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Protein

Natural cytotoxicity triggering receptor 1

Gene

NCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.1 Publication

GO - Biological processi

  • cellular defense response Source: ProtInc
  • natural killer cell activation Source: UniProtKB
  • regulation of immune response Source: Reactome
  • regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Natural cytotoxicity triggering receptor 1
Alternative name(s):
Lymphocyte antigen 94 homolog
NK cell-activating receptor
Natural killer cell p46-related protein
Short name:
NK-p46
Short name:
NKp46
Short name:
hNKp46
CD_antigen: CD335
Gene namesi
Name:NCR1
Synonyms:LY94
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000189430.12
HGNCiHGNC:6731 NCR1
MIMi604530 gene
neXtProtiNX_O76036

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 258ExtracellularSequence analysisAdd BLAST237
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 304CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9437
OpenTargetsiENSG00000189430
PharmGKBiPA30495

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001502722 – 304Natural cytotoxicity triggering receptor 1Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 98Combined sources2 Publications
Disulfide bondi144 ↔ 190Combined sources2 Publications
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication
O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76036
PeptideAtlasiO76036
PRIDEiO76036
ProteomicsDBi50352
50353 [O76036-2]
50354 [O76036-3]
50355 [O76036-4]
50356 [O76036-5]
50357 [O76036-6]

PTM databases

iPTMnetiO76036
PhosphoSitePlusiO76036

Expressioni

Tissue specificityi

Selectively expressed by both resting and activated NK cells.1 Publication

Gene expression databases

BgeeiENSG00000189430 Expressed in 73 organ(s), highest expression level in blood
CleanExiHS_NCR1
ExpressionAtlasiO76036 baseline and differential
GenevisibleiO76036 HS

Organism-specific databases

HPAiHPA049311

Interactioni

Subunit structurei

Interacts with CD247 and FCER1G.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi114828, 5 interactors
IntActiO76036, 8 interactors
STRINGi9606.ENSP00000291890

Structurei

Secondary structure

1304
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO76036
SMRiO76036
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76036

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 118Ig-like 1Add BLAST85
Domaini129 – 211Ig-like 2Add BLAST83

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX2G Eukaryota
ENOG4111ACT LUCA
GeneTreeiENSGT00760000119033
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiO76036
KOiK06741
OrthoDBiEOG091G0JXB
PhylomeDBiO76036
TreeFamiTF336644

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits

Sequences (6+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O76036-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSTLPALLC VGLCLSQRIS AQQQTLPKPF IWAEPHFMVP KEKQVTICCQ
60 70 80 90 100
GNYGAVEYQL HFEGSLFAVD RPKPPERINK VKFYIPDMNS RMAGQYSCIY
110 120 130 140 150
RVGELWSEPS NLLDLVVTEM YDTPTLSVHP GPEVISGEKV TFYCRLDTAT
160 170 180 190 200
SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRC FGSYNNHAWS
210 220 230 240 250
FPSEPVKLLV TGDIENTSLA PEDPTFPADT WGTYLLTTET GLQKDHALWD
260 270 280 290 300
HTAQNLLRMG LAFLVLVALV WFLVEDWLSR KRTRERASRA STWEGRRRLN

TQTL
Note: No experimental confirmation available.
Length:304
Mass (Da):34,481
Last modified:November 1, 1998 - v1
Checksum:iFBCBDE50D2F34CD3
GO
Isoform 2 (identifier: O76036-2) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     228-244: Missing.

Note: No experimental confirmation available.
Show »
Length:287
Mass (Da):32,600
Checksum:i52EB1B062B35C1C4
GO
Isoform 3 (identifier: O76036-3) [UniParc]FASTAAdd to basket
Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     25-119: Missing.

Note: No experimental confirmation available.
Show »
Length:209
Mass (Da):23,505
Checksum:i2C0C8C6AB8B50CF5
GO
Isoform 4 (identifier: O76036-4) [UniParc]FASTAAdd to basket
Also known as: d

The sequence of this isoform differs from the canonical sequence as follows:
     25-119: Missing.
     228-244: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):21,625
Checksum:i172BD05CED2D8D01
GO
Isoform 5 (identifier: O76036-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-118: Missing.

Note: No experimental confirmation available.
Show »
Length:197
Mass (Da):22,220
Checksum:iC509AAB68DB7F731
GO
Isoform 6 (identifier: O76036-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-228: Missing.

