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Entry version 110 (08 May 2019)
Sequence version 1 (01 Nov 1998)
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Protein
Submitted name:

Pteridine reductase

Gene

PTR1

Organism
Trypanosoma brucei brucei
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei14SubstrateCombined sources1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei161Proton donor/acceptorCombined sources1
Active sitei174Proton donor/acceptorCombined sources1
Binding sitei174NADPCombined sources1
Binding sitei178NADPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi14 – 15NADPCombined sources2
Nucleotide bindingi35 – 37NADPCombined sources3
Nucleotide bindingi62 – 64NADPCombined sources3
Nucleotide bindingi93 – 95NADPCombined sources3
Nucleotide bindingi204 – 208NADPCombined sources5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • nucleotide binding Source: UniProtKB-KW
  • pteridine reductase activity Source: CACAO

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandNADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O76290

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pteridine reductaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTR1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrypanosoma brucei bruceiImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C7VX-ray2.20A/B/C/D1-268[»]
2VZ0X-ray1.90A/B/C/D1-268[»]
2WD7X-ray1.90A/B/C/D1-268[»]
2WD8X-ray2.10A/B/C/D1-268[»]
2X9GX-ray1.10A/B/C/D1-268[»]
2X9NX-ray1.15A/B/C/D1-268[»]
2X9VX-ray1.30A/B/C/D1-268[»]
2YHUX-ray2.01A/B/C/D1-268[»]
3BMCX-ray2.60A/B/C/D1-268[»]
3BMNX-ray1.98A/B/C/D1-268[»]
3BMOX-ray1.60A/B/C/D1-268[»]
3BMQX-ray1.70A/B/C/D1-268[»]
3GN1X-ray2.00A/B/C/D1-268[»]
3GN2X-ray1.60A/B/C/D1-268[»]
3MCVX-ray1.70A/B/C/D1-268[»]
4CL8X-ray2.20A/B/C/D1-268[»]
4CLDX-ray1.77A/B/C/D1-268[»]
4CLEX-ray1.80A/B/C/D1-268[»]
4CLHX-ray1.85A/B/C/D1-268[»]
4CLOX-ray1.88A/B/C/D1-268[»]
4CLRX-ray1.75A/B/C/D1-268[»]
4CLXX-ray1.85A/B/C/D1-268[»]
4CM1X-ray1.90A/B/C/D1-268[»]
4CM3X-ray1.95A/B/C/D1-268[»]
4CM4X-ray1.81A/B/C/D1-268[»]
4CM5X-ray1.99A/B/C/D1-268[»]
4CM6X-ray1.70A/B/C/D1-268[»]
4CM7X-ray1.90A/B/C/D1-268[»]
4CM8X-ray1.90A/B/C/D1-268[»]
4CM9X-ray1.90A/B/C/D1-268[»]
4CMAX-ray1.85A/B/C/D1-268[»]
4CMBX-ray1.96A/B/C/D1-268[»]
4CMCX-ray1.85A/B/C/D1-268[»]
4CMEX-ray1.85A/B/C/D1-268[»]
4CMGX-ray2.00A/B/C/D1-268[»]
4CMIX-ray1.90A/B/C/D1-268[»]
4CMJX-ray2.20A/B/C/D1-268[»]
4CMKX-ray2.00A/B/C/D1-268[»]
4WCDX-ray1.68A/B/C/D1-268[»]
4WCFX-ray1.93A/B/C/D1-268[»]
5IZCX-ray1.92A/B/C/D1-268[»]
5JCJX-ray1.76A/B/C/D1-268[»]
5JCXX-ray1.43A/B/C/D1-268[»]
5JDCX-ray1.78A/B/C/D1-268[»]
5JDIX-ray1.38A/B/C/D1-268[»]
5K6AX-ray1.70A/B/C/D1-268[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O76290

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O76290

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR014058 Pteridine_reductase
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00081 GDHRDH
PR00080 SDRFAMILY

