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Protein

Probable cytosolic iron-sulfur protein assembly protein CIAO1

Gene

CIAO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004). Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633).UniRule annotation4 Publications

Miscellaneous

'Ciao' means 'bridge' in Chinese.

GO - Biological processi

  • chromosome segregation Source: UniProtKB-KW
  • iron-sulfur cluster assembly Source: UniProtKB
  • positive regulation of cell proliferation Source: ProtInc
  • protein maturation by iron-sulfur cluster transfer Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: ProtInc

Keywordsi

Biological processChromosome partition

Enzyme and pathway databases

ReactomeiR-HSA-2564830 Cytosolic iron-sulfur cluster assembly
SignaLinkiO76071

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosolic iron-sulfur protein assembly protein CIAO1UniRule annotation
Alternative name(s):
WD repeat-containing protein 39UniRule annotation
Gene namesi
Name:CIAO1UniRule annotation
Synonyms:CIA11 Publication, WDR39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144021.2
HGNCiHGNC:14280 CIAO1
MIMi604333 gene
neXtProtiNX_O76071

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9391
OpenTargetsiENSG00000144021
PharmGKBiPA162382269

Polymorphism and mutation databases

BioMutaiCIAO1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513891 – 339Probable cytosolic iron-sulfur protein assembly protein CIAO1Add BLAST339

Proteomic databases

EPDiO76071
MaxQBiO76071
PaxDbiO76071
PeptideAtlasiO76071
PRIDEiO76071
ProteomicsDBi50373
TopDownProteomicsiO76071

PTM databases

iPTMnetiO76071
PhosphoSitePlusiO76071

Expressioni

Gene expression databases

BgeeiENSG00000144021 Expressed in 219 organ(s), highest expression level in right adrenal gland
CleanExiHS_CIAO1
GenevisibleiO76071 HS

Organism-specific databases

HPAiHPA017882

Interactioni

Subunit structurei

Component of the CIA complex (PubMed:22678361, PubMed:22678362, PubMed:23585563). Interacts with CIAO2A and forms a complex with CIAO2B and MMS19; the interactions with CIAO2A and CIAO2B are mutually exclusive (PubMed:22683786, PubMed:23891004, PubMed:23585563). Interacts with CHD1L, ERCC2, IREB2 and POLD1 (PubMed:23891004). Component of the MMXD complex, which includes CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5 (PubMed:20797633). Interacts with WT1 (PubMed:9556563). Interacts with CIAO3 (PubMed:23585563).UniRule annotation7 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi114791, 85 interactors
IntActiO76071, 26 interactors
MINTiO76071
STRINGi9606.ENSP00000418287

Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO76071
SMRiO76071
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76071

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 53WD 1Add BLAST40
Repeati59 – 98WD 2Add BLAST40
Repeati103 – 142WD 3Add BLAST40
Repeati148 – 187WD 4Add BLAST40
Repeati192 – 231WD 5Add BLAST40
Repeati250 – 289WD 6Add BLAST40
Repeati301 – 339WD 7Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat CIA1 family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0645 Eukaryota
ENOG410XRMA LUCA
GeneTreeiENSGT00890000139406
HOGENOMiHOG000208901
HOVERGENiHBG056532
InParanoidiO76071
OMAiEFECAAV
OrthoDBiEOG091G0AAM
PhylomeDBiO76071
TreeFamiTF318181

