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Protein

Ribosomal L1 domain-containing protein 1

Gene

RSL1D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.2 Publications

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • mRNA 3'-UTR binding Source: CAFA
  • mRNA 5'-UTR binding Source: CAFA
  • RNA binding Source: UniProtKB

GO - Biological processi

  • maturation of LSU-rRNA Source: GO_Central
  • osteoblast differentiation Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • regulation of cellular senescence Source: UniProtKB
  • regulation of protein localization Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal L1 domain-containing protein 1
Alternative name(s):
CATX-11
Cellular senescence-inhibited gene protein1 Publication
Protein PBK1
Gene namesi
Name:RSL1D1
Synonyms:CATX11, CSIG1 Publication, PBK1
ORF Names:L12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000171490.12
HGNCiHGNC:24534 RSL1D1
MIMi615874 gene
neXtProtiNX_O76021

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26156
OpenTargetsiENSG00000171490
PharmGKBiPA142670966

Chemistry databases

ChEMBLiCHEMBL1075139

Polymorphism and mutation databases

BioMutaiRSL1D1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001258441 – 490Ribosomal L1 domain-containing protein 1Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Cross-linki120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei340PhosphothreonineCombined sources1
Modified residuei358PhosphothreonineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei375PhosphothreonineCombined sources1
Cross-linki380Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei392PhosphoserineCombined sources1
Modified residuei396PhosphoserineCombined sources1
Modified residuei415PhosphothreonineCombined sources1
Modified residuei423PhosphothreonineCombined sources1
Modified residuei427PhosphoserineCombined sources1
Cross-linki435Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei443PhosphoserineCombined sources1
Cross-linki461Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei465PhosphothreonineCombined sources1
Modified residuei468N6-acetyllysineCombined sources1
Modified residuei469PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO76021
MaxQBiO76021
PaxDbiO76021
PeptideAtlasiO76021
PRIDEiO76021
ProteomicsDBi50348

2D gel databases

SWISS-2DPAGEiO76021

PTM databases

iPTMnetiO76021
PhosphoSitePlusiO76021
SwissPalmiO76021

Expressioni

Tissue specificityi

Expressed at high intensities in the heart, skeletal muscle, and placenta.2 Publications

Inductioni

Down-regulated during cellular senescence.1 Publication

Gene expression databases

BgeeiENSG00000171490 Expressed in 237 organ(s), highest expression level in intestine
CleanExiHS_RSL1D1
ExpressionAtlasiO76021 baseline and differential
GenevisibleiO76021 HS

Organism-specific databases

HPAiHPA043483

Interactioni

Subunit structurei

Interacts with ING1 (isoform 2).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117587, 93 interactors
CORUMiO76021
IntActiO76021, 49 interactors
MINTiO76021
STRINGi9606.ENSP00000460871

Structurei

3D structure databases

ProteinModelPortaliO76021
SMRiO76021
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili280 – 313Sequence analysisAdd BLAST34

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1685 Eukaryota
ENOG4111W39 LUCA
GeneTreeiENSGT00440000038603
HOVERGENiHBG054786
InParanoidiO76021
KOiK14775
OMAiNENFFLM
OrthoDBiEOG091G0MY8
PhylomeDBiO76021
TreeFamiTF354254

Family and domain databases

CDDicd00403 Ribosomal_L1, 1 hit
Gene3Di3.40.50.790, 1 hit
InterProiView protein in InterPro
IPR023674 Ribosomal_L1-like
IPR028364 Ribosomal_L1/biogenesis
IPR016095 Ribosomal_L1_3-a/b-sand
PfamiView protein in Pfam
PF00687 Ribosomal_L1, 1 hit
SUPFAMiSSF56808 SSF56808, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O76021-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDSASASLS SAAATGTSTS TPAAPTARKQ LDKEQVRKAV DALLTHCKSR
60 70 80 90 100
KNNYGLLLNE NESLFLMVVL WKIPSKELRV RLTLPHSIRS DSEDICLFTK
110 120 130 140 150
DEPNSTPEKT EQFYRKLLNK HGIKTVSQII SLQTLKKEYK SYEAKLRLLS
160 170 180 190 200
SFDFFLTDAR IRRLLPSLIG RHFYQRKKVP VSVNLLSKNL SREINDCIGG
210 220 230 240 250
TVLNISKSGS CSAIRIGHVG MQIEHIIENI VAVTKGLSEK LPEKWESVKL
260 270 280 290 300
LFVKTEKSAA LPIFSSFVSN WDEATKRSLL NKKKKEARRK RRERNFEKQK
310 320 330 340 350
ERKKKRQQAR KTASVLSKDD VAPESGDTTV KKPESKKEQT PEHGKKKRGR
360 370 380 390 400
GKAQVKATNE SEDEIPQLVP IGKKTPANEK VEIQKHATGK KSPAKSPNPS
410 420 430 440 450
TPRGKKRKAL PASETPKAAE SETPGKSPEK KPKIKEEAVK EKSPSLGKKD
460 470 480 490
ARQTPKKPEA KFFTTPSKSV RKASHTPKKW PKKPKVPQST
Length:490
Mass (Da):54,973
Last modified:April 26, 2005 - v3
Checksum:i5E5CDB8AA8BC3709
GO
Isoform 2 (identifier: O76021-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-220: Missing.

