UniProtKB - O76074 (PDE5A_HUMAN)
cGMP-specific 3',5'-cyclic phosphodiesterase
PDE5A
Functioni
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334).
Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).
2 PublicationsCaution
Catalytic activityi
- EC:3.1.4.351 Publication
Cofactori
Protein has several cofactor binding sites:- Zn2+1 PublicationNote: Binds 1 Zn2+ ion per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Tightly binds zinc.1 Publication
- Mg2+1 PublicationNote: Binds 1 Mg2+ ions per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Binds magnesium less tightly than zinc.1 Publication
Activity regulationi
: 3',5'-cyclic GMP degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes GMP from 3',5'-cyclic GMP. This subpathway is part of the pathway 3',5'-cyclic GMP degradation, which is itself part of Purine metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes GMP from 3',5'-cyclic GMP, the pathway 3',5'-cyclic GMP degradation and in Purine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 613 | Proton donorBy similarity | 1 | |
Metal bindingi | 617 | Zinc; via tele nitrogen1 Publication | 1 | |
Metal bindingi | 653 | Zinc; via tele nitrogen1 Publication | 1 | |
Metal bindingi | 654 | Magnesium1 Publication | 1 | |
Metal bindingi | 654 | Zinc1 Publication | 1 | |
Metal bindingi | 764 | Zinc1 Publication | 1 | |
Binding sitei | 817 | 3',5'-cGMP1 Publication | 1 |
GO - Molecular functioni
- 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
- 3',5'-cyclic-nucleotide phosphodiesterase activity Source: GO_Central
- cGMP binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cGMP catabolic process Source: UniProtKB-UniPathway
- negative regulation of cardiac muscle contraction Source: Ensembl
- negative regulation of T cell proliferation Source: Ensembl
- positive regulation of cardiac muscle hypertrophy Source: Ensembl
- positive regulation of MAP kinase activity Source: Ensembl
- positive regulation of oocyte development Source: Ensembl
- regulation of nitric oxide mediated signal transduction Source: Ensembl
- relaxation of cardiac muscle Source: Ensembl
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Allosteric enzyme, Hydrolase |
Ligand | cGMP, cGMP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 3.1.4.35, 2681 |
PathwayCommonsi | O76074 |
Reactomei | R-HSA-418457, cGMP effects R-HSA-9013422, RHOBTB1 GTPase cycle |
SignaLinki | O76074 |
SIGNORi | O76074 |
UniPathwayi | UPA00763;UER00748 |
Names & Taxonomyi
Protein namesi | Recommended name: cGMP-specific 3',5'-cyclic phosphodiesterase (EC:3.1.4.351 Publication)Alternative name(s): cGMP-binding cGMP-specific phosphodiesterase Short name: CGB-PDE |
Gene namesi | Name:PDE5A Synonyms:PDE5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8784, PDE5A |
MIMi | 603310, gene |
neXtProti | NX_O76074 |
VEuPathDBi | HostDB:ENSG00000138735 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 8654 |
OpenTargetsi | ENSG00000138735 |
PharmGKBi | PA33132 |
Miscellaneous databases
Pharosi | O76074, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1827 |
