UniProtKB - O77323 (TCPH_PLAF7)
Protein
T-complex protein 1 subunit eta
Gene
MAL3P3.6
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- unfolded protein binding Source: GeneDB
GO - Biological processi
- protein folding Source: GeneDB
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-PFA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
Names & Taxonomyi
Protein namesi | Recommended name: T-complex protein 1 subunit etaShort name: TCP-1-eta Alternative name(s): CCT-eta |
Gene namesi | ORF Names:MAL3P3.6, PFC0350c |
Organismi | Plasmodium falciparum (isolate 3D7) |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_0308200 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- chaperonin-containing T-complex Source: GeneDB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000128368 | 1 – 539 | T-complex protein 1 subunit etaAdd BLAST | 539 |
Proteomic databases
PRIDEi | O77323 |
PTM databases
SwissPalmi | O77323 |
Interactioni
Subunit structurei
Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
By similarityGO - Molecular functioni
- unfolded protein binding Source: GeneDB
Protein-protein interaction databases
BioGRIDi | 1209650, 4 interactors |
IntActi | O77323, 4 interactors |
Family & Domainsi
Sequence similaritiesi
Belongs to the TCP-1 chaperonin family.Curated
Phylogenomic databases
HOGENOMi | CLU_008891_7_1_1 |
InParanoidi | O77323 |
OMAi | QGCPNAK |
PhylomeDBi | O77323 |
Family and domain databases
CDDi | cd03340, TCP1_eta, 1 hit |
Gene3Di | 1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012720, Chap_CCT_eta IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
PANTHERi | PTHR11353:SF22, PTHR11353:SF22, 1 hit |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02345, chap_CCT_eta, 1 hit |
PROSITEi | View protein in PROSITE PS00750, TCP1_1, 1 hit PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
i Sequence
Sequence statusi: Complete.
O77323-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHLMSLPIV LLKEGTDTAQ GRSQIIRNIN ACQIIVDIVK TTLGPRGMDK
60 70 80 90 100
LIYTERDVTI TNDGATVMNL LNISHPAASI LVDIAKSQDD EVGDGTTSVV
110 120 130 140 150
VVAGELLNEA KGLLNDGIEP NMIIDGFRNA CNVAINKLNE LSLNFSNKNE
160 170 180 190 200
EEKRSILLKC AQTALNSKLV SNHKEFFGEL VVNAVYKLGD NLDKSNIGIK
210 220 230 240 250
KVTGGSCLDT QLIYGVAFKK TFSYAGFEQQ PKKFINPKIL LLNVELELKA
260 270 280 290 300
EKENAEVRIE NPNEYNSIVQ AEWDIIFKKL NLIKDCGANI VLSKLPIGDI
310 320 330 340 350
ATQFFADHDI FCAGRVEDAD LKRTANATGA LVQTSLFNLN DDVLGTCGVF
360 370 380 390 400
EEVQIGNERY NIFKECLKTK SVTIILRGGA KQFIEEVERS INDAIMIVLR
410 420 430 440 450
CITNSEIVPG AGSIEMQLSK YLRIYSRSIC NKEQIVLFSF AKALESIPRH
460 470 480 490 500
LSHNAGYDST DILNKLRKKH SEQTSDIWYG VDCMEGDIIN AYDNCIFEVT
510 520 530
KIKRNVIYSA TEAACLILSI DETIKNPSSA AGTQRSPYS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844502 Genomic DNA Translation: CAB11107.1 |
PIRi | T18430 |
RefSeqi | XP_001351157.1, XM_001351121.1 |
Genome annotation databases
EnsemblProtistsi | CAB11107; CAB11107; PF3D7_0308200 |
GeneDBi | PF3D7_0308200.1:pep |
GeneIDi | 814399 |
KEGGi | pfa:PF3D7_0308200 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844502 Genomic DNA Translation: CAB11107.1 |
PIRi | T18430 |
RefSeqi | XP_001351157.1, XM_001351121.1 |
3D structure databases
SMRi | O77323 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 1209650, 4 interactors |
IntActi | O77323, 4 interactors |
Chemistry databases
DrugBanki | DB11638, Artenimol |
PTM databases
SwissPalmi | O77323 |
Proteomic databases
PRIDEi | O77323 |
Genome annotation databases
EnsemblProtistsi | CAB11107; CAB11107; PF3D7_0308200 |
GeneDBi | PF3D7_0308200.1:pep |
GeneIDi | 814399 |
KEGGi | pfa:PF3D7_0308200 |
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_0308200 |
Phylogenomic databases
HOGENOMi | CLU_008891_7_1_1 |
InParanoidi | O77323 |
OMAi | QGCPNAK |
PhylomeDBi | O77323 |
Enzyme and pathway databases
Reactomei | R-PFA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
Family and domain databases
CDDi | cd03340, TCP1_eta, 1 hit |
Gene3Di | 1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012720, Chap_CCT_eta IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
PANTHERi | PTHR11353:SF22, PTHR11353:SF22, 1 hit |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02345, chap_CCT_eta, 1 hit |
PROSITEi | View protein in PROSITE PS00750, TCP1_1, 1 hit PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TCPH_PLAF7 | |
Accessioni | O77323Primary (citable) accession number: O77323 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | November 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families