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Entry version 136 (29 Sep 2021)
Sequence version 1 (01 Nov 1998)
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Protein
Submitted name:

Hyperpolarization-activated (Ih) channel

Gene
N/A
Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei661cAMPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi610 – 613cAMPCombined sources4
Nucleotide bindingi620 – 621cAMPCombined sources2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandcAMPCombined sources, Nucleotide-bindingCombined sources

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.5.29, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Hyperpolarization-activated (Ih) channelImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStrongylocentrotus purpuratus (Purple sea urchin)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7668 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaCamarodontaEchinideaStrongylocentrotidaeStrongylocentrotus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007110 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei216 – 240HelicalSequence analysisAdd BLAST25
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Transmembranei364 – 381HelicalSequence analysisAdd BLAST18
Transmembranei442 – 467HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-29325N

STRING: functional protein association networks

More...
STRINGi
7668.SPU_026288-tr

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O76977

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini545 – 661Cyclic nucleotide-bindingInterPro annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 91DisorderedSequence analysisAdd BLAST91
Regioni747 – 767DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 56Pro residuesSequence analysisAdd BLAST16
Compositional biasi74 – 91Basic and acidic residuesSequence analysisAdd BLAST18

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0498, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005746_15_2_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QPPHSSM

Database of Orthologous Groups

More...
OrthoDBi
281394at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O76977

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00038, CAP_ED, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018490, cNMP-bd-like
IPR018488, cNMP-bd_CS
IPR000595, cNMP-bd_dom
IPR005821, Ion_trans_dom
IPR013621, Ion_trans_N
IPR014710, RmlC-like_jellyroll

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00027, cNMP_binding, 1 hit
PF00520, Ion_trans, 1 hit
PF08412, Ion_trans_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00100, cNMP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51206, SSF51206, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00888, CNMP_BINDING_1, 1 hit
PS50042, CNMP_BINDING_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O76977-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNKETNGEL EQSDEADPSG QNLDDGETDS KQEENLINVS PPKTPPGPPP
60 70 80 90 100
PLKNGGRGQK PPKIPICHQN GKLPKEVEWT EDRGEDRKDS LTLQSKLDHG
110 120 130 140 150
AYTDEKQDLL TYLDRHGINS PVKLTPDETG GSSALDILGI IEERDTGALG
160 170 180 190 200
SDPSSTMQAM AKPVGFLQRQ LWTVLQPSDN RLSMKLFGSK KGLQKEKYRL
210 220 230 240 250
RKAGVLIIHP CSHFRFYWDL LMLCLIMANV ILLPVVITFF HNKDMSTGWL
260 270 280 290 300
IFNCFSDTFF ILDLICNFRT GIMNPKSAEQ VILNPRQIAY HYLRSWFIID
310 320 330 340 350
LVSSIPMDYI FLLAGGQNRH FLEVSRALKI LRFAKLLSLL RLLRLSRLMR
360 370 380 390 400
FVSQWEQAFN VANAVIRICN LVCMMLLIGH WNGCLQYLVP MLQEYPDQSW
410 420 430 440 450
VAINGLEHAH WWEQYTWALF KALSHMLCIG YGKFPPQSIT DVWLTIVSMV
460 470 480 490 500
SGATCFALFI GHATNLIQSM DSSSRQYREK LKQVEEYMQY RKLPSHLRNK
510 520 530 540 550
ILDYYEYRYR GKMFDERHIF REVSESIRQD VANYNCRDLV ASVPFFVGAD
560 570 580 590 600
SNFVTRVVTL LEFEVFQPAD YVIQEGTFGD RMFFIQQGIV DIIMSDGVIA
610 620 630 640 650
TSLSDGSYFG EICLLTRERR VASVKCETYC TLFSLSVQHF NQVLDEFPAM
660 670 680 690 700
RKTMEEIAVR RLTRIGKESS KLKSRLESPT IRDTAPLFPI PPDTPSFVTD
710 720 730 740 750
IEKNRFFGDD TDDVHIRTRV DVERGSHENV IAIMDGSLSD LRMENEIQAR
760
KSSSGKRRKF QQQTTEL
Length:767
Mass (Da):87,938
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1AE30F42720F72A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y16880 mRNA Translation: CAA76493.1

NCBI Reference Sequences

More...
RefSeqi
NP_999729.1, NM_214564.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
NM_214564; NP_999729; GeneID_373363

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
373363

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spu:373363

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16880 mRNA Translation: CAA76493.1
RefSeqiNP_999729.1, NM_214564.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PTMX-ray1.93A470-665[»]
SMRiO76977
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-29325N
STRINGi7668.SPU_026288-tr

Protein family/group databases

TCDBi1.A.1.5.29, the voltage-gated ion channel (vic) superfamily

Genome annotation databases

EnsemblMetazoaiNM_214564; NP_999729; GeneID_373363
GeneIDi373363
KEGGispu:373363

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
373363

Phylogenomic databases

eggNOGiKOG0498, Eukaryota
HOGENOMiCLU_005746_15_2_1
OMAiQPPHSSM
OrthoDBi281394at2759
PhylomeDBiO76977

Family and domain databases

CDDicd00038, CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490, cNMP-bd-like
IPR018488, cNMP-bd_CS
IPR000595, cNMP-bd_dom
IPR005821, Ion_trans_dom
IPR013621, Ion_trans_N
IPR014710, RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027, cNMP_binding, 1 hit
PF00520, Ion_trans, 1 hit
PF08412, Ion_trans_N, 1 hit
SMARTiView protein in SMART
SM00100, cNMP, 1 hit
SUPFAMiSSF51206, SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS00888, CNMP_BINDING_1, 1 hit
PS50042, CNMP_BINDING_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO76977_STRPU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76977
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: September 29, 2021
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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