DrugBanki | DB07954, 3-isobutyl-1-methyl-7H-xanthine DB08729, 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide DB06237, Avanafil DB00201, Caffeine DB00975, Dipyridamole DB06246, Exisulind DB12010, Fostamatinib DB03597, gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine DB01972, Guanosine-5'-Monophosphate DB09282, Molsidomine DB05415, OSI-461 DB00203, Sildenafil DB00820, Tadalafil DB00277, Theophylline DB09283, Trapidil DB06267, Udenafil DB00862, Vardenafil |
DrugCentrali | O76074 |
GuidetoPHARMACOLOGYi | 1304 |
Genetic variation databases
BioMutai | PDE5A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000198823 | 1 – 875 | cGMP-specific 3',5'-cyclic phosphodiesteraseAdd BLAST | 875 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 102 | PhosphoserineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O76074 |
jPOSTi | O76074 |
MassIVEi | O76074 |
MaxQBi | O76074 |
PaxDbi | O76074 |
PeptideAtlasi | O76074 |
PRIDEi | O76074 |
ProteomicsDBi | 50374 [O76074-1] 50375 [O76074-2] |
PTM databases
iPTMneti | O76074 |
PhosphoSitePlusi | O76074 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000138735, Expressed in intestine and 209 other tissues |
ExpressionAtlasi | O76074, baseline and differential |
Genevisiblei | O76074, HS |
Organism-specific databases
HPAi | ENSG00000138735, Low tissue specificity |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 114205, 13 interactors |
DIPi | DIP-46287N |
IntActi | O76074, 6 interactors |
STRINGi | 9606.ENSP00000347046 |
Chemistry databases
BindingDBi | O76074 |
Miscellaneous databases
RNActi | O76074, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O76074 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O76074 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 164 – 314 | GAF 1Add BLAST | 151 | |
Domaini | 346 – 503 | GAF 2Add BLAST | 158 | |
Domaini | 536 – 860 | PDEasePROSITE-ProRule annotationAdd BLAST | 325 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 78 – 102 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 7 – 27 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 78 – 99 | Polar residuesSequence analysisAdd BLAST | 22 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3689, Eukaryota |
GeneTreei | ENSGT00940000155475 |
OMAi | TKPWEVE |
OrthoDBi | 904682at2759 |
PhylomeDBi | O76074 |
TreeFami | TF316499 |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
DisProti | DP01244 |
Gene3Di | 1.10.1300.10, 1 hit 3.30.450.40, 2 hits |
InterProi | View protein in InterPro IPR003018, GAF IPR029016, GAF-like_dom_sf IPR003607, HD/PDEase_dom IPR023088, PDEase IPR002073, PDEase_catalytic_dom IPR036971, PDEase_catalytic_dom_sf IPR023174, PDEase_CS |
Pfami | View protein in Pfam PF01590, GAF, 2 hits PF00233, PDEase_I, 1 hit |
PRINTSi | PR00387, PDIESTERASE1 |
SMARTi | View protein in SMART SM00065, GAF, 2 hits SM00471, HDc, 1 hit |
PROSITEi | View protein in PROSITE PS00126, PDEASE_I_1, 1 hit PS51845, PDEASE_I_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERAGPSFGQ QRQQQQPQQQ KQQQRDQDSV EAWLDDHWDF TFSYFVRKAT
60 70 80 90 100
REMVNAWFAE RVHTIPVCKE GIRGHTESCS CPLQQSPRAD NSAPGTPTRK
110 120 130 140 150
ISASEFDRPL RPIVVKDSEG TVSFLSDSEK KEQMPLTPPR FDHDEGDQCS
160 170 180 190 200
RLLELVKDIS SHLDVTALCH KIFLHIHGLI SADRYSLFLV CEDSSNDKFL
210 220 230 240 250
