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Protein

Gamma-synuclein

Gene

SNCG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

SIGNORiO76070

Protein family/group databases

TCDBi1.C.77.1.3 the synuclein (synuclein) family

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-synuclein
Alternative name(s):
Breast cancer-specific gene 1 protein
Persyn
Synoretin
Short name:
SR
Gene namesi
Name:SNCG
Synonyms:BCSG1, PERSYN, PRSN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000173267.13
HGNCiHGNC:11141 SNCG
MIMi602998 gene
neXtProtiNX_O76070

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi6623
OpenTargetsiENSG00000173267
PharmGKBiPA35989

Polymorphism and mutation databases

BioMutaiSNCG

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840381 – 127Gamma-synucleinAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei124Phosphoserine; by BARK1, CaMK2 and CK21 Publication1

Post-translational modificationi

Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO76070
PaxDbiO76070
PeptideAtlasiO76070
PRIDEiO76070
ProteomicsDBi50372

PTM databases

iPTMnetiO76070
PhosphoSitePlusiO76070

Expressioni

Tissue specificityi

Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.

Gene expression databases

BgeeiENSG00000173267
CleanExiHS_SNCG
ExpressionAtlasiO76070 baseline and differential
GenevisibleiO76070 HS

Organism-specific databases

HPAiCAB001452
CAB040581
HPA014404

Interactioni

Subunit structurei

May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF1P542742EBI-1053810,EBI-710997

Protein-protein interaction databases

BioGridi112507, 29 interactors
IntActiO76070, 17 interactors
STRINGi9606.ENSP00000361087

Structurei

3D structure databases

DisProtiDP00630
ProteinModelPortaliO76070
SMRiO76070
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 301Add BLAST11
Repeati31 – 412Add BLAST11
Repeati42 – 563; approximateAdd BLAST15
Repeati57 – 674Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 674 X 11 AA tandem repeats of [EGSA]-K-T-K-[EQ]-[GQ]-V-X(4)Add BLAST48

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYGN Eukaryota
ENOG4111VY5 LUCA
GeneTreeiENSGT00390000016161
HOGENOMiHOG000008691
HOVERGENiHBG000481
InParanoidiO76070
OMAiQANMVSD
OrthoDBiEOG091G11PA
PhylomeDBiO76070
TreeFamiTF332776

Family and domain databases

InterProiView protein in InterPro
IPR001058 Synuclein
IPR002462 Synuclein_gamma
PANTHERiPTHR13820 PTHR13820, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01214 GSYNUCLEIN
PR01211 SYNUCLEIN

Sequencei

Sequence statusi: Complete.

O76070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GAKTKENVVQ
60 70 80 90 100
SVTSVAEKTK EQANAVSEAV VSSVNTVATK TVEEAENIAV TSGVVRKEDL
110 120
RPSAPQQEGE ASKEKEEVAE EAQSGGD
Length:127
Mass (Da):13,331
Last modified:March 21, 2006 - v2
Checksum:iF183DEF302DBE688
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13E → K in AAB64109 (PubMed:9044857).Curated1
Sequence conflicti17G → D in AAL05870 (Ref. 4) Curated1
Sequence conflicti68E → K in AAB64109 (PubMed:9044857).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007455110E → V2 PublicationsCorresponds to variant dbSNP:rs9864Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010126 mRNA Translation: AAB64109.1
AF037207 Genomic DNA Translation: AAC36586.1
AF017256 mRNA Translation: AAC36550.1
AF044311 Genomic DNA Translation: AAC27738.1
AF411524 mRNA Translation: AAL05870.1
BC014098 mRNA Translation: AAH14098.1
CCDSiCCDS7380.1
RefSeqiNP_001317049.1, NM_001330120.1
NP_003078.2, NM_003087.2
UniGeneiHs.349470

Genome annotation databases

EnsembliENST00000372017; ENSP00000361087; ENSG00000173267
GeneIDi6623
KEGGihsa:6623

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSYUG_HUMAN
AccessioniPrimary (citable) accession number: O76070
Secondary accession number(s): O15104, Q96P61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: March 21, 2006
Last modified: July 18, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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