UniProtKB - O76027 (ANXA9_HUMAN)
Protein
Annexin A9
Gene
ANXA9
Organism
Homo sapiens (Human)
Status
Functioni
Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.1 Publication
GO - Molecular functioni
- acetylcholine receptor activity Source: UniProtKB
- calcium channel activity Source: GO_Central
- calcium-dependent phospholipid binding Source: GO_Central
- calcium ion binding Source: GO_Central
- phosphatidylinositol-4,5-bisphosphate binding Source: GO_Central
- phosphatidylserine binding Source: UniProtKB
- phospholipase A2 inhibitor activity Source: GO_Central
- phospholipid binding Source: UniProtKB
- protease binding Source: GO_Central
- Rab GTPase binding Source: GO_Central
- virion binding Source: GO_Central
GO - Biological processi
- cell-cell adhesion Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | O76027 |
Names & Taxonomyi
Protein namesi | Recommended name: Annexin A9Alternative name(s): Annexin XXXI Annexin-31 Annexin-9 Pemphaxin |
Gene namesi | Name:ANXA9 Synonyms:ANX31 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000143412.9 |
HGNCi | HGNC:547, ANXA9 |
MIMi | 603319, gene |
neXtProti | NX_O76027 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular space Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell surface Source: UniProtKB
- cytoplasm Source: GO_Central
- synapse Source: GOC
- vesicle Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 8416 |
OpenTargetsi | ENSG00000143412 |
PharmGKBi | PA24837 |
Miscellaneous databases
Pharosi | O76027, Tbio |
Polymorphism and mutation databases
BioMutai | ANXA9 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067505 | 1 – 345 | Annexin A9Add BLAST | 345 |
Proteomic databases
EPDi | O76027 |
jPOSTi | O76027 |
MassIVEi | O76027 |
MaxQBi | O76027 |
PaxDbi | O76027 |
PeptideAtlasi | O76027 |
PRIDEi | O76027 |
ProteomicsDBi | 50350 |
PTM databases
iPTMneti | O76027 |
PhosphoSitePlusi | O76027 |
Expressioni
Tissue specificityi
Expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000143412, Expressed in lower esophagus mucosa and 159 other tissues |
Genevisiblei | O76027, HS |
Organism-specific databases
HPAi | ENSG00000143412, Tissue enhanced (ductus deferens, seminal vesicle) |
Interactioni
Subunit structurei
Homodimer.
1 PublicationBinary interactionsi
O76027
With | #Exp. | IntAct |
---|---|---|
PPL [O60437] | 6 | EBI-720960,EBI-368321 |
GO - Molecular functioni
- protease binding Source: GO_Central
- Rab GTPase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114002, 6 interactors |
IntActi | O76027, 4 interactors |
MINTi | O76027 |
STRINGi | 9606.ENSP00000357943 |
Miscellaneous databases
RNActi | O76027, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 41 – 112 | Annexin 1PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 113 – 184 | Annexin 2PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 197 – 266 | Annexin 3PROSITE-ProRule annotationAdd BLAST | 70 | |
Repeati | 270 – 341 | Annexin 4PROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Keywords - Domaini
Annexin, RepeatPhylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000161835 |
HOGENOMi | CLU_025300_0_0_1 |
InParanoidi | O76027 |
OMAi | VYKHNFQ |
OrthoDBi | 856254at2759 |
PhylomeDBi | O76027 |
TreeFami | TF105452 |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR009116, ANX9 |
PANTHERi | PTHR10502:SF122, PTHR10502:SF122, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR01812, ANNEXINXXXI |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 1 hit PS51897, ANNEXIN_2, 4 hits |
i Sequence
Sequence statusi: Complete.
