UniProtKB - O76054 (S14L2_HUMAN)
SEC14-like protein 2
SEC14L2
Functioni
Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
GO - Molecular functioni
- phospholipid binding Source: UniProtKB
- vitamin E binding Source: UniProtKB
GO - Biological processi
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of cholesterol biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation, Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | O76054 |
SignaLinki | O76054 |
Names & Taxonomyi
Protein namesi | Recommended name: SEC14-like protein 2Alternative name(s): Alpha-tocopherol-associated protein Short name: TAP Short name: hTAP Squalene transfer protein Supernatant protein factor Short name: SPF |
Gene namesi | Name:SEC14L2 Synonyms:C22orf6, KIAA1186, KIAA1658 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10699, SEC14L2 |
MIMi | 607558, gene |
neXtProti | NX_O76054 |
VEuPathDBi | HostDB:ENSG00000100003 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 23541 |
OpenTargetsi | ENSG00000100003 |
PharmGKBi | PA35622 |
Miscellaneous databases
Pharosi | O76054, Tbio |
Chemistry databases
DrugBanki | DB14003, alpha-Tocopherol acetate DB14001, alpha-Tocopherol succinate DB14002, D-alpha-Tocopherol acetate DB11635, Tocofersolan DB11251, Tocopherol DB00163, Vitamin E |
Genetic variation databases
BioMutai | SEC14L2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210755 | 1 – 403 | SEC14-like protein 2Add BLAST | 403 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 51 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 253 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 257 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 393 | N6-succinyllysineBy similarity | 1 |
Proteomic databases
EPDi | O76054 |
jPOSTi | O76054 |
MassIVEi | O76054 |
MaxQBi | O76054 |
PaxDbi | O76054 |
PeptideAtlasi | O76054 |
PRIDEi | O76054 |
ProteomicsDBi | 26377 50365 [O76054-1] 50366 [O76054-4] |
PTM databases
iPTMneti | O76054 |
MetOSitei | O76054 |
PhosphoSitePlusi | O76054 |
SwissPalmi | O76054 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000100003, Expressed in liver and 167 other tissues |
ExpressionAtlasi | O76054, baseline and differential |
Genevisiblei | O76054, HS |
Organism-specific databases
HPAi | ENSG00000100003, Tissue enhanced (epididymis, liver) |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
BioGRIDi | 117085, 4 interactors |
IntActi | O76054, 2 interactors |
MINTi | O76054 |
STRINGi | 9606.ENSP00000478755 |
Miscellaneous databases
RNActi | O76054, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O76054 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O76054 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 76 – 249 | CRAL-TRIOPROSITE-ProRule annotationAdd BLAST | 174 | |
Domaini | 275 – 383 | GOLDPROSITE-ProRule annotationAdd BLAST | 109 |
Phylogenomic databases
eggNOGi | KOG1471, Eukaryota |
GeneTreei | ENSGT00940000160650 |
HOGENOMi | CLU_014001_2_1_1 |
InParanoidi | O76054 |
OMAi | GLCHCEG |
PhylomeDBi | O76054 |
TreeFami | TF313988 |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR011074, CRAL/TRIO_N_dom IPR036273, CRAL/TRIO_N_dom_sf IPR009038, GOLD_dom IPR036598, GOLD_dom_sf |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit |
