SEC14L2

Functionⁱ

Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.

GO - Molecular functionⁱ

phospholipid binding
Source: UniProtKB
Non-traceable author statementⁱ
- 7364757
vitamin E binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10829015

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 11444841
regulation of cholesterol biosynthetic process
Source: UniProtKB
Non-traceable author statementⁱ
- 11226224

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator
Biological process	Transcription, Transcription regulation, Transport
Ligand	Lipid-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SEC14-like protein 2 Alternative name(s): Alpha-tocopherol-associated protein Short name: TAP Short name: hTAP Squalene transfer protein Supernatant protein factor Short name: SPF
Gene namesⁱ	Name:SEC14L2 Synonyms:C22orf6, KIAA1186, KIAA1658
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100003.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10699 SEC14L2
MIMⁱ	607558 gene
neXtProtⁱ	NX_O76054

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23541
Open Targets More...OpenTargetsⁱ	ENSG00000100003
PharmGKBⁱ	PA35622

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB03796 Palmitic Acid DB00163 Vitamin E

DrugBankⁱ

DB03796 Palmitic Acid
DB00163 Vitamin E

Polymorphism and mutation databases

BioMutaⁱ	SEC14L2

BioMutaⁱ

SEC14L2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000210755	1 – 403	SEC14-like protein 2Add BLAST		403

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	51	N6-succinyllysineBy similarity	1
Modified residueⁱ	253	N6-succinyllysineBy similarity	1
Modified residueⁱ	257	N6-succinyllysineBy similarity	1
Modified residueⁱ	393	N6-succinyllysineBy similarity	1

Proteomic databases

EPDⁱ	O76054
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O76054
PaxDbⁱ	O76054
PeptideAtlas More...PeptideAtlasⁱ	O76054
PRIDEⁱ	O76054
ProteomicsDBⁱ	50365 50366 [O76054-4]

PTM databases

iPTMnetⁱ	O76054
PhosphoSitePlusⁱ	O76054
SwissPalmⁱ	O76054

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Strong expression in liver, brain and prostate.1 Publication

Developmental stageⁱ

Low expression in fetal tissues.

Gene expression databases

Bgeeⁱ	ENSG00000100003 Expressed in 149 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_SEC14L2
ExpressionAtlasⁱ	O76054 baseline and differential
Genevisibleⁱ	O76054 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA064466

HPAⁱ

HPA064466

Interactionⁱ

Subunit structureⁱ

Monomer.By similarity

Protein-protein interaction databases

BioGridⁱ	117085, 1 interactor
IntActⁱ	O76054, 1 interactor
Molecular INTeraction database More...MINTⁱ	O76054
STRINGⁱ	9606.ENSP00000316203

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	5 – 7	Combined sources	3
Helixⁱ	10 – 23	Combined sources	14
Turnⁱ	24 – 26	Combined sources	3
Helixⁱ	27 – 29	Combined sources	3
Helixⁱ	35 – 44	Combined sources	10
Turnⁱ	45 – 47	Combined sources	3
Helixⁱ	49 – 65	Combined sources	17
Helixⁱ	68 – 73	Combined sources	6
Helixⁱ	78 – 83	Combined sources	6
Beta strandⁱ	86 – 91	Combined sources	6
Beta strandⁱ	97 – 102	Combined sources	6
Helixⁱ	108 – 114	Combined sources	7
Helixⁱ	117 – 142	Combined sources	26
Beta strandⁱ	149 – 154	Combined sources	6
Helixⁱ	160 – 163	Combined sources	4
Helixⁱ	165 – 181	Combined sources	17
Beta strandⁱ	186 – 193	Combined sources	8
Helixⁱ	198 – 205	Combined sources	8
Helixⁱ	206 – 208	Combined sources	3
Helixⁱ	211 – 215	Combined sources	5
Beta strandⁱ	217 – 219	Combined sources	3
Helixⁱ	224 – 231	Combined sources	8
Helixⁱ	234 – 236	Combined sources	3
Helixⁱ	239 – 241	Combined sources	3
Beta strandⁱ	243 – 245	Combined sources	3
Turnⁱ	255 – 257	Combined sources	3
Helixⁱ	266 – 268	Combined sources	3
Beta strandⁱ	279 – 284	Combined sources	6
Beta strandⁱ	289 – 296	Combined sources	8
Beta strandⁱ	302 – 312	Combined sources	11
Beta strandⁱ	314 – 320	Combined sources	7
Beta strandⁱ	323 – 326	Combined sources	4
Helixⁱ	330 – 332	Combined sources	3
Beta strandⁱ	333 – 342	Combined sources	10
Turnⁱ	344 – 346	Combined sources	3
Beta strandⁱ	349 – 354	Combined sources	6
Beta strandⁱ	359 – 366	Combined sources	8
Beta strandⁱ	374 – 384	Combined sources	11
Helixⁱ	388 – 395	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	O76054
SMRⁱ	O76054
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O76054

