UniProtKB - O76064 (RNF8_HUMAN)
E3 ubiquitin-protein ligase RNF8
RNF8
Functioni
Caution
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.UniRule annotation EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.UniRule annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 403 – 441 | RING-typeUniRule annotationAdd BLAST | 39 |
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- histone binding Source: UniProtKB
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
- ubiquitin binding Source: UniProtKB-UniRule
- ubiquitin protein ligase activity Source: GO_Central
- ubiquitin protein ligase binding Source: UniProtKB
- ubiquitin-protein transferase activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cellular response to DNA damage stimulus Source: UniProtKB
- double-strand break repair Source: UniProtKB
- double-strand break repair via nonhomologous end joining Source: UniProtKB
- histone exchange Source: UniProtKB
- histone H2A K63-linked ubiquitination Source: UniProtKB
- histone H2A ubiquitination Source: UniProtKB
- histone H2B ubiquitination Source: UniProtKB
- interstrand cross-link repair Source: UniProtKB
- isotype switching Source: UniProtKB
- negative regulation of transcription elongation from RNA polymerase II promoter Source: UniProtKB
- positive regulation of DNA repair Source: UniProtKB
- protein autoubiquitination Source: UniProtKB
- protein K48-linked ubiquitination Source: UniProtKB
- protein K63-linked ubiquitination Source: UniProtKB
- protein ubiquitination Source: GO_Central
- response to ionizing radiation Source: UniProtKB
- spermatid development Source: UniProtKB
- spermatogenesis, exchange of chromosomal proteins Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Chromatin regulator, Transferase |
Biological process | Cell cycle, Cell division, DNA damage, DNA repair, Host-virus interaction, Mitosis, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O76064 |
Reactomei | R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693571, Nonhomologous End-Joining (NHEJ) R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-69473, G2/M DNA damage checkpoint |
SIGNORi | O76064 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase RNF8UniRule annotation (EC:2.3.2.27UniRule annotation)Short name: hRNF8 Alternative name(s): RING finger protein 8UniRule annotation RING-type E3 ubiquitin transferase RNF8UniRule annotation |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10071, RNF8 |
MIMi | 611685, gene |
neXtProti | NX_O76064 |
VEuPathDBi | HostDB:ENSG00000112130.16 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation4 Publications
Other locations
Note: Recruited at uncapped telomeres (By similarity). Following DNA damage, such as double-strand breaks, recruited to the sites of damage (PubMed:18001824, PubMed:18077395, PubMed:22266820, PubMed:23233665). During prophase, concomitant with nuclear envelope breakdown, localizes throughout the cell, with a dotted pattern. In telophase, again in the nucleus and also with a discrete dotted pattern in the cytoplasm. In late telophase and during cytokinesis, localizes in the midbody of the tubulin bridge joining the daughter cells. Does not seem to be associated with condensed chromosomes at any time during the cell cycle. During spermatogenesis, sequestered in the cytoplasm by PIWIL1: RNF8 is released following ubiquitination and degradation of PIWIL1.UniRule annotation4 Publications
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromosome, telomeric region Source: UniProtKB
- midbody Source: UniProtKB-SubCell
- site of double-strand break Source: UniProtKB
- ubiquitin ligase complex Source: UniProtKB
Keywords - Cellular componenti
Chromosome, Cytoplasm, Nucleus, TelomerePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 42 | R → A: Abolishes interaction with ATM-phosphorylated MDC1. Abolishes interaction with human herpesvirus 1 ICP0. Abolishes recruitment to DNA damage sites after UV irradiation, ionizing radiation, or treatment with an alkylating agent. 4 Publications | 1 | |
Mutagenesisi | 403 | C → S: Marked reduction of E2-dependent ubiquitination of histone H2A. Loss of UBE2E2- and UBE2N-binding. Loss of nuclear localization. 4 Publications | 1 | |
Mutagenesisi | 405 | I → A: Impairs interaction with UBE2L6/UBCH8 and ability to mediate 'Lys-48'-linked ubiquitination E3 ligase activity, while it still catalyzes 'Lys-63'-linked ubiquitination and still interacts with UBE2N/UBC13. 3 Publications | 1 | |