Note: No experimental confirmation available.
Show »
Length:303
Mass (Da):34,409
Checksum:i94220C5410D12FE4
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQZ0A0A0A0MQZ0_HUMAN
Natural cytotoxicity triggering rec...
NCR1
304Annotation score:
A0A0A0MTU0A0A0A0MTU0_HUMAN
Natural cytotoxicity triggering rec...
NCR1
303Annotation score:
A0A0A0MR94A0A0A0MR94_HUMAN
Natural cytotoxicity triggering rec...
NCR1
287Annotation score:
M0QYD1M0QYD1_HUMAN
Natural cytotoxicity triggering rec...
NCR1
291Annotation score:
A0A0G2JN91A0A0G2JN91_HUMAN
Natural cytotoxicity triggering rec...
NCR1
292Annotation score:
A0A0G2JM39A0A0G2JM39_HUMAN
Natural cytotoxicity triggering rec...
NCR1
291Annotation score:
A0A0G2JM44A0A0G2JM44_HUMAN
Natural cytotoxicity triggering rec...
NCR1
227Annotation score:
A0A0G2JMJ3A0A0G2JMJ3_HUMAN
Natural cytotoxicity triggering rec...
NCR1
132Annotation score:
A0A0G2JN63A0A0G2JN63_HUMAN
Natural cytotoxicity triggering rec...
NCR1
120Annotation score:
A0A0G2JNH1A0A0G2JNH1_HUMAN
Natural cytotoxicity triggering rec...
NCR1
215Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01863382K → Q. Corresponds to variant dbSNP:rs2278428Ensembl.1
Natural variantiVAR_03552787D → Y in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01040612 – 118Missing in isoform 5. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_01040725 – 119Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_010408228 – 244Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_038384228Missing in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006121 mRNA Translation: CAA06872.1
AJ006122 mRNA Translation: CAA06873.1
AJ006123 mRNA Translation: CAA06874.1
AJ001383 mRNA Translation: CAA04714.1
AY346373 mRNA Translation: AAQ54328.1
CU151839 Genomic DNA No translation available.
CU459006 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72308.1
CH471135 Genomic DNA Translation: EAW72310.1
CH471135 Genomic DNA Translation: EAW72311.1
BC064806 mRNA Translation: AAH64806.1
CCDSiCCDS12911.1 [O76036-1]
CCDS46181.1 [O76036-6]
CCDS46182.1 [O76036-2]
CCDS56103.1 [O76036-3]
RefSeqiNP_001138929.2, NM_001145457.2
NP_001138930.2, NM_001145458.2
NP_001229285.1, NM_001242356.2 [O76036-3]
NP_001229286.1, NM_001242357.2 [O76036-4]
NP_004820.2, NM_004829.6
UniGeneiHs.97084

Genome annotation databases

EnsembliENST00000350790; ENSP00000344358; ENSG00000189430 [O76036-3]
ENST00000357397; ENSP00000349972; ENSG00000189430 [O76036-5]
ENST00000610621; ENSP00000483452; ENSG00000273535 [O76036-1]
ENST00000610753; ENSP00000484377; ENSG00000273535 [O76036-3]
ENST00000611098; ENSP00000479222; ENSG00000275156 [O76036-5]
ENST00000611105; ENSP00000483028; ENSG00000278362 [O76036-3]
ENST00000611942; ENSP00000483723; ENSG00000275156 [O76036-2]
ENST00000612239; ENSP00000481692; ENSG00000275156 [O76036-6]
ENST00000612645; ENSP00000481540; ENSG00000275156 [O76036-3]
ENST00000612896; ENSP00000484520; ENSG00000278362 [O76036-1]
ENST00000613135; ENSP00000480145; ENSG00000278362 [O76036-5]
ENST00000613556; ENSP00000482092; ENSG00000273535 [O76036-5]
ENST00000615622; ENSP00000478507; ENSG00000273535 [O76036-1]
ENST00000617154; ENSP00000481971; ENSG00000275156 [O76036-1]
ENST00000617784; ENSP00000482423; ENSG00000278362 [O76036-1]
ENST00000618973; ENSP00000483611; ENSG00000273535 [O76036-2]
ENST00000619077; ENSP00000484221; ENSG00000273535 [O76036-1]
ENST00000619451; ENSP00000482536; ENSG00000278362 [O76036-6]
ENST00000620296; ENSP00000484067; ENSG00000278362 [O76036-2]
ENST00000621059; ENSP00000484831; ENSG00000278362 [O76036-4]
ENST00000621652; ENSP00000477625; ENSG00000273535 [O76036-4]
ENST00000639155; ENSP00000491020; ENSG00000284113 [O76036-5]
ENST00000640377; ENSP00000491933; ENSG00000284208 [O76036-5]
ENST00000640753; ENSP00000492673; ENSG00000284208 [O76036-3]
ENST00000640987; ENSP00000492426; ENSG00000284113 [O76036-3]
GeneIDi9437
KEGGihsa:9437
UCSCiuc002qid.3 human [O76036-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006121 mRNA Translation: CAA06872.1
AJ006122 mRNA Translation: CAA06873.1
AJ006123 mRNA Translation: CAA06874.1
AJ001383 mRNA Translation: CAA04714.1
AY346373 mRNA Translation: AAQ54328.1
CU151839 Genomic DNA No translation available.
CU459006 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72308.1
CH471135 Genomic DNA Translation: EAW72310.1
CH471135 Genomic DNA Translation: EAW72311.1
BC064806 mRNA Translation: AAH64806.1
CCDSiCCDS12911.1 [O76036-1]
CCDS46181.1 [O76036-6]
CCDS46182.1 [O76036-2]
CCDS56103.1 [O76036-3]
RefSeqiNP_001138929.2, NM_001145457.2
NP_001138930.2, NM_001145458.2
NP_001229285.1, NM_001242356.2 [O76036-3]
NP_001229286.1, NM_001242357.2 [O76036-4]
NP_004820.2, NM_004829.6
UniGeneiHs.97084

