Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regulator of G-protein signaling 20

Gene

RGS20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).By similarity1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 20
Short name:
RGS20
Alternative name(s):
Gz-selective GTPase-activating protein
Short name:
G(z)GAP
Short name:
Gz-GAP
Regulator of G-protein signaling Z1
Regulator of Gz-selective protein signaling 1
Gene namesi
Name:RGS20
Synonyms:RGSZ1, ZGAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147509.13
HGNCiHGNC:14600 RGS20
MIMi607193 gene
neXtProtiNX_O76081

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8601
OpenTargetsiENSG00000147509
PharmGKBiPA34373

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042331 – 388Regulator of G-protein signaling 20Add BLAST388

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).By similarity
N- and O-glycosylated in synapsomal membranes.By similarity
Serine phosphorylated in synapsomal membranes.By similarity
Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO76081
PaxDbiO76081
PeptideAtlasiO76081
PRIDEiO76081
ProteomicsDBi50382
50383 [O76081-2]
50384 [O76081-3]
50385 [O76081-4]
50386 [O76081-5]
50387 [O76081-6]

PTM databases

iPTMnetiO76081
PhosphoSitePlusiO76081
SwissPalmiO76081

Expressioni

Tissue specificityi

Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.

Gene expression databases

BgeeiENSG00000147509 Expressed in 121 organ(s), highest expression level in caudate nucleus
CleanExiHS_RGS20
ExpressionAtlasiO76081 baseline and differential
GenevisibleiO76081 HS

Organism-specific databases

HPAiHPA070193

Interactioni

Subunit structurei

Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results in mu-opioid receptor desensitization. Interacts with OPRM1 (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi114161, 87 interactors
CORUMiO76081
IntActiO76081, 50 interactors
MINTiO76081
STRINGi9606.ENSP00000297313

Structurei

3D structure databases

ProteinModelPortaliO76081
SMRiO76081
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini262 – 378RGSPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi208 – 220Poly-CysAdd BLAST13

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiO76081
KOiK16449
OMAiRYNADIH
OrthoDBiEOG091G0BDG
PhylomeDBiO76081
TreeFamiTF315837

Family and domain databases

InterProiView protein in InterPro
IPR016137 RGS
IPR036305 RGS_sf
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 6 (identifier: O76081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPQLSQDNQE CLQKHFSRPS IWTQFLPLFR AQRYNTDIHQ ITENEGDLRA
60 70 80 90 100
VPDIKSFPPA QLPDSPAAPK LFGLLSSPLS SLARFFSHLL RRPPPEAPRR
110 120 130 140 150
RLDFSPLLPA LPAARLSRGH EELPGRLSLL LGAALALPGR PSGGRPLRPP
160 170 180 190 200
HPVAKPREED ATAGQSSPMP QMGSERMEMR KRQMPAAQDT PGAAPGQPGA
210 220 230 240 250
GSRGSNACCF CWCCCCSCSC LTVRNQEDQR PTIASHELRA DLPTWEESPA
260 270 280 290 300
PTLEEVNAWA QSFDKLMVTP AGRNAFREFL RTEFSEENML FWMACEELKK
310 320 330 340 350
EANKNIIEEK ARIIYEDYIS ILSPKEVSLD SRVREVINRN MVEPSQHIFD
360 370 380
DAQLQIYTLM HRDSYPRFMN SAVYKDLLQS LSEKSIEA
Length:388
Mass (Da):43,692
Last modified:October 18, 2001 - v4
Checksum:iF44796D271F1765F
GO
Isoform 1 (identifier: O76081-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-170: Missing.

Show »
Length:273
Mass (Da):31,486
Checksum:i8BF212DBAF70A97E
GO
Isoform 2 (identifier: O76081-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.
     209-220: CFCWCCCCSCSC → MKETSGLFLISS

Show »
Length:180
Mass (Da):21,010
Checksum:iA2F8633711953F26
GO
Isoform 3 (identifier: O76081-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-236: Missing.
     237-247: ELRADLPTWEE → MKETSGLFLIS

Show »
Length:152
Mass (Da):17,735
Checksum:iE0554569F8C0CEA7
GO
Isoform 4 (identifier: O76081-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-55: Missing.
     56-170: Missing.

Show »
Length:220
Mass (Da):25,177
Checksum:iB5EA61FF181DA67C
GO
Isoform 5 (identifier: O76081-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: MPQLSQDNQE...GDLRAVPDIK → MRTADGGEPAGASSPAGRVDGGL
     56-170: Missing.