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02685 pter_reduc_Leis, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00061 ADH_SHORT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O76290-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAPAAVVTG AAKRIGRAIA VKLHQTGYRV VIHYHNSAEA AVSLADELNK
60 70 80 90 100
ERSNTAVVCQ ADLTNSNVLP ASCEEIINSC FRAFGRCDVL VNNASAFYPT
110 120 130 140 150
PLVQGDHEDN SNGKTVETQV AELIGTNAIA PFLLTMSFAQ RQKGTNPNCT
160 170 180 190 200
SSNLSIVNLC DAMVDQPCMA FSLYNMGKHA LVGLTQSAAL ELAPYGIRVN
210 220 230 240 250
GVAPGVSLLP VAMGEEEKDK WRRKVPLGRR EASAEQIADA VIFLVSGSAQ
260
YITGSIIKVD GGLSLVHA
Length:268
Mass (Da):28,470
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i346C8257BDC9DD3D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF049903 mRNA Translation: AAC23562.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049903 mRNA Translation: AAC23562.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C7VX-ray2.20A/B/C/D1-268[»]
2VZ0X-ray1.90A/B/C/D1-268[»]
2WD7X-ray1.90A/B/C/D1-268[»]
2WD8X-ray2.10A/B/C/D1-268[»]
2X9GX-ray1.10A/B/C/D1-268[»]
2X9NX-ray1.15A/B/C/D1-268[»]
2X9VX-ray1.30A/B/C/D1-268[»]
2YHUX-ray2.01A/B/C/D1-268[»]
3BMCX-ray2.60A/B/C/D1-268[»]
3BMNX-ray1.98A/B/C/D1-268[»]
3BMOX-ray1.60A/B/C/D1-268[»]
3BMQX-ray1.70A/B/C/D1-268[»]
3GN1X-ray2.00A/B/C/D1-268[»]
3GN2X-ray1.60A/B/C/D1-268[»]
3MCVX-ray1.70A/B/C/D1-268[»]
4CL8X-ray2.20A/B/C/D1-268[»]
4CLDX-ray1.77A/B/C/D1-268[»]
4CLEX-ray1.80A/B/C/D1-268[»]
4CLHX-ray1.85A/B/C/D1-268[»]
4CLOX-ray1.88A/B/C/D1-268[»]
4CLRX-ray1.75A/B/C/D1-268[»]
4CLXX-ray1.85A/B/C/D1-268[»]
4CM1X-ray1.90A/B/C/D1-268[»]
4CM3X-ray1.95A/B/C/D1-268[»]
4CM4X-ray1.81A/B/C/D1-268[»]
4CM5X-ray1.99A/B/C/D1-268[»]
4CM6X-ray1.70A/B/C/D1-268[»]
4CM7X-ray1.90A/B/C/D1-268[»]
4CM8X-ray1.90A/B/C/D1-268[»]
4CM9X-ray1.90A/B/C/D1-268[»]
4CMAX-ray1.85A/B/C/D1-268[»]
4CMBX-ray1.96A/B/C/D1-268[»]
4CMCX-ray1.85A/B/C/D1-268[»]
4CMEX-ray1.85A/B/C/D1-268[»]
4CMGX-ray2.00A/B/C/D1-268[»]
4CMIX-ray1.90A/B/C/D1-268[»]
4CMJX-ray2.20A/B/C/D1-268[»]
4CMKX-ray2.00A/B/C/D1-268[»]
4WCDX-ray1.68A/B/C/D1-268[»]
4WCFX-ray1.93A/B/C/D1-268[»]
5IZCX-ray1.92A/B/C/D1-268[»]
5JCJX-ray1.76A/B/C/D1-268[»]
5JCXX-ray1.43A/B/C/D1-268[»]
5JDCX-ray1.78A/B/C/D1-268[»]
5JDIX-ray1.38A/B/C/D1-268[»]
5K6AX-ray1.70A/B/C/D1-268[»]
SMRiO76290
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKiO76290

Miscellaneous databases

EvolutionaryTraceiO76290

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR014058 Pteridine_reductase
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02685 pter_reduc_Leis, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO76290_TRYBB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76290
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 8, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
UniProt is an ELIXIR core data resource
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