ISRLFDVAEG STLEEVSNNC IRLEWNKGIV GHVAALGEPL NIKDAYEDPR
260 270 280 290 300
FNAEVDQITG YKTQSILCMP IKNHREEVVG VAQAINKKSG NGGTFTEKDE
310 320 330 340 350
KDFAAYLAFC GIVLHNAQLY ETSLLENKRN QVLLDLASLI FEEQQSLEVI
360 370 380 390 400
LKKIAATIIS FMQVQKCTIF IVDEDCSDSF SSVFHMECEE LEKSSDTLTR
410 420 430 440 450
EHDANKINYM YAQYVKNTME PLNIPDVSKD KRFPWTTENT GNVNQQCIRS
460 470 480 490 500
LLCTPIKNGK KNKVIGVCQL VNKMEENTGK VKPFNRNDEQ FLEAFVIFCG
510 520 530 540 550
LGIQNTQMYE AVERAMAKQM VTLEVLSYHA SAAEEETREL QSLAAAVVPS
560 570 580 590 600
AQTLKITDFS FSDFELSDLE TALCTIRMFT DLNLVQNFQM KHEVLCRWIL
610 620 630 640 650
SVKKNYRKNV AYHNWRHAFN TAQCMFAALK AGKIQNKLTD LEILALLIAA
660 670 680 690 700
LSHDLDHRGV NNSYIQRSEH PLAQLYCHSI MEHHHFDQCL MILNSPGNQI
710 720 730 740 750
LSGLSIEEYK TTLKIIKQAI LATDLALYIK RRGEFFELIR KNQFNLEDPH
760 770 780 790 800
QKELFLAMLM TACDLSAITK PWPIQQRIAE LVATEFFDQG DRERKELNIE
810 820 830 840 850
PTDLMNREKK NKIPSMQVGF IDAICLQLYE ALTHVSEDCF PLLDGCRKNR
860 870
QKWQALAEQQ EKMLINGESG QAKRN
The sequence of this isoform differs from the canonical sequence as follows:
1-49: MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKA → MLPFGDK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E9C5 | G5E9C5_HUMAN | Phosphodiesterase | PDE5A hCG_38154 | 823 | Annotation score: | ||
H0YA14 | H0YA14_HUMAN | cGMP-specific 3',5'-cyclic phosphod... | PDE5A | 185 | Annotation score: | ||
C9JGT3 | C9JGT3_HUMAN | cGMP-specific 3',5'-cyclic phosphod... | PDE5A | 224 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 159 | I → V in AAP31235 (PubMed:10393044).Curated | 1 | |
Sequence conflicti | 310 | C → G in AAP31235 (PubMed:10393044).Curated | 1 | |
Sequence conflicti | 381 | S → F in AAP31235 (PubMed:10393044).Curated | 1 | |
Sequence conflicti | 406 | K → R in AAP31235 (PubMed:10393044).Curated | 1 | |
Sequence conflicti | 642 | E → G in BAA81667 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027775 | 93 | A → V5 PublicationsCorresponds to variant dbSNP:rs3733526Ensembl. | 1 | |
Natural variantiVAR_027776 | 181 | S → A. Corresponds to variant dbSNP:rs17051276Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004591 | 1 – 49 | MERAG…FVRKA → MLPFGDK in isoform PDE5A2. 3 PublicationsAdd BLAST | 49 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF043731 mRNA Translation: AAC63967.1 AF043732 mRNA Translation: AAC63968.1 AB001635 Genomic DNA Translation: BAA33372.2 D89094 mRNA Translation: BAA28945.1 AJ004865 mRNA Translation: CAA06170.1 AB015656 mRNA Translation: BAA81667.1 AY264918 mRNA Translation: AAP21809.1 AK290189 mRNA Translation: BAF82878.1 AC093752 Genomic DNA No translation available. AC080089 Genomic DNA No translation available. BC126233 mRNA Translation: AAI26234.1 AY266363 mRNA Translation: AAP31235.1 |
CCDSi | CCDS34055.1 [O76074-2] CCDS3713.1 [O76074-1] |
PIRi | JW0106 |
RefSeqi | NP_001074.2, NM_001083.3 [O76074-1] NP_236914.2, NM_033430.2 [O76074-2] NP_246273.2, NM_033437.3 |
Genome annotation databases
Ensembli | ENST00000264805; ENSP00000264805; ENSG00000138735 [O76074-2] ENST00000354960; ENSP00000347046; ENSG00000138735 |
GeneIDi | 8654 |
KEGGi | hsa:8654 |
MANE-Selecti | ENST00000354960.8; ENSP00000347046.3; NM_001083.4; NP_001074.2 |
UCSCi | uc003idf.4, human [O76074-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF043731 mRNA Translation: AAC63967.1 AF043732 mRNA Translation: AAC63968.1 AB001635 Genomic DNA Translation: BAA33372.2 D89094 mRNA Translation: BAA28945.1 AJ004865 mRNA Translation: CAA06170.1 AB015656 mRNA Translation: BAA81667.1 AY264918 mRNA Translation: AAP21809.1 AK290189 mRNA Translation: BAF82878.1 AC093752 Genomic DNA No translation available. AC080089 Genomic DNA No translation available. BC126233 mRNA Translation: AAI26234.1 AY266363 mRNA Translation: AAP31235.1 |
CCDSi | CCDS34055.1 [O76074-2] CCDS3713.1 [O76074-1] |
PIRi | JW0106 |
RefSeqi | NP_001074.2, NM_001083.3 [O76074-1] NP_236914.2, NM_033430.2 [O76074-2] NP_246273.2, NM_033437.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1RKP | X-ray | 2.05 | A | 535-860 | [»] | |
1T9R | X-ray | 2.10 | A | 531-875 | [»] | |
1T9S | X-ray | 2.00 | A/B | 534-858 | [»] | |
1TBF | X-ray | 1.30 | A | 534-858 | [»] | |
1UDT | X-ray | 2.30 | A | 537-860 | [»] | |
1UDU | X-ray | 2.83 | A/B | 537-860 | [»] | |
1UHO | X-ray | 2.50 | A | 537-860 | [»] | |
1XOZ | X-ray | 1.37 | A | 534-875 | [»] | |
1XP0 | X-ray | 1.79 | A | 534-875 | [»] | |
2CHM | X-ray | 1.60 | A | 534-656 | [»] | |
A | 682-858 | [»] | ||||
2H40 | X-ray | 1.85 | A | 535-860 | [»] | |
2H42 | X-ray | 2.30 | A/B/C | 535-860 | [»] | |
2H44 | X-ray | 1.80 | A | 535-860 | [»] | |
2XSS | X-ray | 2.50 | A/B | 346-509 | [»] | |
3B2R | X-ray | 2.07 | A/B | 535-860 | [»] | |
3BJC | X-ray | 2.00 | A | 1-875 | [»] | |
3HC8 | X-ray | 1.79 | A | 536-657 | [»] | |
A | 682-858 | [»] | ||||
3HDZ | X-ray | 1.80 | A | 536-657 | [»] | |
A | 682-858 | [»] | ||||
3JWQ | X-ray | 2.87 | A/B/C/D | 535-786 | [»] | |
A/B/C/D | 827-860 | [»] | ||||
3JWR | X-ray | 2.99 | A/B | 535-786 | [»] | |
A/B | 827-860 | [»] | ||||
3LFV | X-ray | 2.80 | A/B | 98-518 | [»] | |
3MF0 | X-ray | 3.10 | A/B | 89-518 | [»] | |
3SHY | X-ray | 2.65 | A | 535-860 | [»] | |
3SHZ | X-ray | 2.45 | A | 535-860 | [»] | |
3SIE | X-ray | 1.93 | A/B | 535-860 | [»] | |
3TGE | X-ray | 1.96 | A | 534-656 | [»] | |
A | 682-858 | [»] | ||||
3TGG | X-ray | 1.91 | A | 534-660 | [»] | |
A | 662-858 | [»] | ||||
4G2W | X-ray | 2.28 | A | 535-860 | [»] | |
4G2Y | X-ray | 2.40 | A | 535-860 | [»] | |
4I9Z | X-ray | 2.08 | A | 535-860 | [»] | |
4IA0 | X-ray | 2.17 | A | 535-860 | [»] | |
4MD6 | X-ray | 2.00 | A | 535-860 | [»] | |
4OEW | X-ray | 2.44 | A | 535-860 | [»] | |
4OEX | X-ray | 2.14 | A | 535-860 | [»] | |
5JO3 | X-ray | 1.49 | B | 534-858 | [»] | |
5ZZ2 | X-ray | 2.60 | A | 535-860 | [»] | |
6ACB | X-ray | 2.80 | A | 535-860 | [»] | |
6IWI | X-ray | 2.15 | A | 535-860 | [»] | |
6L6E | X-ray | 1.92 | A | 536-861 | [»] | |
6VBI | X-ray | 2.30 | A/B | 535-859 | [»] | |
SMRi | O76074 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114205, 13 interactors |
DIPi | DIP-46287N |
IntActi | O76074, 6 interactors |
STRINGi | 9606.ENSP00000347046 |
Chemistry databases
BindingDBi | O76074 |
ChEMBLi | CHEMBL1827 |
DrugBanki | DB07954, 3-isobutyl-1-methyl-7H-xanthine DB08729, 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide DB06237, Avanafil DB00201, Caffeine DB00975, Dipyridamole DB06246, Exisulind DB12010, Fostamatinib DB03597, gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine DB01972, Guanosine-5'-Monophosphate DB09282, Molsidomine DB05415, OSI-461 DB00203, Sildenafil DB00820, Tadalafil DB00277, Theophylline DB09283, Trapidil DB06267, Udenafil DB00862, Vardenafil |
DrugCentrali | O76074 |
GuidetoPHARMACOLOGYi | 1304 |
PTM databases
iPTMneti | O76074 |
PhosphoSitePlusi | O76074 |
Genetic variation databases
BioMutai | PDE5A |
Proteomic databases
EPDi | O76074 |
jPOSTi | O76074 |
MassIVEi | O76074 |
MaxQBi | O76074 |
PaxDbi | O76074 |
PeptideAtlasi | O76074 |
PRIDEi | O76074 |
ProteomicsDBi | 50374 [O76074-1] 50375 [O76074-2] |
Protocols and materials databases
Antibodypediai | 1386, 172 antibodies from 36 providers |
DNASUi | 8654 |
Genome annotation databases
Ensembli | ENST00000264805; ENSP00000264805; ENSG00000138735 [O76074-2] ENST00000354960; ENSP00000347046; ENSG00000138735 |
GeneIDi | 8654 |
KEGGi | hsa:8654 |
MANE-Selecti | ENST00000354960.8; ENSP00000347046.3; NM_001083.4; NP_001074.2 |
UCSCi | uc003idf.4, human [O76074-1] |
Organism-specific databases
CTDi | 8654 |
DisGeNETi | 8654 |
GeneCardsi | PDE5A |
HGNCi | HGNC:8784, PDE5A |
HPAi | ENSG00000138735, Low tissue specificity |
MIMi | 603310, gene |
neXtProti | NX_O76074 |
OpenTargetsi | ENSG00000138735 |
PharmGKBi | PA33132 |
VEuPathDBi | HostDB:ENSG00000138735 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3689, Eukaryota |
GeneTreei | ENSGT00940000155475 |
OMAi | TKPWEVE |
OrthoDBi | 904682at2759 |
PhylomeDBi | O76074 |
TreeFami | TF316499 |
Enzyme and pathway databases
UniPathwayi | UPA00763;UER00748 |
BRENDAi | 3.1.4.35, 2681 |
PathwayCommonsi | O76074 |
Reactomei | R-HSA-418457, cGMP effects R-HSA-9013422, RHOBTB1 GTPase cycle |
SignaLinki | O76074 |
SIGNORi | O76074 |
Miscellaneous databases
BioGRID-ORCSi | 8654, 5 hits in 1043 CRISPR screens |
ChiTaRSi | PDE5A, human |
EvolutionaryTracei | O76074 |
GeneWikii | CGMP-specific_phosphodiesterase_type_5 |
GenomeRNAii | 8654 |
Pharosi | O76074, Tclin |
PROi | PR:O76074 |
RNActi | O76074, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138735, Expressed in intestine and 209 other tissues |
ExpressionAtlasi | O76074, baseline and differential |
Genevisiblei | O76074, HS |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
DisProti | DP01244 |
Gene3Di | 1.10.1300.10, 1 hit 3.30.450.40, 2 hits |
InterProi | View protein in InterPro IPR003018, GAF IPR029016, GAF-like_dom_sf IPR003607, HD/PDEase_dom IPR023088, PDEase IPR002073, PDEase_catalytic_dom IPR036971, PDEase_catalytic_dom_sf IPR023174, PDEase_CS |
Pfami | View protein in Pfam PF01590, GAF, 2 hits PF00233, PDEase_I, 1 hit |
PRINTSi | PR00387, PDIESTERASE1 |
SMARTi | View protein in SMART SM00065, GAF, 2 hits SM00471, HDc, 1 hit |
PROSITEi | View protein in PROSITE PS00126, PDEASE_I_1, 1 hit PS51845, PDEASE_I_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PDE5A_HUMAN | |
Accessioni | O76074Primary (citable) accession number: O76074 Secondary accession number(s): A0AV69 Q9Y6Z6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 23, 2022 | |
This is version 201 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families