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Protein

Protein JTB

Gene

JTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • mitotic cell cycle Source: UniProtKB
  • mitotic cytokinesis Source: UniProtKB
  • positive regulation of protein kinase activity Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Cell cycle, Cell division, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein JTB
Alternative name(s):
Jumping translocation breakpoint protein
Prostate androgen-regulated protein
Short name:
PAR protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JTB
ORF Names:HSPC222
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000143543.14

Human Gene Nomenclature Database

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HGNCi
HGNC:6201 JTB

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604671 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O76095

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 105ExtracellularSequence analysisAdd BLAST75
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 146CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10899

Open Targets

More...
OpenTargetsi
ENSG00000143543

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30003

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
JTB

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002153531 – 146Protein JTBAdd BLAST116

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O76095

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O76095

MaxQB - The MaxQuant DataBase

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MaxQBi
O76095

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O76095

PeptideAtlas

More...
PeptideAtlasi
O76095

PRoteomics IDEntifications database

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PRIDEi
O76095

ProteomicsDB human proteome resource

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ProteomicsDBi
50413
50414 [O76095-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O76095

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O76095

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.4 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Protein levels increase during the S phase of the cell cycle, are highest during G2 and mitosis, and decrease to low levels at G1. Levels are lowest at the transition from G1 to S phase.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000143543 Expressed in 227 organ(s), highest expression level in parotid gland

CleanEx database of gene expression profiles

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CleanExi
HS_JTB

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O76095 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA006514

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116105, 33 interactors

Protein interaction database and analysis system

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IntActi
O76095, 6 interactors

Molecular INTeraction database

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MINTi
O76095

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000271843

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KJXNMR-A47-104[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O76095

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O76095

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O76095

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JTB family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4084 Eukaryota
ENOG4111VSR LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000016136

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294204

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000952

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O76095

Identification of Orthologs from Complete Genome Data

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OMAi
ECAPCSN

Database of Orthologous Groups

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OrthoDBi
1375062at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O76095

TreeFam database of animal gene trees

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TreeFami
TF316934

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008657 JTB

The PANTHER Classification System

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PANTHERi
PTHR13041 PTHR13041, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05439 JTB, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD151382 JTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O76095-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLAGAGRPGL PQGRHLCWLL CAFTLKLCQA EAPVQEEKLS ASTSNLPCWL
60 70 80 90 100
VEEFVVAEEC SPCSNFRAKT TPECGPTGYV EKITCSSSKR NEFKSCRSAL
110 120 130 140
MEQRLFWKFE GAVVCVALIF ACLVIIRQRQ LDRKALEKVR KQIESI
Length:146
Mass (Da):16,358
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA7080543591C319
GO
Isoform 2 (identifier: O76095-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEK → MAWGWHLSF

Show »
Length:117
Mass (Da):13,356
Checksum:i39BB62469FA5541B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03399416L → F. Corresponds to variant dbSNP:rs34686244Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0414001 – 38MLAGA…VQEEK → MAWGWHLSF in isoform 2. 2 PublicationsAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB016492 Genomic DNA Translation: BAA33735.1
AB016488 mRNA Translation: BAA33731.1
AB016493 Genomic DNA Translation: BAA33736.1
AF115850 mRNA Translation: AAD09822.2
AF131797 mRNA Translation: AAD20045.1
AF151056 mRNA Translation: AAF36142.1
BT007285 mRNA Translation: AAP35949.1
CR456985 mRNA Translation: CAG33266.1
AK312106 mRNA Translation: BAG35042.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53241.1
CH471121 Genomic DNA Translation: EAW53242.1
CH471121 Genomic DNA Translation: EAW53244.1
BC000499 mRNA Translation: AAH00499.1
BC000996 mRNA Translation: AAH00996.1
BC001363 mRNA Translation: AAH01363.1
BC001667 mRNA Translation: AAH01667.1
BC004239 mRNA Translation: AAH04239.1
BC019277 mRNA Translation: AAH19277.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1057.1 [O76095-1]

