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Protein

G antigen 7

Gene

GAGE7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 7
Short name:
GAGE-7
Alternative name(s):
AL4
Cancer/testis antigen 4.7
Short name:
CT4.7
GAGE-12I
GAGE-7B
GAGE-8
Gene namesi
Name:GAGE7
Synonyms:GAGE12I, GAGE7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000215269.5
HostDB:ENSG00000236362.7
HGNCiHGNC:4104 GAGE7
MIMi300601 gene
300637 gene
neXtProtiNX_O76087

Pathology & Biotechi

Organism-specific databases

DisGeNETi100008586
2579
26748
645073
PharmGKBiPA145148778

Polymorphism and mutation databases

BioMutaiGAGE7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483451 – 117G antigen 7Add BLAST117

Proteomic databases

PaxDbiO76087
PRIDEiO76087
ProteomicsDBi50407
TopDownProteomicsiO76087

PTM databases

iPTMnetiO76087
PhosphoSitePlusiO76087

Expressioni

Tissue specificityi

Expressed in some prostate cancer tissues but not in normal prostate tissue.

Gene expression databases

BgeeiENSG00000215269 Expressed in 56 organ(s), highest expression level in right testis
CleanExiHS_GAGE7
ExpressionAtlasiO76087 baseline
GenevisibleiO76087 HS

Organism-specific databases

HPAiHPA043232

Interactioni

Protein-protein interaction databases

BioGridi117808, 2 interactors
STRINGi9606.ENSP00000416249

Structurei

3D structure databases

ProteinModelPortaliO76087
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
HOVERGENiHBG056227
InParanoidiO76087
OrthoDBiEOG091G0UGV
PhylomeDBiO76087

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

Sequencei

Sequence statusi: Complete.

O76087-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,978
Last modified:November 1, 1998 - v1
Checksum:i365ED8D41361C7AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058988 mRNA Translation: AAC25989.1
AF055474 mRNA Translation: AAC33677.1
AF055475 Genomic DNA Translation: AAC33678.1
BX649339 Genomic DNA Translation: CAI95423.1
BC031628 mRNA Translation: AAH31628.1
BC104951 mRNA Translation: AAI04952.1
BC121182 mRNA Translation: AAI21183.1
BC121183 mRNA Translation: AAI21184.1
BC144193 mRNA Translation: AAI44194.1
RefSeqiNP_001091875.1, NM_001098405.2
NP_001091879.1, NM_001098409.1
NP_001120817.1, NM_001127345.1
NP_001468.1, NM_001477.1
NP_066946.1, NM_021123.2
UniGeneiHs.460641
Hs.632808
Hs.632812
Hs.695912

Genome annotation databases

GeneIDi100008586
2579
26748
645073
729428
KEGGihsa:100008586
hsa:2579
hsa:26748
hsa:645073
hsa:729428

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058988 mRNA Translation: AAC25989.1
AF055474 mRNA Translation: AAC33677.1
AF055475 Genomic DNA Translation: AAC33678.1
BX649339 Genomic DNA Translation: CAI95423.1
BC031628 mRNA Translation: AAH31628.1
BC104951 mRNA Translation: AAI04952.1
BC121182 mRNA Translation: AAI21183.1
BC121183 mRNA Translation: AAI21184.1
BC144193 mRNA Translation: AAI44194.1
RefSeqiNP_001091875.1, NM_001098405.2
NP_001091879.1, NM_001098409.1
NP_001120817.1, NM_001127345.1
NP_001468.1, NM_001477.1
NP_066946.1, NM_021123.2
UniGeneiHs.460641
Hs.632808
Hs.632812
Hs.695912

3D structure databases

ProteinModelPortaliO76087
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117808, 2 interactors
STRINGi9606.ENSP00000416249

PTM databases

iPTMnetiO76087
PhosphoSitePlusiO76087

Polymorphism and mutation databases

BioMutaiGAGE7

Proteomic databases

PaxDbiO76087
PRIDEiO76087
ProteomicsDBi50407
TopDownProteomicsiO76087

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008586
2579
26748
645073
729428
KEGGihsa:100008586
hsa:2579
hsa:26748
hsa:645073
hsa:729428

Organism-specific databases

CTDi100008586
2579
26748
645073
729428
DisGeNETi100008586
2579
26748
645073
EuPathDBiHostDB:ENSG00000215269.5
HostDB:ENSG00000236362.7
GeneCardsiGAGE7
HGNCiHGNC:4104 GAGE7
HPAiHPA043232
MIMi300601 gene
300637 gene
neXtProtiNX_O76087
PharmGKBiPA145148778
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
HOVERGENiHBG056227
InParanoidiO76087
OrthoDBiEOG091G0UGV
PhylomeDBiO76087

Miscellaneous databases

PROiPR:O76087
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215269 Expressed in 56 organ(s), highest expression level in right testis
CleanExiHS_GAGE7
ExpressionAtlasiO76087 baseline
GenevisibleiO76087 HS

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGAGE7_HUMAN
AccessioniPrimary (citable) accession number: O76087
Secondary accession number(s): B7ZM13, Q4V324
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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