Mutagenesisi | 406 | C → S: Abolishes ubiquitin-ligase activity. 1 Publication | 1 | |
Mutagenesisi | 443 | D → R: Does not affect the monomeric structure but abolishes ability to monoubiquitinate H2A in nucleosomes. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9025 |
OpenTargetsi | ENSG00000112130 |
PharmGKBi | PA34445 |
Miscellaneous databases
Pharosi | O76064, Tbio |
Genetic variation databases
BioMutai | RNF8 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056048 | 1 – 485 | E3 ubiquitin-protein ligase RNF8Add BLAST | 485 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 157 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O76064 |
jPOSTi | O76064 |
MassIVEi | O76064 |
MaxQBi | O76064 |
PaxDbi | O76064 |
PeptideAtlasi | O76064 |
PRIDEi | O76064 |
ProteomicsDBi | 50370 [O76064-1] 50371 [O76064-2] |
PTM databases
iPTMneti | O76064 |
PhosphoSitePlusi | O76064 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000112130, Expressed in frontal cortex and 230 other tissues |
ExpressionAtlasi | O76064, baseline and differential |
Genevisiblei | O76064, HS |
Organism-specific databases
HPAi | ENSG00000112130, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2.
Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N.
Interacts with RXRA.
Interacts (via FHA domain) with ATM-phosphorylated MDC1.
Interacts (via FHA domain) with 'Thr-4827' phosphorylated HERC2 (via C-terminus).
Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm (By similarity).
Interacts with WRAP53/TCAB1 (PubMed:25512560).
By similarity12 Publications(Microbial infection) Interacts (via FHA domain) with phosphorylated human herpesvirus 1 ICP0 protein; leading to RNF8 degradation by the proteasome.
1 PublicationBinary interactionsi
O76064
Isoform 1 [O76064-1]
With | #Exp. | IntAct |
---|---|---|
MDC1 [Q14676] | 2 | EBI-15964690,EBI-495644 |
GO - Molecular functioni
- histone binding Source: UniProtKB
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
- ubiquitin binding Source: UniProtKB-UniRule
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114492, 110 interactors |
CORUMi | O76064 |
DIPi | DIP-31265N |
IntActi | O76064, 78 interactors |
MINTi | O76064 |
STRINGi | 9606.ENSP00000362578 |
Miscellaneous databases
RNActi | O76064, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | O76064 |
SASBDBi | O76064 |
SMRi | O76064 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O76064 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 92 | FHAUniRule annotationAdd BLAST | 55 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 68 – 72 | Required for interaction with PIWIL1UniRule annotation | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 276 – 345 | Gln-richAdd BLAST | 70 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 403 – 441 | RING-typeUniRule annotationAdd BLAST | 39 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3872, Eukaryota |
GeneTreei | ENSGT00400000022349 |
HOGENOMi | CLU_023453_1_0_1 |
InParanoidi | O76064 |
OMAi | SYCISEW |
OrthoDBi | 1585372at2759 |
PhylomeDBi | O76064 |
TreeFami | TF330957 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
HAMAPi | MF_03067, RNF8, 1 hit |
IDEALi | IID00118 |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR017335, RNF8 IPR008984, SMAD_FHA_dom_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00498, FHA, 1 hit |
PIRSFi | PIRSF037950, E3_ubiquit_lig_RNF8, 1 hit |
SMARTi | View protein in SMART SM00240, FHA, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGEPGFFVTG DRAGGRSWCL RRVGMSAGWL LLEDGCEVTV GRGFGVTYQL
60 70 80 90 100
VSKICPLMIS RNHCVLKQNP EGQWTIMDNK SLNGVWLNRA RLEPLRVYSI
110 120 130 140 150
HQGDYIQLGV PLENKENAEY EYEVTEEDWE TIYPCLSPKN DQMIEKNKEL
160 170 180 190 200
RTKRKFSLDE LAGPGAEGPS NLKSKINKVS CESGQPVKSQ GKGEVASTPS
210 220 230 240 250
DNLDPKLTAL EPSKTTGAPI YPGFPKVTEV HHEQKASNSS ASQRSLQMFK
260 270 280 290 300
VTMSRILRLK IQMQEKHEAV MNVKKQTQKG NSKKVVQMEQ ELQDLQSQLC
310 320 330 340 350
AEQAQQQARV EQLEKTFQEE EQHLQGLEIA QGEKDLKQQL AQALQEHWAL
360 370 380 390 400
MEELNRSKKD FEAIIQAKNK ELEQTKEEKE KMQAQKEEVL SHMNDVLENE
410 420 430 440 450
LQCIICSEYF IEAVTLNCAH SFCSYCINEW MKRKIECPIC RKDIKSKTYS
460 470 480
LVLDNCINKM VNNLSSEVKE RRIVLIRERK AKRLF
The sequence of this isoform differs from the canonical sequence as follows:
81-98: SLNGVWLNRARLEPLRVY → SFPSEKAEDFTAAGERFL
99-485: Missing.
