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Protein

Olfactory receptor 7A10

Gene

OR7A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7A10
Alternative name(s):
OST027
Olfactory receptor OR19-18
Gene namesi
Name:OR7A10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000127515.1
HGNCiHGNC:8356 OR7A10
neXtProtiNX_O76100

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 309CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32611

Polymorphism and mutation databases

BioMutaiOR7A10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506441 – 309Olfactory receptor 7A10Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76100
PRIDEiO76100
ProteomicsDBi50417
TopDownProteomicsiO76100

Expressioni

Gene expression databases

BgeeiENSG00000127515 Expressed in 5 organ(s), highest expression level in zone of skin
CleanExiHS_OR7A10
ExpressionAtlasiO76100 baseline and differential
GenevisibleiO76100 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000248058

Structurei

3D structure databases

ProteinModelPortaliO76100
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1 Eukaryota
ENOG410YBQN LUCA
GeneTreeiENSGT00760000118801
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiO76100
KOiK04257
OMAiPLPFCTH
OrthoDBiEOG091G0B53
PhylomeDBiO76100
TreeFamiTF337210

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O76100-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSWNNTIIL EFLLLGISEE PELQAFLFGL FLSMYLVTVL GNLLIILATI
60 70 80 90 100
SDSHLHTPMY FFLSNLSFVD ICFVSTTVPK MLVNIQTHNK VITYAGCITQ
110 120 130 140 150
MCFFLLFVGL DNFLLTVMAY DRFVAICHPL HYMVIMNPQL CGLLVLASWI
160 170 180 190 200
MSVLNSMLQS LMVLPLPFCT HMEIPHFFCE INQVVHLACS DTFLNDIVMY
210 220 230 240 250
FAVALLGGGP LTGILYSYSK IVSSIRAISS AQGKYKAFST CASHLSVVSL
260 270 280 290 300
FYGTCLGVYL SSAATHNSHT GAAASVMYTV VTPMLNPFIY SLRNKHIKGA

MKTFFRGKQ
Length:309
Mass (Da):34,406
Last modified:November 1, 1998 - v1
Checksum:i8761B3C97FE3ADB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70D → G in AAK95027 (PubMed:12213199).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053225151M → T. Corresponds to variant dbSNP:rs12972670Ensembl.1
Natural variantiVAR_034254183Q → E. Corresponds to variant dbSNP:rs9305052Ensembl.1
Natural variantiVAR_053226225I → L. Corresponds to variant dbSNP:rs11880955Ensembl.1
Natural variantiVAR_053227273A → T. Corresponds to variant dbSNP:rs10221530Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005255 Genomic DNA Translation: AAC25627.1
AF399542 Genomic DNA Translation: AAK95027.1
BK004222 Genomic DNA Translation: DAA04620.1
CCDSiCCDS32936.1
RefSeqiNP_001005190.1, NM_001005190.1
UniGeneiHs.553776

Genome annotation databases

EnsembliENST00000248058; ENSP00000248058; ENSG00000127515
ENST00000641129; ENSP00000493055; ENSG00000127515
GeneIDi390892
KEGGihsa:390892
UCSCiuc002mzx.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005255 Genomic DNA Translation: AAC25627.1
AF399542 Genomic DNA Translation: AAK95027.1
BK004222 Genomic DNA Translation: DAA04620.1
CCDSiCCDS32936.1
RefSeqiNP_001005190.1, NM_001005190.1
UniGeneiHs.553776

3D structure databases

ProteinModelPortaliO76100
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000248058

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR7A10

Proteomic databases

PaxDbiO76100
PRIDEiO76100
ProteomicsDBi50417
TopDownProteomicsiO76100

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248058; ENSP00000248058; ENSG00000127515
ENST00000641129; ENSP00000493055; ENSG00000127515
GeneIDi390892
KEGGihsa:390892
UCSCiuc002mzx.1 human

Organism-specific databases

CTDi390892
EuPathDBiHostDB:ENSG00000127515.1
GeneCardsiOR7A10
HGNCiHGNC:8356 OR7A10
neXtProtiNX_O76100
PharmGKBiPA32611
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB1 Eukaryota
ENOG410YBQN LUCA
GeneTreeiENSGT00760000118801
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiO76100
KOiK04257
OMAiPLPFCTH
OrthoDBiEOG091G0B53
PhylomeDBiO76100
TreeFamiTF337210

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR7A10
GenomeRNAii390892
PROiPR:O76100

Gene expression databases

BgeeiENSG00000127515 Expressed in 5 organ(s), highest expression level in zone of skin
CleanExiHS_OR7A10
ExpressionAtlasiO76100 baseline and differential
GenevisibleiO76100 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR7AA_HUMAN
AccessioniPrimary (citable) accession number: O76100
Secondary accession number(s): Q6IFP0, Q96R97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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