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Entry version 138 (18 Sep 2019)
Sequence version 2 (05 Jul 2004)
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Protein
Submitted name:

SD17974p

Gene

EG:125H10.1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SD17974pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EG:125H10.1Imported
Synonyms:BEST:CK01670Imported, CK01670Imported, Dmel\CG3777Imported
ORF Names:CG3777Imported, Dmel_CG3777Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0024989 CG3777

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509680820 – 879Sequence analysisAdd BLAST860

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0024989 Expressed in 29 organ(s), highest expression level in embryo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0070065

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni215 – 270DisorderedSequence analysisAdd BLAST56
Regioni439 – 552DisorderedSequence analysisAdd BLAST114
Regioni580 – 879DisorderedSequence analysisAdd BLAST300

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili103 – 130Sequence analysisAdd BLAST28
Coiled coili342 – 369Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi215 – 235PolyampholyteSequence analysisAdd BLAST21
Compositional biasi236 – 257PolarSequence analysisAdd BLAST22
Compositional biasi439 – 478PolarSequence analysisAdd BLAST40
Compositional biasi500 – 529PolarSequence analysisAdd BLAST30
Compositional biasi603 – 617PolarSequence analysisAdd BLAST15
Compositional biasi651 – 671PolarSequence analysisAdd BLAST21
Compositional biasi697 – 713PolarSequence analysisAdd BLAST17
Compositional biasi714 – 729PolyampholyteSequence analysisAdd BLAST16
Compositional biasi808 – 822PolyampholyteSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J4QJ Eukaryota
ENOG4112A7J LUCA

Identification of Orthologs from Complete Genome Data

More...
OMAi
HEEFVNQ

Database of Orthologous Groups

More...
OrthoDBi
902831at2759

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O76874-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLKVFLLVF IATHHLVDSA GPLSNIASES KPKSFEEILP SAVPFETSHK
60 70 80 90 100
HPGAGEWVEG FQTSHKISIR ATDSADYSMN LLPTKERPEL NPVLSALINE
110 120 130 140 150
DVMKSIEAKR AIEEEELAEV RREIEQAAVL ELAQKRGFTT TETPALLLTT
160 170 180 190 200
LPTAGKKLDN LDEDIVLDPH EDFINQNFAL ESAGSENSKK SRIEIKKGPN
210 220 230 240 250
GQDYEYEYVY YYEEDDDSSK VDPSAEPDTR GKTRYTNIER STTATPSGNS
260 270 280 290 300
LQSDKAKGRS SDTSEDIEAE RLPMITRFPS RGKNIEVPPT AALDSLEIAA
310 320 330 340 350
ERKKISVKRP SLELVDSATF NTDEKQTKAA RKGENELKPV IAIEQEEAAR
360 370 380 390 400
KKMQQVKEEQ ARKEKETEMS IDQEDFEQTT PSMEKAALDL YAILTNENLN
410 420 430 440 450
NEQTTVIPDT VGSEGFTTLA TETASTDEDE AGVMTTLINE ISSSTSTTTT
460 470 480 490 500
AATTTTTTTT TEPPTTTSTT TTTTAAPSLF GGRRAGLSGL GGRNRFKLTR
510 520 530 540 550
AEGGSTTTST TEASVAAETN KTGRNRFSRP SIGGRSRPGA RTTTAPDATS
560 570 580 590 600
VAAPDAEEGI VVAKEVKPVS TSFARGRPRN RFSLRVSTTT ARPSEESPAE
610 620 630 640 650
DDAPAESSST TTRSTLRGRP GLGLRGRSRT TTTKAPASSE GAEAVEPNAT
660 670 680 690 700
ASSEDVKSGL ISPSTGESGR PSRFNIHRAG SNRLLSRGKL GRSGVSTEAP
710 720 730 740 750
KESQTAEDSA AESSSHLNDV KEEQMSAGEF SEKTNEAGDS AAVVPAAPVS
760 770 780 790 800
GLNRLRTRPR LNALTHKTDA VKPKASAAPA PAPRKINPLL AKRRLQLGAT
810 820 830 840 850
STTESPAEEE HLALDSSAEQ SDKEESFAGG SNETGGEGPG KPEHETTEAT
860 870
EATTKQQPRG LGLLGQRRRL PLRKPGTIL
Length:879
Mass (Da):94,369
Last modified:July 5, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB2DDF8B410E5B7B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45496.2
AE014298 Genomic DNA Translation: AAN09013.2
AE014298 Genomic DNA Translation: AAN09014.2
BT010204 mRNA Translation: AAQ23522.1
AE014298 Genomic DNA Translation: AHN59204.1
AE014298 Genomic DNA Translation: AHN59205.1

NCBI Reference Sequences

More...
RefSeqi
NP_001284733.1, NM_001297804.1
NP_001284734.1, NM_001297805.1
NP_569839.2, NM_130483.3
NP_726664.2, NM_166840.2
NP_726665.2, NM_166841.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
30979

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3777

UCSC genome browser

More...
UCSCi
CG3777-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45496.2
AE014298 Genomic DNA Translation: AAN09013.2
AE014298 Genomic DNA Translation: AAN09014.2
BT010204 mRNA Translation: AAQ23522.1
AE014298 Genomic DNA Translation: AHN59204.1
AE014298 Genomic DNA Translation: AHN59205.1
RefSeqiNP_001284733.1, NM_001297804.1
NP_001284734.1, NM_001297805.1
NP_569839.2, NM_130483.3
NP_726664.2, NM_166840.2
NP_726665.2, NM_166841.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0070065

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30979
KEGGidme:Dmel_CG3777
UCSCiCG3777-RA d. melanogaster

Organism-specific databases

FlyBaseiFBgn0024989 CG3777

Phylogenomic databases

eggNOGiENOG410J4QJ Eukaryota
ENOG4112A7J LUCA
OMAiHEEFVNQ
OrthoDBi902831at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CG3777 fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
30979

Gene expression databases

BgeeiFBgn0024989 Expressed in 29 organ(s), highest expression level in embryo

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO76874_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76874
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: July 5, 2004
Last modified: September 18, 2019
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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