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Protein

Protein JTB

Gene

JTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • mitotic cell cycle Source: UniProtKB
  • mitotic cytokinesis Source: UniProtKB
  • positive regulation of protein kinase activity Source: UniProtKB

Keywordsi

Biological processApoptosis, Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein JTB
Alternative name(s):
Jumping translocation breakpoint protein
Prostate androgen-regulated protein
Short name:
PAR protein
Gene namesi
Name:JTB
ORF Names:HSPC222
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143543.14
HGNCiHGNC:6201 JTB
MIMi604671 gene
neXtProtiNX_O76095

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 105ExtracellularSequence analysisAdd BLAST75
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 146CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi10899
OpenTargetsiENSG00000143543
PharmGKBiPA30003

Polymorphism and mutation databases

BioMutaiJTB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000002153531 – 146Protein JTBAdd BLAST116

Proteomic databases

EPDiO76095
MaxQBiO76095
PaxDbiO76095
PeptideAtlasiO76095
PRIDEiO76095
ProteomicsDBi50413
50414 [O76095-2]

PTM databases

iPTMnetiO76095
PhosphoSitePlusiO76095

Expressioni

Tissue specificityi

Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.4 Publications

Inductioni

Protein levels increase during the S phase of the cell cycle, are highest during G2 and mitosis, and decrease to low levels at G1. Levels are lowest at the transition from G1 to S phase.1 Publication

Gene expression databases

BgeeiENSG00000143543 Expressed in 227 organ(s), highest expression level in parotid gland
CleanExiHS_JTB
GenevisibleiO76095 HS

Organism-specific databases

HPAiHPA006514

Interactioni

Subunit structurei

Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116105, 33 interactors
IntActiO76095, 6 interactors
MINTiO76095
STRINGi9606.ENSP00000271843

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO76095
SMRiO76095
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76095

Family & Domainsi

Sequence similaritiesi

Belongs to the JTB family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4084 Eukaryota
ENOG4111VSR LUCA
GeneTreeiENSGT00390000016136
HOGENOMiHOG000294204
HOVERGENiHBG000952
InParanoidiO76095
OMAiECAPCSN
OrthoDBiEOG091G0PNA
PhylomeDBiO76095
TreeFamiTF316934

Family and domain databases

InterProiView protein in InterPro
IPR008657 JTB
PANTHERiPTHR13041 PTHR13041, 1 hit
PfamiView protein in Pfam
PF05439 JTB, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD151382 JTB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O76095-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLAGAGRPGL PQGRHLCWLL CAFTLKLCQA EAPVQEEKLS ASTSNLPCWL
60 70 80 90 100
VEEFVVAEEC SPCSNFRAKT TPECGPTGYV EKITCSSSKR NEFKSCRSAL
110 120 130 140
MEQRLFWKFE GAVVCVALIF ACLVIIRQRQ LDRKALEKVR KQIESI
Length:146
Mass (Da):16,358
Last modified:November 1, 1998 - v1
Checksum:iCA7080543591C319
GO
Isoform 2 (identifier: O76095-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEK → MAWGWHLSF

Show »
Length:117
Mass (Da):13,356
Checksum:i39BB62469FA5541B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03399416L → F. Corresponds to variant dbSNP:rs34686244Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0414001 – 38MLAGA…VQEEK → MAWGWHLSF in isoform 2. 2 PublicationsAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016492 Genomic DNA Translation: BAA33735.1
AB016488 mRNA Translation: BAA33731.1
AB016493 Genomic DNA Translation: BAA33736.1
AF115850 mRNA Translation: AAD09822.2
AF131797 mRNA Translation: AAD20045.1
AF151056 mRNA Translation: AAF36142.1
BT007285 mRNA Translation: AAP35949.1
CR456985 mRNA Translation: CAG33266.1
AK312106 mRNA Translation: BAG35042.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53241.1
CH471121 Genomic DNA Translation: EAW53242.1
CH471121 Genomic DNA Translation: EAW53244.1
BC000499 mRNA Translation: AAH00499.1
BC000996 mRNA Translation: AAH00996.1
BC001363 mRNA Translation: AAH01363.1
BC001667 mRNA Translation: AAH01667.1
BC004239 mRNA Translation: AAH04239.1
BC019277 mRNA Translation: AAH19277.1
CCDSiCCDS1057.1 [O76095-1]
RefSeqiNP_006685.1, NM_006694.3 [O76095-1]
UniGeneiHs.6396

