Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback. Take me to UniProt BETA

UniProtKB - O76906 (CRM_DROME)

Entry version 147 (25 May 2022)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Protein cramped

Gene

crm

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (Bx-C) complexes, and hence for the maintenance of segmental determination. Can act as a modifier of position effect variegation (PEV).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: FlyBase
  • DNA binding Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein cramped
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:crm
ORF Names:CG2714
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0000376, crm

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0000376

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001971381 – 982Protein crampedAdd BLAST982

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei431Phosphoserine1 Publication1
Modified residuei437Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O76906

PRoteomics IDEntifications database

More...PRIDEi		O76906

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O76906

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed throughout embryonic development. High expression is detected in CNS and gonads.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0000376, Expressed in cleaving embryo and 34 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O76906, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		57799, 11 interactors

Protein interaction database and analysis system

More...IntActi		O76906, 6 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0070472

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O76906

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O76906

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini109 – 173SANTAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 37DisorderedSequence analysisAdd BLAST37
Regioni71 – 111DisorderedSequence analysisAdd BLAST41
Regioni323 – 349DisorderedSequence analysisAdd BLAST27
Regioni407 – 456DisorderedSequence analysisAdd BLAST50
Regioni822 – 851DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 24Pro residuesSequence analysisAdd BLAST24
Compositional biasi86 – 100Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi411 – 425Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi823 – 850Polar residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cramped family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4468, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003337

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_311066_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O76906

Database for complete collections of gene phylogenies

More...PhylomeDBi		O76906

Family and domain databases

Conserved Domains Database

More...CDDi		cd00167, SANT, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001005, SANT/Myb

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00717, SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O76906-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEELSKQPPP PPLTQPPPPS SSVSIEEPLP NGKGGGAVVV NSIAKLPEEE 
        60         70         80         90        100
LLGSVTMHNC PGTRASARVI QKMKQDQTRP MTPPPSEREP NKKEEKAAQK 
       110        120        130        140        150
TPSQLKTGSG KTTWTNVERN CFFDALNEFG KDFEAVANCI NAKLKRRNAN 
       160        170        180        190        200
SDYSFKTKDQ VRQHYYQTHH KICKYVRFSE ELKKPAQELY TLINYGEMRR 
       210        220        230        240        250
KLQFLTEKHF MKLKQLVYQG QITVRCKGKN IRIKTPSCKA LRRLNQLDDS 
       260        270        280        290        300
LEDIRLPSKV EVLVTPANME AFGRVQSLAQ NPRGRIIVPL HKKLISFIKT 
       310        320        330        340        350
FEYKWRSANQ RLHEEKSAYF SSSLPSAASN NNNNNNETEP LQPSVASLDP 
       360        370        380        390        400
SMCFQPRPGV AIHRPLLSIT AYLSSISICL TAYEERMGFK VRSETLGNLA 
       410        420        430        440        450
GMSVAANKRL RTESGSEKRS PETKKPKSSA SPPLEKSLDD GPLEGNLMKM 
       460        470        480        490        500
ENSSGDELGE EIHEFLGDIL EAMQHPQAAT IPALSATTGD TTNVAVALET 
       510        520        530        540        550
SHDPVQQAYP ANADLSNAMA TSVLQTSCAA APAPSTPVTG SLAAPSVARS 
       560        570        580        590        600
KRKEAKEAAA AAQARNFKPL LSDDILKRIR KGWTQANAAD ITIGDLYVVF 
       610        620        630        640        650
GQDSKLELEY YWCEVDSSTA MASSILTINT VTPSSSSVGT QTGSAASNAN 
       660        670        680        690        700
QTGASSNCYV SASSNSSTSS TSLPYNPNDC DSVERVRAVT TSSVSNKLKH 
       710        720        730        740        750
LLLVANLSER VRKRQCNCGH TCDRKRDLMT KAQQLAEATA TGGVGGMVEG 
       760        770        780        790        800
NFRTPMLPVR RPISNIDPVR QLSALTRQKI SRQVLVQRRL LPPTSAGDRP 
       810        820        830        840        850
YDLLSVRQLH SGLFEPIDRV DGTSSAGIST SGSKPDCSMN AMTASQDQEP 
       860        870        880        890        900
GDQGALEFLN DEATQVSARD MPNLDICVAT NRTDVSSSLN EAAQDGSTTQ 
       910        920        930        940        950
SFFQGSMSPM HLLRDSTSNA RWLEDNINDF SLTSLLGHLD EIDATRDILD 
       960        970        980 
PSSSMSVISE SSVDFRHKFQ EIAALLQQQE KD
Length:982
Mass (Da):107,416
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37DC1820DB3ABBA3
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB55550 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti645A → S in CAB55550 (PubMed:9310333).Curated1
Sequence conflicti645A → S in AAN04260 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04261 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04262 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04263 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04264 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04265 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04266 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04267 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04268 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04269 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04270 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04271 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04272 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04273 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04274 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04275 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04276 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04277 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04278 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04279 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04280 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04281 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04282 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04283 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04284 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04285 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04286 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04287 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04288 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04289 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04290 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04291 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04292 (PubMed:12351680).Curated1
Sequence conflicti645A → S in AAN04293 (PubMed:12351680).Curated1
Sequence conflicti645A → S in CAA16818 (PubMed:10731137).Curated1
Sequence conflicti653G → S in CAB55550 (PubMed:9310333).Curated1
Sequence conflicti653G → S in AAN04260 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04261 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04262 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04263 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04264 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04265 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04266 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04267 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04268 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04269 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04270 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04271 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04272 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04273 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04274 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04275 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04276 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04277 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04278 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04279 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04280 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04281 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04282 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04283 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04284 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04285 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04286 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04287 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04288 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04289 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04290 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04291 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04292 (PubMed:12351680).Curated1
Sequence conflicti653G → S in AAN04293 (PubMed:12351680).Curated1
Sequence conflicti653G → S in CAA16818 (PubMed:10731137).Curated1
Sequence conflicti965F → L in CAB55550 (PubMed:9310333).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti322S → N in strain: k3 and k5. 1
Natural varianti402M → I in strain: k5. 1
Natural varianti493N → T in strain: Berkeley, k1, k8, Oregon-R, pe7 and pe10. 1
Natural varianti527S → T in strain: k2. 1
Natural varianti639G → A in strain: Berkeley, k1, k2, k3, k5, k8, k9 and k11. 1
Natural varianti747M → I in strain: k5. 1
Natural varianti823T → I in strain: Berkeley, k9, wi10 and wi19. 1
Natural varianti830T → S in strain: k1. 1
Natural varianti837C → S in strain: Berkeley, k3, k8, k9, wi10 and wi19. 1
Natural varianti842M → T in strain: Berkeley, k1, k2, k3, k5, k8, k9, k11, pe1, pe4, pe45, pe5, wi4, wi7, wi10, wi13, wi18 and wi19. 1
Natural varianti845S → P in strain: k8. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y13674 mRNA Translation: CAB55550.1 Frameshift.
AF365364 Genomic DNA Translation: AAN04260.1
AF365365 Genomic DNA Translation: AAN04261.1
AF365366 Genomic DNA Translation: AAN04262.1
AF365367 Genomic DNA Translation: AAN04263.1
AF365368 Genomic DNA Translation: AAN04264.1
AF365369 Genomic DNA Translation: AAN04265.1
AF365370 Genomic DNA Translation: AAN04266.1
AF365371 Genomic DNA Translation: AAN04267.1
AF365372 Genomic DNA Translation: AAN04268.1
AF365373 Genomic DNA Translation: AAN04269.1
AF365374 Genomic DNA Translation: AAN04270.1
AF365375 Genomic DNA Translation: AAN04271.1
AF365376 Genomic DNA Translation: AAN04272.1
AF365377 Genomic DNA Translation: AAN04273.1
AF365378 Genomic DNA Translation: AAN04274.1
AF365379 Genomic DNA Translation: AAN04275.1
AF365380 Genomic DNA Translation: AAN04276.1
AF365381 Genomic DNA Translation: AAN04277.1
AF365382 Genomic DNA Translation: AAN04278.1
AF365383 Genomic DNA Translation: AAN04279.1
AF365384 Genomic DNA Translation: AAN04280.1
AF365385 Genomic DNA Translation: AAN04281.1
AF365386 Genomic DNA Translation: AAN04282.1
AF365387 Genomic DNA Translation: AAN04283.1
AF365388 Genomic DNA Translation: AAN04284.1
AF365389 Genomic DNA Translation: AAN04285.1
AF365390 Genomic DNA Translation: AAN04286.1
AF365391 Genomic DNA Translation: AAN04287.1
AF365392 Genomic DNA Translation: AAN04288.1
AF365393 Genomic DNA Translation: AAN04289.1
AF365394 Genomic DNA Translation: AAN04290.1
AF365396 Genomic DNA Translation: AAN04291.1
AF365397 Genomic DNA Translation: AAN04292.1
AF365398 Genomic DNA Translation: AAN04293.1
AE014298 Genomic DNA Translation: AAG22402.1
AL021728 Genomic DNA Translation: CAA16818.1
AY051767 mRNA Translation: AAK93191.1