NCBI Reference Sequences

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RefSeqi
NP_006685.1, NM_006694.3 [O76095-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.6396

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000271843; ENSP00000271843; ENSG00000143543 [O76095-1]
ENST00000356648; ENSP00000349069; ENSG00000143543 [O76095-2]
ENST00000368589; ENSP00000357578; ENSG00000143543 [O76095-2]
ENST00000428469; ENSP00000395250; ENSG00000143543 [O76095-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10899

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10899

UCSC genome browser

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UCSCi
uc001fds.4 human [O76095-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016492 Genomic DNA Translation: BAA33735.1
AB016488 mRNA Translation: BAA33731.1
AB016493 Genomic DNA Translation: BAA33736.1
AF115850 mRNA Translation: AAD09822.2
AF131797 mRNA Translation: AAD20045.1
AF151056 mRNA Translation: AAF36142.1
BT007285 mRNA Translation: AAP35949.1
CR456985 mRNA Translation: CAG33266.1
AK312106 mRNA Translation: BAG35042.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53241.1
CH471121 Genomic DNA Translation: EAW53242.1
CH471121 Genomic DNA Translation: EAW53244.1
BC000499 mRNA Translation: AAH00499.1
BC000996 mRNA Translation: AAH00996.1
BC001363 mRNA Translation: AAH01363.1
BC001667 mRNA Translation: AAH01667.1
BC004239 mRNA Translation: AAH04239.1
BC019277 mRNA Translation: AAH19277.1
CCDSiCCDS1057.1 [O76095-1]
RefSeqiNP_006685.1, NM_006694.3 [O76095-1]
UniGeneiHs.6396

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KJXNMR-A47-104[»]
ProteinModelPortaliO76095
SMRiO76095
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116105, 33 interactors
IntActiO76095, 6 interactors
MINTiO76095
STRINGi9606.ENSP00000271843

PTM databases

iPTMnetiO76095
PhosphoSitePlusiO76095

Polymorphism and mutation databases

BioMutaiJTB

Proteomic databases

EPDiO76095
jPOSTiO76095
MaxQBiO76095
PaxDbiO76095
PeptideAtlasiO76095
PRIDEiO76095
ProteomicsDBi50413
50414 [O76095-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10899
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271843; ENSP00000271843; ENSG00000143543 [O76095-1]
ENST00000356648; ENSP00000349069; ENSG00000143543 [O76095-2]
ENST00000368589; ENSP00000357578; ENSG00000143543 [O76095-2]
ENST00000428469; ENSP00000395250; ENSG00000143543 [O76095-2]
GeneIDi10899
KEGGihsa:10899
UCSCiuc001fds.4 human [O76095-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10899
DisGeNETi10899
EuPathDBiHostDB:ENSG00000143543.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
JTB
HGNCiHGNC:6201 JTB
HPAiHPA006514
MIMi604671 gene
neXtProtiNX_O76095
OpenTargetsiENSG00000143543
PharmGKBiPA30003

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4084 Eukaryota
ENOG4111VSR LUCA
GeneTreeiENSGT00390000016136
HOGENOMiHOG000294204
HOVERGENiHBG000952
InParanoidiO76095
OMAiECAPCSN
OrthoDBi1375062at2759
PhylomeDBiO76095
TreeFamiTF316934

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
JTB human
EvolutionaryTraceiO76095

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
JTB_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10899

Protein Ontology

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PROi
PR:O76095

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143543 Expressed in 227 organ(s), highest expression level in parotid gland
CleanExiHS_JTB
GenevisibleiO76095 HS

Family and domain databases

InterProiView protein in InterPro
IPR008657 JTB
PANTHERiPTHR13041 PTHR13041, 1 hit
PfamiView protein in Pfam
PF05439 JTB, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD151382 JTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJTB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76095
Secondary accession number(s): O95442, Q6IB19, Q9P0Q4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: January 16, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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