Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O76081 (RGS20_HUMAN)

Entry version 193 (02 Jun 2021)
Sequence version 4 (18 Oct 2001)
Previous versions | rss
Add a publicationFeedback
Protein

Regulator of G-protein signaling 20

Gene

RGS20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: ProtInc
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O76081

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418594, G alpha (i) signalling events
R-HSA-418597, G alpha (z) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of G-protein signaling 20
Short name:
RGS20
Alternative name(s):
Gz-selective GTPase-activating protein
Short name:
G(z)GAP
Short name:
Gz-GAP
Regulator of G-protein signaling Z1
Regulator of Gz-selective protein signaling 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGS20
Synonyms:RGSZ1, ZGAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14600, RGS20

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607193, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O76081

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000147509.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8601

Open Targets

More...OpenTargetsi		ENSG00000147509

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34373

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O76081, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RGS20

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002042331 – 388Regulator of G-protein signaling 20Add BLAST388

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).By similarity
N- and O-glycosylated in synapsomal membranes.By similarity
Serine phosphorylated in synapsomal membranes.By similarity
Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O76081

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O76081

MaxQB - The MaxQuant DataBase

More...MaxQBi		O76081

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O76081

PeptideAtlas

More...PeptideAtlasi		O76081

PRoteomics IDEntifications database

More...PRIDEi		O76081

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50382 [O76081-1]
50383 [O76081-2]
50384 [O76081-3]
50385 [O76081-4]
50386 [O76081-5]
50387 [O76081-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O76081

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O76081

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O76081

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000147509, Expressed in caudate nucleus and 139 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O76081, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O76081, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000147509, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results in mu-opioid receptor desensitization.