Protein sequence database of the Protein Information Resource

More...PIRi		T13653

NCBI Reference Sequences

More...RefSeqi		NP_477105.2, NM_057757.4
NP_726829.1, NM_166951.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0070495; FBpp0070472; FBgn0000376
FBtr0070496; FBpp0070473; FBgn0000376

Database of genes from NCBI RefSeq genomes

More...GeneIDi		31268

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG2714

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13674 mRNA Translation: CAB55550.1 Frameshift.
AF365364 Genomic DNA Translation: AAN04260.1
AF365365 Genomic DNA Translation: AAN04261.1
AF365366 Genomic DNA Translation: AAN04262.1
AF365367 Genomic DNA Translation: AAN04263.1
AF365368 Genomic DNA Translation: AAN04264.1
AF365369 Genomic DNA Translation: AAN04265.1
AF365370 Genomic DNA Translation: AAN04266.1
AF365371 Genomic DNA Translation: AAN04267.1
AF365372 Genomic DNA Translation: AAN04268.1
AF365373 Genomic DNA Translation: AAN04269.1
AF365374 Genomic DNA Translation: AAN04270.1
AF365375 Genomic DNA Translation: AAN04271.1
AF365376 Genomic DNA Translation: AAN04272.1
AF365377 Genomic DNA Translation: AAN04273.1
AF365378 Genomic DNA Translation: AAN04274.1
AF365379 Genomic DNA Translation: AAN04275.1
AF365380 Genomic DNA Translation: AAN04276.1
AF365381 Genomic DNA Translation: AAN04277.1
AF365382 Genomic DNA Translation: AAN04278.1
AF365383 Genomic DNA Translation: AAN04279.1
AF365384 Genomic DNA Translation: AAN04280.1
AF365385 Genomic DNA Translation: AAN04281.1
AF365386 Genomic DNA Translation: AAN04282.1
AF365387 Genomic DNA Translation: AAN04283.1
AF365388 Genomic DNA Translation: AAN04284.1
AF365389 Genomic DNA Translation: AAN04285.1
AF365390 Genomic DNA Translation: AAN04286.1
AF365391 Genomic DNA Translation: AAN04287.1
AF365392 Genomic DNA Translation: AAN04288.1
AF365393 Genomic DNA Translation: AAN04289.1
AF365394 Genomic DNA Translation: AAN04290.1
AF365396 Genomic DNA Translation: AAN04291.1
AF365397 Genomic DNA Translation: AAN04292.1
AF365398 Genomic DNA Translation: AAN04293.1
AE014298 Genomic DNA Translation: AAG22402.1
AL021728 Genomic DNA Translation: CAA16818.1
AY051767 mRNA Translation: AAK93191.1
PIRiT13653
RefSeqiNP_477105.2, NM_057757.4
NP_726829.1, NM_166951.2

3D structure databases

AlphaFoldDBiO76906
SMRiO76906
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi57799, 11 interactors
IntActiO76906, 6 interactors
STRINGi7227.FBpp0070472

PTM databases

iPTMnetiO76906

Proteomic databases

PaxDbiO76906
PRIDEiO76906

Genome annotation databases

EnsemblMetazoaiFBtr0070495; FBpp0070472; FBgn0000376
FBtr0070496; FBpp0070473; FBgn0000376
GeneIDi31268
KEGGidme:Dmel_CG2714

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		109545
FlyBaseiFBgn0000376, crm
VEuPathDBiVectorBase:FBgn0000376

Phylogenomic databases

eggNOGiKOG4468, Eukaryota
GeneTreeiENSGT00390000003337
HOGENOMiCLU_311066_0_0_1
InParanoidiO76906
PhylomeDBiO76906

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		31268, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		31268

Protein Ontology

More...PROi		PR:O76906

Gene expression databases

BgeeiFBgn0000376, Expressed in cleaving embryo and 34 other tissues
GenevisibleiO76906, DM

Family and domain databases

CDDicd00167, SANT, 1 hit
InterProiView protein in InterPro
IPR001005, SANT/Myb
SMARTiView protein in SMART
SM00717, SANT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRM_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76906
Secondary accession number(s): Q0KHW5
, Q8MM10, Q8MM41, Q8MM71, Q8MX89, Q8MX90, Q8MX91, Q8MX92, Q8MX93, Q8MX94, Q8MX95, Q9W4V7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: January 23, 2007
Last modified: May 25, 2022
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again