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Entry version 185 (02 Jun 2021)
Sequence version 1 (01 Nov 1998)
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Protein
Submitted name:

CG5915 protein

Gene

Rab7

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6798695, Neutrophil degranulation
R-DME-8854214, TBC/RABGAPs
R-DME-8873719, RAB geranylgeranylation
R-DME-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CG5915 proteinImported
Submitted name:
CG5915-PAImported
Submitted name:
GH03685pImported
Submitted name:
MIP21169pImported
Submitted name:
Rab7 proteinImported
Submitted name:
Rab7, isoform AImported
Submitted name:
Rab7, isoform BImported
Submitted name:
Rab7, isoform CImported
Submitted name:
Small ras-like GTPaseImported
Submitted name:
Small ras-like GTPase RAB7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rab7Imported
Synonyms:AAF56218Imported, Dm Rab7Imported, Dmel\CG5915Imported, DmRab7Imported, DRAB7Imported, DRab7Imported, Drab7Imported, dRab7Imported, drab7Imported, O76742Imported, Rab-7Imported, Rab-r7Imported, RAB7Imported, rab7Imported, Rab7AImported
ORF Names:CG5915Imported, Dmel_CG5915Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0015795, Rab7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O76742

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0015795, Expressed in embryonic/larval hemocyte (Drosophila) and 39 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O76742, 3 interactors

Molecular INTeraction database

More...
MINTi
O76742

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0083891

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O76742

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0394, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155864

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041217_10_6_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QSYGCNC

Database of Orthologous Groups

More...
OrthoDBi
1172019at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00071, Ras, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00231, small_GTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O76742-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRKKSLLK VIILGDSSVG KTSLMNQYVN KRFSNQYKAT IGADFCTKEV
60 70 80 90 100
VVNDRVVTMQ IWDTAGQERF QSLGVAFYRG ADCCVLVYDV TAPNSFKNLD
110 120 130 140 150
SWRDEFLIQA SPRDPDHFPF VVLGNKVDLD NRQVSTRRAQ QWCQSKNDIP
160 170 180 190 200
YYETSAKEGI NVEMAFQVIA KNALELEAEA EVINDFPDQI TLGSQNNRPG

NPDNCQC
Length:207
Mass (Da):23,331
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFC76D3630287AEB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF079459 Genomic DNA Translation: AAC32270.1
AE014297 Genomic DNA Translation: AAF56218.1
AF263363 mRNA Translation: AAF73041.1
AY060236 mRNA Translation: AAL25275.1
BT124755 mRNA Translation: ADF28796.1
AE014297 Genomic DNA Translation: AFH06594.1
AE014297 Genomic DNA Translation: AFH06595.1
AB035672 mRNA Translation: BAA88245.1
AM294823 Genomic DNA Translation: CAL26809.1
AM294824 Genomic DNA Translation: CAL26810.1
AM294825 Genomic DNA Translation: CAL26811.1
AM294826 Genomic DNA Translation: CAL26812.1
AM294827 Genomic DNA Translation: CAL26813.1
AM294828 Genomic DNA Translation: CAL26814.1
AM294829 Genomic DNA Translation: CAL26815.1
AM294830 Genomic DNA Translation: CAL26816.1
AM294831 Genomic DNA Translation: CAL26817.1
AM294832 Genomic DNA Translation: CAL26818.1
AM294833 Genomic DNA Translation: CAL26819.1
FM245635 Genomic DNA Translation: CAR93561.1
FM245636 Genomic DNA Translation: CAR93562.1
FM245637 Genomic DNA Translation: CAR93563.1
FM245638 Genomic DNA Translation: CAR93564.1
FM245639 Genomic DNA Translation: CAR93565.1
FM245640 Genomic DNA Translation: CAR93566.1
FM245641 Genomic DNA Translation: CAR93567.1
FM245642 Genomic DNA Translation: CAR93568.1
FM245643 Genomic DNA Translation: CAR93569.1
FM245644 Genomic DNA Translation: CAR93570.1
FM245645 Genomic DNA Translation: CAR93571.1

NCBI Reference Sequences

More...
RefSeqi
NP_001247276.1, NM_001260347.1
NP_001247277.1, NM_001260348.2
NP_524472.1, NM_079748.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0084503; FBpp0083891; FBgn0015795
FBtr0308611; FBpp0300835; FBgn0015795
FBtr0308612; FBpp0300836; FBgn0015795

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
42841

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5915

UCSC genome browser

More...
UCSCi
CG5915-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079459 Genomic DNA Translation: AAC32270.1
AE014297 Genomic DNA Translation: AAF56218.1
AF263363 mRNA Translation: AAF73041.1
AY060236 mRNA Translation: AAL25275.1
BT124755 mRNA Translation: ADF28796.1
AE014297 Genomic DNA Translation: AFH06594.1
AE014297 Genomic DNA Translation: AFH06595.1
AB035672 mRNA Translation: BAA88245.1
AM294823 Genomic DNA Translation: CAL26809.1
AM294824 Genomic DNA Translation: CAL26810.1
AM294825 Genomic DNA Translation: CAL26811.1
AM294826 Genomic DNA Translation: CAL26812.1
AM294827 Genomic DNA Translation: CAL26813.1
AM294828 Genomic DNA Translation: CAL26814.1
AM294829 Genomic DNA Translation: CAL26815.1
AM294830 Genomic DNA Translation: CAL26816.1
AM294831 Genomic DNA Translation: CAL26817.1
AM294832 Genomic DNA Translation: CAL26818.1
AM294833 Genomic DNA Translation: CAL26819.1
FM245635 Genomic DNA Translation: CAR93561.1
FM245636 Genomic DNA Translation: CAR93562.1
FM245637 Genomic DNA Translation: CAR93563.1
FM245638 Genomic DNA Translation: CAR93564.1
FM245639 Genomic DNA Translation: CAR93565.1
FM245640 Genomic DNA Translation: CAR93566.1
FM245641 Genomic DNA Translation: CAR93567.1
FM245642 Genomic DNA Translation: CAR93568.1
FM245643 Genomic DNA Translation: CAR93569.1
FM245644 Genomic DNA Translation: CAR93570.1
FM245645 Genomic DNA Translation: CAR93571.1
RefSeqiNP_001247276.1, NM_001260347.1
NP_001247277.1, NM_001260348.2
NP_524472.1, NM_079748.4

3D structure databases

SMRiO76742
ModBaseiSearch...

Protein-protein interaction databases

IntActiO76742, 3 interactors
MINTiO76742
STRINGi7227.FBpp0083891

Proteomic databases

PRIDEiO76742

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
42841

Genome annotation databases

EnsemblMetazoaiFBtr0084503; FBpp0083891; FBgn0015795
FBtr0308611; FBpp0300835; FBgn0015795
FBtr0308612; FBpp0300836; FBgn0015795
GeneIDi42841
KEGGidme:Dmel_CG5915
UCSCiCG5915-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
19349
FlyBaseiFBgn0015795, Rab7

Phylogenomic databases

eggNOGiKOG0394, Eukaryota
GeneTreeiENSGT00940000155864
HOGENOMiCLU_041217_10_6_1
OMAiQSYGCNC
OrthoDBi1172019at2759

Enzyme and pathway databases

ReactomeiR-DME-6798695, Neutrophil degranulation
R-DME-8854214, TBC/RABGAPs
R-DME-8873719, RAB geranylgeranylation
R-DME-8876198, RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
42841, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
42841

Gene expression databases

BgeeiFBgn0015795, Expressed in embryonic/larval hemocyte (Drosophila) and 39 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase
PfamiView protein in Pfam
PF00071, Ras, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00231, small_GTP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO76742_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76742
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: June 2, 2021
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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