Interacts with OPRM1 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O76081
With#Exp.IntAct
AQP1 [P29972]3EBI-1052678,EBI-745213
CATSPER1 [Q8NEC5]4EBI-1052678,EBI-744545
CRCT1 [Q9UGL9]3EBI-1052678,EBI-713677
CREB5 - isoform 3 [Q02930-3]3EBI-1052678,EBI-10192698
FASLG [P48023]3EBI-1052678,EBI-495538
GLRX3 [O76003]4EBI-1052678,EBI-374781
HOXA1 [P49639]5EBI-1052678,EBI-740785
HSPD1 [P10809]3EBI-1052678,EBI-352528
KLHL38 [Q2WGJ6]3EBI-1052678,EBI-6426443
KRTAP4-2 [Q9BYR5]3EBI-1052678,EBI-10172511
KRTAP5-9 [P26371]3EBI-1052678,EBI-3958099
LCE1B [Q5T7P3]5EBI-1052678,EBI-10245913
LCE2D [Q5TA82]3EBI-1052678,EBI-10246750
LCE3E [Q5T5B0]3EBI-1052678,EBI-10245456
LCE4A [Q5TA78]3EBI-1052678,EBI-10246358
MAPKBP1 [O60336]3EBI-1052678,EBI-947402
MTNR1A [P48039]6EBI-1052678,EBI-1188238
MTNR1B [P49286]2EBI-1052678,EBI-1188341
NECTIN3 [Q9NQS3]3EBI-1052678,EBI-2826725
OTX1 [P32242]5EBI-1052678,EBI-740446
PTGER3 - isoform 12 [P43115-12]3EBI-1052678,EBI-10234038
Q9NWL93EBI-1052678,EBI-10315054
Hoxa1 [P09022] from Mus musculus.3EBI-1052678,EBI-3957603
Isoform 5 [O76081-6]
With#Exp.IntAct
ALPP [P05187]3EBI-10178530,EBI-1211484
AQP1 [P29972]3EBI-10178530,EBI-745213
CATSPER1 [Q8NEC5]3EBI-10178530,EBI-744545
COL8A1 [P27658]3EBI-10178530,EBI-747133
CRCT1 [Q9UGL9]6EBI-10178530,EBI-713677
CREB5 - isoform 3 [Q02930-3]6EBI-10178530,EBI-10192698
FASLG [P48023]6EBI-10178530,EBI-495538
GLRX3 [O76003]3EBI-10178530,EBI-374781
GNAI2 [P04899]3EBI-10178530,EBI-353997
HOXA1 [P49639]3EBI-10178530,EBI-740785
HRG [P04196]3EBI-10178530,EBI-3915012
HSPD1 [P10809]3EBI-10178530,EBI-352528
INS [I3WAC9]3EBI-10178530,EBI-10178524
KLHL38 [Q2WGJ6]3EBI-10178530,EBI-6426443
KRTAP4-2 [Q9BYR5]6EBI-10178530,EBI-10172511
KRTAP5-11 [Q6L8G4]3EBI-10178530,EBI-11993296
KRTAP5-6 [Q6L8G9]6EBI-10178530,EBI-10250562
KRTAP5-9 [P26371]6EBI-10178530,EBI-3958099
KRTAP9-3 [Q9BYQ3]3EBI-10178530,EBI-1043191
KRTAP9-8 [Q9BYQ0]3EBI-10178530,EBI-11958364
LCE1A [Q5T7P2]3EBI-10178530,EBI-11962058
LCE1B [Q5T7P3]6EBI-10178530,EBI-10245913
LCE1F [Q5T754]3EBI-10178530,EBI-11958008
LCE2A [Q5TA79]3EBI-10178530,EBI-10246607
LCE2B [O14633]3EBI-10178530,EBI-11478468
LCE2C [Q5TA81]3EBI-10178530,EBI-11973993
LCE3A [Q5TA76]3EBI-10178530,EBI-9394625
LCE3C [Q5T5A8]3EBI-10178530,EBI-10245291
LCE3D [Q9BYE3]3EBI-10178530,EBI-6658837
LCE3E [Q5T5B0]6EBI-10178530,EBI-10245456
LCE4A [Q5TA78]8EBI-10178530,EBI-10246358
LCE5A [Q5TCM9]3EBI-10178530,EBI-11955689
LNX1 [Q8TBB1]3EBI-10178530,EBI-739832
MAPKBP1 [O60336]3EBI-10178530,EBI-947402
NECTIN2 - isoform Alpha [Q92692-2]3EBI-10178530,EBI-6979889
NEK8 [Q86SG6]3EBI-10178530,EBI-1752987
NUFIP2 [Q7Z417]3EBI-10178530,EBI-1210753
OTX1 [P32242]3EBI-10178530,EBI-740446
PTGER3 - isoform 12 [P43115-12]3EBI-10178530,EBI-10234038
PTPMT1 [Q8WUK0]6EBI-10178530,EBI-7199479
VASN [Q6EMK4]3EBI-10178530,EBI-10249550
A0A384ME253EBI-10178530,EBI-10211777
Q9NWL93EBI-10178530,EBI-10315054

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114161, 107 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O76081

Protein interaction database and analysis system

More...IntActi		O76081, 53 interactors

Molecular INTeraction database

More...MINTi		O76081

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000297313

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O76081, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		O76081

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O76081

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini262 – 378RGSPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni138 – 199DisorderedSequence analysisAdd BLAST62

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3589, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159123

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_059863_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O76081

Identification of Orthologs from Complete Genome Data

More...OMAi		HQTMENE

Database of Orthologous Groups

More...OrthoDBi		1409647at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O76081