EvolutionaryTraceⁱ

O76054

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	76 – 249	CRAL-TRIOPROSITE-ProRule annotationAdd BLAST		174
Domainⁱ	275 – 383	GOLDPROSITE-ProRule annotationAdd BLAST		109

Phylogenomic databases

eggNOGⁱ	KOG1471 Eukaryota ENOG410XRSQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074580
HOGENOMⁱ	HOG000232201
HOVERGENⁱ	HBG055336
InParanoidⁱ	O76054
OMAⁱ	GLCHCEG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MI9
PhylomeDBⁱ	O76054
TreeFamⁱ	TF313988

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00170 SEC14, 1 hit
Gene3Dⁱ	3.40.525.10, 1 hit
InterProⁱ	View protein in InterPro IPR001251 CRAL-TRIO_dom IPR036865 CRAL-TRIO_dom_sf IPR011074 CRAL/TRIO_N_dom IPR036273 CRAL/TRIO_N_dom_sf IPR009038 GOLD_dom IPR036598 GOLD_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00650 CRAL_TRIO, 1 hit
SMARTⁱ	View protein in SMART SM01100 CRAL_TRIO_N, 1 hit SM00516 SEC14, 1 hit
SUPFAMⁱ	SSF101576 SSF101576, 1 hit SSF46938 SSF46938, 1 hit SSF52087 SSF52087, 1 hit
PROSITEⁱ	View protein in PROSITE PS50191 CRAL_TRIO, 1 hit PS50866 GOLD, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O76054-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGRVGDLSP RQKEALAKFR ENVQDVLPAL PNPDDYFLLR WLRARSFDLQ 
        60         70         80         90        100
KSEAMLRKHV EFRKQKDIDN IISWQPPEVI QQYLSGGMCG YDLDGCPVWY 
       110        120        130        140        150
DIIGPLDAKG LLFSASKQDL LRTKMRECEL LLQECAHQTT KLGRKVETIT 
       160        170        180        190        200
IIYDCEGLGL KHLWKPAVEA YGEFLCMFEE NYPETLKRLF VVKAPKLFPV 
       210        220        230        240        250
AYNLIKPFLS EDTRKKIMVL GANWKEVLLK HISPDQVPVE YGGTMTDPDG 
       260        270        280        290        300
NPKCKSKINY GGDIPRKYYV RDQVKQQYEH SVQISRGSSH QVEYEILFPG 
       310        320        330        340        350
CVLRWQFMSD GADVGFGIFL KTKMGERQRA GEMTEVLPNQ RYNSHLVPED 
       360        370        380        390        400
GTLTCSDPGI YVLRFDNTYS FIHAKKVNFT VEVLLPDKAS EEKMKQLGAG 

TPK

Length:403

Mass (Da):46,145

Last modified:November 1, 1998 - v1

Checksum:ⁱD846747EC8D1513E

GO

Isoform 2 (identifier: O76054-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
361-403: YVLRFDNTYSFIHAKKVNFTVEVLLPDKASEEKMKQLGAGTPK → CKYLCLGNALKPHVQLSACEVPLPPWIFGSEC