Show »
Length:241
Mass (Da):27,060
Checksum:i776410A4D698D622
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KSW4B3KSW4_HUMAN
Regulator of G-protein-signaling 20
RGS20
122Annotation score:
E5RH54E5RH54_HUMAN
Regulator of G-protein-signaling 20
RGS20
70Annotation score:
E5RGA3E5RGA3_HUMAN
Regulator of G-protein-signaling 20
RGS20
58Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0056981 – 236Missing in isoform 3. 1 PublicationAdd BLAST236
Alternative sequenceiVSP_0056971 – 208Missing in isoform 2. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_0056941 – 55MPQLS…VPDIK → MRTADGGEPAGASSPAGRVD GGL in isoform 5. 2 PublicationsAdd BLAST55
Alternative sequenceiVSP_0056953 – 55Missing in isoform 4. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_00569656 – 170Missing in isoform 1, isoform 4 and isoform 5. 5 PublicationsAdd BLAST115
Alternative sequenceiVSP_005699209 – 220CFCWC…CSCSC → MKETSGLFLISS in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_005700237 – 247ELRADLPTWEE → MKETSGLFLIS in isoform 3. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060877 mRNA Translation: AAC62009.2
AF366054 mRNA Translation: AAK54122.1
AF366055 mRNA Translation: AAK54123.1
AF366056 mRNA Translation: AAK54124.1
AF366057 mRNA Translation: AAK54125.1
AF074979 mRNA Translation: AAC62013.1
AF493940 mRNA Translation: AAM12654.1
BC015614 mRNA Translation: AAH15614.2
BC063490 mRNA Translation: AAH63490.1
AY046538 mRNA Translation: AAL03971.1
CCDSiCCDS6155.1 [O76081-1]
CCDS6156.1 [O76081-6]
CCDS69482.1 [O76081-2]
RefSeqiNP_001273602.1, NM_001286673.1 [O76081-2]
NP_001273603.1, NM_001286674.1 [O76081-4]
NP_001273604.1, NM_001286675.1 [O76081-3]
NP_003693.2, NM_003702.4 [O76081-6]
NP_733466.1, NM_170587.3 [O76081-1]
XP_011515924.1, XM_011517622.2
UniGeneiHs.368733

Genome annotation databases

EnsembliENST00000276500; ENSP00000276500; ENSG00000147509 [O76081-6]
ENST00000297313; ENSP00000297313; ENSG00000147509 [O76081-1]
ENST00000344277; ENSP00000344630; ENSG00000147509 [O76081-2]
GeneIDi8601
KEGGihsa:8601
UCSCiuc003xrp.5 human [O76081-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060877 mRNA Translation: AAC62009.2
AF366054 mRNA Translation: AAK54122.1
AF366055 mRNA Translation: AAK54123.1
AF366056 mRNA Translation: AAK54124.1
AF366057 mRNA Translation: AAK54125.1
AF074979 mRNA Translation: AAC62013.1
AF493940 mRNA Translation: AAM12654.1
BC015614 mRNA Translation: AAH15614.2
BC063490 mRNA Translation: AAH63490.1
AY046538 mRNA Translation: AAL03971.1
CCDSiCCDS6155.1 [O76081-1]
CCDS6156.1 [O76081-6]
CCDS69482.1 [O76081-2]
RefSeqiNP_001273602.1, NM_001286673.1 [O76081-2]
NP_001273603.1, NM_001286674.1 [O76081-4]
NP_001273604.1, NM_001286675.1 [O76081-3]
NP_003693.2, NM_003702.4 [O76081-6]
NP_733466.1, NM_170587.3 [O76081-1]
XP_011515924.1, XM_011517622.2
UniGeneiHs.368733

3D structure databases

ProteinModelPortaliO76081
SMRiO76081
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114161, 87 interactors
CORUMiO76081
IntActiO76081, 50 interactors
MINTiO76081
STRINGi9606.ENSP00000297313

PTM databases

iPTMnetiO76081
PhosphoSitePlusiO76081
SwissPalmiO76081

Proteomic databases

MaxQBiO76081
PaxDbiO76081
PeptideAtlasiO76081
PRIDEiO76081
ProteomicsDBi50382
50383 [O76081-2]
50384 [O76081-3]
50385 [O76081-4]
50386 [O76081-5]
50387 [O76081-6]

Protocols and materials databases

DNASUi8601
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276500; ENSP00000276500; ENSG00000147509 [O76081-6]
ENST00000297313; ENSP00000297313; ENSG00000147509 [O76081-1]
ENST00000344277; ENSP00000344630; ENSG00000147509 [O76081-2]
GeneIDi8601
KEGGihsa:8601
UCSCiuc003xrp.5 human [O76081-1]

Organism-specific databases

CTDi8601
DisGeNETi8601
EuPathDBiHostDB:ENSG00000147509.13
GeneCardsiRGS20
HGNCiHGNC:14600 RGS20
HPAiHPA070193
MIMi607193 gene
neXtProtiNX_O76081
OpenTargetsiENSG00000147509
PharmGKBiPA34373
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiO76081
KOiK16449
OMAiRYNADIH
OrthoDBiEOG091G0BDG
PhylomeDBiO76081
TreeFamiTF315837

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events

Miscellaneous databases

ChiTaRSiRGS20 human
GeneWikiiRGS20
GenomeRNAii8601
PROiPR:O76081
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147509 Expressed in 121 organ(s), highest expression level in caudate nucleus
CleanExiHS_RGS20
ExpressionAtlasiO76081 baseline and differential
GenevisibleiO76081 HS

Family and domain databases

InterProiView protein in InterPro
IPR016137 RGS
IPR036305 RGS_sf
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS20_HUMAN
AccessioniPrimary (citable) accession number: O76081
Secondary accession number(s): Q96BG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 18, 2001
Last modified: November 7, 2018
This is version 174 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again