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Entry version 156 (12 Aug 2020)
Sequence version 1 (01 Nov 1998)
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Protein

Protein aubergine

Gene

aub

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end. In testis, associates with Su(Ste) antisense piRNAs (most abundant class of piRNAs found in complex with aub in testes) and negatively regulates Ste expression, most likely by cleaving its transcripts. Also in testis, may repress translation of vas when associated with a piRNA derived from chromosome X, termed AT-chX-1, whose sequence shows strong complementarity to vas mRNA. Aub-piRNA complexes from ovary and testis possess RNA cleavage activity. Involved in telomere regulation by repressing specialized telomeric retroelements HeT-A and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Also involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans, in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the suppression of meiotic drive of sex chromosomes and autosomes. Involved in transposon silencing in the adult brain. Required for dorsal-ventral as well as anterior-posterior patterning of the egg. Required during oogenesis for primordial germ cell formation and activation of RNA interference. During early oogenesis, required for osk mRNA silencing and polarization of the microtubule cytoskeleton. During mid-oogenesis, required for osk mRNA localization to the posterior pole and efficient translation of osk and grk. During embryogenesis, required for posterior localization of nos mRNA, independently of osk, and pole cell formation. Essential for the formation and/or structural integrity of perinuclear nuage particles. Required for the localization of Mael to the meiotic nuage. Forms a complex with smg, twin, AGO3 and specific piRNAs that targets nos mRNA (and probably other maternal mRNAS) for deadenylation promoting its decay during early embryogenesis.21 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Oogenesis, RNA-mediated gene silencing, Translation regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein aubergineImported
Alternative name(s):
Protein stingImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aub
ORF Names:CG6137
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000146, aub

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Female sterility, consequence of a maternal lethal effect. Approximately 2% of the embryos from aub mutant females are fertilized and secrete a recognizable cuticle, while all of them lack abdominal segments. Male sterility accompanied by production of Ste protein crystals in primary spermatocytes and by meiotic non-disjunction and drive of sex chromosomes and autosomes.4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi11 – 17RGRGRGR → KGKGKGK: Abolishes methylation and interaction with tud. Does not affect piRNA binding. 2 Publications7
Mutagenesisi721E → A: Putative catalytic mutant. Enhances meiotic drive. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004229151 – 866Protein aubergineAdd BLAST866

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1
Modified residuei11Symmetric dimethylarginine2 Publications1
Modified residuei13Symmetric dimethylarginine2 Publications1
Modified residuei15Symmetric dimethylarginine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Symmetrical dimethylation on Arg-11, Arg-13 and/or Arg-15, most likely by csul, is required for binding to tud, localization to the pole plasm and association with the correct piRNAs.1 Publication4 Publications

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O76922

PRoteomics IDEntifications database

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PRIDEi
O76922

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O76922

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in ovary. In the germarium, found in germline stem and cyst cells. In egg chambers from stage 6, expressed both in nurse cells and oocytes. In embryos, accumulates in the pole cells, although low expression is detected throughout the entire embryo. In testis, expressed in germline stem cells, gonialblast and spermatogonia cells (at protein level). In the adult brain, expressed in the ellipsoid body, the mushroom body subdivision in the peduncle and the cell body layer. Expressed specifically in alpha'/beta' and gamma neurons.10 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed maternally in oocytes and 0-6 hours old embryos (at protein level).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0000146, Expressed in egg chamber and 25 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O76922, differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O76922, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with vas and AGO3 (PubMed:18590813, PubMed:19959991).

Interacts (when methylated on arginine residues) with tud (PubMed:18590813, PubMed:19926723, PubMed:19959991, PubMed:20713507).

Forms a complex with smg, twin, AGO3, nos mRNA and piRNAs that targets the nos 3'-untranslated region, in early embryos (PubMed:20953170).

Interacts with nos mRNA and rump (in an RNA-dependent manner) (PubMed:20937269).

Interacts with papi and vret (PubMed:21447556, PubMed:21831924).

Interacts with me31B (PubMed:28945271).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
60589, 67 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3181, aubergine-tudor complex

Protein interaction database and analysis system

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IntActi
O76922, 4 interactors

Molecular INTeraction database

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MINTi
O76922

STRING: functional protein association networks

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STRINGi
7227.FBpp0079754

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O76922

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O76922

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini274 – 383PAZPROSITE-ProRule annotationAdd BLAST110
Domaini555 – 852PiwiPROSITE-ProRule annotationAdd BLAST298

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the argonaute family. Piwi subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1042, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000183200

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O76922

KEGG Orthology (KO)

