Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cathepsin D

Gene

ctsD

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease that may act during cell growth and/or development.

Catalytic activityi

Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81PROSITE-ProRule annotation1
Active sitei268PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • programmed cell death Source: dictyBase
  • protein catabolic process Source: GO_Central
  • proteolysis Source: GO_Central

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-DDI-2132295 MHC class II antigen presentation
R-DDI-5683826 Surfactant metabolism
R-DDI-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiA01.A89

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin D (EC:3.4.23.5)
Alternative name(s):
Ddp44
Gene namesi
Name:ctsD
Synonyms:CatD
ORF Names:DDB_G0279411
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0279411 ctsD

Subcellular locationi

  • Lysosome 1 Publication
  • Secreted 1 Publication

GO - Cellular componenti

  • early endosome Source: dictyBase
  • early phagosome Source: dictyBase
  • extracellular region Source: dictyBase
  • lysosome Source: dictyBase
  • phagocytic vesicle Source: dictyBase

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000032778819 – 481 PublicationAdd BLAST30
ChainiPRO_500014729149 – 383Cathepsin DAdd BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 101By similarity
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi259 ↔ 263By similarity
Disulfide bondi302 ↔ 339By similarity
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated on 2 out of the 3 potential sites. Glycans contain sulfated Mannose.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiO76856

Expressioni

Developmental stagei

Expressed in both vegetative and differentiating cells, with a higher level in vegetative cells.1 Publication

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi44689.DDB0215012

Structurei

3D structure databases

ProteinModelPortaliO76856
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 378Peptidase A1PROSITE-ProRule annotationAdd BLAST316

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
InParanoidiO76856
KOiK01379
OMAiWNGQYTV
PhylomeDBiO76856

Family and domain databases

Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 2 hits
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 1 hit
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLILTLFL ATIVLAQALT VPLNFHQASR ESRRRVPQKW SNRLSALNAG
60 70 80 90 100
TTIPISDFED AQYYGAITIG TPGQAFKVVF DTGSSNLWIP SKKCPITVVA
110 120 130 140 150
CDLHNKYNSG ASSTYVANGT DFTIQYGSGA MSGFVSQDSV TVGSLTVKDQ
160 170 180 190 200
LFAEATAEPG IAFDFAKFDG ILGLAFQSIS VNSIPPVFYN MLSQGLVSST
210 220 230 240 250
LFSFWLSRTP GANGGELSFG SIDNTKYTGD ITYVPLTNET YWEFVMDDFA
260 270 280 290 300
IDGQSAGFCG TTCHAICDSG TSLIAGPMAD ITALNEKLGA VILNGEGVFS
310 320 330 340 350
DCSVINTLPN VTITVAGREF VLTPKEYVLE VTEFGKTECL SGFMGIELNM
360 370 380
GNFWILGDVF ISAYYTVFDF GNKQVGFATA IQG
Length:383
Mass (Da):41,121
Last modified:November 1, 1998 - v1
Checksum:iCC8DE423AEA1A280
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16962 mRNA Translation: CAA76563.1
AJ243946 Genomic DNA Translation: CAB57223.1
AAFI02000031 Genomic DNA Translation: EAL67644.1
RefSeqiXP_641645.1, XM_636553.1

Genome annotation databases

EnsemblProtistsiEAL67644; EAL67644; DDB_G0279411
GeneIDi8622052
KEGGiddi:DDB_G0279411

Similar proteinsi

Entry informationi

Entry nameiCATD_DICDI
AccessioniPrimary (citable) accession number: O76856
Secondary accession number(s): Q54WS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health