RGS20

Functionⁱ

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

GTPase activator activity
Source: ProtInc
Traceable author statementⁱ
- 9748279

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of signal transduction Source: UniProtKB-KW
regulation of G protein-coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 9748279

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Signal transduction inhibitor

Molecular function

Signal transduction inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-418597 G alpha (z) signalling events

Reactomeⁱ

R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of G-protein signaling 20 Short name: RGS20 Alternative name(s): Gz-selective GTPase-activating protein Short name: G(z)GAP Short name: Gz-GAP Regulator of G-protein signaling Z1 Regulator of Gz-selective protein signaling 1
Gene namesⁱ	Name:RGS20 Synonyms:RGSZ1, ZGAP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000147509.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14600 RGS20
MIMⁱ	607193 gene
neXtProtⁱ	NX_O76081

Keywords - Cellular componentⁱ

Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8601
Open Targets More...OpenTargetsⁱ	ENSG00000147509
PharmGKBⁱ	PA34373

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204233	1 – 388	Regulator of G-protein signaling 20Add BLAST		388

Post-translational modificationⁱ

Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).By similarity

N- and O-glycosylated in synapsomal membranes.By similarity

Serine phosphorylated in synapsomal membranes.By similarity

Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity).By similarity

Keywords - PTMⁱ

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O76081
PaxDbⁱ	O76081
PeptideAtlas More...PeptideAtlasⁱ	O76081
PRIDEⁱ	O76081
ProteomicsDBⁱ	50382 50383 [O76081-2] 50384 [O76081-3] 50385 [O76081-4] 50386 [O76081-5] 50387 [O76081-6]

PTM databases

iPTMnetⁱ	O76081
PhosphoSitePlusⁱ	O76081
SwissPalmⁱ	O76081

Expressionⁱ

Tissue specificityⁱ

Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.

Gene expression databases

Bgeeⁱ	ENSG00000147509 Expressed in 121 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_RGS20
ExpressionAtlasⁱ	O76081 baseline and differential
Genevisibleⁱ	O76081 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA070193

HPAⁱ

HPA070193

Interactionⁱ

Subunit structureⁱ

Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results in mu-opioid receptor desensitization. Interacts with OPRM1 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	Q9NWL9	3	EBI-1052678,EBI-10315054
AQP1	P29972	3	EBI-10178530,EBI-745213
CATSPER1	Q8NEC5	4	EBI-1052678,EBI-744545
CRCT1	Q9UGL9	5	EBI-10178530,EBI-713677
CREB5	Q02930-3	5	EBI-10178530,EBI-10192698
FASLG	P48023	5	EBI-10178530,EBI-495538
GLRX3	O76003	3	EBI-1052678,EBI-374781
GNAI2	P04899	3	EBI-10178530,EBI-353997
HOXA1	P49639	3	EBI-1052678,EBI-740785
Hoxa1	P09022	3	EBI-1052678,EBI-3957603	From Mus musculus.
HSPD1	P10809	3	EBI-10178530,EBI-352528
INS	I3WAC9	3	EBI-10178530,EBI-10178524
KLHL38	Q2WGJ6	3	EBI-10178530,EBI-6426443
KRTAP4-2	Q9BYR5	5	EBI-10178530,EBI-10172511
KRTAP5-6	Q6L8G9	5	EBI-10178530,EBI-10250562
KRTAP5-9	P26371	5	EBI-10178530,EBI-3958099
LCE1B	Q5T7P3	5	EBI-10178530,EBI-10245913
LCE2A	Q5TA79	3	EBI-10178530,EBI-10246607
LCE2D	Q5TA82	3	EBI-1052678,EBI-10246750
LCE3E	Q5T5B0	5	EBI-10178530,EBI-10245456
LCE4A	Q5TA78	5	EBI-10178530,EBI-10246358
MAPKBP1	O60336	3	EBI-10178530,EBI-947402
MTNR1A	P48039	6	EBI-1052678,EBI-1188238
MTNR1B	P49286	2	EBI-1052678,EBI-1188341
NECTIN3	Q9NQS3	3	EBI-1052678,EBI-2826725
OTX1	P32242	4	EBI-1052678,EBI-740446
PTGER3	P43115-12	3	EBI-10178530,EBI-10234038
PTPMT1	Q8WUK0	5	EBI-10178530,EBI-7199479

Protein-protein interaction databases

BioGridⁱ	114161, 87 interactors
CORUMⁱ	O76081
IntActⁱ	O76081, 50 interactors
Molecular INTeraction database More...MINTⁱ	O76081
STRINGⁱ	9606.ENSP00000297313

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O76081
SMRⁱ	O76081
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	262 – 378	RGSPROSITE-ProRule annotationAdd BLAST		117

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	208 – 220	Poly-CysAdd BLAST		13

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119142
HOGENOMⁱ	HOG000233513
HOVERGENⁱ	HBG013233
InParanoidⁱ	O76081
KEGG Orthology (KO) More...KOⁱ	K16449
OMAⁱ	RYNADIH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	O76081
TreeFamⁱ	TF315837

Family and domain databases

InterProⁱ	View protein in InterPro IPR016137 RGS IPR036305 RGS_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 6 (identifier: O76081-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQLSQDNQE CLQKHFSRPS IWTQFLPLFR AQRYNTDIHQ ITENEGDLRA 
        60         70         80         90        100
VPDIKSFPPA QLPDSPAAPK LFGLLSSPLS SLARFFSHLL RRPPPEAPRR 
       110        120        130        140        150
RLDFSPLLPA LPAARLSRGH EELPGRLSLL LGAALALPGR PSGGRPLRPP 
       160        170        180        190        200
HPVAKPREED ATAGQSSPMP QMGSERMEMR KRQMPAAQDT PGAAPGQPGA 
       210        220        230        240        250
GSRGSNACCF CWCCCCSCSC LTVRNQEDQR PTIASHELRA DLPTWEESPA 
       260        270        280        290        300
PTLEEVNAWA QSFDKLMVTP AGRNAFREFL RTEFSEENML FWMACEELKK 
       310        320        330        340        350
EANKNIIEEK ARIIYEDYIS ILSPKEVSLD SRVREVINRN MVEPSQHIFD 
       360        370        380 
DAQLQIYTLM HRDSYPRFMN SAVYKDLLQS LSEKSIEA

Length:388

Mass (Da):43,692

Last modified:October 18, 2001 - v4

Checksum:ⁱF44796D271F1765F

GO

Isoform 1 (identifier: O76081-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
56-170: Missing.

« Hide

        10         20         30         40         50
MPQLSQDNQE CLQKHFSRPS IWTQFLPLFR AQRYNTDIHQ ITENEGDLRA 
        60         70         80         90        100
VPDIKQMGSE RMEMRKRQMP AAQDTPGAAP GQPGAGSRGS NACCFCWCCC 
       110        120        130        140        150
CSCSCLTVRN QEDQRPTIAS HELRADLPTW EESPAPTLEE VNAWAQSFDK 
       160        170        180        190        200
LMVTPAGRNA FREFLRTEFS EENMLFWMAC EELKKEANKN IIEEKARIIY 
       210        220        230        240        250
EDYISILSPK EVSLDSRVRE VINRNMVEPS QHIFDDAQLQ IYTLMHRDSY 
       260        270 
PRFMNSAVYK DLLQSLSEKS IEA

Show »

Length:273

Mass (Da):31,486

Checksum:ⁱ8BF212DBAF70A97E

GO

Isoform 2 (identifier: O76081-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-208: Missing.
209-220: CFCWCCCCSCSC → MKETSGLFLISS

« Hide

        10         20         30         40         50
MKETSGLFLI SSLTVRNQED QRPTIASHEL RADLPTWEES PAPTLEEVNA 
        60         70         80         90        100
WAQSFDKLMV TPAGRNAFRE FLRTEFSEEN MLFWMACEEL KKEANKNIIE 
       110        120        130        140        150
EKARIIYEDY ISILSPKEVS LDSRVREVIN RNMVEPSQHI FDDAQLQIYT 
       160        170        180
LMHRDSYPRF MNSAVYKDLL QSLSEKSIEA

Show »

Length:180

Mass (Da):21,010

Checksum:ⁱA2F8633711953F26

GO

Isoform 3 (identifier: O76081-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-236: Missing.
237-247: ELRADLPTWEE → MKETSGLFLIS

« Hide

        10         20         30         40         50
MKETSGLFLI SSPAPTLEEV NAWAQSFDKL MVTPAGRNAF REFLRTEFSE 
        60         70         80         90        100
ENMLFWMACE ELKKEANKNI IEEKARIIYE DYISILSPKE VSLDSRVREV 
       110        120        130        140        150
INRNMVEPSQ HIFDDAQLQI YTLMHRDSYP RFMNSAVYKD LLQSLSEKSI 

EA

Show »

Length:152

Mass (Da):17,735

Checksum:ⁱE0554569F8C0CEA7

GO

Isoform 4 (identifier: O76081-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
3-55: Missing.
56-170: Missing.

« Hide

        10         20         30         40         50
MPQMGSERME MRKRQMPAAQ DTPGAAPGQP GAGSRGSNAC CFCWCCCCSC 
        60         70         80         90        100
SCLTVRNQED QRPTIASHEL RADLPTWEES PAPTLEEVNA WAQSFDKLMV 
       110        120        130        140        150
TPAGRNAFRE FLRTEFSEEN MLFWMACEEL KKEANKNIIE EKARIIYEDY 
       160        170        180        190        200
ISILSPKEVS LDSRVREVIN RNMVEPSQHI FDDAQLQIYT LMHRDSYPRF 
       210        220
MNSAVYKDLL QSLSEKSIEA

Show »

Length:220

Mass (Da):25,177

Checksum:ⁱB5EA61FF181DA67C

GO

Isoform 5 (identifier: O76081-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-55: MPQLSQDNQE...GDLRAVPDIK → MRTADGGEPAGASSPAGRVDGGL
56-170: Missing.

« Hide

        10         20         30         40         50
MRTADGGEPA GASSPAGRVD GGLQMGSERM EMRKRQMPAA QDTPGAAPGQ 
        60         70         80         90        100
PGAGSRGSNA CCFCWCCCCS CSCLTVRNQE DQRPTIASHE LRADLPTWEE 
       110        120        130        140        150
SPAPTLEEVN AWAQSFDKLM VTPAGRNAFR EFLRTEFSEE NMLFWMACEE 
       160        170        180        190        200
LKKEANKNII EEKARIIYED YISILSPKEV SLDSRVREVI NRNMVEPSQH 
       210        220        230        240 
IFDDAQLQIY TLMHRDSYPR FMNSAVYKDL LQSLSEKSIE A

Show »

Length:241

Mass (Da):27,060

Checksum:ⁱ776410A4D698D622

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B3KSW4	B3KSW4_HUMAN	Regulator of G-protein-signaling 20 Regulator of G-protein-signaling 20 (cDNA FLJ37184 fis, clone BRALZ2001559, highly similar to Regulator of G-protein signaling 20)	RGS20	122	Annotation score:
E5RH54	E5RH54_HUMAN	Regulator of G-protein-signaling 20 Regulator of G-protein-signaling 20	RGS20	70	Annotation score:
E5RGA3	E5RGA3_HUMAN	Regulator of G-protein-signaling 20 Regulator of G-protein-signaling 20	RGS20	58	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_005698	1 – 236	Missing in isoform 3. 1 PublicationAdd BLAST	236
Alternative sequenceⁱVSP_005697	1 – 208	Missing in isoform 2. 1 PublicationAdd BLAST	208
Alternative sequenceⁱVSP_005694	1 – 55	MPQLS…VPDIK → MRTADGGEPAGASSPAGRVD GGL in isoform 5. 2 PublicationsAdd BLAST	55
Alternative sequenceⁱVSP_005695	3 – 55	Missing in isoform 4. 2 PublicationsAdd BLAST	53
Alternative sequenceⁱVSP_005696	56 – 170	Missing in isoform 1, isoform 4 and isoform 5. 5 PublicationsAdd BLAST	115
Alternative sequenceⁱVSP_005699	209 – 220	CFCWC…CSCSC → MKETSGLFLISS in isoform 2. 1 PublicationAdd BLAST	12
Alternative sequenceⁱVSP_005700	237 – 247	ELRADLPTWEE → MKETSGLFLIS in isoform 3. 1 PublicationAdd BLAST	11

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF060877 mRNA Translation: AAC62009.2 AF366054 mRNA Translation: AAK54122.1 AF366055 mRNA Translation: AAK54123.1 AF366056 mRNA Translation: AAK54124.1 AF366057 mRNA Translation: AAK54125.1 AF074979 mRNA Translation: AAC62013.1 AF493940 mRNA Translation: AAM12654.1 BC015614 mRNA Translation: AAH15614.2 BC063490 mRNA Translation: AAH63490.1 AY046538 mRNA Translation: AAL03971.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6155.1 [O76081-1] CCDS6156.1 [O76081-6] CCDS69482.1 [O76081-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273602.1, NM_001286673.1 [O76081-2] NP_001273603.1, NM_001286674.1 [O76081-4] NP_001273604.1, NM_001286675.1 [O76081-3] NP_003693.2, NM_003702.4 [O76081-6] NP_733466.1, NM_170587.3 [O76081-1] XP_011515924.1, XM_011517622.2
UniGeneⁱ	Hs.368733