TreeFam database of animal gene trees

More...TreeFami		TF315837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016137, RGS
IPR036305, RGS_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00615, RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01301, RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00315, RGS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48097, SSF48097, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50132, RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 6 (identifier: O76081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPQLSQDNQE CLQKHFSRPS IWTQFLPLFR AQRYNTDIHQ ITENEGDLRA 
        60         70         80         90        100
VPDIKSFPPA QLPDSPAAPK LFGLLSSPLS SLARFFSHLL RRPPPEAPRR 
       110        120        130        140        150
RLDFSPLLPA LPAARLSRGH EELPGRLSLL LGAALALPGR PSGGRPLRPP 
       160        170        180        190        200
HPVAKPREED ATAGQSSPMP QMGSERMEMR KRQMPAAQDT PGAAPGQPGA 
       210        220        230        240        250
GSRGSNACCF CWCCCCSCSC LTVRNQEDQR PTIASHELRA DLPTWEESPA 
       260        270        280        290        300
PTLEEVNAWA QSFDKLMVTP AGRNAFREFL RTEFSEENML FWMACEELKK 
       310        320        330        340        350
EANKNIIEEK ARIIYEDYIS ILSPKEVSLD SRVREVINRN MVEPSQHIFD 
       360        370        380 
DAQLQIYTLM HRDSYPRFMN SAVYKDLLQS LSEKSIEA
Length:388
Mass (Da):43,692
Last modified:October 18, 2001 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF44796D271F1765F
GO
Isoform 1 (identifier: O76081-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-170: Missing.

Show »
Length:273
Mass (Da):31,486
Checksum:i8BF212DBAF70A97E
GO
Isoform 2 (identifier: O76081-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.
     209-220: CFCWCCCCSCSC → MKETSGLFLISS

Show »
Length:180
Mass (Da):21,010
Checksum:iA2F8633711953F26
GO
Isoform 3 (identifier: O76081-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-236: Missing.
     237-247: ELRADLPTWEE → MKETSGLFLIS

Show »
Length:152
Mass (Da):17,735
Checksum:iE0554569F8C0CEA7
GO
Isoform 4 (identifier: O76081-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-55: Missing.
     56-170: Missing.

Show »
Length:220
Mass (Da):25,177
Checksum:iB5EA61FF181DA67C
GO
Isoform 5 (identifier: O76081-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: MPQLSQDNQE...GDLRAVPDIK → MRTADGGEPAGASSPAGRVDGGL
     56-170: Missing.

Show »
Length:241
Mass (Da):27,060
Checksum:i776410A4D698D622
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KSW4B3KSW4_HUMAN
Regulator of G-protein-signaling 20
RGS20
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RH54E5RH54_HUMAN
Regulator of G-protein-signaling 20
RGS20
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGA3E5RGA3_HUMAN
Regulator of G-protein-signaling 20
RGS20
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0056981 – 236Missing in isoform 3. 1 PublicationAdd BLAST236
Alternative sequenceiVSP_0056971 – 208Missing in isoform 2. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_0056941 – 55MPQLS…VPDIK → MRTADGGEPAGASSPAGRVD GGL in isoform 5. 2 PublicationsAdd BLAST55
Alternative sequenceiVSP_0056953 – 55Missing in isoform 4. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_00569656 – 170Missing in isoform 1, isoform 4 and isoform 5. 5 PublicationsAdd BLAST115
Alternative sequenceiVSP_005699209 – 220CFCWC…CSCSC → MKETSGLFLISS in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_005700237 – 247ELRADLPTWEE → MKETSGLFLIS in isoform 3. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF060877 mRNA Translation: AAC62009.2
AF366054 mRNA Translation: AAK54122.1
AF366055 mRNA Translation: AAK54123.1
AF366056 mRNA Translation: AAK54124.1
AF366057 mRNA Translation: AAK54125.1
AF074979 mRNA Translation: AAC62013.1
AF493940 mRNA Translation: AAM12654.1
BC015614 mRNA Translation: AAH15614.2
BC063490 mRNA Translation: AAH63490.1
AY046538 mRNA Translation: AAL03971.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6155.1 [O76081-1]
CCDS6156.1 [O76081-6]
CCDS69482.1 [O76081-2]

NCBI Reference Sequences

More...RefSeqi		NP_001273602.1, NM_001286673.1 [O76081-2]
NP_001273603.1, NM_001286674.1 [O76081-4]
NP_001273604.1, NM_001286675.1 [O76081-3]
NP_003693.2, NM_003702.4 [O76081-6]
NP_733466.1, NM_170587.3 [O76081-1]
XP_011515924.1, XM_011517622.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000276500; ENSP00000276500; ENSG00000147509 [O76081-6]
ENST00000297313; ENSP00000297313; ENSG00000147509 [O76081-1]
ENST00000344277; ENSP00000344630; ENSG00000147509 [O76081-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8601