« Hide

        10         20         30         40         50
MSGRVGDLSP RQKEALAKFR ENVQDVLPAL PNPDDYFLLR WLRARSFDLQ 
        60         70         80         90        100
KSEAMLRKHV EFRKQKDIDN IISWQPPEVI QQYLSGGMCG YDLDGCPVWY 
       110        120        130        140        150
DIIGPLDAKG LLFSASKQDL LRTKMRECEL LLQECAHQTT KLGRKVETIT 
       160        170        180        190        200
IIYDCEGLGL KHLWKPAVEA YGEFLCMFEE NYPETLKRLF VVKAPKLFPV 
       210        220        230        240        250
AYNLIKPFLS EDTRKKIMVL GANWKEVLLK HISPDQVPVE YGGTMTDPDG 
       260        270        280        290        300
NPKCKSKINY GGDIPRKYYV RDQVKQQYEH SVQISRGSSH QVEYEILFPG 
       310        320        330        340        350
CVLRWQFMSD GADVGFGIFL KTKMGERQRA GEMTEVLPNQ RYNSHLVPED 
       360        370        380        390 
GTLTCSDPGI CKYLCLGNAL KPHVQLSACE VPLPPWIFGS EC

Note: No experimental confirmation available.

Show »

Length:392

Mass (Da):44,748

Checksum:ⁱ11A833345968FE5A

GO

Isoform 3 (identifier: O76054-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
58-140: Missing.

« Hide

        10         20         30         40         50
MSGRVGDLSP RQKEALAKFR ENVQDVLPAL PNPDDYFLLR WLRARSFDLQ 
        60         70         80         90        100
KSEAMLRKLG RKVETITIIY DCEGLGLKHL WKPAVEAYGE FLCMFEENYP 
       110        120        130        140        150
ETLKRLFVVK APKLFPVAYN LIKPFLSEDT RKKIMVLGAN WKEVLLKHIS 
       160        170        180        190        200
PDQVPVEYGG TMTDPDGNPK CKSKINYGGD IPRKYYVRDQ VKQQYEHSVQ 
       210        220        230        240        250
ISRGSSHQVE YEILFPGCVL RWQFMSDGAD VGFGIFLKTK MGERQRAGEM 
       260        270        280        290        300
TEVLPNQRYN SHLVPEDGTL TCSDPGIYVL RFDNTYSFIH AKKVNFTVEV 
       310        320
LLPDKASEEK MKQLGAGTPK

Note: No experimental confirmation available.

Show »

Length:320

Mass (Da):36,636

Checksum:ⁱ64CCC92D4A8149C7

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B3KRD8	B3KRD8_HUMAN	SEC14-like 2 (S. cerevisiae), isofo... SEC14-like 2 (S. cerevisiae), isoform CRA_c (cDNA FLJ34083 fis, clone FCBBF3004409, highly similar to SEC14-like protein 2)	SEC14L2 hCG_41297	329	Annotation score:
C9JZI9	C9JZI9_HUMAN	SEC14-like protein 2 SEC14-like protein 2	SEC14L2	203	Annotation score:
F8WEE7	F8WEE7_HUMAN	SEC14-like protein 2 SEC14-like protein 2	SEC14L2	84	Annotation score:
C9JTM4	C9JTM4_HUMAN	SEC14-like protein 2 SEC14-like protein 2	SEC14L2	125	Annotation score:
C9JYY7	C9JYY7_HUMAN	SEC14-like protein 2 SEC14-like protein 2	SEC14L2	84	Annotation score:
F8WED8	F8WED8_HUMAN	SEC14-like protein 2 SEC14-like protein 2	SEC14L2	53	Annotation score:

Sequence cautionⁱ

The sequence BAA86500 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	36	Y → H (PubMed:11444841).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_024626	11	R → K2 PublicationsCorresponds to variant dbSNP:rs757660Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045880	58 – 140	Missing in isoform 3. 1 PublicationAdd BLAST		83
Alternative sequenceⁱVSP_042021	361 – 403	YVLRF…AGTPK → CKYLCLGNALKPHVQLSACE VPLPPWIFGSEC in isoform 2. 1 PublicationAdd BLAST		43

