UniProtKB - O76742 (O76742_DROME)
Protein
Submitted name:
CG5915 protein
Gene
Rab7
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- GTPase activity Source: FlyBase
- GTP binding Source: InterPro
- protein-containing complex binding Source: FlyBase
GO - Biological processi
- border follicle cell migration Source: FlyBase
- clathrin-dependent endocytosis involved in vitellogenesis Source: FlyBase
- dsRNA transport Source: FlyBase
- endocytosis Source: FlyBase
- endosomal transport Source: FlyBase
- endosomal vesicle fusion Source: UniProtKB
- endosome to lysosome transport Source: FlyBase
- endosome to lysosome transport via multivesicular body sorting pathway Source: FlyBase
- exosomal secretion Source: FlyBase
- phagosome-lysosome fusion Source: GO_Central
- Rab protein signal transduction Source: FlyBase
- vesicle-mediated transport Source: FlyBase
- wing disc dorsal/ventral pattern formation Source: FlyBase
Enzyme and pathway databases
Reactomei | R-DME-6798695, Neutrophil degranulation R-DME-8854214, TBC/RABGAPs R-DME-8873719, RAB geranylgeranylation R-DME-8876198, RAB GEFs exchange GTP for GDP on RABs |
Names & Taxonomyi
Protein namesi | Submitted name: CG5915 proteinImportedSubmitted name: CG5915-PAImportedSubmitted name: GH03685pImportedSubmitted name: MIP21169pImportedSubmitted name: Rab7 proteinImportedSubmitted name: Rab7, isoform AImportedSubmitted name: Rab7, isoform BImportedSubmitted name: Rab7, isoform CImportedSubmitted name: Small ras-like GTPaseImportedSubmitted name: Small ras-like GTPase RAB7Imported |
Gene namesi | Name:Rab7Imported Synonyms:AAF56218Imported, Dm Rab7Imported, Dmel\CG5915Imported, DmRab7Imported, DRAB7Imported, DRab7Imported, Drab7Imported, dRab7Imported, drab7Imported, O76742Imported, Rab-7Imported, Rab-r7Imported, RAB7Imported, rab7Imported, Rab7AImported ORF Names:CG5915Imported, Dmel_CG5915Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0015795, Rab7 |
Subcellular locationi
Endosome
- late endosome Source: FlyBase
- late endosome membrane Source: FlyBase
Lysosome
- lysosome Source: GO_Central
Plasma Membrane
- plasma membrane Source: FlyBase
Other locations
- cell cortex Source: FlyBase
- neuronal cell body Source: FlyBase
- phagocytic vesicle Source: GO_Central
- synapse Source: FlyBase
- vesicle Source: FlyBase
Expressioni
Gene expression databases
Bgeei | FBgn0015795, Expressed in embryonic/larval hemocyte (Drosophila) and 39 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | O76742, 3 interactors |
STRINGi | 7227.FBpp0083891 |
Family & Domainsi
Phylogenomic databases
eggNOGi | KOG0394, Eukaryota |
GeneTreei | ENSGT00940000155864 |
HOGENOMi | CLU_041217_10_6_1 |
OMAi | QSYGCNC |
OrthoDBi | 1172019at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
i Sequence
Sequence statusi: Complete.
O76742-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGRKKSLLK VIILGDSSVG KTSLMNQYVN KRFSNQYKAT IGADFCTKEV
60 70 80 90 100
VVNDRVVTMQ IWDTAGQERF QSLGVAFYRG ADCCVLVYDV TAPNSFKNLD
110 120 130 140 150
SWRDEFLIQA SPRDPDHFPF VVLGNKVDLD NRQVSTRRAQ QWCQSKNDIP
160 170 180 190 200
YYETSAKEGI NVEMAFQVIA KNALELEAEA EVINDFPDQI TLGSQNNRPG
NPDNCQC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF079459 Genomic DNA Translation: AAC32270.1 AE014297 Genomic DNA Translation: AAF56218.1 AF263363 mRNA Translation: AAF73041.1 AY060236 mRNA Translation: AAL25275.1 BT124755 mRNA Translation: ADF28796.1 AE014297 Genomic DNA Translation: AFH06594.1 AE014297 Genomic DNA Translation: AFH06595.1 AB035672 mRNA Translation: BAA88245.1 AM294823 Genomic DNA Translation: CAL26809.1 AM294824 Genomic DNA Translation: CAL26810.1 AM294825 Genomic DNA Translation: CAL26811.1 AM294826 Genomic DNA Translation: CAL26812.1 AM294827 Genomic DNA Translation: CAL26813.1 AM294828 Genomic DNA Translation: CAL26814.1 AM294829 Genomic DNA Translation: CAL26815.1 AM294830 Genomic DNA Translation: CAL26816.1 AM294831 Genomic DNA Translation: CAL26817.1 AM294832 Genomic DNA Translation: CAL26818.1 AM294833 Genomic DNA Translation: CAL26819.1 FM245635 Genomic DNA Translation: CAR93561.1 FM245636 Genomic DNA Translation: CAR93562.1 FM245637 Genomic DNA Translation: CAR93563.1 FM245638 Genomic DNA Translation: CAR93564.1 FM245639 Genomic DNA Translation: CAR93565.1 FM245640 Genomic DNA Translation: CAR93566.1 FM245641 Genomic DNA Translation: CAR93567.1 FM245642 Genomic DNA Translation: CAR93568.1 FM245643 Genomic DNA Translation: CAR93569.1 FM245644 Genomic DNA Translation: CAR93570.1 FM245645 Genomic DNA Translation: CAR93571.1 |
RefSeqi | NP_001247276.1, NM_001260347.1 NP_001247277.1, NM_001260348.2 NP_524472.1, NM_079748.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0084503; FBpp0083891; FBgn0015795 FBtr0308611; FBpp0300835; FBgn0015795 FBtr0308612; FBpp0300836; FBgn0015795 |
GeneIDi | 42841 |
KEGGi | dme:Dmel_CG5915 |
UCSCi | CG5915-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF079459 Genomic DNA Translation: AAC32270.1 AE014297 Genomic DNA Translation: AAF56218.1 AF263363 mRNA Translation: AAF73041.1 AY060236 mRNA Translation: AAL25275.1 BT124755 mRNA Translation: ADF28796.1 AE014297 Genomic DNA Translation: AFH06594.1 AE014297 Genomic DNA Translation: AFH06595.1 AB035672 mRNA Translation: BAA88245.1 AM294823 Genomic DNA Translation: CAL26809.1 AM294824 Genomic DNA Translation: CAL26810.1 AM294825 Genomic DNA Translation: CAL26811.1 AM294826 Genomic DNA Translation: CAL26812.1 AM294827 Genomic DNA Translation: CAL26813.1 AM294828 Genomic DNA Translation: CAL26814.1 AM294829 Genomic DNA Translation: CAL26815.1 AM294830 Genomic DNA Translation: CAL26816.1 AM294831 Genomic DNA Translation: CAL26817.1 AM294832 Genomic DNA Translation: CAL26818.1 AM294833 Genomic DNA Translation: CAL26819.1 FM245635 Genomic DNA Translation: CAR93561.1 FM245636 Genomic DNA Translation: CAR93562.1 FM245637 Genomic DNA Translation: CAR93563.1 FM245638 Genomic DNA Translation: CAR93564.1 FM245639 Genomic DNA Translation: CAR93565.1 FM245640 Genomic DNA Translation: CAR93566.1 FM245641 Genomic DNA Translation: CAR93567.1 FM245642 Genomic DNA Translation: CAR93568.1 FM245643 Genomic DNA Translation: CAR93569.1 FM245644 Genomic DNA Translation: CAR93570.1 FM245645 Genomic DNA Translation: CAR93571.1 |
RefSeqi | NP_001247276.1, NM_001260347.1 NP_001247277.1, NM_001260348.2 NP_524472.1, NM_079748.4 |
3D structure databases
SMRi | O76742 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | O76742, 3 interactors |
STRINGi | 7227.FBpp0083891 |
Proteomic databases
PRIDEi | O76742 |
Genome annotation databases
EnsemblMetazoai | FBtr0084503; FBpp0083891; FBgn0015795 FBtr0308611; FBpp0300835; FBgn0015795 FBtr0308612; FBpp0300836; FBgn0015795 |
GeneIDi | 42841 |
KEGGi | dme:Dmel_CG5915 |
UCSCi | CG5915-RA, d. melanogaster |
Organism-specific databases
CTDi | 19349 |
FlyBasei | FBgn0015795, Rab7 |
Phylogenomic databases
eggNOGi | KOG0394, Eukaryota |
GeneTreei | ENSGT00940000155864 |
HOGENOMi | CLU_041217_10_6_1 |
OMAi | QSYGCNC |
OrthoDBi | 1172019at2759 |
Enzyme and pathway databases
Reactomei | R-DME-6798695, Neutrophil degranulation R-DME-8854214, TBC/RABGAPs R-DME-8873719, RAB geranylgeranylation R-DME-8876198, RAB GEFs exchange GTP for GDP on RABs |
Miscellaneous databases
BioGRID-ORCSi | 42841, 1 hit in 1 CRISPR screen |
GenomeRNAii | 42841 |
Gene expression databases
Bgeei | FBgn0015795, Expressed in embryonic/larval hemocyte (Drosophila) and 39 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O76742_DROME | |
Accessioni | O76742Primary (citable) accession number: O76742 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1998 |
Last sequence update: | November 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |