CG5915 protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• GTPase activity Source: FlyBase
• GTP binding Source: InterPro
• protein-containing complex binding Source: FlyBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control."
    Dong B., Kakihara K., Otani T., Wada H., Hayashi S.
    Nat Commun 4:1358-1358(2013) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• border follicle cell migration Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration."
    Chen D.Y., Li M.Y., Wu S.Y., Lin Y.L., Tsai S.P., Lai P.L., Lin Y.T., Kuo J.C., Meng T.C., Chen G.C.
    J Cell Sci 125:4841-4852(2012) [PubMed] [Europe PMC] [Abstract]
• clathrin-dependent endocytosis involved in vitellogenesis Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Efficient Endocytic Uptake and Maturation in Drosophila Oocytes Requires Dynamitin/p50."
    Liu G., Sanghavi P., Bollinger K.E., Perry L., Marshall B., Roon P., Tanaka T., Nakamura A., Gonsalvez G.B.
    Genetics 201:631-649(2015) [PubMed] [Europe PMC] [Abstract]
• dsRNA transport Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing."
    Saleh M.-C., van Rij R.P., Hekele A., Gillis A., Foley E., O'Farrell P.H., Andino R.
    Nat. Cell Biol. 8:793-802(2006) [PubMed] [Europe PMC] [Abstract]
• endocytosis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing."
    Rives A.F., Rochlin K.M., Wehrli M., Schwartz S.L., DiNardo S.
    Dev Biol 293:268-283(2006) [PubMed] [Europe PMC] [Abstract]
• endosomal transport Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Gradient formation of the TGF-beta homolog Dpp."
    Entchev E.V., Schwabedissen A., Gonzalez-Gaitan M.
    Cell 103:981-991(2000) [PubMed] [Europe PMC] [Abstract]
• endosomal vesicle fusion Source: UniProtKB <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "MiniCORVET is a Vps8-containing early endosomal tether in Drosophila."
    Lorincz P., Lakatos Z., Varga A., Maruzs T., Simon-Vecsei Z., Darula Z., Benko P., Csordas G., Lippai M., Ando I., Hegedus K., Medzihradszky K.F., Takats S., Juhasz G.
    Elife 5:0-0(2016) [PubMed] [Europe PMC] [Abstract]
• endosome to lysosome transport Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway."
    Wilkin M., Tongngok P., Gensch N., Clemence S., Motoki M., Yamada K., Hori K., Taniguchi-Kanai M., Franklin E., Matsuno K., Baron M.
    Dev Cell 15:762-772(2008) [PubMed] [Europe PMC] [Abstract]
• endosome to lysosome transport via multivesicular body sorting pathway Source: FlyBaseInferred from direct assayⁱ
  • "Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila."
    Yousefian J., Troost T., Grawe F., Sasamura T., Fortini M., Klein T.
    J Cell Sci 126:1583-1594(2013) [PubMed] [Europe PMC] [Abstract]
• exosomal secretion Source: FlyBaseInferred from mutant phenotypeⁱ
  • "BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior."
    Corrigan L., Redhai S., Leiblich A., Fan S.J., Perera S.M., Patel R., Gandy C., Wainwright S.M., Morris J.F., Hamdy F., Goberdhan D.C., Wilson C.
    J Cell Biol 206:671-688(2014) [PubMed] [Europe PMC] [Abstract]
• phagosome-lysosome fusion Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• Rab protein signal transduction Source: FlyBase
• vesicle-mediated transport Source: FlyBase
• viral entry into host cell Source: FlyBaseInferred from high throughput mutant phenotypeⁱ
  • "Identification of insect genes involved in baculovirus AcMNPV entry into insect cells."
    Hodgson J.J., Buchon N., Blissard G.W.
    Virology 527:1-11(2019) [PubMed] [Europe PMC] [Abstract]
• wing disc dorsal/ventral pattern formation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway."
    Wilkin M., Tongngok P., Gensch N., Clemence S., Motoki M., Yamada K., Hori K., Taniguchi-Kanai M., Franklin E., Matsuno K., Baron M.
    Dev Cell 15:762-772(2008) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSGRKKSLLK VIILGDSSVG KTSLMNQYVN KRFSNQYKAT IGADFCTKEV 
        60         70         80         90        100
VVNDRVVTMQ IWDTAGQERF QSLGVAFYRG ADCCVLVYDV TAPNSFKNLD 
       110        120        130        140        150
SWRDEFLIQA SPRDPDHFPF VVLGNKVDLD NRQVSTRRAQ QWCQSKNDIP 
       160        170        180        190        200
YYETSAKEGI NVEMAFQVIA KNALELEAEA EVINDFPDQI TLGSQNNRPG 

NPDNCQC                                                

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