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Entry version 79 (19 Jan 2022)
Sequence version 1 (01 Nov 1998)
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Protein

DNA-directed RNA polymerase subunit

Gene

RPB1

Organism
Breviata anathema (Amoeboid flagellate)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation, NucleotidyltransferaseUniRule annotationARBA annotation, Transferase
Biological processTranscription
LigandMagnesiumARBA annotation, Metal-bindingARBA annotation, ZincARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation (EC:2.7.7.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPB1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBreviata anathema (Amoeboid flagellate)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri81100 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaBreviateaBreviata

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotationARBA annotation, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini146 – 445RPOLA_NInterPro annotationAdd BLAST300

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1586 – 1690DisorderedSequence analysisAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili604 – 624Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.30, 1 hit
1.10.274.100, 1 hit
3.30.1360.140, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR045867, DNA-dir_RpoC_beta_prime
IPR000722, RNA_pol_asu
IPR000684, RNA_pol_II_repeat_euk
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR007075, RNA_pol_Rpb1_6
IPR007073, RNA_pol_Rpb1_7
IPR038593, RNA_pol_Rpb1_7_sf
IPR038120, Rpb1_funnel_sf

The PANTHER Classification System

More...
PANTHERi
PTHR19376, PTHR19376, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 1 hit
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit
PF04992, RNA_pol_Rpb1_6, 1 hit
PF04990, RNA_pol_Rpb1_7, 1 hit
PF05001, RNA_pol_Rpb1_R, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00663, RPOLA_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