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KOi
K02156

Identification of Orthologs from Complete Genome Data

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OMAi
SLNMTCA

Database for complete collections of gene phylogenies

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PhylomeDBi
O76922

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003100, PAZ_dom
IPR036085, PAZ_dom_sf
IPR003165, Piwi
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF02170, PAZ, 1 hit
PF02171, Piwi, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00949, PAZ, 1 hit
SM00950, Piwi, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF101690, SSF101690, 1 hit
SSF53098, SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50821, PAZ, 1 hit
PS50822, PIWI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A7 Publications (identifier: O76922-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLPPNPVIA RGRGRGRKPN NVEANRGFAP SLGQKSDPSH SEGNQASGGN
60 70 80 90 100
GGGGDAQVGP SIEKSSLSAV QMHKSEGDPR GSVRGRRLIT DLVYSRPPGM
110 120 130 140 150
TSKKGVVGTH ITVQANYFKV LKRPNWTIYQ YRVDFTPDVE ATRLRRSFLY
160 170 180 190 200
EHKGILGGYI FDGTNMFCIN QFKAVQDSPY VLELVTKSRA GENIEIKIKA
210 220 230 240 250
VGSVQSTDAE QFQVLNLILR RAMEGLDLKL VSRYYYDPQA KINLENFRMQ
260 270 280 290 300
LWPGYQTSIR QHENDILLCS EICHKVMRTE TLYNILSDAI RDSDDYQSTF
310 320 330 340 350
KRAVMGMVIL TDYNNKTYRI DDVDFQSTPL CKFKTNDGEI SYVDYYKKRY
360 370 380 390 400
NIIIRDLKQP LVMSRPTDKN IRGGNDQAIM IIPELARATG MTDAMRADFR
410 420 430 440 450
TLRAMSEHTR LNPDRRIERL RMFNKRLKSC KQSVETLKSW NIELDSALVE
460 470 480 490 500
IPARVLPPEK ILFGNQKIFV CDARADWTNE FRTCSMFKNV HINRWYVITP
510 520 530 540 550
SRNLRETQEF VQMCIRTASS MKMNICNPIY EEIPDDRNGT YSQAIDNAAA
560 570 580 590 600
NDPQIVMVVM RSPNEEKYSC IKKRTCVDRP VPSQVVTLKV IAPRQQKPTG
610 620 630 640 650
LMSIATKVVI QMNAKLMGAP WQVVIPLHGL MTVGFDVCHS PKNKNKSYGA
660 670 680 690 700
FVATMDQKES FRYFSTVNEH IKGQELSEQM SVNMACALRS YQEQHRSLPE
710 720 730 740 750
RILFFRDGVG DGQLYQVVNS EVNTLKDRLD EIYKSAGKQE GCRMTFIIVS
760 770 780 790 800
KRINSRYFTG HRNPVPGTVV DDVITLPERY DFFLVSQAVR IGTVSPTSYN
810 820 830 840 850
VISDNMGLNA DKLQMLSYKM THMYYNYSGT IRVPAVCHYA HKLAFLVAES
860
INRAPSAGLQ NQLYFL
Length:866
Mass (Da):98,559
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F84CF1B0B89103B
GO
Isoform C3 Publications (identifier: O76922-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Show »
Length:795
Mass (Da):91,455
Checksum:i4D16FF13551CC5EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8V → G in AGA18939 (PubMed:22997235).Curated1
Sequence conflicti8V → G in AGA18942 (PubMed:22997235).Curated1
Sequence conflicti118F → S in AFX62835 (Ref. 7) Curated1
Sequence conflicti193N → T in AGA18939 (PubMed:22997235).Curated1
Sequence conflicti193N → T in AGA18941 (PubMed:22997235).Curated1
Sequence conflicti193N → T in AGA18942 (PubMed:22997235).Curated1
Sequence conflicti193N → T in AFX62834 (Ref. 7) Curated1
Sequence conflicti295D → G in AFX62833 (Ref. 7) Curated1
Sequence conflicti551N → K in AFX62833 (Ref. 7) Curated1
Sequence conflicti551N → K in AFX62834 (Ref. 7) Curated1
Sequence conflicti578D → G in AFX62834 (Ref. 7) Curated1
Sequence conflicti615K → R in AFX62834 (Ref. 7) Curated1
Sequence conflicti685A → S in AGA18946 (PubMed:22997235).Curated1
Sequence conflicti747I → T in AFX62834 (Ref. 7) Curated1
Sequence conflicti755S → T in AGA18940 (PubMed:22997235).Curated1
Sequence conflicti755S → T in AGA18942 (PubMed:22997235).Curated1
Sequence conflicti755S → T in AGA18946 (PubMed:22997235).Curated1
Sequence conflicti755S → T in AFX62833 (Ref. 7) Curated1
Sequence conflicti755S → T in AFX62834 (Ref. 7) Curated1
Sequence conflicti823M → T in AFX62833 (Ref. 7) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0473561 – 71Missing in isoform C. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X94613 Genomic DNA Translation: CAA64320.1
KC116210 Genomic DNA Translation: AGA18939.1
KC116211 Genomic DNA Translation: AGA18940.1
KC116212 Genomic DNA Translation: AGA18941.1
KC116213 Genomic DNA Translation: AGA18942.1
KC116214 Genomic DNA Translation: AGA18943.1
KC116215 Genomic DNA Translation: AGA18944.1
KC116216 Genomic DNA Translation: AGA18945.1
KC116217 Genomic DNA Translation: AGA18946.1
AE014134 Genomic DNA Translation: AAF53046.1
AE014134 Genomic DNA Translation: ABV53667.1
AF145680 mRNA Translation: AAD38655.1
JX656893 mRNA Translation: AFX62833.1
JX656894 mRNA Translation: AFX62834.1
JX656895 mRNA Translation: AFX62835.1

