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Protein

Putative riboflavin kinase

Gene

anon-84Ea

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN).By similarity

Catalytic activityi

ATP + riboflavin = ADP + FMN.By similarity

Cofactori

Zn2+By similarity, Mg2+By similarityNote: Zinc or magnesium.By similarity

Pathwayi: FMN biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FMN from riboflavin (ATP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Putative riboflavin kinase (anon-84Ea)
This subpathway is part of the pathway FMN biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FMN from riboflavin (ATP route), the pathway FMN biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi28Magnesium or zincBy similarity1
Active sitei80NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Flavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-196843 Vitamin B2 (riboflavin) metabolism
UniPathwayiUPA00276; UER00406

Names & Taxonomyi

Protein namesi
Recommended name:
Putative riboflavin kinase (EC:2.7.1.26)
Alternative name(s):
ATP:riboflavin 5'-phosphotransferase
Flavokinase
Gene namesi
Name:anon-84Ea
ORF Names:CG2846
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0014930 CG2846

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941501 – 153Putative riboflavin kinaseAdd BLAST153

Proteomic databases

PaxDbiO76206
PRIDEiO76206

Expressioni

Gene expression databases

BgeeiFBgn0014930
ExpressionAtlasiO76206 baseline and differential
GenevisibleiO76206 DM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi7227.FBpp0081260

Structurei

3D structure databases

ProteinModelPortaliO76206
SMRiO76206
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3110 Eukaryota
COG0196 LUCA
GeneTreeiENSGT00390000015537
InParanoidiO76206
KOiK00861
OMAiGKDLGCP
OrthoDBiEOG091G0Z4E
PhylomeDBiO76206

Family and domain databases

Gene3Di2.40.30.30, 1 hit
InterProiView protein in InterPro
IPR023468 Riboflavin_kinase
IPR015865 Riboflavin_kinase_bac/euk
IPR023465 Riboflavin_kinase_dom_sf
PANTHERiPTHR22749 PTHR22749, 1 hit
PfamiView protein in Pfam
PF01687 Flavokinase, 1 hit
SMARTiView protein in SMART
SM00904 Flavokinase, 1 hit
SUPFAMiSSF82114 SSF82114, 1 hit

Sequencei

Sequence statusi: Complete.

O76206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSQLPLFAG GEIVRGFGRG SKELGIPTAN FPLEVVKSLP ESLPTGAYYG
60 70 80 90 100
WANVDNGPVH KMVLSIGWNP FYNNKEKSVE THMLHDFNCD LYGQTLKICI
110 120 130 140 150
VGYLRPERSF DSLESLIAAI RGDIEQAKAF LDEADKAKLK EAPFFTEKLC

SSK
Length:153
Mass (Da):16,986
Last modified:November 1, 1998 - v1
Checksum:i56FF3B5C043C0D22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24L → M in AAL28446 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017096 Genomic DNA Translation: AAC39087.1
AE014297 Genomic DNA Translation: AAF54164.1
AY071393 mRNA Translation: AAL49015.1
AY060898 mRNA Translation: AAL28446.1
BT050515 mRNA Translation: ACJ13222.1
RefSeqiNP_001287218.1, NM_001300289.1
NP_649749.2, NM_141492.3
UniGeneiDm.1095

Genome annotation databases

EnsemblMetazoaiFBtr0081763; FBpp0081260; FBgn0014930
FBtr0339712; FBpp0308769; FBgn0014930
GeneIDi40936
KEGGidme:Dmel_CG2846

Similar proteinsi

Entry informationi

Entry nameiRIFK_DROME
AccessioniPrimary (citable) accession number: O76206
Secondary accession number(s): B6IDS5, Q95S97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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