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Entry version 60 (10 Feb 2021)
Sequence version 1 (01 Nov 1998)
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Protein

Hyalin

Gene
N/A
Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major constituent of the hyaline layer. The hyaline layer of echinoderm embryos is an extraembryonic matrix that functions as a substrate for cell adhesion through early development.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hyalin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7668 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaCamarodontaEchinideaStrongylocentrotidaeStrongylocentrotus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007110 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000084099‹1 – ›1200HyalinAdd BLAST›1200

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.

Keywords - PTMi

Glycoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer in presence of calcium.

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini‹1 – 39HYR 1PROSITE-ProRule annotationAdd BLAST›39
Domaini40 – 123HYR 2PROSITE-ProRule annotationAdd BLAST84
Domaini124 – 207HYR 3PROSITE-ProRule annotationAdd BLAST84
Domaini208 – 292HYR 4PROSITE-ProRule annotationAdd BLAST85
Domaini293 – 376HYR 5PROSITE-ProRule annotationAdd BLAST84
Domaini377 – 460HYR 6PROSITE-ProRule annotationAdd BLAST84
Domaini461 – 544HYR 7PROSITE-ProRule annotationAdd BLAST84
Domaini546 – 629HYR 8PROSITE-ProRule annotationAdd BLAST84
Domaini630 – 713HYR 9PROSITE-ProRule annotationAdd BLAST84
Domaini714 – 797HYR 10PROSITE-ProRule annotationAdd BLAST84
Domaini798 – 881HYR 11PROSITE-ProRule annotationAdd BLAST84
Domaini882 – 966HYR 12PROSITE-ProRule annotationAdd BLAST85
Domaini967 – 1050HYR 13PROSITE-ProRule annotationAdd BLAST84
Domaini1051 – 1133HYR 14PROSITE-ProRule annotationAdd BLAST83
Domaini1134 – ›1200HYR 15PROSITE-ProRule annotationAdd BLAST›67

Keywords - Domaini

Repeat

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003410, HYR_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02494, HYR, 15 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50825, HYR, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

O76536-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SSHNPGQSFT TGTTTTVVYT ATDAFANVGQ CAFTITVTAT DTTPPVVTVS
60 70 80 90 100
SSTITRQVEV GTPGVNVFFT EPTATDNSGQ AILISRTNQP GDFFSVGQTI
110 120 130 140 150
VTYTFQDPSG NPASGTVTIN VIEVDTTPPV VTVPSTTITR QVEVGSSGVN
160 170 180 190 200
VFYTEPTATD NSGQAILTSR TNQPGDFFPV GQTTVTYTFQ DPSGNPASGT
210 220 230 240 250
VTINVIEVDT TPPVVTVPST TITRQVEVGS SGVNVFYTEP TATDNSGQAI
260 270 280 290 300
LTSRTNQPGD FFPVGQTTVT YTFSQDPSGN PASATVTINV IEVDTTPPVV
310 320 330 340 350
TVPSTTITRQ VEIGTPGVNV FYTEPTATDN SGIANLVSRT NQPGDFFPVG
360 370 380 390 400
QTDVTYTFQD PSGNPSSGTV TINVVEVDTT SPVITVPSNT ITREVELGTP
410 420 430 440 450
GVNVFYTEPT ATDNSGIANL VSRTNQPGDF FNVGQTVVTY TFQDPSGNPA
460 470 480 490 500
SGTVTINVVE VDTTPPQVFV TTGEVVRTAP FGSSGVNVFF TEPVAIDNSG
510 520 530 540 550
TADLVSQTAQ PGDFFPIGST VVTYRYRDAS GNEATGTFTV TVEEMVDTTP
560 570 580 590 600
PTVTVSGGNI VRTVELGQSR LSVIYTEPTA TDNSGEANLV SRTAQPGDLF
610 620 630 640 650
PVGTTTVEYV YQDPAGNEGR GQFTVTVIAV DTTPPSVNCP NNVFQEVELG
660 670 680 690 700
TSSAPVFFTE PTAFDISGQA NLVTRTAAPG DSFPVGTTSV SYIFSDNSGN
710 720 730 740 750
EAEPCTFTVT ISAVDTTPPT VNCINNVAQT VQLGTGSTQV FFTEPTAFDI
760 770 780 790 800
SGQTSLVTRT SAPGDSFPVG TTSVTYIFTD ASGNNAQPCT FNVVINAVDT
810 820 830 840 850
TPPTVNCANN IAQTIELGST SAVVNYAEPS ATDISGTAFL VSRSSSPGDS
860 870 880 890 900
FPIGSTTVTY IFSDQSGNEA PPCVFTVTIG TVDTMMPMFT SCPNNIVQSV
910 920 930 940 950
ELGVPGTVIS WTTPTANDAA GIASIVSNLQ PGSFFTVGES ATVTYVATDN
960 970 980 990 1000
SGLTDNSCSF TVTVFAVDTT PPSVVCTNNV FQTVELGTNP VQVFYTEPTA
1010 1020 1030 1040 1050
SDISGQANLV SRTNVPGDSF PVGTSTVTYV FADNSGNTAD ACSFTITVTA
1060 1070 1080 1090 1100
QDTTPPTVNC ITNIVRTVEL GTSSVQVFYN EPTASDLGQA SLVSRTAQPG
1110 1120 1130 1140 1150
DNFPVGVNPV TYVFGDNSGN QADPCTFTIT VNTQDTTPPT VTCISDITRV
1160 1170 1180 1190 1200
VELGTTSVGI SYTEPTATDI SGTATLDSRS HTPGQNFPVG STVVSYFFSD
Length:1,200
Mass (Da):124,743
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57A52B7CDE68A629
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11
Non-terminal residuei12001

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF076472 mRNA Translation: AAC31909.1

Protein sequence database of the Protein Information Resource

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PIRi
T17404

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076472 mRNA Translation: AAC31909.1
PIRiT17404

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR003410, HYR_dom
PfamiView protein in Pfam
PF02494, HYR, 15 hits
PROSITEiView protein in PROSITE
PS50825, HYR, 15 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHYAL_STRPU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76536
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1998
Last modified: February 10, 2021
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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