ANXA9

Functionⁱ

Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.1 Publication

GO - Molecular functionⁱ

acetylcholine receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10899159
calcium-dependent phospholipid binding Source: InterPro
calcium ion binding Source: InterPro
phosphatidylserine binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12832069
phospholipid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10899159
protein homodimerization activity
Source: UniProtKB
Traceable author statementⁱ
- 10899159

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell-cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 10899159

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Annexin A9 Alternative name(s): Annexin XXXI Annexin-31 Annexin-9 Pemphaxin
Gene namesⁱ	Name:ANXA9 Synonyms:ANX31
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143412.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:547 ANXA9
MIMⁱ	603319 gene
neXtProtⁱ	NX_O76027

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8416
Open Targets More...OpenTargetsⁱ	ENSG00000143412
PharmGKBⁱ	PA24837

Polymorphism and mutation databases

BioMutaⁱ	ANXA9

BioMutaⁱ

ANXA9

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000067505	1 – 345	Annexin A9Add BLAST		345

Proteomic databases

EPDⁱ	O76027
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O76027
PaxDbⁱ	O76027
PeptideAtlas More...PeptideAtlasⁱ	O76027
PRIDEⁱ	O76027
ProteomicsDBⁱ	50350

PTM databases

iPTMnetⁱ	O76027
PhosphoSitePlusⁱ	O76027

Expressionⁱ

Tissue specificityⁱ

Expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000143412 Expressed in 136 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_ANXA9
Genevisibleⁱ	O76027 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028404 HPA028698

HPAⁱ

HPA028404
HPA028698

Interactionⁱ

Subunit structureⁱ

Homodimer.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PPL	O60437	6	EBI-720960,EBI-368321

With

Entry

#Exp.

IntAct

Notes

PPL

O60437

6

EBI-720960,EBI-368321

GO - Molecular functionⁱ

protein homodimerization activity
Source: UniProtKB
Traceable author statementⁱ
- 10899159

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114002, 5 interactors
IntActⁱ	O76027, 3 interactors
Molecular INTeraction database More...MINTⁱ	O76027
STRINGⁱ	9606.ENSP00000357943

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O76027
SMRⁱ	O76027
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	43 – 110	Annexin 1Add BLAST	68
Repeatⁱ	115 – 182	Annexin 2Add BLAST	68
Repeatⁱ	199 – 264	Annexin 3Add BLAST	66
Repeatⁱ	272 – 339	Annexin 4Add BLAST	68

Sequence similaritiesⁱ

Belongs to the annexin family.Curated

Keywords - Domainⁱ

Annexin, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0819 Eukaryota ENOG410XPUN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140975
HOGENOMⁱ	HOG000158803
HOVERGENⁱ	HBG061815
InParanoidⁱ	O76027
KEGG Orthology (KO) More...KOⁱ	K17090
OMAⁱ	TQRNPEH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B7B
PhylomeDBⁱ	O76027
TreeFamⁱ	TF105452

Family and domain databases

Gene3Dⁱ	1.10.220.10, 4 hits
InterProⁱ	View protein in InterPro IPR001464 Annexin IPR018502 Annexin_repeat IPR018252 Annexin_repeat_CS IPR037104 Annexin_sf IPR009116 ANX9
PANTHERⁱ	PTHR10502:SF122 PTHR10502:SF122, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00191 Annexin, 4 hits
PRINTSⁱ	PR00196 ANNEXIN PR01812 ANNEXINXXXI
SMARTⁱ	View protein in SMART SM00335 ANX, 4 hits
PROSITEⁱ	View protein in PROSITE PS00223 ANNEXIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O76027-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSVTGGKMAP SLTQEILSHL GLASKTAAWG TLGTLRTFLN FSVDKDAQRL 
        60         70         80         90        100
LRAITGQGVD RSAIVDVLTN RSREQRQLIS RNFQERTQQD LMKSLQAALS 
       110        120        130        140        150
GNLERIVMAL LQPTAQFDAQ ELRTALKASD SAVDVAIEIL ATRTPPQLQE 
       160        170        180        190        200
CLAVYKHNFQ VEAVDDITSE TSGILQDLLL ALAKGGRDSY SGIIDYNLAE 
       210        220        230        240        250
QDVQALQRAE GPSREETWVP VFTQRNPEHL IRVFDQYQRS TGQELEEAVQ 
       260        270        280        290        300
NRFHGDAQVA LLGLASVIKN TPLYFADKLH QALQETEPNY QVLIRILISR 
       310        320        330        340 
CETDLLSIRA EFRKKFGKSL YSSLQDAVKG DCQSALLALC RAEDM