SMARTi | View protein in SMART SM01100, CRAL_TRIO_N, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF101576, SSF101576, 1 hit SSF46938, SSF46938, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit PS50866, GOLD, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGRVGDLSP RQKEALAKFR ENVQDVLPAL PNPDDYFLLR WLRARSFDLQ
60 70 80 90 100
KSEAMLRKHV EFRKQKDIDN IISWQPPEVI QQYLSGGMCG YDLDGCPVWY
110 120 130 140 150
DIIGPLDAKG LLFSASKQDL LRTKMRECEL LLQECAHQTT KLGRKVETIT
160 170 180 190 200
IIYDCEGLGL KHLWKPAVEA YGEFLCMFEE NYPETLKRLF VVKAPKLFPV
210 220 230 240 250
AYNLIKPFLS EDTRKKIMVL GANWKEVLLK HISPDQVPVE YGGTMTDPDG
260 270 280 290 300
NPKCKSKINY GGDIPRKYYV RDQVKQQYEH SVQISRGSSH QVEYEILFPG
310 320 330 340 350
CVLRWQFMSD GADVGFGIFL KTKMGERQRA GEMTEVLPNQ RYNSHLVPED
360 370 380 390 400
GTLTCSDPGI YVLRFDNTYS FIHAKKVNFT VEVLLPDKAS EEKMKQLGAG
TPK
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JZI9 | C9JZI9_HUMAN | SEC14-like protein 2 | SEC14L2 | 203 | Annotation score: | ||
B3KRD8 | B3KRD8_HUMAN | SEC14-like 2 (S. cerevisiae), isofo... | SEC14L2 hCG_41297 | 329 | Annotation score: | ||
F8WED8 | F8WED8_HUMAN | SEC14-like protein 2 | SEC14L2 | 53 | Annotation score: | ||
C9JTM4 | C9JTM4_HUMAN | SEC14-like protein 2 | SEC14L2 | 125 | Annotation score: | ||
F8WEE7 | F8WEE7_HUMAN | SEC14-like protein 2 | SEC14L2 | 84 | Annotation score: | ||
C9JYY7 | C9JYY7_HUMAN | SEC14-like protein 2 | SEC14L2 | 84 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 36 | Y → H (PubMed:11444841).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024626 | 11 | R → K2 PublicationsCorresponds to variant dbSNP:rs757660Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045880 | 58 – 140 | Missing in isoform 3. 1 PublicationAdd BLAST | 83 | |
Alternative sequenceiVSP_042021 | 361 – 403 | YVLRF…AGTPK → CKYLCLGNALKPHVQLSACE VPLPPWIFGSEC in isoform 2. 1 PublicationAdd BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL096881 mRNA Translation: CAB51405.1 AB033012 mRNA Translation: BAA86500.2 Different initiation. CR456571 mRNA Translation: CAG30457.1 AK303751 mRNA Translation: BAH14037.1 AK223587 mRNA Translation: BAD97307.1 AC004832 Genomic DNA Translation: AAF19256.1 BC058915 mRNA Translation: AAH58915.1 |
CCDSi | CCDS13876.1 [O76054-1] CCDS46685.1 [O76054-4] CCDS56228.1 [O76054-5] |
PIRi | JC7708 |
RefSeqi | NP_001191133.1, NM_001204204.2 [O76054-5] NP_036561.1, NM_012429.4 [O76054-1] NP_203740.1, NM_033382.2 [O76054-4] |
Genome annotation databases
Ensembli | ENST00000402592; ENSP00000383882; ENSG00000100003 [O76054-5] ENST00000405717; ENSP00000385186; ENSG00000100003 [O76054-4] ENST00000615189; ENSP00000478755; ENSG00000100003 |
GeneIDi | 23541 |
KEGGi | hsa:23541 |
MANE-Selecti | ENST00000615189.5; ENSP00000478755.1; NM_012429.5; NP_036561.1 |
UCSCi | uc003ahq.5, human [O76054-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL096881 mRNA Translation: CAB51405.1 AB033012 mRNA Translation: BAA86500.2 Different initiation. CR456571 mRNA Translation: CAG30457.1 AK303751 mRNA Translation: BAH14037.1 AK223587 mRNA Translation: BAD97307.1 AC004832 Genomic DNA Translation: AAF19256.1 BC058915 mRNA Translation: AAH58915.1 |
CCDSi | CCDS13876.1 [O76054-1] CCDS46685.1 [O76054-4] CCDS56228.1 [O76054-5] |
PIRi | JC7708 |