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL096881 mRNA Translation: CAB51405.1 AB033012 mRNA Translation: BAA86500.2 Different initiation. CR456571 mRNA Translation: CAG30457.1 AK303751 mRNA Translation: BAH14037.1 AK223587 mRNA Translation: BAD97307.1 AC004832 Genomic DNA Translation: AAF19256.1 BC058915 mRNA Translation: AAH58915.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13876.1 [O76054-1] CCDS46685.1 [O76054-4] CCDS56228.1 [O76054-5]
PIRⁱ	JC7708
NCBI Reference Sequences More...RefSeqⁱ	NP_001191133.1, NM_001204204.2 [O76054-5] NP_036561.1, NM_012429.4 [O76054-1] NP_203740.1, NM_033382.2 [O76054-4]
UniGeneⁱ	Hs.335614

Genome annotation databases

Ensemblⁱ	ENST00000402592; ENSP00000383882; ENSG00000100003 [O76054-5] ENST00000405717; ENSP00000385186; ENSG00000100003 [O76054-4] ENST00000615189; ENSP00000478755; ENSG00000100003 [O76054-1]
GeneIDⁱ	23541
KEGGⁱ	hsa:23541
UCSC genome browser More...UCSCⁱ	uc003ahq.5 human [O76054-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O76054	SEC14-like 2 (S. cerevisiae), isoform CRA_b		HUMAN		403	UniRef100_O76054
cDNA FLJ54104, highly similar to SEC14-like protein 2		HUMAN		349
SEC14-like protein 2 (Fragment)		HUMAN		203

Protein	Similar proteins		Species	Score	Length	Source
O76054	SEC14-like protein 2		RAT		403	UniRef90_O76054
SEC14-like protein 2		MOUSE		403
SEC14-like protein 2		BOVIN		403
SEC14-like 2 (S. cerevisiae), isoform CRA_b		HUMAN		403
Uncharacterized protein		PIG		468
+142
O76054-4	Uncharacterized protein		PAPAN		407	UniRef90_O76054-4
Uncharacterized protein		MACMU		203
Uncharacterized protein		PROCO		401
Uncharacterized protein		AOTNA		397
Uncharacterized protein		MACFA		392
+18
O76054-5	Uncharacterized protein		SAIBB		320	UniRef90_O76054-5
Uncharacterized protein		PROCO		320
Uncharacterized protein		MACMU		320
Uncharacterized protein		CERAT		320
Uncharacterized protein		PAPAN		320
+25

Protein	Similar proteins		Species	Score	Length	Source
O76054	SEC14-like protein 2		MOUSE		403	UniRef50_O76054
SEC14-like protein 2		BOVIN		403
SEC14-like protein 2		RAT		403
Putative SEC14-like protein 6		HUMAN		397
Uncharacterized protein		PIG		468
+448
O76054-4	Uncharacterized protein		PAPAN		407	UniRef50_O76054-4
Uncharacterized protein		MACMU		203
Uncharacterized protein		PROCO		401
Uncharacterized protein		AOTNA		397
Uncharacterized protein		SAIBB		392
+59
O76054-5	SEC14-like protein 2 isoform X2		Enhydra lutris kenyoni		320	UniRef50_O76054-5
Uncharacterized protein		MANLE		320
Uncharacterized protein		RHIRO		320
Uncharacterized protein		RHIBE		320
Uncharacterized protein		SAIBB		320
+63

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL096881 mRNA Translation: CAB51405.1 AB033012 mRNA Translation: BAA86500.2 Different initiation. CR456571 mRNA Translation: CAG30457.1 AK303751 mRNA Translation: BAH14037.1 AK223587 mRNA Translation: BAD97307.1 AC004832 Genomic DNA Translation: AAF19256.1 BC058915 mRNA Translation: AAH58915.1
CCDSⁱ	CCDS13876.1 [O76054-1] CCDS46685.1 [O76054-4] CCDS56228.1 [O76054-5]
PIRⁱ	JC7708
RefSeqⁱ	NP_001191133.1, NM_001204204.2 [O76054-5] NP_036561.1, NM_012429.4 [O76054-1] NP_203740.1, NM_033382.2 [O76054-4]
UniGeneⁱ	Hs.335614

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1O6U	X-ray	2.05	A/C/E	1-403	[»]
	1OLM	X-ray	1.95	A/C/E	1-403	[»]
	4OMJ	X-ray	1.60	A/B	1-275	[»]
	4OMK	X-ray	1.75	A/B	1-275	[»]
ProteinModelPortalⁱ	O76054
SMRⁱ	O76054
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117085, 1 interactor
IntActⁱ	O76054, 1 interactor
MINTⁱ	O76054
STRINGⁱ	9606.ENSP00000316203

Chemistry databases

DrugBankⁱ	DB03796 Palmitic Acid DB00163 Vitamin E

DrugBankⁱ

DB03796 Palmitic Acid
DB00163 Vitamin E

PTM databases

iPTMnetⁱ	O76054
PhosphoSitePlusⁱ	O76054
SwissPalmⁱ	O76054

Polymorphism and mutation databases

BioMutaⁱ	SEC14L2

BioMutaⁱ

SEC14L2

Proteomic databases

EPDⁱ	O76054
MaxQBⁱ	O76054
PaxDbⁱ	O76054
PeptideAtlasⁱ	O76054
PRIDEⁱ	O76054
ProteomicsDBⁱ	50365 50366 [O76054-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23541
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000402592; ENSP00000383882; ENSG00000100003 [O76054-5] ENST00000405717; ENSP00000385186; ENSG00000100003 [O76054-4] ENST00000615189; ENSP00000478755; ENSG00000100003 [O76054-1]
GeneIDⁱ	23541
KEGGⁱ	hsa:23541
UCSCⁱ	uc003ahq.5 human [O76054-1]

Organism-specific databases

CTDⁱ	23541
DisGeNETⁱ	23541
EuPathDBⁱ	HostDB:ENSG00000100003.17
GeneCardsⁱ	SEC14L2
HGNCⁱ	HGNC:10699 SEC14L2
HPAⁱ	HPA064466
MIMⁱ	607558 gene
neXtProtⁱ	NX_O76054
OpenTargetsⁱ	ENSG00000100003
PharmGKBⁱ	PA35622
HUGEⁱ	Search... Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1471 Eukaryota ENOG410XRSQ LUCA
GeneTreeⁱ	ENSGT00550000074580
HOGENOMⁱ	HOG000232201
HOVERGENⁱ	HBG055336
InParanoidⁱ	O76054
OMAⁱ	GLCHCEG
OrthoDBⁱ	EOG091G0MI9
PhylomeDBⁱ	O76054
TreeFamⁱ	TF313988

Miscellaneous databases

ChiTaRSⁱ	SEC14L2 human
EvolutionaryTraceⁱ	O76054
GeneWikiⁱ	SEC14L2
GenomeRNAiⁱ	23541
Protein Ontology More...PROⁱ	PR:O76054
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100003 Expressed in 149 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_SEC14L2
ExpressionAtlasⁱ	O76054 baseline and differential
Genevisibleⁱ	O76054 HS

Family and domain databases

CDDⁱ	cd00170 SEC14, 1 hit
Gene3Dⁱ	3.40.525.10, 1 hit
InterProⁱ	View protein in InterPro IPR001251 CRAL-TRIO_dom IPR036865 CRAL-TRIO_dom_sf IPR011074 CRAL/TRIO_N_dom IPR036273 CRAL/TRIO_N_dom_sf IPR009038 GOLD_dom IPR036598 GOLD_dom_sf
Pfamⁱ	View protein in Pfam PF00650 CRAL_TRIO, 1 hit
SMARTⁱ	View protein in SMART SM01100 CRAL_TRIO_N, 1 hit SM00516 SEC14, 1 hit
SUPFAMⁱ	SSF101576 SSF101576, 1 hit SSF46938 SSF46938, 1 hit SSF52087 SSF52087, 1 hit
PROSITEⁱ	View protein in PROSITE PS50191 CRAL_TRIO, 1 hit PS50866 GOLD, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S14L2_HUMAN
Accessionⁱ	O76054Primary (citable) accession number: O76054 Secondary accession number(s): B7Z8Q1 , F5H3U4, Q53EQ2, Q6PD61, Q9ULN4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O76054 (S14L2_HUMAN)

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SEC14-like protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