Genome annotation databases

Ensemblⁱ	ENST00000276500; ENSP00000276500; ENSG00000147509 [O76081-6] ENST00000297313; ENSP00000297313; ENSG00000147509 [O76081-1] ENST00000344277; ENSP00000344630; ENSG00000147509 [O76081-2]
GeneIDⁱ	8601
KEGGⁱ	hsa:8601
UCSC genome browser More...UCSCⁱ	uc003xrp.5 human [O76081-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O76081	Isoform 4 of Regulator of G-protein signaling 20		HUMAN		220	UniRef100_O76081
UPI0000169825		HUMAN		217
O76081-6	Regulator of G-protein signaling 20 variant 2		HUMAN		241	UniRef100_H9NIM5
RGS20 isoform 8		PANTR		241
Uncharacterized protein		PANPA		241
Regulator of G protein signaling 20		GORGO		241

Protein	Similar proteins		Species	Score	Length	Source
O76081	Isoform 4 of Regulator of G-protein signaling 20		HUMAN		220	UniRef90_O76081
Regulator of G protein signaling 20		CHLSB		392
Uncharacterized protein		MACMU		388
Uncharacterized protein		Cebus capucinus imitator		388
Uncharacterized protein		COLAP		388
+33
O76081-2	Uncharacterized protein		MACMU		273	UniRef90_O76081-2
Uncharacterized protein		Cebus capucinus imitator		273
Uncharacterized protein		COLAP		273
RGS20 isoform 3		PONAB		273
RGS20 isoform 3		PANTR		273
+37
O76081-3	Isoform 3 of Regulator of G-protein signaling 20		HUMAN		152	UniRef90_O76081-3
UPI000533249F		RHIRO		189
UPI0005F3BDF8		COLAP		180
UPI00062A9800		NOMLE		189
UPI0008F51317		GORGO		189
+2
O76081-4	Isoform 2 of Regulator of G-protein signaling 20		HUMAN		180	UniRef90_O76081-3
UPI000533249F		RHIRO		189
UPI0005F3BDF8		COLAP		180
UPI00062A9800		NOMLE		189
UPI0008F51317		GORGO		189
+2
O76081-6	Isoform 1 of Regulator of G-protein signaling 20		HUMAN		273	UniRef90_O76081-2
Uncharacterized protein		MACMU		273
Uncharacterized protein		Cebus capucinus imitator		273
Uncharacterized protein		COLAP		273
RGS20 isoform 3		PONAB		273
+37

Protein	Similar proteins		Species	Score	Length	Source
O76081	Isoform 4 of Regulator of G-protein signaling 20		HUMAN		220	UniRef50_O76081
Regulator of G protein signaling 20		CHLSB		392
Uncharacterized protein		MANLE		388
Uncharacterized protein		PANPA		388
Regulator of G protein signaling 20		GORGO		388
+67
O76081-2	Regulator of G-protein signaling 19	)	HUMAN		217	UniRef50_O76081-2
Regulator of G-protein signaling 19		RAT		216
Uncharacterized protein		PANPA		273
Uncharacterized protein		MANLE		273
Uncharacterized protein		NOMLE		273
+369
O76081-3	Isoform 3 of Regulator of G-protein signaling 20		HUMAN		152	UniRef50_O76081-3
Uncharacterized protein		GLOFF		201
Uncharacterized protein		GLOPL		201
Uncharacterized protein		GLOAU		201
regulator of G-protein signaling 20-like isoform X7		ICTPU		186
+14
O76081-4	Isoform 2 of Regulator of G-protein signaling 20		HUMAN		180	UniRef50_O76081-3
Uncharacterized protein		GLOFF		201
Uncharacterized protein		GLOPL		201
Uncharacterized protein		GLOAU		201
regulator of G-protein signaling 20-like isoform X7		ICTPU		186
+14
O76081-6	Isoform 1 of Regulator of G-protein signaling 20		HUMAN		273	UniRef50_O76081-2
Regulator of G-protein signaling 19		RAT		216
Uncharacterized protein		PANPA		273
Uncharacterized protein		MANLE		273
Uncharacterized protein		NOMLE		273
+369

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF060877 mRNA Translation: AAC62009.2 AF366054 mRNA Translation: AAK54122.1 AF366055 mRNA Translation: AAK54123.1 AF366056 mRNA Translation: AAK54124.1 AF366057 mRNA Translation: AAK54125.1 AF074979 mRNA Translation: AAC62013.1 AF493940 mRNA Translation: AAM12654.1 BC015614 mRNA Translation: AAH15614.2 BC063490 mRNA Translation: AAH63490.1 AY046538 mRNA Translation: AAL03971.1
CCDSⁱ	CCDS6155.1 [O76081-1] CCDS6156.1 [O76081-6] CCDS69482.1 [O76081-2]
RefSeqⁱ	NP_001273602.1, NM_001286673.1 [O76081-2] NP_001273603.1, NM_001286674.1 [O76081-4] NP_001273604.1, NM_001286675.1 [O76081-3] NP_003693.2, NM_003702.4 [O76081-6] NP_733466.1, NM_170587.3 [O76081-1] XP_011515924.1, XM_011517622.2
UniGeneⁱ	Hs.368733

3D structure databases

ProteinModelPortalⁱ	O76081
SMRⁱ	O76081
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114161, 87 interactors
CORUMⁱ	O76081
IntActⁱ	O76081, 50 interactors
MINTⁱ	O76081
STRINGⁱ	9606.ENSP00000297313

PTM databases

iPTMnetⁱ	O76081
PhosphoSitePlusⁱ	O76081
SwissPalmⁱ	O76081

Proteomic databases

MaxQBⁱ	O76081
PaxDbⁱ	O76081
PeptideAtlasⁱ	O76081
PRIDEⁱ	O76081
ProteomicsDBⁱ	50382 50383 [O76081-2] 50384 [O76081-3] 50385 [O76081-4] 50386 [O76081-5] 50387 [O76081-6]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8601
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000276500; ENSP00000276500; ENSG00000147509 [O76081-6] ENST00000297313; ENSP00000297313; ENSG00000147509 [O76081-1] ENST00000344277; ENSP00000344630; ENSG00000147509 [O76081-2]
GeneIDⁱ	8601
KEGGⁱ	hsa:8601
UCSCⁱ	uc003xrp.5 human [O76081-1]

Organism-specific databases

CTDⁱ	8601
DisGeNETⁱ	8601
EuPathDBⁱ	HostDB:ENSG00000147509.13
GeneCardsⁱ	RGS20
HGNCⁱ	HGNC:14600 RGS20
HPAⁱ	HPA070193
MIMⁱ	607193 gene
neXtProtⁱ	NX_O76081
OpenTargetsⁱ	ENSG00000147509
PharmGKBⁱ	PA34373
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
GeneTreeⁱ	ENSGT00760000119142
HOGENOMⁱ	HOG000233513
HOVERGENⁱ	HBG013233
InParanoidⁱ	O76081
KOⁱ	K16449
OMAⁱ	RYNADIH
OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	O76081
TreeFamⁱ	TF315837

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-418597 G alpha (z) signalling events

Reactomeⁱ

R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events

Miscellaneous databases

ChiTaRSⁱ	RGS20 human
GeneWikiⁱ	RGS20
GenomeRNAiⁱ	8601
Protein Ontology More...PROⁱ	PR:O76081
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000147509 Expressed in 121 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_RGS20
ExpressionAtlasⁱ	O76081 baseline and differential
Genevisibleⁱ	O76081 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016137 RGS IPR036305 RGS_sf
Pfamⁱ	View protein in Pfam PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit
PROSITEⁱ	View protein in PROSITE PS50132 RGS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGS20_HUMAN
Accessionⁱ	O76081Primary (citable) accession number: O76081 Secondary accession number(s): Q96BG9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
	Last sequence update:	October 18, 2001
	Last modified:	November 7, 2018
	This is version 174 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniProtKB - O76081 (RGS20_HUMAN)

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Regulator of G-protein signaling 20

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Enzyme and pathway databases

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Organism-specific databases

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Organism-specific databases

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Molecule processing

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Proteomic databases

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Gene expression databases

Organism-specific databases

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3D structure databases

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

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Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