GIKTSINTEE ERIPHIKNTY DNKENTQIIF
560 570 580 590 600
NTFNYDNKLK EKNTFGFYNN SLLQNALEND NIDLDIIYMS DKESQKYDNL
610 620 630 640 650
YFNSKVTSKE GLCEKLKHMI YYYYEEYVMK NSEKKYFFIA DDDTFVNVKN
660 670 680 690 700
LIDVTNLTLN TCSHSKKYMY DKYIKSYDFV KENEALFLQN FPKKTLFLYS
710 720 730 740 750
YLKDTFAKTI QTLKKYDYVP KYCQGGILSK KHKNNDSDDD HDHHVGNKQN
760 770 780 790 800
NDSTNHQDIE KNQVNVINNN NNNNNNKAKS IPIYLGRRYS YNTFSTNSNE
810 820 830 840 850
YFYDYLTGGA GILINDETAK RIYECKECTC PSTNSSMDDM IFGKWAKELG
860 870 880 890 900
ILAINFEGYF QNSPLDYNKK YINTLVPITY HRLNKNRTTK ESRDMYFNYL
910 920 930 940 950
VNYNRNDKEQ NKDIYVDYLD RNHKNMIDNV FHYFFYVNMY DEKNKVVTKI
960 970 980 990 1000
EHNADMNSKK NKSKNPQKLN NTQGDKNVND DENVNDDENV KGDENVKGDE
1010 1020 1030 1040 1050
NVKGDEYMKG DENVKGDENV KDDENVKDDE NIKGDDNNYN VDNMENIDDI
1060 1070 1080 1090 1100
INMVESVDDD VMERNKKGTG KEKKDDKNHN NKEKATDVKK SSVPTNNIDK
1110 1120 1130 1140 1150
NEDTTKYVIK MNEKIYNRMQ ESGKYKQLFD INKFFKKEIE GHPYFQKIKK
1160 1170 1180 1190 1200
KNEKAKKEKE KMNQLKKQKD YTNNYFHTSN MQGNFNQQKM GNYQNQENEE
1210 1220 1230 1240 1250
NDFFDQRPEI EEDAINPMDY EEYMENLSNF EDDGEPYDEY DDYDDFVNTI
1260 1270 1280 1290
NADKLKINDQ NKHLYEQIKD IAQPPVNFQN DQNSNTFDFD TDEL
Length:1,294
Mass (Da):154,089
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49743A4991CC3B89
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844502 Genomic DNA Translation: CAA15616.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18473

NCBI Reference Sequences

More...
RefSeqi
XP_001351177.1, XM_001351141.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAA15616; CAA15616; PF3D7_0310400

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0310400.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
814419

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0310400

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844502 Genomic DNA Translation: CAA15616.1
PIRiT18473
RefSeqiXP_001351177.1, XM_001351141.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiO77361, 3 interactors

Chemistry databases

DrugBankiDB11638, Artenimol

PTM databases

SwissPalmiO77361

Proteomic databases

PRIDEiO77361

Genome annotation databases

EnsemblProtistsiCAA15616; CAA15616; PF3D7_0310400
GeneDBiPF3D7_0310400.1:pep
GeneIDi814419
KEGGipfa:PF3D7_0310400

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_0310400

Phylogenomic databases

HOGENOMiCLU_006426_0_0_1
InParanoidiO77361
OMAiKLKHMIY

Family and domain databases

InterProiView protein in InterPro
IPR003378, Fringe-like
PfamiView protein in Pfam
PF02434, Fringe, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO77361_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O77361
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: June 2, 2021
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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