NCBI Reference Sequences

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RefSeqi
NP_001097144.1, NM_001103674.3 [O76922-2]
NP_476734.1, NM_057386.5 [O76922-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0080165; FBpp0079754; FBgn0000146 [O76922-1]
FBtr0112793; FBpp0111705; FBgn0000146 [O76922-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
34524

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG6137

UCSC genome browser

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UCSCi
CG6137-RA, d. melanogaster [O76922-1]
CG6137-RC, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94613 Genomic DNA Translation: CAA64320.1
KC116210 Genomic DNA Translation: AGA18939.1
KC116211 Genomic DNA Translation: AGA18940.1
KC116212 Genomic DNA Translation: AGA18941.1
KC116213 Genomic DNA Translation: AGA18942.1
KC116214 Genomic DNA Translation: AGA18943.1
KC116215 Genomic DNA Translation: AGA18944.1
KC116216 Genomic DNA Translation: AGA18945.1
KC116217 Genomic DNA Translation: AGA18946.1
AE014134 Genomic DNA Translation: AAF53046.1
AE014134 Genomic DNA Translation: ABV53667.1
AF145680 mRNA Translation: AAD38655.1
JX656893 mRNA Translation: AFX62833.1
JX656894 mRNA Translation: AFX62834.1
JX656895 mRNA Translation: AFX62835.1
RefSeqiNP_001097144.1, NM_001103674.3 [O76922-2]
NP_476734.1, NM_057386.5 [O76922-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NTHX-ray2.80C10-15[»]
3NTIX-ray2.80C6-18[»]
SMRiO76922
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi60589, 67 interactors
ComplexPortaliCPX-3181, aubergine-tudor complex
IntActiO76922, 4 interactors
MINTiO76922
STRINGi7227.FBpp0079754

PTM databases

iPTMnetiO76922

Proteomic databases

PaxDbiO76922
PRIDEiO76922

Genome annotation databases

EnsemblMetazoaiFBtr0080165; FBpp0079754; FBgn0000146 [O76922-1]
FBtr0112793; FBpp0111705; FBgn0000146 [O76922-2]
GeneIDi34524
KEGGidme:Dmel_CG6137
UCSCiCG6137-RA, d. melanogaster [O76922-1]
CG6137-RC, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
34524
FlyBaseiFBgn0000146, aub

Phylogenomic databases

eggNOGiKOG1042, Eukaryota
GeneTreeiENSGT00950000183200
InParanoidiO76922
KOiK02156
OMAiSLNMTCA
PhylomeDBiO76922

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
34524, 0 hits in 5 CRISPR screens
EvolutionaryTraceiO76922

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
34524

Protein Ontology

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PROi
PR:O76922

Gene expression databases

BgeeiFBgn0000146, Expressed in egg chamber and 25 other tissues
ExpressionAtlasiO76922, differential
GenevisibleiO76922, DM

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR003100, PAZ_dom
IPR036085, PAZ_dom_sf
IPR003165, Piwi
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
PfamiView protein in Pfam
PF02170, PAZ, 1 hit
PF02171, Piwi, 1 hit
SMARTiView protein in SMART
SM00949, PAZ, 1 hit
SM00950, Piwi, 1 hit
SUPFAMiSSF101690, SSF101690, 1 hit
SSF53098, SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50821, PAZ, 1 hit
PS50822, PIWI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAUB_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76922
Secondary accession number(s): A8DYZ0
, K7WQ34, K7X543, K7XHY9, L0CPY1, L0CQ70, L0CRA0, L0CRA6, L0CRP1, L0CRZ4, L0CS00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: November 1, 1998
Last modified: August 12, 2020
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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