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Protein

Annexin A9

Gene

ANXA9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.1 Publication

GO - Molecular functioni

  • acetylcholine receptor activity Source: UniProtKB
  • calcium-dependent phospholipid binding Source: InterPro
  • calcium ion binding Source: InterPro
  • phosphatidylserine binding Source: UniProtKB
  • phospholipid binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A9
Alternative name(s):
Annexin XXXI
Annexin-31
Annexin-9
Pemphaxin
Gene namesi
Name:ANXA9
Synonyms:ANX31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143412.9
HGNCiHGNC:547 ANXA9
MIMi603319 gene
neXtProtiNX_O76027

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi8416
OpenTargetsiENSG00000143412
PharmGKBiPA24837

Polymorphism and mutation databases

BioMutaiANXA9

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675051 – 345Annexin A9Add BLAST345

Proteomic databases

EPDiO76027
MaxQBiO76027
PaxDbiO76027
PeptideAtlasiO76027
PRIDEiO76027
ProteomicsDBi50350

PTM databases

iPTMnetiO76027
PhosphoSitePlusiO76027

Expressioni

Tissue specificityi

Expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000143412 Expressed in 136 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_ANXA9
GenevisibleiO76027 HS

Organism-specific databases

HPAiHPA028404
HPA028698

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPLO604376EBI-720960,EBI-368321

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114002, 5 interactors
IntActiO76027, 3 interactors
MINTiO76027
STRINGi9606.ENSP00000357943

Structurei

3D structure databases

ProteinModelPortaliO76027
SMRiO76027
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 110Annexin 1Add BLAST68
Repeati115 – 182Annexin 2Add BLAST68
Repeati199 – 264Annexin 3Add BLAST66
Repeati272 – 339Annexin 4Add BLAST68

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00900000140975
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiO76027
KOiK17090
OMAiTQRNPEH
OrthoDBiEOG091G0B7B
PhylomeDBiO76027
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR009116 ANX9
PANTHERiPTHR10502:SF122 PTHR10502:SF122, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR01812 ANNEXINXXXI
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 1 hit

Sequencei

Sequence statusi: Complete.

O76027-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVTGGKMAP SLTQEILSHL GLASKTAAWG TLGTLRTFLN FSVDKDAQRL
60 70 80 90 100
LRAITGQGVD RSAIVDVLTN RSREQRQLIS RNFQERTQQD LMKSLQAALS
110 120 130 140 150
GNLERIVMAL LQPTAQFDAQ ELRTALKASD SAVDVAIEIL ATRTPPQLQE
160 170 180 190 200
CLAVYKHNFQ VEAVDDITSE TSGILQDLLL ALAKGGRDSY SGIIDYNLAE
210 220 230 240 250
QDVQALQRAE GPSREETWVP VFTQRNPEHL IRVFDQYQRS TGQELEEAVQ
260 270 280 290 300
NRFHGDAQVA LLGLASVIKN TPLYFADKLH QALQETEPNY QVLIRILISR
310 320 330 340
CETDLLSIRA EFRKKFGKSL YSSLQDAVKG DCQSALLALC RAEDM
Length:345
Mass (Da):38,364
Last modified:March 20, 2007 - v3
Checksum:iDF0FE611CA6D56B9
GO

Sequence cautioni

The sequence AAH05830 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA08933 differs from that shown. Reason: Frameshift at position 7.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04825528A → T. Corresponds to variant dbSNP:rs16832595Ensembl.1
Natural variantiVAR_048256114T → A. Corresponds to variant dbSNP:rs7536645Ensembl.1
Natural variantiVAR_048257119A → T. Corresponds to variant dbSNP:rs16832602Ensembl.1
Natural variantiVAR_022814166D → G3 PublicationsCorresponds to variant dbSNP:rs267733Ensembl.1
Natural variantiVAR_031212225R → Q. Corresponds to variant dbSNP:rs775255778Ensembl.1
Natural variantiVAR_048258232R → Q. Corresponds to variant dbSNP:rs7542365Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009985 mRNA Translation: CAA08933.1 Frameshift.
AF230929 mRNA Translation: AAG16780.1
AL590133 Genomic DNA No translation available.
BC005830 mRNA Translation: AAH05830.2 Different initiation.
CR536481 mRNA Translation: CAG38720.1
CCDSiCCDS975.2
RefSeqiNP_003559.2, NM_003568.2
UniGeneiHs.3346

Genome annotation databases

EnsembliENST00000368947; ENSP00000357943; ENSG00000143412
GeneIDi8416
KEGGihsa:8416
UCSCiuc001ewa.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009985 mRNA Translation: CAA08933.1 Frameshift.
AF230929 mRNA Translation: AAG16780.1
AL590133 Genomic DNA No translation available.
BC005830 mRNA Translation: AAH05830.2 Different initiation.
CR536481 mRNA Translation: CAG38720.1
CCDSiCCDS975.2
RefSeqiNP_003559.2, NM_003568.2
UniGeneiHs.3346

3D structure databases

ProteinModelPortaliO76027
SMRiO76027
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114002, 5 interactors
IntActiO76027, 3 interactors
MINTiO76027
STRINGi9606.ENSP00000357943

PTM databases

iPTMnetiO76027
PhosphoSitePlusiO76027

Polymorphism and mutation databases

BioMutaiANXA9

Proteomic databases

EPDiO76027
MaxQBiO76027
PaxDbiO76027
PeptideAtlasiO76027
PRIDEiO76027
ProteomicsDBi50350

Protocols and materials databases

DNASUi8416
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368947; ENSP00000357943; ENSG00000143412
GeneIDi8416
KEGGihsa:8416
UCSCiuc001ewa.3 human

Organism-specific databases

CTDi8416
DisGeNETi8416
EuPathDBiHostDB:ENSG00000143412.9
GeneCardsiANXA9
HGNCiHGNC:547 ANXA9
HPAiHPA028404
HPA028698
MIMi603319 gene
neXtProtiNX_O76027
OpenTargetsiENSG00000143412
PharmGKBiPA24837
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00900000140975
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiO76027
KOiK17090
OMAiTQRNPEH
OrthoDBiEOG091G0B7B
PhylomeDBiO76027
TreeFamiTF105452

Miscellaneous databases

ChiTaRSiANXA9 human
GeneWikiiANXA9
GenomeRNAii8416
PROiPR:O76027
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143412 Expressed in 136 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_ANXA9
GenevisibleiO76027 HS

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR009116 ANX9
PANTHERiPTHR10502:SF122 PTHR10502:SF122, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR01812 ANNEXINXXXI
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiANXA9_HUMAN
AccessioniPrimary (citable) accession number: O76027
Secondary accession number(s): Q5SZF1
, Q6FI55, Q9BS00, Q9HBJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: March 20, 2007
Last modified: September 12, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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