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):30,354
Checksum:i83491FBC2D92689C
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QSV6J3QSV6_HUMAN
Ribosomal L1 domain-containing prot...
RSL1D1
430Annotation score:
I3L3U9I3L3U9_HUMAN
Ribosomal L1 domain-containing prot...
RSL1D1
296Annotation score:
I3L3C4I3L3C4_HUMAN
Ribosomal L1 domain-containing prot...
RSL1D1
158Annotation score:
I3L234I3L234_HUMAN
Ribosomal L1 domain-containing prot...
RSL1D1
98Annotation score:
I3L1Y4I3L1Y4_HUMAN
Ribosomal L1 domain-containing prot...
RSL1D1
47Annotation score:
I3L1A3I3L1A3_HUMAN
Ribosomal L1 domain-containing prot...
RSL1D1
93Annotation score:
I3L4T8I3L4T8_HUMAN
Ribosomal L1 domain-containing prot...
RSL1D1
46Annotation score:
J3KPU7J3KPU7_HUMAN
Ribosomal L1 domain-containing prot...
RSL1D1
39Annotation score:
I3L2F2I3L2F2_HUMAN
Ribosomal L1 domain-containing prot...
RSL1D1
43Annotation score:

Sequence cautioni

The sequence AAF98239 differs from that shown. Reason: Frameshift at position 394.Curated
The sequence AAH19069 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA07491 differs from that shown. Reason: Frameshift at position 486.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50R → G in AAN46298 (Ref. 3) Curated1
Sequence conflicti189N → D in CAB43231 (PubMed:17974005).Curated1
Sequence conflicti294R → G in AAN46298 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561431 – 220Missing in isoform 2. 1 PublicationAdd BLAST220

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007398 mRNA Translation: CAA07491.1 Frameshift.
AY598331 mRNA Translation: AAT06742.1
AY154473 mRNA Translation: AAN46298.1
AK295935 mRNA Translation: BAG58720.1
AC010654 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85133.1
CH471112 Genomic DNA Translation: EAW85135.1
BC019069 mRNA Translation: AAH19069.2 Different initiation.
BC112228 mRNA Translation: AAI12229.1
BC113699 mRNA Translation: AAI13700.1
AL049999 mRNA Translation: CAB43231.2
AF083127 mRNA Translation: AAF98239.1 Frameshift.
CCDSiCCDS10551.1 [O76021-1]
PIRiT08693
RefSeqiNP_056474.2, NM_015659.2 [O76021-1]
UniGeneiHs.401842

Genome annotation databases

EnsembliENST00000571133; ENSP00000460871; ENSG00000171490 [O76021-1]
GeneIDi26156
KEGGihsa:26156
UCSCiuc002dbp.3 human [O76021-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007398 mRNA Translation: CAA07491.1 Frameshift.
AY598331 mRNA Translation: AAT06742.1
AY154473 mRNA Translation: AAN46298.1
AK295935 mRNA Translation: BAG58720.1
AC010654 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85133.1
CH471112 Genomic DNA Translation: EAW85135.1
BC019069 mRNA Translation: AAH19069.2 Different initiation.
BC112228 mRNA Translation: AAI12229.1
BC113699 mRNA Translation: AAI13700.1
AL049999 mRNA Translation: CAB43231.2
AF083127 mRNA Translation: AAF98239.1 Frameshift.
CCDSiCCDS10551.1 [O76021-1]
PIRiT08693
RefSeqiNP_056474.2, NM_015659.2 [O76021-1]
UniGeneiHs.401842

3D structure databases

ProteinModelPortaliO76021
SMRiO76021
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117587, 93 interactors
CORUMiO76021
IntActiO76021, 49 interactors
MINTiO76021
STRINGi9606.ENSP00000460871

Chemistry databases

ChEMBLiCHEMBL1075139

PTM databases

iPTMnetiO76021
PhosphoSitePlusiO76021
SwissPalmiO76021

Polymorphism and mutation databases

BioMutaiRSL1D1

2D gel databases

SWISS-2DPAGEiO76021

Proteomic databases

EPDiO76021
MaxQBiO76021
PaxDbiO76021
PeptideAtlasiO76021
PRIDEiO76021
ProteomicsDBi50348

Protocols and materials databases

DNASUi26156
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000571133; ENSP00000460871; ENSG00000171490 [O76021-1]
GeneIDi26156
KEGGihsa:26156
UCSCiuc002dbp.3 human [O76021-1]

Organism-specific databases

CTDi26156
DisGeNETi26156
EuPathDBiHostDB:ENSG00000171490.12
GeneCardsiRSL1D1
HGNCiHGNC:24534 RSL1D1
HPAiHPA043483
MIMi615874 gene
neXtProtiNX_O76021
OpenTargetsiENSG00000171490
PharmGKBiPA142670966
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1685 Eukaryota
ENOG4111W39 LUCA
GeneTreeiENSGT00440000038603
HOVERGENiHBG054786
InParanoidiO76021
KOiK14775
OMAiNENFFLM
OrthoDBiEOG091G0MY8
PhylomeDBiO76021
TreeFamiTF354254

Miscellaneous databases

ChiTaRSiRSL1D1 human
GeneWikiiRSL1D1
GenomeRNAii26156
PROiPR:O76021
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171490 Expressed in 237 organ(s), highest expression level in intestine
CleanExiHS_RSL1D1
ExpressionAtlasiO76021 baseline and differential
GenevisibleiO76021 HS

Family and domain databases

CDDicd00403 Ribosomal_L1, 1 hit
Gene3Di3.40.50.790, 1 hit
InterProiView protein in InterPro
IPR023674 Ribosomal_L1-like
IPR028364 Ribosomal_L1/biogenesis
IPR016095 Ribosomal_L1_3-a/b-sand
PfamiView protein in Pfam
PF00687 Ribosomal_L1, 1 hit
SUPFAMiSSF56808 SSF56808, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL1D1_HUMAN
AccessioniPrimary (citable) accession number: O76021
Secondary accession number(s): B4DJ58
, D3DUG7, Q2M1T7, Q6PL22, Q8IWS7, Q8WUZ1, Q9HDA9, Q9Y3Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 7, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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