Length:345

Mass (Da):38,364

Last modified:March 20, 2007 - v3

Checksum:ⁱDF0FE611CA6D56B9

GO

Sequence cautionⁱ

The sequence AAH05830 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAA08933 differs from that shown. Reason: Frameshift at position 7.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_048255	28	A → T. Corresponds to variant dbSNP:rs16832595Ensembl.	1
Natural variantⁱVAR_048256	114	T → A. Corresponds to variant dbSNP:rs7536645Ensembl.	1
Natural variantⁱVAR_048257	119	A → T. Corresponds to variant dbSNP:rs16832602Ensembl.	1
Natural variantⁱVAR_022814	166	D → G3 PublicationsCorresponds to variant dbSNP:rs267733Ensembl.	1
Natural variantⁱVAR_031212	225	R → Q. Corresponds to variant dbSNP:rs775255778Ensembl.	1
Natural variantⁱVAR_048258	232	R → Q. Corresponds to variant dbSNP:rs7542365Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ009985 mRNA Translation: CAA08933.1 Frameshift. AF230929 mRNA Translation: AAG16780.1 AL590133 Genomic DNA No translation available. BC005830 mRNA Translation: AAH05830.2 Different initiation. CR536481 mRNA Translation: CAG38720.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS975.2
NCBI Reference Sequences More...RefSeqⁱ	NP_003559.2, NM_003568.2
UniGeneⁱ	Hs.3346

Genome annotation databases

Ensemblⁱ	ENST00000368947; ENSP00000357943; ENSG00000143412
GeneIDⁱ	8416
KEGGⁱ	hsa:8416
UCSC genome browser More...UCSCⁱ	uc001ewa.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O76027	Annexin		PANTR		345	UniRef90_O76027
Annexin		PANPA		345
Annexin		GORGO		345
Annexin		RHIBE		345
Annexin		PONAB		345
+6

Protein	Similar proteins		Species	Score	Length	Source
O76027	Annexin		GORGO		345	UniRef50_O76027
Annexin		PANTR		345
Annexin		RHIBE		345
Annexin		PONAB		345
Annexin		PANPA		345
+35

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ009985 mRNA Translation: CAA08933.1 Frameshift. AF230929 mRNA Translation: AAG16780.1 AL590133 Genomic DNA No translation available. BC005830 mRNA Translation: AAH05830.2 Different initiation. CR536481 mRNA Translation: CAG38720.1
CCDSⁱ	CCDS975.2
RefSeqⁱ	NP_003559.2, NM_003568.2
UniGeneⁱ	Hs.3346

3D structure databases

ProteinModelPortalⁱ	O76027
SMRⁱ	O76027
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114002, 5 interactors
IntActⁱ	O76027, 3 interactors
MINTⁱ	O76027
STRINGⁱ	9606.ENSP00000357943

PTM databases

iPTMnetⁱ	O76027
PhosphoSitePlusⁱ	O76027

Polymorphism and mutation databases

BioMutaⁱ	ANXA9

BioMutaⁱ

ANXA9

Proteomic databases

EPDⁱ	O76027
MaxQBⁱ	O76027
PaxDbⁱ	O76027
PeptideAtlasⁱ	O76027
PRIDEⁱ	O76027
ProteomicsDBⁱ	50350

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8416
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368947; ENSP00000357943; ENSG00000143412
GeneIDⁱ	8416
KEGGⁱ	hsa:8416
UCSCⁱ	uc001ewa.3 human

Organism-specific databases

CTDⁱ	8416
DisGeNETⁱ	8416
EuPathDBⁱ	HostDB:ENSG00000143412.9
GeneCardsⁱ	ANXA9
HGNCⁱ	HGNC:547 ANXA9
HPAⁱ	HPA028404 HPA028698
MIMⁱ	603319 gene
neXtProtⁱ	NX_O76027
OpenTargetsⁱ	ENSG00000143412
PharmGKBⁱ	PA24837
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0819 Eukaryota ENOG410XPUN LUCA
GeneTreeⁱ	ENSGT00900000140975
HOGENOMⁱ	HOG000158803
HOVERGENⁱ	HBG061815
InParanoidⁱ	O76027
KOⁱ	K17090
OMAⁱ	TQRNPEH
OrthoDBⁱ	EOG091G0B7B
PhylomeDBⁱ	O76027
TreeFamⁱ	TF105452

Miscellaneous databases

ChiTaRSⁱ	ANXA9 human
GeneWikiⁱ	ANXA9
GenomeRNAiⁱ	8416
Protein Ontology More...PROⁱ	PR:O76027
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143412 Expressed in 136 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_ANXA9
Genevisibleⁱ	O76027 HS

Family and domain databases

Gene3Dⁱ	1.10.220.10, 4 hits
InterProⁱ	View protein in InterPro IPR001464 Annexin IPR018502 Annexin_repeat IPR018252 Annexin_repeat_CS IPR037104 Annexin_sf IPR009116 ANX9
PANTHERⁱ	PTHR10502:SF122 PTHR10502:SF122, 1 hit
Pfamⁱ	View protein in Pfam PF00191 Annexin, 4 hits
PRINTSⁱ	PR00196 ANNEXIN PR01812 ANNEXINXXXI
SMARTⁱ	View protein in SMART SM00335 ANX, 4 hits
PROSITEⁱ	View protein in PROSITE PS00223 ANNEXIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ANXA9_HUMAN
Accessionⁱ	O76027Primary (citable) accession number: O76027 Secondary accession number(s): Q5SZF1 , Q6FI55, Q9BS00, Q9HBJ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	March 20, 2007
	Last modified:	September 12, 2018
	This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O76027 (ANXA9_HUMAN)

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Annexin A9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