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J858 | C9J858_HUMAN | E3 ubiquitin-protein ligase RNF8 | RNF8 | 205 | Annotation score: | ||
H7C4L7 | H7C4L7_HUMAN | E3 ubiquitin-protein ligase RNF8 | RNF8 | 208 | Annotation score: | ||
F8WEW6 | F8WEW6_HUMAN | E3 ubiquitin-protein ligase RNF8 | RNF8 | 89 | Annotation score: | ||
F8WDH8 | F8WDH8_HUMAN | E3 ubiquitin-protein ligase RNF8 | RNF8 | 49 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 230 | V → A in BAD96485 (Ref. 6) Curated | 1 | |
Sequence conflicti | 334 | K → R in BAD96485 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052096 | 162 | A → T. Corresponds to variant dbSNP:rs34338974Ensembl. | 1 | |
Natural variantiVAR_052097 | 473 | I → V. Corresponds to variant dbSNP:rs1139944Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036671 | 81 – 98 | SLNGV…PLRVY → SFPSEKAEDFTAAGERFL in isoform 2. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_037831 | 99 – 485 | Missing in isoform 2. 1 PublicationAdd BLAST | 387 | |
Alternative sequenceiVSP_054037 | 413 – 448 | AVTLN…IKSKT → QRDCSEDRALRAFERLPGSA SLRWSGGFSLAVTPLL in isoform 3. CuratedAdd BLAST | 36 | |
Alternative sequenceiVSP_054038 | 449 – 485 | Missing in isoform 3. CuratedAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB012770 Genomic DNA Translation: BAA33557.1 AF334675 mRNA Translation: AAQ14887.1 AB014546 mRNA Translation: BAA31621.2 Different initiation. AK298319 mRNA Translation: BAG60572.1 Sequence problems. BT007446 mRNA Translation: AAP36114.1 AK222765 mRNA Translation: BAD96485.1 AL096712 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03944.1 CH471081 Genomic DNA Translation: EAX03945.1 Sequence problems. BC007517 mRNA Translation: AAH07517.1 |
CCDSi | CCDS4833.1 [O76064-3] CCDS4834.1 [O76064-1] |
RefSeqi | NP_003949.1, NM_003958.3 [O76064-1] NP_898901.1, NM_183078.2 [O76064-3] |
Genome annotation databases
Ensembli | ENST00000229866; ENSP00000229866; ENSG00000112130 [O76064-2] ENST00000373479; ENSP00000362578; ENSG00000112130 [O76064-1] ENST00000469731; ENSP00000418879; ENSG00000112130 [O76064-3] |
GeneIDi | 9025 |
KEGGi | hsa:9025 |
UCSCi | uc003onq.4, human [O76064-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB012770 Genomic DNA Translation: BAA33557.1 AF334675 mRNA Translation: AAQ14887.1 AB014546 mRNA Translation: BAA31621.2 Different initiation. AK298319 mRNA Translation: BAG60572.1 Sequence problems. BT007446 mRNA Translation: AAP36114.1 AK222765 mRNA Translation: BAD96485.1 AL096712 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03944.1 CH471081 Genomic DNA Translation: EAX03945.1 Sequence problems. BC007517 mRNA Translation: AAH07517.1 |
CCDSi | CCDS4833.1 [O76064-3] CCDS4834.1 [O76064-1] |
RefSeqi | NP_003949.1, NM_003958.3 [O76064-1] NP_898901.1, NM_183078.2 [O76064-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CSW | NMR | - | A | 8-139 | [»] | |
2PIE | X-ray | 1.35 | A | 13-146 | [»] | |
4AYC | X-ray | 1.90 | A/B | 351-485 | [»] | |
4ORH | X-ray | 4.80 | C/G/H/K/L | 345-485 | [»] | |