O76027-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVTGGKMAP SLTQEILSHL GLASKTAAWG TLGTLRTFLN FSVDKDAQRL
60 70 80 90 100
LRAITGQGVD RSAIVDVLTN RSREQRQLIS RNFQERTQQD LMKSLQAALS
110 120 130 140 150
GNLERIVMAL LQPTAQFDAQ ELRTALKASD SAVDVAIEIL ATRTPPQLQE
160 170 180 190 200
CLAVYKHNFQ VEAVDDITSE TSGILQDLLL ALAKGGRDSY SGIIDYNLAE
210 220 230 240 250
QDVQALQRAE GPSREETWVP VFTQRNPEHL IRVFDQYQRS TGQELEEAVQ
260 270 280 290 300
NRFHGDAQVA LLGLASVIKN TPLYFADKLH QALQETEPNY QVLIRILISR
310 320 330 340
CETDLLSIRA EFRKKFGKSL YSSLQDAVKG DCQSALLALC RAEDM
Sequence cautioni
The sequence AAH05830 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA08933 differs from that shown. Reason: Frameshift.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048255 | 28 | A → T. Corresponds to variant dbSNP:rs16832595Ensembl. | 1 | |
Natural variantiVAR_048256 | 114 | T → A. Corresponds to variant dbSNP:rs7536645Ensembl. | 1 | |
Natural variantiVAR_048257 | 119 | A → T. Corresponds to variant dbSNP:rs16832602Ensembl. | 1 | |
Natural variantiVAR_022814 | 166 | D → G3 PublicationsCorresponds to variant dbSNP:rs267733Ensembl. | 1 | |
Natural variantiVAR_031212 | 225 | R → Q. Corresponds to variant dbSNP:rs775255778Ensembl. | 1 | |
Natural variantiVAR_048258 | 232 | R → Q. Corresponds to variant dbSNP:rs7542365Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ009985 mRNA Translation: CAA08933.1 Frameshift. AF230929 mRNA Translation: AAG16780.1 AL590133 Genomic DNA No translation available. BC005830 mRNA Translation: AAH05830.2 Different initiation. CR536481 mRNA Translation: CAG38720.1 |
CCDSi | CCDS975.2 |
RefSeqi | NP_003559.2, NM_003568.2 |
Genome annotation databases
Ensembli | ENST00000368947; ENSP00000357943; ENSG00000143412 |
GeneIDi | 8416 |
KEGGi | hsa:8416 |
UCSCi | uc001ewa.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ009985 mRNA Translation: CAA08933.1 Frameshift. AF230929 mRNA Translation: AAG16780.1 AL590133 Genomic DNA No translation available. BC005830 mRNA Translation: AAH05830.2 Different initiation. CR536481 mRNA Translation: CAG38720.1 |
CCDSi | CCDS975.2 |
RefSeqi | NP_003559.2, NM_003568.2 |
3D structure databases
SMRi | O76027 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114002, 6 interactors |
IntActi | O76027, 4 interactors |
MINTi | O76027 |
STRINGi | 9606.ENSP00000357943 |
PTM databases
iPTMneti | O76027 |
PhosphoSitePlusi | O76027 |
Polymorphism and mutation databases
BioMutai | ANXA9 |
Proteomic databases
EPDi | O76027 |
jPOSTi | O76027 |
MassIVEi | O76027 |
MaxQBi | O76027 |
PaxDbi | O76027 |
PeptideAtlasi | O76027 |
PRIDEi | O76027 |
ProteomicsDBi | 50350 |
Protocols and materials databases
Antibodypediai | 34042, 204 antibodies |
DNASUi | 8416 |
Genome annotation databases
Ensembli | ENST00000368947; ENSP00000357943; ENSG00000143412 |
GeneIDi | 8416 |
KEGGi | hsa:8416 |
UCSCi | uc001ewa.3, human |
Organism-specific databases
CTDi | 8416 |
DisGeNETi | 8416 |
EuPathDBi | HostDB:ENSG00000143412.9 |
GeneCardsi | ANXA9 |
HGNCi | HGNC:547, ANXA9 |
HPAi | ENSG00000143412, Tissue enhanced (ductus deferens, seminal vesicle) |
MIMi | 603319, gene |
neXtProti | NX_O76027 |
OpenTargetsi | ENSG00000143412 |
PharmGKBi | PA24837 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000161835 |
HOGENOMi | CLU_025300_0_0_1 |
InParanoidi | O76027 |
OMAi | VYKHNFQ |
OrthoDBi | 856254at2759 |
PhylomeDBi | O76027 |
TreeFami | TF105452 |
Enzyme and pathway databases
PathwayCommonsi | O76027 |
Miscellaneous databases
BioGRID-ORCSi | 8416, 7 hits in 842 CRISPR screens |
ChiTaRSi | ANXA9, human |
GeneWikii | ANXA9 |
GenomeRNAii | 8416 |
Pharosi | O76027, Tbio |
PROi | PR:O76027 |
RNActi | O76027, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143412, Expressed in lower esophagus mucosa and 159 other tissues |
Genevisiblei | O76027, HS |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR009116, ANX9 |
PANTHERi | PTHR10502:SF122, PTHR10502:SF122, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR01812, ANNEXINXXXI |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 1 hit PS51897, ANNEXIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANXA9_HUMAN | |
Accessioni | O76027Primary (citable) accession number: O76027 Secondary accession number(s): Q5SZF1 Q9HBJ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | March 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations