Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cystatin-F

Gene

CST7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei37Reactive site1

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: ProtInc
  • endopeptidase inhibitor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.007

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-F
Alternative name(s):
Cystatin-7
Cystatin-like metastasis-associated protein
Short name:
CMAP
Leukocystatin
Gene namesi
Name:CST7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000077984.5
HGNCiHGNC:2479 CST7
MIMi603253 gene
neXtProtiNX_O76096

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8530
OpenTargetsiENSG00000077984
PharmGKBiPA26980

Polymorphism and mutation databases

BioMutaiCST7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisCombined sourcesAdd BLAST19
ChainiPRO_000000664620 – 145Cystatin-FAdd BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26Interchain (with C-63)1 Publication
Glycosylationi62N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi63Interchain (with C-26)1 Publication
Disulfide bondi99 ↔ 1101 Publication
Glycosylationi115N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi124 ↔ 1441 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO76096
PaxDbiO76096
PeptideAtlasiO76096
PRIDEiO76096
ProteomicsDBi50415

PTM databases

iPTMnetiO76096
PhosphoSitePlusiO76096

Expressioni

Tissue specificityi

Primarily expressed in peripheral blood cells and spleen.

Gene expression databases

BgeeiENSG00000077984 Expressed in 122 organ(s), highest expression level in blood
CleanExiHS_CST7
GenevisibleiO76096 HS

Organism-specific databases

HPAiHPA040442

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CTSCP536342EBI-2807448,EBI-1047323

Protein-protein interaction databases

BioGridi114100, 9 interactors
IntActiO76096, 2 interactors
MINTiO76096
STRINGi9606.ENSP00000420384

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO76096
SMRiO76096
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76096

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 85Secondary area of contact5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J26J Eukaryota
ENOG41121KX LUCA
GeneTreeiENSGT00900000140934
HOGENOMiHOG000112134
HOVERGENiHBG009556
InParanoidiO76096
KOiK13903
OMAiDNCDFQT
OrthoDBiEOG091G0TP1
PhylomeDBiO76096

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76096-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAAGTLLAF CCLVLSTTGG PSPDTCSQDL NSRVKPGFPK TIKTNDPGVL
60 70 80 90 100
QAARYSVEKF NNCTNDMFLF KESRITRALV QIVKGLKYML EVEIGRTTCK
110 120 130 140
KNQHLRLDDC DFQTNHTLKQ TLSCYSEVWV VPWLQHFEVP VLRCH
Length:145
Mass (Da):16,454
Last modified:November 1, 1998 - v1
Checksum:iB2BCC4F76857CB0F
GO

Sequence cautioni

The sequence AAH15507 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAP88827 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA34941 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB11886 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031824 mRNA Translation: AAC39788.1
AF036342 mRNA Translation: AAC35747.1
AB029636 Genomic DNA Translation: BAB11886.1 Different initiation.
AJ510167
, AJ510168, AJ510169, AJ510170 Genomic DNA Translation: CAD52872.1
AB015225 mRNA Translation: BAA34941.1 Different initiation.
BT009825 mRNA Translation: AAP88827.1 Different initiation.
CR541860 mRNA Translation: CAG46658.1
CR541878 mRNA Translation: CAG46676.1
AL035661 Genomic DNA No translation available.
BC015507 mRNA Translation: AAH15507.1 Different initiation.
CCDSiCCDS13165.2
RefSeqiNP_003641.3, NM_003650.3
UniGeneiHs.143212

Genome annotation databases

EnsembliENST00000480798; ENSP00000420384; ENSG00000077984
GeneIDi8530
KEGGihsa:8530
UCSCiuc002wtx.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031824 mRNA Translation: AAC39788.1
AF036342 mRNA Translation: AAC35747.1
AB029636 Genomic DNA Translation: BAB11886.1 Different initiation.
AJ510167
, AJ510168, AJ510169, AJ510170 Genomic DNA Translation: CAD52872.1
AB015225 mRNA Translation: BAA34941.1 Different initiation.
BT009825 mRNA Translation: AAP88827.1 Different initiation.
CR541860 mRNA Translation: CAG46658.1
CR541878 mRNA Translation: CAG46676.1
AL035661 Genomic DNA No translation available.
BC015507 mRNA Translation: AAH15507.1 Different initiation.
CCDSiCCDS13165.2
RefSeqiNP_003641.3, NM_003650.3
UniGeneiHs.143212

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CH9X-ray2.10A20-145[»]
ProteinModelPortaliO76096
SMRiO76096
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114100, 9 interactors
IntActiO76096, 2 interactors
MINTiO76096
STRINGi9606.ENSP00000420384

Protein family/group databases

MEROPSiI25.007

PTM databases

iPTMnetiO76096
PhosphoSitePlusiO76096

Polymorphism and mutation databases

BioMutaiCST7

Proteomic databases

EPDiO76096
PaxDbiO76096
PeptideAtlasiO76096
PRIDEiO76096
ProteomicsDBi50415

Protocols and materials databases

DNASUi8530
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000480798; ENSP00000420384; ENSG00000077984
GeneIDi8530
KEGGihsa:8530
UCSCiuc002wtx.2 human

Organism-specific databases

CTDi8530
DisGeNETi8530
EuPathDBiHostDB:ENSG00000077984.5
GeneCardsiCST7
HGNCiHGNC:2479 CST7
HPAiHPA040442
MIMi603253 gene
neXtProtiNX_O76096
OpenTargetsiENSG00000077984
PharmGKBiPA26980
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J26J Eukaryota
ENOG41121KX LUCA
GeneTreeiENSGT00900000140934
HOGENOMiHOG000112134
HOVERGENiHBG009556
InParanoidiO76096
KOiK13903
OMAiDNCDFQT
OrthoDBiEOG091G0TP1
PhylomeDBiO76096

Miscellaneous databases

ChiTaRSiCST7 human
EvolutionaryTraceiO76096
GeneWikiiCST7_(gene)
GenomeRNAii8530
PROiPR:O76096
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000077984 Expressed in 122 organ(s), highest expression level in blood
CleanExiHS_CST7
GenevisibleiO76096 HS

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYTF_HUMAN
AccessioniPrimary (citable) accession number: O76096
Secondary accession number(s): Q6FH95, Q7Z4J8, Q9UED4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again