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UniProtKB - O76924 (ARI2_DROME)

Entry version 159 (10 Feb 2021)
Sequence version 1 (01 Nov 1998)
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Protein

Potential E3 ubiquitin-protein ligase ariadne-2

Gene

ari-2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.

Miscellaneous

Overexpression does not rescue clustering of muscle nuceli in ari-1 mutants.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.By similarity EC:2.3.2.31

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi153Zinc 1PROSITE-ProRule annotation1
Metal bindingi156Zinc 1PROSITE-ProRule annotation1
Metal bindingi170Zinc 2PROSITE-ProRule annotation1
Metal bindingi172Zinc 2; via pros nitrogenPROSITE-ProRule annotation1
Metal bindingi175Zinc 1PROSITE-ProRule annotation1
Metal bindingi178Zinc 1PROSITE-ProRule annotation1
Metal bindingi197Zinc 2PROSITE-ProRule annotation1
Metal bindingi202Zinc 2PROSITE-ProRule annotation1
Metal bindingi242Zinc 3PROSITE-ProRule annotation1
Metal bindingi247Zinc 3PROSITE-ProRule annotation1
Metal bindingi263Zinc 3PROSITE-ProRule annotation1
Metal bindingi266Zinc 3PROSITE-ProRule annotation1
Metal bindingi271Zinc 4PROSITE-ProRule annotation1
Metal bindingi274Zinc 4PROSITE-ProRule annotation1
Metal bindingi279Zinc 4; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi284Zinc 4PROSITE-ProRule annotation1
Metal bindingi311Zinc 5PROSITE-ProRule annotation1
Metal bindingi314Zinc 5PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei324PROSITE-ProRule annotation1
Metal bindingi329Zinc 5PROSITE-ProRule annotation1
Metal bindingi332Zinc 5PROSITE-ProRule annotation1
Metal bindingi337Zinc 6PROSITE-ProRule annotation1
Metal bindingi340Zinc 6PROSITE-ProRule annotation1
Metal bindingi347Zinc 6; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi354Zinc 6PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri153 – 202RING-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri222 – 284IBR-typePROSITE-ProRule annotationAdd BLAST63
Zinc fingeri311 – 340RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potential E3 ubiquitin-protein ligase ariadne-2 (EC:2.3.2.31By similarity)
Alternative name(s):
Protein ariadne-21 Publication
RING-type E3 ubiquitin transferase ariadne-2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ari-21 PublicationImported
Synonyms:ari2, TRIAD1
ORF Names:CG5709Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0025186, ari-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000557571 – 509Potential E3 ubiquitin-protein ligase ariadne-2Add BLAST509

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O76924

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0025186, Expressed in eye disc (Drosophila) and 38 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O76924, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O76924, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Ubc10 (PubMed:10880484).

Interacts with park (PubMed:29689197).

Interacts with ari-1 (PubMed:29689197).

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		63159, 33 interactors

Database of interacting proteins

More...DIPi		DIP-17813N

Protein interaction database and analysis system

More...IntActi		O76924, 6 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0071688

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni149 – 358TRIAD supradomainPROSITE-ProRule annotationAdd BLAST210

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili387 – 410Sequence analysisAdd BLAST24
Coiled coili452 – 503Sequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 64Asp/Glu-rich (acidic)Add BLAST63
Compositional biasi123 – 128Poly-Ala6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RBR family. Ariadne subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri153 – 202RING-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri222 – 284IBR-typePROSITE-ProRule annotationAdd BLAST63
Zinc fingeri311 – 340RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1812, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154875

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009823_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O76924

Identification of Orthologs from Complete Genome Data

More...OMAi		DRFNNHE

Database of Orthologous Groups

More...OrthoDBi		469819at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O76924

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031126, Ariadne-2
IPR031127, E3_UB_ligase_RBR
IPR002867, IBR_dom
IPR044066, TRIAD_supradom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