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OLLX-ray1.93A25-212[»]
1P6FX-ray2.20A22-263[»]
ProteinModelPortaliO76036
SMRiO76036
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114828, 5 interactors
IntActiO76036, 8 interactors
STRINGi9606.ENSP00000291890

PTM databases

iPTMnetiO76036
PhosphoSitePlusiO76036

Proteomic databases

PaxDbiO76036
PeptideAtlasiO76036
PRIDEiO76036
ProteomicsDBi50352
50353 [O76036-2]
50354 [O76036-3]
50355 [O76036-4]
50356 [O76036-5]
50357 [O76036-6]

Protocols and materials databases

DNASUi9437
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350790; ENSP00000344358; ENSG00000189430 [O76036-3]
ENST00000357397; ENSP00000349972; ENSG00000189430 [O76036-5]
ENST00000610621; ENSP00000483452; ENSG00000273535 [O76036-1]
ENST00000610753; ENSP00000484377; ENSG00000273535 [O76036-3]
ENST00000611098; ENSP00000479222; ENSG00000275156 [O76036-5]
ENST00000611105; ENSP00000483028; ENSG00000278362 [O76036-3]
ENST00000611942; ENSP00000483723; ENSG00000275156 [O76036-2]
ENST00000612239; ENSP00000481692; ENSG00000275156 [O76036-6]
ENST00000612645; ENSP00000481540; ENSG00000275156 [O76036-3]
ENST00000612896; ENSP00000484520; ENSG00000278362 [O76036-1]
ENST00000613135; ENSP00000480145; ENSG00000278362 [O76036-5]
ENST00000613556; ENSP00000482092; ENSG00000273535 [O76036-5]
ENST00000615622; ENSP00000478507; ENSG00000273535 [O76036-1]
ENST00000617154; ENSP00000481971; ENSG00000275156 [O76036-1]
ENST00000617784; ENSP00000482423; ENSG00000278362 [O76036-1]
ENST00000618973; ENSP00000483611; ENSG00000273535 [O76036-2]
ENST00000619077; ENSP00000484221; ENSG00000273535 [O76036-1]
ENST00000619451; ENSP00000482536; ENSG00000278362 [O76036-6]
ENST00000620296; ENSP00000484067; ENSG00000278362 [O76036-2]
ENST00000621059; ENSP00000484831; ENSG00000278362 [O76036-4]
ENST00000621652; ENSP00000477625; ENSG00000273535 [O76036-4]
ENST00000639155; ENSP00000491020; ENSG00000284113 [O76036-5]
ENST00000640377; ENSP00000491933; ENSG00000284208 [O76036-5]
ENST00000640753; ENSP00000492673; ENSG00000284208 [O76036-3]
ENST00000640987; ENSP00000492426; ENSG00000284113 [O76036-3]
GeneIDi9437
KEGGihsa:9437
UCSCiuc002qid.3 human [O76036-1]

Organism-specific databases

CTDi9437
DisGeNETi9437
EuPathDBiHostDB:ENSG00000189430.12
GeneCardsiNCR1
HGNCiHGNC:6731 NCR1
HPAiHPA049311
MIMi604530 gene
neXtProtiNX_O76036
OpenTargetsiENSG00000189430
PharmGKBiPA30495
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX2G Eukaryota
ENOG4111ACT LUCA
GeneTreeiENSGT00760000119033
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiO76036
KOiK06741
OrthoDBiEOG091G0JXB
PhylomeDBiO76036
TreeFamiTF336644

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSiNCR1 human
EvolutionaryTraceiO76036
GeneWikiiNCR1
GenomeRNAii9437
PROiPR:O76036
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189430 Expressed in 73 organ(s), highest expression level in blood
CleanExiHS_NCR1
ExpressionAtlasiO76036 baseline and differential
GenevisibleiO76036 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNCTR1_HUMAN
AccessioniPrimary (citable) accession number: O76036
Secondary accession number(s): B0V3L2
, B0V3L3, B0V3L4, B0V3L5, B8JL03, O76016, O76017, O76018
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: November 1, 1998
Last modified: October 10, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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