O77165-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CPGHFGHVTL AKAVYHLAYI RTVCRVLQCV CMNCSRLLVD RKISASTRLR
60 70 80 90 100
NGAVRLNEVS KMCLQYKTCG ECAVKTENAQ VTRTGCGARQ PLWRVSKLSI
110 120 130 140 150
TRVPRDSSGG ELPEVQDSEE VVRILKNISD EDCVLIGLNP RFARPEWMMI
160 170 180 190 200
TLLPVPPMTV RPSIAFGSVG RAEDDLTKQL STIVKNNAQI RKLKLDGAAP
210 220 230 240 250
INIQDTLDVL QINVACFFDN SVPSLEKAKN GNRPIKSLSE RLRGKEGRVR
260 270 280 290 300
GQLMGKRVDF SARSVITPDP TLALNELGVP RTVASNLTVP EMVSPLNIHR
310 320 330 340 350
LAALVRNGPG TYPGAKYVIR DDGARIALTS RGDMPIVPGY IIERHLMDGD
360 370 380 390 400
HVVFNRQPSL HKMSMMGHQV RVLPYSSFRL NLSVTTPYNA DFDGDEMNMH
410 420 430 440 450
VPNSLEAISE VKNLMAVPFQ IVTPQKNSPC MGVVQDSLLG CSLISRRDTF
460 470 480 490 500
LTEDVMMNLA LVISYDPDKI PQPAILRPKP LWTGKQAFSM LLPKDLSYKG
510 520 530 540 550
KCGFYFNAEQ SVSREVAAAQ EEYMNSLLDS VVRIKKGQLH TGVITNKAVG
560 570 580 590 600
KSGQGSIIHI LWKDQGPMAA RDFLSRVQLL TNAYILTRGF SVGTEDTLAD
610 620 630 640 650
PDTLQAVKAE IEGAKRNVKI HIDDARAGRL KVQAGRSLVE SFEAKTNKSL
660 670 680 690 700
QDALSNAGKK SLSSLKYDNN FKLMIESGSK GSEMNICQIT GMVGQQNVEG
710 720 730 740 750
KRIAFGFQRR TLPHFRKDDY EPEARGFVEN SYVSGLSPQE FFFHMMGGRE
760 770 780 790 800
GLIDTAVKTS ESGYIQRKLM KSMEDISVKY DTTVRNAAGM ILQFAYGEDG
810 820 830 840 850
IDGTAHENQD IPSLNADDAK MRKLYDWNTA DWDQYRPDFA PETLDEIRRD
860 870 880 890 900
ARVAEVVERE FAQLMADRAT VRAIKHATGA RDDNVFLPVH VGRIIAKAKQ
910 920 930 940 950
HYHISETTRS DLSPADIYTT LDLLITRELN ITGAAYAEGR RADPLGEEQR
960 970 980 990 1000
STALTMFAIM LRAQLASKVM ILKHHITLDC WGYIIGEVRE KFGRALVAPG
1010 1020 1030 1040 1050
EMVGAIAAQS FGEPTTQMTL NTFHSAGVGT KNVTLGVPRL KELINVNMAL
1060 1070 1080 1090 1100
RTPNISIFVQ DPFCNSEENA TKVPLHIKHT TVRDLVSRAE IIYDPMYVVD
1110 1120 1130 1140 1150
QMTGEAYFDC TRTVVPEDEF FVQDNYMQAD RLNYQTHSYS SFVLRVMLDT
1160 1170 1180 1190 1200
KVMQQMELKE ESVVSIVKAE FEDAVEIIST VNDLNKPRMR IRLVRERAEA
1210 1220 1230 1240 1250
EAAVDEDRGE DDRLRDMEEI IMGLHVHGIR GMTKVMVDDS RTEKWVDERG
1260 1270 1280 1290 1300
ALQTRRFWPL DGEVKKDTAP PLLDVMVHPA VDPYRTTTNS ITVINDVLGV
1310 1320 1330 1340 1350
EAARAALLKE LRDVLGFDGS YINIRHLLML VDVMTFRGYL MSITRFGMNR
1360 1370 1380 1390 1400
TDNGILMRAS FEETVDVLQD AAQFAGHDEL RGVSDNIMLG QVAPVGTGTF
1410 1420 1430 1440 1450
DLLLDAALLR EAYQFRTTTE SDARGAIISP VGSSPQHTPY SSHMLSPQAQ
1460 1470 1480 1490 1500
AIDNTYGLMF SPSVTMSPSG GFGMGMGMGM GDIPVPSSPG PFGYIPVPGS
1510 1520 1530 1540 1550
PAAAGYSPAS PAYSPASPAY SPASPAYSPA SPAYSPASPA YSPASPAYSP
1560 1570 1580 1590 1600
ASPAYSPASP AYSPASPAYS PASPAYSPAS PAYSPASPAY SPASPAYSPA
1610 1620 1630 1640 1650
SPAYSPASPA YSPASPAYSP ASPAYSPASP AYSPASPAYS PASPAYSPAS
1660 1670 1680 1690
PAYGPASPAY SPASPAYSPA SPAYSPASPA YDPAEPYDRR
Length:1,690
Mass (Da):184,995
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i012CDF8B3DD20F64
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF083338 Genomic DNA Translation: AAC62246.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T31670

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083338 Genomic DNA Translation: AAC62246.1
PIRiT31670

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.132.30, 1 hit
1.10.274.100, 1 hit
3.30.1360.140, 1 hit
InterProiView protein in InterPro
IPR045867, DNA-dir_RpoC_beta_prime
IPR000722, RNA_pol_asu
IPR000684, RNA_pol_II_repeat_euk
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR007075, RNA_pol_Rpb1_6
IPR007073, RNA_pol_Rpb1_7
IPR038593, RNA_pol_Rpb1_7_sf
IPR038120, Rpb1_funnel_sf
PANTHERiPTHR19376, PTHR19376, 1 hit
PfamiView protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 1 hit
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit
PF04992, RNA_pol_Rpb1_6, 1 hit
PF04990, RNA_pol_Rpb1_7, 1 hit
PF05001, RNA_pol_Rpb1_R, 12 hits
SMARTiView protein in SMART
SM00663, RPOLA_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO77165_BREAA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O77165
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: January 19, 2022
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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