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Protein

Calcium-transporting ATPase

Gene

mca-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processCalcium transportUniRule annotation, Ion transport, Transport
LigandATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-418359 Reduction of cytosolic Ca++ levels
R-CEL-5578775 Ion homeostasis
R-CEL-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:mca-2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei85 – 104HelicalUniRule annotationAdd BLAST20
Transmembranei124 – 144HelicalUniRule annotationAdd BLAST21
Transmembranei319 – 345HelicalUniRule annotationAdd BLAST27
Transmembranei365 – 392HelicalUniRule annotationAdd BLAST28
Transmembranei821 – 843HelicalUniRule annotationAdd BLAST23
Transmembranei849 – 868HelicalUniRule annotationAdd BLAST20
Transmembranei889 – 911HelicalUniRule annotationAdd BLAST23
Transmembranei931 – 950HelicalUniRule annotationAdd BLAST20
Transmembranei970 – 988HelicalUniRule annotationAdd BLAST19
Transmembranei1000 – 1023HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiO76833
PeptideAtlasiO76833

Expressioni

Gene expression databases

BgeeiWBGene00019875 Expressed in 4 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiO76833 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliO76833
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 106Cation_ATPase_NInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0204 Eukaryota
ENOG410XNNC LUCA
HOGENOMiHOG000265623

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR022141 ATP_Ca_trans_C
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006408 P-type_ATPase_IIB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF12424 ATP_Ca_trans_C, 1 hit
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01517 ATPase-IIB_Ca, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

O76833-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSSDDYDCS ISELKLLMEL RGAEALEKVN STYNGVEGLC RKLKTDPING
60 70 80 90 100
LPNDTKELEH RRTAFGKNEI PPAPSKSFFR LAWEALQDIT LVILLVAALV
110 120 130 140 150
SLGLSFYKPP AEHASNDSSE SEAGWIEGVA ILVAVLVVVL VTALNDWTKE
160 170 180 190 200
KQFRGLQSKI ETEHKFSVIR GGEPLDIVVN ELVVGDIARV KYGDLLPADG
210 220 230 240 250
LLIQSNDLKI DESSLTGESD LIRKSEEFDP VLLSGTHAME GSGRFLVTAV
260 270 280 290 300
GLNSQTGIIM SLLGAAKEKK DDKKEEPTTL TNGNHMNGLG NGVDKAAELP
310 320 330 340 350
VPEEEEVGRM SKSVLQTKLS NLALQIGYIG SIVAAATVLI LIIRHCISKY
360 370 380 390 400
AIEGKSFEAS DISHFVNFII IGVTVLVIAV PEGLPLAITL ALTYSVKKMM
410 420 430 440 450
KNNNLVRHLD ACETMGNATS ICSDKTGTLT TNRMTCVQQY INSEFYKGNA
460 470 480 490 500
PKYEQMDPST RDILFNGIVI NSGYNSTVVT PKNPGEQRGQ IGNKTECSLL
510 520 530 540 550
GFIMDSGRSY EDLRRQFPEE KLYKVYTFNS SRKSMMTVIE LGDKKYRIYA
560 570 580 590 600
KGASEIILTR CNYIFGKSGK IEQFGPKEAA VMTKNVIEPM ASDGLRTIGL
610 620 630 640 650
AFKDLVPAGS KKYEYEEEYD GEIDWEDEEK IREGQTVIAV MGIQDPVRPE
660 670 680 690 700
VPAAIAKCQK AGITVRMVTG DNINTARSIA TQCGIMQPGG DFLALEGKEF
710 720 730 740 750
NARIRDADGK VNQQKFDAIW PKLRVLARAQ PSDKYVLVKG IIESTVTKNR
760 770 780 790 800
EVVAVTGDGT NDAPALKKAD VGFAMGIAGT DVAKEASDII LTDDNFSSIV
810 820 830 840 850
KAVMWGRNVY DSIAKFLQFQ LTVNVVAVTI AFIGACAISD SPLKAVQMLW
860 870 880 890 900
VNLIMDTLAS LALATEMPTE DLLNRKPYGR TKSLISRTMV KNIVGHAVYQ
910 920 930 940 950
LAILFAIMFW GDKLIPNTPS GRNAELGSPP SAHFTIIFNA FVLMTLVNEI
960 970 980 990 1000
NARKIHGERN VFKGIFTNPI FCVIWITTLI SHILIVQFGG QWFSTAPLDL
1010 1020 1030 1040 1050
TQWIICICCG VGELFWGQII NCIPASILPK SFRFGKGDVQ PTSIMLSGEY
1060 1070 1080 1090 1100
DMPSTASTLP MKDGAAADHQ RAGQSLWLLG LTRLQTQIRV VKAFQSVNDD
1110 1120 1130 1140 1150
SHPNSLTTST ADRLRASYRR LRIARELEQQ KRAGGLRASG QVYSTETNAK

DTSGIRFA
Length:1,158
Mass (Da):126,920
Last modified:November 1, 1998 - v1
Checksum:i16F1C35418573BCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010708 mRNA Translation: CAA09308.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010708 mRNA Translation: CAA09308.1

3D structure databases

ProteinModelPortaliO76833
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiO76833
PeptideAtlasiO76833

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0204 Eukaryota
ENOG410XNNC LUCA
HOGENOMiHOG000265623

Enzyme and pathway databases

ReactomeiR-CEL-418359 Reduction of cytosolic Ca++ levels
R-CEL-5578775 Ion homeostasis
R-CEL-936837 Ion transport by P-type ATPases

Gene expression databases

BgeeiWBGene00019875 Expressed in 4 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiO76833 baseline and differential

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR022141 ATP_Ca_trans_C
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006408 P-type_ATPase_IIB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF12424 ATP_Ca_trans_C, 1 hit
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01517 ATPase-IIB_Ca, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO76833_CAEEL
AccessioniPrimary (citable) accession number: O76833
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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