4WHV | X-ray | 8.30 | C/D/I/J | 345-485 | [»] | |
BMRBi | O76064 | |||||
SASBDBi | O76064 | |||||
SMRi | O76064 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114492, 110 interactors |
CORUMi | O76064 |
DIPi | DIP-31265N |
IntActi | O76064, 78 interactors |
MINTi | O76064 |
STRINGi | 9606.ENSP00000362578 |
PTM databases
iPTMneti | O76064 |
PhosphoSitePlusi | O76064 |
Genetic variation databases
BioMutai | RNF8 |
Proteomic databases
EPDi | O76064 |
jPOSTi | O76064 |
MassIVEi | O76064 |
MaxQBi | O76064 |
PaxDbi | O76064 |
PeptideAtlasi | O76064 |
PRIDEi | O76064 |
ProteomicsDBi | 50370 [O76064-1] 50371 [O76064-2] |
Protocols and materials databases
Antibodypediai | 15585, 323 antibodies |
DNASUi | 9025 |
Genome annotation databases
Ensembli | ENST00000229866; ENSP00000229866; ENSG00000112130 [O76064-2] ENST00000373479; ENSP00000362578; ENSG00000112130 [O76064-1] ENST00000469731; ENSP00000418879; ENSG00000112130 [O76064-3] |
GeneIDi | 9025 |
KEGGi | hsa:9025 |
UCSCi | uc003onq.4, human [O76064-1] |
Organism-specific databases
CTDi | 9025 |
DisGeNETi | 9025 |
GeneCardsi | RNF8 |
HGNCi | HGNC:10071, RNF8 |
HPAi | ENSG00000112130, Low tissue specificity |
MIMi | 611685, gene |
neXtProti | NX_O76064 |
OpenTargetsi | ENSG00000112130 |
PharmGKBi | PA34445 |
VEuPathDBi | HostDB:ENSG00000112130.16 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3872, Eukaryota |
GeneTreei | ENSGT00400000022349 |
HOGENOMi | CLU_023453_1_0_1 |
InParanoidi | O76064 |
OMAi | SYCISEW |
OrthoDBi | 1585372at2759 |
PhylomeDBi | O76064 |
TreeFami | TF330957 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | O76064 |
Reactomei | R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693571, Nonhomologous End-Joining (NHEJ) R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-69473, G2/M DNA damage checkpoint |
SIGNORi | O76064 |
Miscellaneous databases
BioGRID-ORCSi | 9025, 351 hits in 880 CRISPR screens |
ChiTaRSi | RNF8, human |
EvolutionaryTracei | O76064 |
GeneWikii | RNF8 |
GenomeRNAii | 9025 |
Pharosi | O76064, Tbio |
PROi | PR:O76064 |
RNActi | O76064, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112130, Expressed in frontal cortex and 230 other tissues |
ExpressionAtlasi | O76064, baseline and differential |
Genevisiblei | O76064, HS |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
HAMAPi | MF_03067, RNF8, 1 hit |
IDEALi | IID00118 |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR017335, RNF8 IPR008984, SMAD_FHA_dom_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00498, FHA, 1 hit |
PIRSFi | PIRSF037950, E3_ubiquit_lig_RNF8, 1 hit |
SMARTi | View protein in SMART SM00240, FHA, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RNF8_HUMAN | |
Accessioni | O76064Primary (citable) accession number: O76064 Secondary accession number(s): A6NN24 Q5NKW5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 6, 2002 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 202 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants