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Protein

Calcium-transporting ATPase

Gene

mca-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processCalcium transportUniRule annotation, Ion transport, Transport
LigandATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-418359 Reduction of cytosolic Ca++ levels
R-CEL-5578775 Ion homeostasis
R-CEL-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:mca-3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei86 – 103HelicalUniRule annotationAdd BLAST18
Transmembranei123 – 142HelicalUniRule annotationAdd BLAST20
Transmembranei330 – 353HelicalUniRule annotationAdd BLAST24
Transmembranei373 – 402HelicalUniRule annotationAdd BLAST30
Transmembranei823 – 842HelicalUniRule annotationAdd BLAST20
Transmembranei854 – 875HelicalUniRule annotationAdd BLAST22
Transmembranei896 – 917HelicalUniRule annotationAdd BLAST22
Transmembranei937 – 956HelicalUniRule annotationAdd BLAST20
Transmembranei976 – 996HelicalUniRule annotationAdd BLAST21
Transmembranei1008 – 1029HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiO76832

Expressioni

Gene expression databases

BgeeiWBGene00003153 Expressed in 5 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiO76832 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliO76832
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 103Cation_ATPase_NInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0204 Eukaryota
ENOG410XNNC LUCA
HOGENOMiHOG000265623

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR022141 ATP_Ca_trans_C
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006408 P-type_ATPase_IIB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF12424 ATP_Ca_trans_C, 1 hit
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01517 ATPase-IIB_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

O76832-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEYGASLEE LRALMEYRSA EAKEKIETDY GGTTGLCERL KTDPNNGLPN
60 70 80 90 100
NEEELERRRN VFGANEIPPH PPKCFLQLVW EALQDVTLVI LLVSAIVSLA
110 120 130 140 150
LSFYRPPGED TAGSDDSEHD AGWIEGVAIL ISVIVVVLVT ALNDYTKERQ
160 170 180 190 200
FRGLQAKIET EHRFFVLRGG QSVQVVVNEL VVGDIAQIKY GDLIPSDGII
210 220 230 240 250
IQSNDLKMDE SSLTGESDQI RKSPEHDPII LSGTHVMEGS GKMLVTAVGV
260 270 280 290 300
NSQTGIIMTL LGAAKTVAEE ERKTAKREGG DGASGAEEGT AQALLDSKGD
310 320 330 340 350
EAMANGKAVA AAESDGKKER SVLQAKLTRL AIQIGYAGSF VAGCTVLILI
360 370 380 390 400
IRFCISRYAI DGKSFSLADF QHFINFLIIG VTVLVVAVPE GLPLAVTLSL
410 420 430 440 450
AYSVKKMMLD NNLVRHLDAC ETMGNATAIC SDKTGTLTTN RMTVVQSFVN
460 470 480 490 500
DVHYKDTPKI ESLDQNTAKL MMDCISINSS YSSQVIPPKQ LGEQATQLGN
510 520 530 540 550
KTECGMLGFV LALGKSYQEI RDRHPEETIP KVYTFNSVRK SMSTVINLPD
560 570 580 590 600
GGYRVFSKGA SEIVTKRCKY FLGKNGTLTK FSSKDAENLV RDVIEPMASD
610 620 630 640 650
GLRTICVAYK DYVPSSKKTA DNQIAYSSEP DWENEEMIVG DMTAIAVLGI
660 670 680 690 700
QDPVRPEVPA AITRCQEAGI TVRMVTGDNI NTARSIATAC GILKPGEDFI
710 720 730 740 750
ALEGKEFNAR IRDENGEVSQ EKLDLIWPKL RVLARAQPSD KYVLVKGIID
760 770 780 790 800
SRVTDSREVV AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD
810 820 830 840 850
DNFTSIVKAV MWGRNVYDSI AKFLQFQLTV NVVAVVVAFV GACAIQDTPL
860 870 880 890 900
KAVQMLWVNL IMDTLASLAL ATEMPTEELL KRKPYGRTSP LISRTMCKYI
910 920 930 940 950
LGHAVYQLVI LFTLIFYGEV CFNIPSGRWA PLHSPPSKHF TIVFNTFVMM
960 970 980 990 1000
TLFNEINARK IHGERNIFKG LFSNPIYYVI WIATMISQVV IIQFGGRWFS
1010 1020 1030 1040 1050
TSALNTTEWL WCLAFGVGTL LWGQIVTSIP TGSLPANMTI GSGEAPTNDP
1060 1070 1080 1090 1100
LMPDYEDSDT HEKRSGQILW VRGLTRLQTQ LRVVKAFRSS LEEFDERRSI
1110 1120 1130 1140 1150
ASTHSVQSMR GGFWSGGGRH TTTAASPEPA GQRIAMAAIT HRQSPQPYPY
1160 1170 1180 1190 1200
YHHQQPRTPS PQPHIVVENG TSSGNNGQAA TAAAAAPKAE TNGKTEKVPL
1210 1220 1230
VQQWSPDTNS SYTQTQRTST RACLLILQFL LLTCNSF
Length:1,237
Mass (Da):135,272
Last modified:November 1, 1998 - v1
Checksum:iEE4089F3438562BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010646 Genomic DNA Translation: CAA09303.1

Genome annotation databases

UCSCiY67D8C.10c c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010646 Genomic DNA Translation: CAA09303.1

3D structure databases

ProteinModelPortaliO76832
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiO76832

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiY67D8C.10c c. elegans

Phylogenomic databases

eggNOGiKOG0204 Eukaryota
ENOG410XNNC LUCA
HOGENOMiHOG000265623

Enzyme and pathway databases

ReactomeiR-CEL-418359 Reduction of cytosolic Ca++ levels
R-CEL-5578775 Ion homeostasis
R-CEL-936837 Ion transport by P-type ATPases

Gene expression databases

BgeeiWBGene00003153 Expressed in 5 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiO76832 baseline and differential

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR022141 ATP_Ca_trans_C
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006408 P-type_ATPase_IIB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF12424 ATP_Ca_trans_C, 1 hit
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01517 ATPase-IIB_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO76832_CAEEL
AccessioniPrimary (citable) accession number: O76832
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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