The PANTHER Classification System

More...PANTHERi		PTHR11685, PTHR11685, 1 hit
PTHR11685:SF210, PTHR11685:SF210, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01485, IBR, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00647, IBR, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51873, TRIAD, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O76924-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSDIEMDME SDNDGEYDDD YDYYNTGEDC DVERLDPKRA DPEYFEYECL 
        60         70         80         90        100
TVEDIEKLLN ERVEKLNTIL QITPSLAKVL LLEHQWNNVA VVEKYRQDAN 
       110        120        130        140        150
ALLVTARIKP PSVAVTDTAS TSAAAASAQL LRLGSSGYKT TASATPQYRS 
       160        170        180        190        200
QMCPVCASSQ LGDKFYSLAC GHSFCKDCWT IYFETQIFQG ISTQIGCMAQ 
       210        220        230        240        250
MCNVRVPEDL VLTLVTRPVM RDKYQQFAFK DYVKSHPELR FCPGPNCQII 
       260        270        280        290        300
VQSSEISAKR AICKACHTGF CFRCGMDYHA PTDCQVIKKW LTKCADDSET 
       310        320        330        340        350
ANYISAHTKD CPKCHICIEK NGGCNHMQCF NCKHDFCWMC LGDWKTHGSE 
       360        370        380        390        400
YYECSRYKDN PNIANESVHV QAREALKKYL HYYERWENHS KSLKLEQQTI 
       410        420        430        440        450
DRLRQRINSK VMNGSGTWID WQYLFNAAAL LAKCRYTLQY TYPYAYYMEA 
       460        470        480        490        500
GSRKNLFEYQ QAQLEAEIEN LSWKIERAET TDLGDLENQM DIAEKRRTTL 

LKDFFPVDA
Length:509
Mass (Da):58,627
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FB82E5ACF05E900
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ010169 mRNA Translation: CAA09030.1
AE013599 Genomic DNA Translation: AAF46823.1

NCBI Reference Sequences

More...RefSeqi		NP_477374.1, NM_058026.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0071774; FBpp0071688; FBgn0025186

Database of genes from NCBI RefSeq genomes

More...GeneIDi		37542

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG5709

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010169 mRNA Translation: CAA09030.1
AE013599 Genomic DNA Translation: AAF46823.1
RefSeqiNP_477374.1, NM_058026.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi63159, 33 interactors
DIPiDIP-17813N
IntActiO76924, 6 interactors
STRINGi7227.FBpp0071688

Proteomic databases

PaxDbiO76924

Genome annotation databases

EnsemblMetazoaiFBtr0071774; FBpp0071688; FBgn0025186
GeneIDi37542
KEGGidme:Dmel_CG5709

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		37542
FlyBaseiFBgn0025186, ari-2

Phylogenomic databases

eggNOGiKOG1812, Eukaryota
GeneTreeiENSGT00940000154875
HOGENOMiCLU_009823_0_1_1
InParanoidiO76924
OMAiDRFNNHE
OrthoDBi469819at2759
PhylomeDBiO76924

Enzyme and pathway databases

ReactomeiR-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		37542, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		37542

Protein Ontology

More...PROi		PR:O76924

Gene expression databases

BgeeiFBgn0025186, Expressed in eye disc (Drosophila) and 38 other tissues
ExpressionAtlasiO76924, baseline and differential
GenevisibleiO76924, DM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR031126, Ariadne-2
IPR031127, E3_UB_ligase_RBR
IPR002867, IBR_dom
IPR044066, TRIAD_supradom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PANTHERiPTHR11685, PTHR11685, 1 hit
PTHR11685:SF210, PTHR11685:SF210, 1 hit
PfamiView protein in Pfam
PF01485, IBR, 2 hits
SMARTiView protein in SMART
SM00647, IBR, 2 hits
PROSITEiView protein in PROSITE
PS51873, TRIAD, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARI2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76924
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1998
Last modified: February 10, 2021
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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