Genome annotation databases

EnsembliENST00000271843; ENSP00000271843; ENSG00000143543 [O76095-1]
ENST00000356648; ENSP00000349069; ENSG00000143543 [O76095-2]
ENST00000368589; ENSP00000357578; ENSG00000143543 [O76095-2]
ENST00000428469; ENSP00000395250; ENSG00000143543 [O76095-2]
GeneIDi10899
KEGGihsa:10899
UCSCiuc001fds.4 human [O76095-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016492 Genomic DNA Translation: BAA33735.1
AB016488 mRNA Translation: BAA33731.1
AB016493 Genomic DNA Translation: BAA33736.1
AF115850 mRNA Translation: AAD09822.2
AF131797 mRNA Translation: AAD20045.1
AF151056 mRNA Translation: AAF36142.1
BT007285 mRNA Translation: AAP35949.1
CR456985 mRNA Translation: CAG33266.1
AK312106 mRNA Translation: BAG35042.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53241.1
CH471121 Genomic DNA Translation: EAW53242.1
CH471121 Genomic DNA Translation: EAW53244.1
BC000499 mRNA Translation: AAH00499.1
BC000996 mRNA Translation: AAH00996.1
BC001363 mRNA Translation: AAH01363.1
BC001667 mRNA Translation: AAH01667.1
BC004239 mRNA Translation: AAH04239.1
BC019277 mRNA Translation: AAH19277.1
CCDSiCCDS1057.1 [O76095-1]
RefSeqiNP_006685.1, NM_006694.3 [O76095-1]
UniGeneiHs.6396

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KJXNMR-A47-104[»]
ProteinModelPortaliO76095
SMRiO76095
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116105, 33 interactors
IntActiO76095, 6 interactors
MINTiO76095
STRINGi9606.ENSP00000271843

PTM databases

iPTMnetiO76095
PhosphoSitePlusiO76095

Polymorphism and mutation databases

BioMutaiJTB

Proteomic databases

EPDiO76095
MaxQBiO76095
PaxDbiO76095
PeptideAtlasiO76095
PRIDEiO76095
ProteomicsDBi50413
50414 [O76095-2]

Protocols and materials databases

DNASUi10899
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271843; ENSP00000271843; ENSG00000143543 [O76095-1]
ENST00000356648; ENSP00000349069; ENSG00000143543 [O76095-2]
ENST00000368589; ENSP00000357578; ENSG00000143543 [O76095-2]
ENST00000428469; ENSP00000395250; ENSG00000143543 [O76095-2]
GeneIDi10899
KEGGihsa:10899
UCSCiuc001fds.4 human [O76095-1]

Organism-specific databases

CTDi10899
DisGeNETi10899
EuPathDBiHostDB:ENSG00000143543.14
GeneCardsiJTB
HGNCiHGNC:6201 JTB
HPAiHPA006514
MIMi604671 gene
neXtProtiNX_O76095
OpenTargetsiENSG00000143543
PharmGKBiPA30003
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4084 Eukaryota
ENOG4111VSR LUCA
GeneTreeiENSGT00390000016136
HOGENOMiHOG000294204
HOVERGENiHBG000952
InParanoidiO76095
OMAiECAPCSN
OrthoDBiEOG091G0PNA
PhylomeDBiO76095
TreeFamiTF316934

Miscellaneous databases

ChiTaRSiJTB human
EvolutionaryTraceiO76095
GeneWikiiJTB_(gene)
GenomeRNAii10899
PROiPR:O76095
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143543 Expressed in 227 organ(s), highest expression level in parotid gland
CleanExiHS_JTB
GenevisibleiO76095 HS

Family and domain databases

InterProiView protein in InterPro
IPR008657 JTB
PANTHERiPTHR13041 PTHR13041, 1 hit
PfamiView protein in Pfam
PF05439 JTB, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD151382 JTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJTB_HUMAN
AccessioniPrimary (citable) accession number: O76095
Secondary accession number(s): O95442, Q6IB19, Q9P0Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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