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Protein

WNT1-inducible-signaling pathway protein 2

Gene

WISP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • cell-cell signaling Source: ProtInc
  • negative regulation of cell death Source: GO_Central
  • regulation of cell growth Source: InterPro
  • signal transduction Source: ProtInc

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

SignaLinkiO76076

Names & Taxonomyi

Protein namesi
Recommended name:
WNT1-inducible-signaling pathway protein 2
Short name:
WISP-2
Alternative name(s):
CCN family member 5
Connective tissue growth factor-like protein
Short name:
CTGF-L
Connective tissue growth factor-related protein 58
Gene namesi
Name:WISP2
Synonyms:CCN5, CT58, CTGFL
ORF Names:UNQ228/PRO261
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000064205.10
HGNCiHGNC:12770 WISP2
MIMi603399 gene
neXtProtiNX_O76076

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8839
OpenTargetsiENSG00000064205
PharmGKBiPA37373

Polymorphism and mutation databases

BioMutaiWISP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001440924 – 250WNT1-inducible-signaling pathway protein 2Add BLAST227

Proteomic databases

PaxDbiO76076
PeptideAtlasiO76076
PRIDEiO76076
ProteomicsDBi50380

Expressioni

Tissue specificityi

Expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart.

Gene expression databases

BgeeiENSG00000064205
CleanExiHS_WISP2
GenevisibleiO76076 HS

Organism-specific databases

HPAiCAB019273

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114366, 9 interactors
IntActiO76076, 4 interactors
STRINGi9606.ENSP00000190983

Structurei

3D structure databases

ProteinModelPortaliO76076
SMRiO76076
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 94IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST71
Domaini98 – 164VWFCPROSITE-ProRule annotationAdd BLAST67
Domaini194 – 238TSP type-1PROSITE-ProRule annotationAdd BLAST45

Sequence similaritiesi

Belongs to the CCN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWPW Eukaryota
ENOG410YSW1 LUCA
GeneTreeiENSGT00760000119225
HOGENOMiHOG000231462
HOVERGENiHBG000635
InParanoidiO76076
OMAiSNQNRFC
OrthoDBiEOG091G0SQP
PhylomeDBiO76076
TreeFamiTF326070

Family and domain databases

InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O76076-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGTPKTHLL AFSLLCLLSK VRTQLCPTPC TCPWPPPRCP LGVPLVLDGC
60 70 80 90 100
GCCRVCARRL GEPCDQLHVC DASQGLVCQP GAGPGGRGAL CLLAEDDSSC
110 120 130 140 150
EVNGRLYREG ETFQPHCSIR CRCEDGGFTC VPLCSEDVRL PSWDCPHPRR
160 170 180 190 200
VEVLGKCCPE WVCGQGGGLG TQPLPAQGPQ FSGLVSSLPP GVPCPEWSTA
210 220 230 240 250
WGPCSTTCGL GMATRVSNQN RFCRLETQRR LCLSRPCPPS RGRSPQNSAF
Length:250
Mass (Da):26,825
Last modified:November 1, 1998 - v1
Checksum:iC499837EF42FEEAC
GO
Isoform 2 (identifier: O76076-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-218: LAEDDSSCEV...GLGMATRVSN → CKQDPSFLAL...AWVHHAEHQY
     219-250: Missing.

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):22,577
Checksum:i2A8A79681111542B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04956659R → Q. Corresponds to variant dbSNP:rs33932543Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05629893 – 218LAEDD…TRVSN → CKQDPSFLALSLPCPLVSPA QNGARPGDPARPPVGWAWPP GCPTRTASADWRPSAACACP GPAHPPGVAVHKTVPSRAGL GMGTRCPPSPAGGPVPGPWA DGRWSVPRPLAAGNTLAWVH HAEHQY in isoform 2. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_056299219 – 250Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083500 mRNA Translation: AAC70350.1
AF074604 mRNA Translation: AAC26794.1
AF100780 mRNA Translation: AAC96322.1
AY358915 mRNA Translation: AAQ89274.1
AK313853 mRNA Translation: BAG36581.1
AL139352 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75902.1
CH471077 Genomic DNA Translation: EAW75903.1
BC017782 mRNA Translation: AAH17782.1
BC058074 mRNA Translation: AAH58074.1
BC064379 mRNA Translation: AAH64379.1
CCDSiCCDS13336.1 [O76076-1]
CCDS82619.1 [O76076-2]
RefSeqiNP_001310298.1, NM_001323369.1 [O76076-2]
NP_001310299.1, NM_001323370.1 [O76076-1]
NP_003872.1, NM_003881.3 [O76076-1]
UniGeneiHs.592145

Genome annotation databases

EnsembliENST00000190983; ENSP00000190983; ENSG00000064205 [O76076-1]
ENST00000372865; ENSP00000361956; ENSG00000064205 [O76076-2]
ENST00000372868; ENSP00000361959; ENSG00000064205 [O76076-1]
GeneIDi8839
KEGGihsa:8839
UCSCiuc002xmp.4 human [O76076-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWISP2_HUMAN
AccessioniPrimary (citable) accession number: O76076
Secondary accession number(s): B2R9N4, E1P612, Q6PEG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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