RefSeqi | NP_001191133.1, NM_001204204.2 [O76054-5] NP_036561.1, NM_012429.4 [O76054-1] NP_203740.1, NM_033382.2 [O76054-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1O6U | X-ray | 2.05 | A/C/E | 1-403 | [»] | |
1OLM | X-ray | 1.95 | A/C/E | 1-403 | [»] | |
4OMJ | X-ray | 1.60 | A/B | 1-275 | [»] | |
4OMK | X-ray | 1.75 | A/B | 1-275 | [»] | |
SMRi | O76054 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117085, 4 interactors |
IntActi | O76054, 2 interactors |
MINTi | O76054 |
STRINGi | 9606.ENSP00000478755 |
Chemistry databases
DrugBanki | DB14003, alpha-Tocopherol acetate DB14001, alpha-Tocopherol succinate DB14002, D-alpha-Tocopherol acetate DB11635, Tocofersolan DB11251, Tocopherol DB00163, Vitamin E |
PTM databases
iPTMneti | O76054 |
MetOSitei | O76054 |
PhosphoSitePlusi | O76054 |
SwissPalmi | O76054 |
Genetic variation databases
BioMutai | SEC14L2 |
Proteomic databases
EPDi | O76054 |
jPOSTi | O76054 |
MassIVEi | O76054 |
MaxQBi | O76054 |
PaxDbi | O76054 |
PeptideAtlasi | O76054 |
PRIDEi | O76054 |
ProteomicsDBi | 26377 50365 [O76054-1] 50366 [O76054-4] |
Protocols and materials databases
Antibodypediai | 10725, 266 antibodies from 24 providers |
DNASUi | 23541 |
Genome annotation databases
Ensembli | ENST00000402592; ENSP00000383882; ENSG00000100003 [O76054-5] ENST00000405717; ENSP00000385186; ENSG00000100003 [O76054-4] ENST00000615189; ENSP00000478755; ENSG00000100003 |
GeneIDi | 23541 |
KEGGi | hsa:23541 |
MANE-Selecti | ENST00000615189.5; ENSP00000478755.1; NM_012429.5; NP_036561.1 |
UCSCi | uc003ahq.5, human [O76054-1] |
Organism-specific databases
CTDi | 23541 |
DisGeNETi | 23541 |
GeneCardsi | SEC14L2 |
HGNCi | HGNC:10699, SEC14L2 |
HPAi | ENSG00000100003, Tissue enhanced (epididymis, liver) |
MIMi | 607558, gene |
neXtProti | NX_O76054 |
OpenTargetsi | ENSG00000100003 |
PharmGKBi | PA35622 |
VEuPathDBi | HostDB:ENSG00000100003 |
HUGEi | Search... Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1471, Eukaryota |
GeneTreei | ENSGT00940000160650 |
HOGENOMi | CLU_014001_2_1_1 |
InParanoidi | O76054 |
OMAi | GLCHCEG |
PhylomeDBi | O76054 |
TreeFami | TF313988 |
Enzyme and pathway databases
PathwayCommonsi | O76054 |
SignaLinki | O76054 |
Miscellaneous databases
BioGRID-ORCSi | 23541, 11 hits in 1042 CRISPR screens |
ChiTaRSi | SEC14L2, human |
EvolutionaryTracei | O76054 |
GeneWikii | SEC14L2 |
GenomeRNAii | 23541 |
Pharosi | O76054, Tbio |
PROi | PR:O76054 |
RNActi | O76054, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100003, Expressed in liver and 167 other tissues |
ExpressionAtlasi | O76054, baseline and differential |
Genevisiblei | O76054, HS |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR011074, CRAL/TRIO_N_dom IPR036273, CRAL/TRIO_N_dom_sf IPR009038, GOLD_dom IPR036598, GOLD_dom_sf |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit |
SMARTi | View protein in SMART SM01100, CRAL_TRIO_N, 1 hit SM00516, SEC14, 1 hit |
SUPFAMi | SSF101576, SSF101576, 1 hit SSF46938, SSF46938, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit PS50866, GOLD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S14L2_HUMAN | |
Accessioni | O76054Primary (citable) accession number: O76054 Secondary accession number(s): B7Z8Q1 Q9ULN4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2002 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 187 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references