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Protein

Stanniocalcin-2

Gene

STC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • heme binding Source: UniProtKB
  • hormone activity Source: UniProtKB-KW
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Stanniocalcin-2
Short name:
STC-2
Alternative name(s):
Stanniocalcin-related protein
Short name:
STC-related protein
Short name:
STCRP
Gene namesi
Name:STC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113739.10
HGNCiHGNC:11374 STC2
MIMi603665 gene
neXtProtiNX_O76061

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8614
OpenTargetsiENSG00000113739
PharmGKBiPA36191

Polymorphism and mutation databases

BioMutaiSTC2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003330325 – 302Stanniocalcin-2Add BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei250Phosphoserine; by FAM20C1 Publication1
Modified residuei251Phosphoserine; by FAM20C1 Publication1
Modified residuei254Phosphothreonine; by FAM20C1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO76061
PaxDbiO76061
PeptideAtlasiO76061
PRIDEiO76061
ProteomicsDBi50367

PTM databases

GlyConnecti1769
iPTMnetiO76061
PhosphoSitePlusiO76061

Expressioni

Tissue specificityi

Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000113739 Expressed in 124 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_STC2
ExpressionAtlasiO76061 baseline and differential
GenevisibleiO76061 HS

Organism-specific databases

HPAiHPA045372

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114172, 21 interactors
IntActiO76061, 12 interactors
STRINGi9606.ENSP00000265087

Structurei

3D structure databases

ProteinModelPortaliO76061
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the stanniocalcin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIGP Eukaryota
ENOG410XT17 LUCA
GeneTreeiENSGT00390000005989
HOGENOMiHOG000220830
HOVERGENiHBG001048
InParanoidiO76061
OMAiFCTSAIQ
OrthoDBiEOG091G0HC1
PhylomeDBiO76061
TreeFamiTF324693

Family and domain databases

InterProiView protein in InterPro
IPR004978 Stanniocalcin
PANTHERiPTHR11245 PTHR11245, 1 hit
PfamiView protein in Pfam
PF03298 Stanniocalcin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O76061-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCAERLGQFM TLALVLATFD PARGTDATNP PEGPQDRSSQ QKGRLSLQNT
60 70 80 90 100
AEIQHCLVNA GDVGCGVFEC FENNSCEIRG LHGICMTFLH NAGKFDAQGK
110 120 130 140 150
SFIKDALKCK AHALRHRFGC ISRKCPAIRE MVSQLQRECY LKHDLCAAAQ
160 170 180 190 200
ENTRVIVEMI HFKDLLLHEP YVDLVNLLLT CGEEVKEAIT HSVQVQCEQN
210 220 230 240 250
WGSLCSILSF CTSAIQKPPT APPERQPQVD RTKLSRAHHG EAGHHLPEPS
260 270 280 290 300
SRETGRGAKG ERGSKSHPNA HARGRVGGLG AQGPSGSSEW EDEQSEYSDI

RR
Length:302
Mass (Da):33,249
Last modified:November 1, 1998 - v1
Checksum:i9B90D8911524FA22
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RG57E5RG57_HUMAN
Stanniocalcin-2
STC2
53Annotation score:
H0YB13H0YB13_HUMAN
Stanniocalcin-2
STC2
123Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055460 mRNA Translation: AAC27036.1
AB012664 mRNA Translation: BAA33489.1
AF098462 mRNA Translation: AAC97948.1
AF031036 mRNA Translation: AAD01922.1
BT019591 mRNA Translation: AAV38398.1
BC000658 mRNA Translation: AAH00658.1
BC006352 mRNA Translation: AAH06352.1
BC013958 mRNA Translation: AAH13958.1
CCDSiCCDS4388.1
PIRiJE0357
RefSeqiNP_003705.1, NM_003714.2
UniGeneiHs.233160

Genome annotation databases

EnsembliENST00000265087; ENSP00000265087; ENSG00000113739
GeneIDi8614
KEGGihsa:8614

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055460 mRNA Translation: AAC27036.1
AB012664 mRNA Translation: BAA33489.1
AF098462 mRNA Translation: AAC97948.1
AF031036 mRNA Translation: AAD01922.1
BT019591 mRNA Translation: AAV38398.1
BC000658 mRNA Translation: AAH00658.1
BC006352 mRNA Translation: AAH06352.1
BC013958 mRNA Translation: AAH13958.1
CCDSiCCDS4388.1
PIRiJE0357
RefSeqiNP_003705.1, NM_003714.2
UniGeneiHs.233160

3D structure databases

ProteinModelPortaliO76061
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114172, 21 interactors
IntActiO76061, 12 interactors
STRINGi9606.ENSP00000265087

PTM databases

GlyConnecti1769
iPTMnetiO76061
PhosphoSitePlusiO76061

Polymorphism and mutation databases

BioMutaiSTC2

Proteomic databases

EPDiO76061
PaxDbiO76061
PeptideAtlasiO76061
PRIDEiO76061
ProteomicsDBi50367

Protocols and materials databases

DNASUi8614
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265087; ENSP00000265087; ENSG00000113739
GeneIDi8614
KEGGihsa:8614

Organism-specific databases

CTDi8614
DisGeNETi8614
EuPathDBiHostDB:ENSG00000113739.10
GeneCardsiSTC2
HGNCiHGNC:11374 STC2
HPAiHPA045372
MIMi603665 gene
neXtProtiNX_O76061
OpenTargetsiENSG00000113739
PharmGKBiPA36191
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIGP Eukaryota
ENOG410XT17 LUCA
GeneTreeiENSGT00390000005989
HOGENOMiHOG000220830
HOVERGENiHBG001048
InParanoidiO76061
OMAiFCTSAIQ
OrthoDBiEOG091G0HC1
PhylomeDBiO76061
TreeFamiTF324693

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiSTC2 human
GeneWikiiSTC2
GenomeRNAii8614
PROiPR:O76061
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113739 Expressed in 124 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_STC2
ExpressionAtlasiO76061 baseline and differential
GenevisibleiO76061 HS

Family and domain databases

InterProiView protein in InterPro
IPR004978 Stanniocalcin
PANTHERiPTHR11245 PTHR11245, 1 hit
PfamiView protein in Pfam
PF03298 Stanniocalcin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTC2_HUMAN
AccessioniPrimary (citable) accession number: O76061
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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