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03037 ciao1, 1 hit
InterProiView protein in InterPro
IPR028608 CIAO1/Cia1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19920 PTHR19920, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 6 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O76071-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDSLVLLGR VPAHPDSRCW FLAWNPAGTL LASCGGDRRI RIWGTEGDSW
60 70 80 90 100
ICKSVLSEGH QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT
110 120 130 140 150
LEGHENEVKS VAWAPSGNLL ATCSRDKSVW VWEVDEEDEY ECVSVLNSHT
160 170 180 190 200
QDVKHVVWHP SQELLASASY DDTVKLYREE EDDWVCCATL EGHESTVWSL
210 220 230 240 250
AFDPSGQRLA SCSDDRTVRI WRQYLPGNEQ GVACSGSDPS WKCICTLSGF
260 270 280 290 300
HSRTIYDIAW CQLTGALATA CGDDAIRVFQ EDPNSDPQQP TFSLTAHLHQ
310 320 330
AHSQDVNCVA WNPKEPGLLA SCSDDGEVAF WKYQRPEGL
Length:339
Mass (Da):37,840
Last modified:November 1, 1998 - v1
Checksum:i63A8D8257A204FC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243C → G in BAD96977 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63810 mRNA Translation: AAC24948.1
EF011618 mRNA Translation: ABK41108.1
AC004020 Genomic DNA Translation: AAC23493.1
CR456802 mRNA Translation: CAG33083.1
AK223257 mRNA Translation: BAD96977.1
BC001395 mRNA Translation: AAH01395.1
BC032812 mRNA Translation: AAH32812.1
CCDSiCCDS2019.1
RefSeqiNP_004795.1, NM_004804.2
UniGeneiHs.12109

Genome annotation databases

EnsembliENST00000488633; ENSP00000418287; ENSG00000144021
GeneIDi9391
KEGGihsa:9391
UCSCiuc002svs.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63810 mRNA Translation: AAC24948.1
EF011618 mRNA Translation: ABK41108.1
AC004020 Genomic DNA Translation: AAC23493.1
CR456802 mRNA Translation: CAG33083.1
AK223257 mRNA Translation: BAD96977.1
BC001395 mRNA Translation: AAH01395.1
BC032812 mRNA Translation: AAH32812.1
CCDSiCCDS2019.1
RefSeqiNP_004795.1, NM_004804.2
UniGeneiHs.12109

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FM0X-ray1.70A1-339[»]
ProteinModelPortaliO76071
SMRiO76071
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114791, 85 interactors
IntActiO76071, 26 interactors
MINTiO76071
STRINGi9606.ENSP00000418287

PTM databases

iPTMnetiO76071
PhosphoSitePlusiO76071

Polymorphism and mutation databases

BioMutaiCIAO1

Proteomic databases

EPDiO76071
MaxQBiO76071
PaxDbiO76071
PeptideAtlasiO76071
PRIDEiO76071
ProteomicsDBi50373
TopDownProteomicsiO76071

Protocols and materials databases

DNASUi9391
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000488633; ENSP00000418287; ENSG00000144021
GeneIDi9391
KEGGihsa:9391
UCSCiuc002svs.4 human

Organism-specific databases

CTDi9391
DisGeNETi9391
EuPathDBiHostDB:ENSG00000144021.2
GeneCardsiCIAO1
HGNCiHGNC:14280 CIAO1
HPAiHPA017882
MIMi604333 gene
neXtProtiNX_O76071
OpenTargetsiENSG00000144021
PharmGKBiPA162382269
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0645 Eukaryota
ENOG410XRMA LUCA
GeneTreeiENSGT00890000139406
HOGENOMiHOG000208901
HOVERGENiHBG056532
InParanoidiO76071
OMAiEFECAAV
OrthoDBiEOG091G0AAM
PhylomeDBiO76071
TreeFamiTF318181

Enzyme and pathway databases

ReactomeiR-HSA-2564830 Cytosolic iron-sulfur cluster assembly
SignaLinkiO76071

Miscellaneous databases

ChiTaRSiCIAO1 human
EvolutionaryTraceiO76071
GeneWikiiCIAO1
GenomeRNAii9391
PROiPR:O76071
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144021 Expressed in 219 organ(s), highest expression level in right adrenal gland
CleanExiHS_CIAO1
GenevisibleiO76071 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03037 ciao1, 1 hit
InterProiView protein in InterPro
IPR028608 CIAO1/Cia1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19920 PTHR19920, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 6 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCIAO1_HUMAN
AccessioniPrimary (citable) accession number: O76071
Secondary accession number(s): A0MNN9, Q53FM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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