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8601

UCSC genome browser

More...UCSCi		uc003xrp.5, human [O76081-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060877 mRNA Translation: AAC62009.2
AF366054 mRNA Translation: AAK54122.1
AF366055 mRNA Translation: AAK54123.1
AF366056 mRNA Translation: AAK54124.1
AF366057 mRNA Translation: AAK54125.1
AF074979 mRNA Translation: AAC62013.1
AF493940 mRNA Translation: AAM12654.1
BC015614 mRNA Translation: AAH15614.2
BC063490 mRNA Translation: AAH63490.1
AY046538 mRNA Translation: AAL03971.1
CCDSiCCDS6155.1 [O76081-1]
CCDS6156.1 [O76081-6]
CCDS69482.1 [O76081-2]
RefSeqiNP_001273602.1, NM_001286673.1 [O76081-2]
NP_001273603.1, NM_001286674.1 [O76081-4]
NP_001273604.1, NM_001286675.1 [O76081-3]
NP_003693.2, NM_003702.4 [O76081-6]
NP_733466.1, NM_170587.3 [O76081-1]
XP_011515924.1, XM_011517622.2

3D structure databases

BMRBiO76081
SMRiO76081
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114161, 107 interactors
CORUMiO76081
IntActiO76081, 53 interactors
MINTiO76081
STRINGi9606.ENSP00000297313

PTM databases

iPTMnetiO76081
PhosphoSitePlusiO76081
SwissPalmiO76081

Genetic variation databases

BioMutaiRGS20

Proteomic databases

jPOSTiO76081
MassIVEiO76081
MaxQBiO76081
PaxDbiO76081
PeptideAtlasiO76081
PRIDEiO76081
ProteomicsDBi50382 [O76081-1]
50383 [O76081-2]
50384 [O76081-3]
50385 [O76081-4]
50386 [O76081-5]
50387 [O76081-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11664, 168 antibodies

The DNASU plasmid repository

More...DNASUi		8601

Genome annotation databases

EnsembliENST00000276500; ENSP00000276500; ENSG00000147509 [O76081-6]
ENST00000297313; ENSP00000297313; ENSG00000147509 [O76081-1]
ENST00000344277; ENSP00000344630; ENSG00000147509 [O76081-2]
GeneIDi8601
KEGGihsa:8601
UCSCiuc003xrp.5, human [O76081-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8601
DisGeNETi8601

GeneCards: human genes, protein and diseases

More...GeneCardsi		RGS20
HGNCiHGNC:14600, RGS20
HPAiENSG00000147509, Tissue enriched (brain)
MIMi607193, gene
neXtProtiNX_O76081
OpenTargetsiENSG00000147509
PharmGKBiPA34373
VEuPathDBiHostDB:ENSG00000147509.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3589, Eukaryota
GeneTreeiENSGT00940000159123
HOGENOMiCLU_059863_0_0_1
InParanoidiO76081
OMAiHQTMENE
OrthoDBi1409647at2759
PhylomeDBiO76081
TreeFamiTF315837

Enzyme and pathway databases

PathwayCommonsiO76081
ReactomeiR-HSA-418594, G alpha (i) signalling events
R-HSA-418597, G alpha (z) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8601, 3 hits in 992 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RGS20, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RGS20

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8601
PharosiO76081, Tbio

Protein Ontology

More...PROi		PR:O76081
RNActiO76081, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000147509, Expressed in caudate nucleus and 139 other tissues
ExpressionAtlasiO76081, baseline and differential
GenevisibleiO76081, HS

Family and domain databases

InterProiView protein in InterPro
IPR016137, RGS
IPR036305, RGS_sf
PfamiView protein in Pfam
PF00615, RGS, 1 hit
PRINTSiPR01301, RGSPROTEIN
SMARTiView protein in SMART
SM00315, RGS, 1 hit
SUPFAMiSSF48097, SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132, RGS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGS20_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76081
Secondary accession number(s): Q96BG9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 18, 2001
Last modified: June 2, 2021
This is version 193 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again